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检索条件"主题词=Bnip3"
514 条 记 录,以下是141-150 订阅
排序:
Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and bnip3-mediated mitophagy
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REDOX BIOLOGY 2018年 18卷 229-243页
作者: Li, Ruibing Xin, Ting Li, Dandan Wang, Chengbin Zhu, Hang Zhou, Hao Chinese Peoples Liberat Army Gen Hosp Med Sch Chinese PLA Beijing Peoples R China Tianjin First Cent Hosp Dept Cardiol Tianjin 300192 Peoples R China Wyoming Univ Ctr Cardiovasc Res & Alternat Med Laramie WY 82071 USA
Increased mitochondrial damage is related to the progression of a diet-induced nonalcoholic fatty liver disease. The aim of our study is to investigate the role of Sirtuin 3 (Sirt3) in treating nonalcoholic fatty live... 详细信息
来源: 评论
The interplay between epigenetic silencing, oncogenic KRas and HIF-1 regulatory pathways in control of bnip3 expression in human colorectal cancer cells
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2013年 第4期441卷 707-712页
作者: Swiderek, Ewelina Kalas, Wojciech Wysokinska, Edyta Pawlak, Alicja Rak, Janusz Strzadala, Leon Polish Acad Sci Ludwik Hirszfeld Inst Immunol & Expt Therapy Wroclaw Poland McGill Univ Montreal Childrens Hosp Res Inst Montreal PQ H3A 2T5 Canada
Bcl-2/adenovirus E1B-19 kDa-interacting protein 3 (bnip3) is an important mediator of cell survival and a member of the Bcl-2 family of proteins that regulate programmed cell death and autophagy. We have previously es... 详细信息
来源: 评论
Expression of bnip3 and its correlations to hypoxia-induced autophagy and clinicopathological features in salivary adenoid cystic carcinoma
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CANCER BIOMARKERS 2015年 第4期15卷 467-475页
作者: Chen, Zhanwei Wu, Haiwei Huang, Shengyun Li, Wengang Zhang, Shizhou Zheng, Peihui Zhou, Xiaoqing Liu, Wenlei Zhang, Dongsheng Shandong Univ Shandong Prov Hosp Dept Oral & Maxillofacial Surg Jinan 250021 Shandong Peoples R China
BACKGROUND: The expression of Bcl-2/adenovirus E1B 19 kDa-interacting protein3 (bnip3) has been explored in many human malignancies, but not in adenoid cystic carcinoma (ACC). OBJECTIVE: This study investigated the cl... 详细信息
来源: 评论
Popdc1/Bves Functions in the Preservation of Cardiomyocyte Viability While Affecting Rac1 Activity and bnip3 Expression
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JOURNAL OF CELLULAR BIOCHEMISTRY 2017年 第6期118卷 1505-1517页
作者: Kliminski, Vitaly Uziel, Orit Kessler-Icekson, Gania Tel Aviv Univ Sackler Fac Med Felsenstein Med Res Ctr Tel Aviv Israel Tel Aviv Univ Rabin Med Ctr Tel Aviv Israel
The Popeye domain containing1, also called Bves (Popdc1/Bves), is a transmembrane protein that functions in muscle regeneration, heart rate regulation, hypoxia tolerance, and ischemia preconditioning. The expression o... 详细信息
来源: 评论
Cobaltosic oxide-polyethylene glycol-triphenylphosphine nanoparticles ameliorate the acute-to-chronic kidney disease transition by inducing bnip3-mediated mitophagy
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KIDNEY INTERNATIONAL 2023年 第5期103卷 903-916页
作者: Qin, Shaozong Liu, Chi Chen, Yin Yao, Mengying Liao, Shuyi Xin, Wang Gong, Shuiqin Guan, Xu Li, Yan Xiong, Jiachuan Chen, Jing Shen, Yunzhu Liu, Yong Zhao, Jinghong Huang, Yinghui Army Med Univ Mil Med Univ 3 Xinqiao Hosp Chongqing Clin Res Ctr Kidney & Urol DisDept Neph Chongqing Peoples R China Army Med Univ Mil Med Univ 3 Inst Combined Injury Coll Prevent MedChongqing Engn Res Ctr NanomedSt Chongqing Peoples R China Army Med Univ Mil Med Univ 3 Xinqiao Hosp Chongqing Clin Res Ctr Kidney & Urol DisDept Neph 83 Xinqiao St Chongqing 400037 Peoples R China
Accumulating evidence highlights mitochondrial dysfunction as a crucial factor in the pathogenesis of acute kidney injury (AKI);thus, novel therapeutic strategies maintaining mitochondrial homeostasis are highly antic... 详细信息
来源: 评论
Transcriptional regulation of bnip3 by Sp3 in prostate cancer
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PROSTATE 2015年 第14期75卷 1556-1567页
作者: Huang, Ying Shen, Pengfei Chen, Xueqin Chen, Zhibin Zhao, Tao Chen, Ni Gong, Jing Nie, Ling Xu, Miao Li, Xinglan Zeng, Hao Zhou, Qiao Sichuan Univ West China Hosp Dept Pathol & Lab Pathol Chengdu 610041 Peoples R China Fujian Prov Hosp Dept Pathol Fuzhou Peoples R China Sichuan Univ West China Hosp Dept Urol Chengdu 610041 Peoples R China
BACKGROUNDThe transcription factors Sp3/Sp1 are expressed in a various types of cancers and bnip3 is overexpressed in prostate cancer. Although it has been demonstrated that bnip3 is transcriptionally regulated by HIF... 详细信息
来源: 评论
RNA methylation reading protein YTHDF2 relieves myocardial ischemia-reperfusion injury by downregulating bnip3 via m6A modification
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HUMAN CELL 2023年 第6期36卷 1948-1964页
作者: Cai, Xinyong Zou, Pengtao Hong, Lang Chen, Yanmei Zhan, Yuliang Liu, Yuanyuan Shao, Liang Nanchang Med Coll Affiliated Hosp 1 Jiangxi Prov Peoples Hosp Dept Cardiol 92 Aiguo Rd Nanchang 330006 Jiangxi Peoples R China
bnip3 is reported to be involved in hypoxia-induced mitochondrial defect and cell death in cardiomyocytes. However, little is known about the specific function and molecular mechanism of bnip3-mediated mitophagy in my... 详细信息
来源: 评论
Expression of bnip3 correlates with hypoxia-inducible factor (HIF)-1α, HIF-2α and the androgen receptor in prostate cancer and is regulated directly by hypoxia but not androgens in cell lines
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PROSTATE 2008年 第3期68卷 336-343页
作者: Shaida, Nadeem Launchbury, Rosalind Boddy, Jane L. Jones, Catherine Campo, Leticia Turley, Helen Kanga, Suresh Banham, Alison H. Malone, Peter R. Harris, Adrian L. Fox, Stephen B. Peter MacCallum Canc Ctr Melbourne Vic 3002 Australia Royal Berkshire Hosp Harold Hopkins Dept Urol Reading Berks England Univ Oxford John Radcliffe Hosp Nuffield Dept Clin Lab Sci Oxford OX1 2JD England Univ Oxford John Radcliffe Hosp Weatherall Inst Mol Med Mol Oncol Lab Oxford OX1 2JD England
BACKGROUND. bnip3 is a hypoxia-induced protein involved in cell death and survival but its role in human tumors is unclear. This study investigated the role of bnip3 in prostate cancer. METHODS. The expression of bnip... 详细信息
来源: 评论
Mitophagy defects arising from bnip3 loss promote mammary tumor progression to metastasis
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EMBO REPORTS 2015年 第9期16卷 1145-1163页
作者: Chourasia, Aparajita H. Tracy, Kristin Frankenberger, Casey Boland, Michelle L. Sharifi, Marina N. Drake, Lauren E. Sachleben, Joseph R. Asara, John M. Locasale, Jason W. Karczmar, Gregory S. Macleod, Kay F. Univ Chicago Ben May Dept Canc Res Chicago IL 60637 USA Comm Canc Biol Chicago IL USA Comm Mol Metab & Nutr Chicago IL USA Comm Mol Pathogenesis & Mol Med Chicago IL USA Univ Chicago Biomol NMR Facil Chicago IL 60637 USA Beth Israel Deaconess Med Ctr Div Signal Transduct Boston MA 02215 USA Harvard Univ Sch Med Boston MA USA Cornell Univ Div Nutr Sci Ithaca NY USA Univ Chicago Dept Radiol Chicago IL 60637 USA
bnip3 is a hypoxia-inducible protein that targets mitochondria for autophagosomal degradation. We report a novel tumor suppressor role for bnip3 in a clinically relevant mouse model of mammary tumorigenesis. bnip3 del... 详细信息
来源: 评论
Astragalus polysaccharide ameliorates steroid-induced osteonecrosis of femoral head through miR-206/HIF-1α/bnip3 axis
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KAOHSIUNG JOURNAL OF MEDICAL SCIENCES 2021年 第12期37卷 1089-1100页
作者: Zhang, Shen-Yao Wang, Fan Zeng, Xiang-Jing Huang, Zhen Dong, Ke-Fang Hunan Univ Chinese Med Dept Orthoped Affiliated Hosp 2 233 CAIERs North Rd Changsha 410005 Peoples R China
Declining autophagy and rising apoptosis are the main factors driving the development of steroid-induced osteonecrosis of the femoral head (SONFH). Here, we showed that astragalus polysaccharide (APS) improved femoral... 详细信息
来源: 评论