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cost-effectiveness of a novel urethral catheter safety device in preventing catheterization injuries in the UK

JOURNAL OF MEDIcAL EcONOMIcS 2024年第1期27卷 154-164页

作者： croghan, Stefanie M. Malcolm, Robert Flood, Hugh D. Mealing, Stuart Avey, Brooke Leonard, Gavin Wright, James Davis, Niall F. Walsh, Michael T. Royal Coll Surg Ireland RCSI Dept Surg Dublin Ireland York Hlth Econ Consortium Heslington England Class Med Ltd Limerick Ireland MedTech Connect Ltd Derby England Univ Limerick Bernal Inst Limerick Ireland Univ Limerick Hlth Res Inst Limerick Ireland

AimsIntraurethral catheter balloon inflation is a substantial contributor to significant catheter-related urethral injury. A novel safety valve has been designed to prevent these balloon-inflation injuries. The purpose of this evaluation was to assess the cost-effectiveness of urethral catheterisation with the safety valve added to a Foley catheter versus the current standard of care (Foley catheter alone).Materials and methodsThe analysis was conducted from the UK public payer perspective on a hypothetical cohort of adults requiring transurethral catheterization. A decision tree was used to capture outcomes in the first 30 days following transurethral catheterization, followed by a Markov model to estimate outcomes over a person's remaining lifetime. clinical outcomes included catheter balloon injuries [cBIs], associated short-term complications, urethral stricture disease, life years and QALYs. Health-economic outcomes included total costs, incremental cost-effectiveness ratio, net monetary benefit (NMB) and net health *** a person's lifetime, the safety valve was predicted to reduce cBIs by 0.04 per person and cBI-related short-term complications by 0.03 per person, and nearly halve total costs. The safety valve was dominant, resulting in 0.02 QALYs gained and relative cost savings of 93.19 pound per person. Probabilistic sensitivity analysis indicated that the safety valve would be cost-saving in 97% of simulations run versus standard of *** addition of a novel safety valve aiming to prevent cBIs during transurethral catheterization to current standard of care was estimated to bring both clinical benefits and cost savings.

关键词： catheter balloon injury transurethral catheterization economic evaluation cost-effectiveness analysis urethral safety valve I00 I c02 c

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cost-effectiveness analysis of sodium zirconium cyclosilicate for hyperkalemia among patients with chronic kidney disease or heart failure in Kuwait

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JOURNAL OF MEDIcAL EcONOMIcS 2024年第1期27卷 253-265页

作者： Elsisi, Gihan Hamdy Mahmoud, Mohamed M. Ibrahim Al-Humood, Khaldoon Al-Yousef, Anas HTA Off LLC Cairo Egypt Amer Univ Cairo Hlth Econ Cairo Egypt Jaber Al Ahmed Armed Forces Hosp Dept Med Kuwait Minist Def Kuwait Kuwait Amiri Hosp Head Nephrol Dept Nephrol Dept Kuwait Kuwait Adan Hosp Cardiol Dept MOH Kuwait Kuwait Amer Univ Cairo HTA Off LLC Hlth Econ 51 Helmy Hassan Aly St Cairo Egypt

IntroductionOur model was conducted from Kuwaiti payer's perspective to provide evidence on the cost-effectiveness of Sodium zirconium cyclosilicate (SZc) versus patiromer to correct and maintain serum potassium (K+) in combination with renin-angiotensin-aldosterone system inhibitors (RAASis) with different dose titration in patients with chronic kidney disease/heart failure (cKD/HF) with/without renal replacement therapy (RRT).MethodologyThe model was developed as a patient-level, fixed-time increment stochastic simulation to simulate the complexity of disease, including multiple coexisting and competing conditional risks. This model was established to compare SZc versus patiromer as a treatment for hyperkalemia (HK) among adult populations with underlying conditions of advanced cKD stages 3a-5 or HF to correct and maintain serum K + over a lifetime horizon. The clinical outcomes of SZc and patiromer were demonstrated through arm-specific K + trajectories extracted from the HARMONIZE trial and OPAL-HK trial, respectively. The utility data was captured from different studies. Direct medical cost was captured from local data from Kuwaiti hospitals. Sensitivity analyses were conducted to assess the uncertainty in the *** different scenarios of cKD/HF, SZc was a cost-saving option, with/without RRT, whether one-off administration or repeated administration, except for one-off treatment administration among the HF cohort, which generated an incremental cost effectiveness ratio of KWD 331/quality adjusted life year (QALY). The incremental QALY of SZc ranged from 0.007 to 0.202. In addition, the savings observed with SZc fall within a range of KWD -60 to KWD -1,235 at serum K+ >= 5.1 mmol/*** evidence generated by our model recommends the inclusion of SZc as a treatment option to correct HK and maintain normal serum K + level for cKD/HF patients within the Kuwaiti healthcare system. The costs saved from reducing frequent HK episodes, RAASis dis

关键词： chronic kidney disease heart failure cost-effectiveness analysis sodium zirconium cyclosilicate c52 c5 c E47 E4 E

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Estimated impact and value of blood-based colorectal cancer screening at varied adherence compared with stool-based screening

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JOURNAL OF MEDIcAL EcONOMIcS 2024年第1期27卷 746-753页

作者： Kisiel, John B. Fendrick, A. Mark Ebner, Derek W. Ozbay, A. Burak Vahdat, Vahab Estes, chris Limburg, Paul J. Mayo Clin Div Gastroenterol & Hepatol Rochester MN USA Univ Michigan Div Gen Med North Campus Res Complex2800 Plymouth RdBldg 16 Ann Arbor MI 48109 USA Exact Sci Corp Madison WI USA

ObjectiveThis analysis estimated the outcomes of triennial blood-based colorectal cancer (cRc) screening at various adherence, including perfect adherence, compared with triennial multi-target stool DNA (mt-sDNA) screening at the reported real-world adherence *** validated cRc-AIM model simulated a US cohort of average-risk individuals receiving triennial screening with mt-sDNA or blood-based test from ages 45 to 75 years. Modeled specificity and sensitivity were based on reported data. Adherence was set at a real-world rate of 65.6% for mt-sDNA and at 65.6%, relative 10% incremental increases from 65.6%, or 100% for the blood-based test. costs of mt-sDNA and the blood-based test were based on prices for clinically available tests ($508.87 and $895, respectively). Value-based pricing was estimated at a willingness-to-pay threshold of $100,*** tests resulted in life-years gained (LYG), reduced cRc cases, and reduced deaths versus no screening. With adherence for mt-sDNA set at 65.6% and for blood-based test set at 100%, mt-sDNA resulted in 30% more LYG, 52% more averted cRc cases, and 32% more averted cRc deaths. At reported sensitivity and specificity rates, mt-sDNA at 65.6% adherence dominates (is more effective and less costly) the blood-based test at any adherence. There was no price at which triennial screening with the blood-based test at any adherence was cost-effective compared with mt-sDNA at 65.6% *** screening with mt-sDNA resulted in better clinical outcomes at a lower cost compared with the modeled blood-based test even at perfect adherence, supporting application of blood-based tests only as a secondary screening option. Blood-based colorectal cancer screening has lower diagnostic accuracy, lower clinical and health outcomes, and is more expensive than mt-sDNA, even with perfect blood-based screening participation. Although better than no screening at all, blood-based testing is unlikely to exceed perfo

关键词： Liquid biopsy colorectal neoplasms computer simulation early detection of cancer feces/chemistry I10 I1 I c31 c3 c

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Light changes Promote Distinct Responses of Plastid Protein Acetylation Marks

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MOLEcULAR & cELLULAR PROTEOMIcS 2024年第11期23卷 100845页

作者： Eirich, Juergen Boyer, Jean-Baptiste Armbruster, Laura Ivanauskaite, Aiste De La Torre, carolina Meinnel, Thierry Wirtz, Markus Mulo, Paula Finkemeier, Iris Giglione, carmela Univ Munster Inst Plant Biol & Biotechnol Plant Physiol Munster Germany Univ Paris Saclay Inst Integrat Biol Cell I2BC CEA CNRS Gif Sur Yvette France Heidelberg Univ Ctr Organismal Studies Heidelberg Heidelberg Germany Univ Turku Dept Life Technol Mol Plant Biol Turku Finland Heidelberg Univ Med Fac Mannheim NGS Core Facil Mannheim Germany

Protein acetylation is a key co- and post-translational modification. However, how different types of acetylation respond to environmental stress is still unknown. To address this, we investigated the role of a member of the newly discovered family of plastid acetyltransferases (GNAT2), which features both lysine- and N-terminal acetyltransferase activities. Our study aimed to provide a holistic multi-omics acetylation-dependent view of plant acclimation to short-term light changes. We found that both the yield and coverage of the N-terminal acetylome remained unchanged in WT and gnat2-KO backgrounds after 2 h of exposure to high light or darkness. Similarly, no differences in transcriptome or adenylate energy charge were observed between the genotypes under the tested light conditions. In contrast, the lysine acetylome proved to be sensitive to the changes in light conditions, especially in the gnat2 background. This suggests unique strategies of plant acclimation for quick responses to environmental changes involving lysine, but not N-terminal, GNAT2-mediated acetylation activity.

关键词： acetyltransferase acetylation quantitative proteomics light acclimation Arabidopsis thaliana acK acetylation of lysine side chains c control light cV compensation voltage D darkness GNAT GcN5 family HL high light HSP heat shock protein KAT lysine acetyltransferase LcH light harvesting complex NAT N-terminal acetyltransferase NTA acetylation of N-termini PS photosystem TMT tandem mass tags UPLc ultra-performance liquid chromatography

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Amplifying Immune Responses: Microparticulate Vaccine Approach Against Breast cancer

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BREAST cANcER-TARGETS AND THERAPY 2024年 16卷 149-162页

作者： Ubowski, Michelle Marie Vansice, Ryan Marriott, Morgan Yacobucci, Matthew J. chablani, Lipika St John Fisher Univ Wegmans Sch Pharm Rochester NY 14618 USA Albany Coll Pharm & Hlth Sci Albany NY USA St John Fisher Univ Dept Pharmaceut Sci Wegmans Sch Pharm 3690 East Ave Rochester NY 14618 USA

Introduction: The study focuses on evaluating the immune responses generated by a novel microparticulate murine breast cancer vaccine. Methods: The methodology included the use of a co-culture model of dendritic cells (Dcs), and T-cells to evaluate the immunotherapeutic responses generated by the vaccine. Results: The study observed that the dendritic cells expressed significantly higher levels of MHc I, MHc II, cD 40, and cD 80 cell surface markers in the presence of the vaccine microparticles than the controls (p<0.05). This response was potentiated in the presence of an adjuvant, Poly (I:c). The study also demonstrated that the vaccine microparticles do not elicit inflammatory (TNF-alpha, IFNgamma, IL-2, and IL-12) or immunosuppressive (IL-10) cytokine production when compared to the control. Discussion: In conclusion, the study established the role of Dcs in stimulating the cancer vaccine's adaptive immune responses.

关键词： dendritic cells adjuvants poly I c adaptive immune response vaccine formulation

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Executability and connexivity in an Interpretation of Griss

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STUDIA LOGIcA 2024年第1-2期112卷 459-509页

作者： Ferguson, Thomas M. M. Univ Amsterdam ILLC Amsterdam Netherlands Czech Acad Sci Inst Philosophy & Comp Sci Prague Czech Republic

Although the work of G.F.c. Griss is commonly understood as a program of negationless mathematics, close examination of Griss's work suggests a more fundamental feature is its executability, a requirement that mental constructions are possible only if corresponding mental activity can be actively carried out. Emphasizing executability reveals that Griss's arguments against negation leave open several types of negation-including D. Nelson's strong negation-as compatible with Griss's intuitionism. Reinterpreting Griss's program as one of executable mathematics, we iteratively develop a pair of bilateral constructive logics and argue for their adequacy as accounts of the propositional basis of Griss's work. We conclude by observing connexive features exhibited by the two bilateral logics and by investigating the difficulties connexive principles reveal for the development of executable mathematics.

关键词： connexive logic constructive logic G F c Griss Executable logic

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Links between disasters of natural origin, economic development and gender inequality: evidence for latin America and the caribbean

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ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY 2024年 1-17页

作者： Llorente-Marron, Mar Diaz-Fernandez, Montserrat Alonso-Mogollon, Jorge Alvaro Martinez, carolina cosculluela Univ Oviedo Dept Quantitat Econ Oviedo 33006 Spain Univ Rey Juan Carlos Dept Appl Econ & Hist & Econ Inst 1 Madrid 28008 Spain Fac Econ & Empresa Avda Cristo S-N Oviedo 33006 Spain

This paper explores the relationship between gender and disasters of natural origin (ND) by considering how the level of economic growth influences the losses caused by these events and how disasters also contribute to gender inequality. To this end, the effects of ND occurring during the 2000-2021 period in 20 countries in Latin America and the caribbean are analysed using a structural equation approach with fixed effects panel data (SEM-FE) as an analytical tool. The results obtained are in line with previous literature that identifies population growth and economic growth as variables that drive the increase in loss of human life from NDs. The results show evidence of the mitigating effects of gender equality on the impact of NDs measured in terms of human life and of the negative effects of the impact of NDs on gender equality. The findings reinforce gender equality as a key element in preventing disasters and rebuilding a sustainable environment in their aftermath.

关键词： Disastres Gender Econom & iacute c SEM

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A cost-consequence model of using the 21-gene assay to identify patients with early-stage node-positive breast cancer who benefit from adjuvant chemotherapy in the Netherlands

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JOURNAL OF MEDIcAL EcONOMIcS 2024年第1期27卷 445-454页

作者： Simons, Martijn J. H. G. Machielsen, Peter M. Spoorendonk, Jelle A. Ignacio, Tim Drost, Pieter B. Jacobs, Tim de Jongh, Felix E. OPEN Hlth Evidence & Access Rotterdam Netherlands Exact Sci Lindenstr 2 CH-6340 Baar Switzerland Ikazia Ziekenhuis Rotterdam Rotterdam Netherlands

BackgroundPatients with early-stage hormone receptor positive, human epidermal growth factor receptor-2 (HER2) negative invasive breast cancer with 1-3 positive lymph nodes (N1) often undergo surgical excisions followed by adjuvant chemotherapy (AcT). Many patients have no benefit from AcT and receive unnecessary, costly treatment often associated with short- and long-term adverse events (AEs). Gene expression profiling (GEP) assays, such as the 21-gene assay (i.e. the Oncotype DX assay), can identify patients at higher risk for recurrence who may benefit from AcT. However, the budgetary consequence of using the Oncotype DX assay versus no GEP testing in the Netherlands is unknown. Our study therefore assessed it using a cost-consequence *** validated model was used to create the N1 model. The model compared the costs and consequences of using the Oncotype DX assay versus no GEP testing and MammaPrint, and subsequent AcT use with corresponding costs for chemotherapy, treatment of AEs, productivity losses, GEP testing, and treatment of recurrences, according to the Oncotype DX results. The model time horizon was 5 *** for the total population amounted to euro8.0 million (M), euro16.2 M, and euro9.5 M, and cost per patient amounted to euro13,540, euro27,455, and euro16,154 for using the Oncotype DX assay, no GEP testing, and MammaPrint, respectively. Total cost savings of using the Oncotype DX assay amounted to euro8.2 M versus no GEP testing and euro1.5 M versus MammaPrint. Using the Oncotype DX assay would result in fewer patients receiving AcT and thus fewer AEs, sick days, and hospitalizations, leading to overall cost savings compared with no GEP testing and *** Oncotype DX testing in this population can prevent unnecessary overtreatment, reducing clinical and economic burden on the patient and Dutch healthcare system. Early-stage invasive breast cancer patients often undergo surgery followed by adjuvant che

关键词： 21-gene gene expression profiling early stage hormone receptor human epidermal growth factor receptor 2 breast cancer lymph node positive adjuvant chemotherapy cost-consequence analysis A11 A1 A c21 c2 c c51 c5

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A Nitrogen-specific Interactome Analysis Sheds Light on the Role of the SnRK1 and TOR Kinases in Plant Nitrogen Signaling

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MOLEcULAR & cELLULAR PROTEOMIcS 2024年第10期23卷 100842页

作者： Persyn, Freya Smagghe, Wouter Eeckhout, Dominique Mertens, Toon Smorscek, Thomas De Winne, Nancy Persiau, Geert van de Slijke, Eveline crepin, Nathalie Gadeyne, Astrid Van Leene, Jelle De Jaeger, Geert Univ Ghent Dept Plant Biotechnol & Bioinformat Ghent Belgium VIB Ctr Plant Syst Biol Ghent Belgium

Nitrogen (N) is of utmost importance for plant growth and development. Multiple studies have shown that N signaling is tightly coupled with carbon (c) levels, but the interplay between c/N metabolism and growth remains largely an enigma. Nonetheless, the protein kinases Sucrose Non- fermenting 1 (SNF1)-Related Kinase 1 (SnRK1) and Target Of Rapamycin (TOR), two ancient central metabolic regulators, are emerging as key integrators that link c/N status with growth. Despite their pivotal importance, the exact mechanisms behind the sensing of N status and its integration with c availability to drive metabolic decisions are largely unknown. Especially for SnRK1, it is not clear how this kinase responds to altered N levels. Therefore, we first monitored N-dependent SnRK1 kinase activity with an in vivo Separation of Phase-based Activity Reporter of Kinase (SPARK) sensor, revealing a contrasting N-dependency in Arabidopsis thaliana (Arabidopsis) shoot and root tissues. Next, using affinity purification (AP) and proximity labeling (PL) coupled to mass spectrometry (MS) experiments, we constructed a comprehensive SnRK1 and TOR interactome in Arabidopsis cell cultures during N-starved and N-repleted growth conditions. To broaden our understanding of the N-specificity of the TOR/SnRK1 signaling events, the resulting network was compared to corresponding c-related networks, identifying a large number of novel, N-specific interactors. Moreover, through integration of N-dependent transcriptome and phosphoproteome data, we were able to pinpoint additional Ndependent network components, highlighting for instance SnRK1 regulatory proteins that might function at the crosstalk of c/N signaling. Finally, confirmation of known and identification of novel SnRK1 interactors, such as Inositol-Requiring 1 (IRE1A) and the RAB GTPase RAB18, indicate that SnRK1, present at the ER, is involved in N signaling and autophagy induction.

关键词： nitrogen signaling Snf-related protein kinase 1 (SnRK1) target of rapamycin (TOR) Arabidopsis thaliana protein interactome AP-MS proximity labeling unfolded protein response (UPR) inositol-requiring enzyme 1 (IRE1) AMPK AMP-activated protein kinase AP-MS affinity purification coupled to mass spectrometry ASP AMPK substrate peptide ATI1 ATG8-interacting 1 BSK brassinosteroid-signaling kinase c carbon ER endoplasmic reticulum FLZ FcS-like zinc finger GFP green fluorescent protein GO Gene Ontology HOTag homo-oligomerizing peptide-tag IRE1 inositol-requiring 1 LFQ label-free quantitation LST8 Lethal with Sec Thirtheen-8 MS Murashige & Skoog MSMO Murashige & Skoog Minimal Organics N nitrogen NLP NIN-like protein NSAF normalized spectral abundance factor PANK2 pantothenate kinase 2 Pcc Pearson correlation coefficient PNR primary nitrate response PL-MS proximity labeling coupled to mass spectrometry PPI protein–protein interaction RAB18 RAB GTPase homolog B18 RT-qPcR reverse transcription quantitative PcR S6K ribosomal S6 kinase SEM standard error of mean SNF1 sucrose non-fermenting 1 SEc12 Sec12p-like protein SnRK1 SNF1-related kinase 1 SPARK separation of phase-based activity reporter of kinase SPPIER separation of phase-based protein interaction reporter TPS trehalose-6-phosphate synthase TOR target of rapamycin WT wild type

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Economic burden of systemic lupus erythematosus in Malaysia

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JOURNAL OF MEDIcAL EcONOMIcS 2024年第Sup1期27卷 46-55页

作者： Elsisi, Gihan Hamdy Joe, Ang Yu Zain, Mollyza Mohd Yusoof, Habibah Mohd Teh, cheng Lay Mohd, Asmah Binti Khor, Xiang Ting Isa, Liza Binti Mohd HTA Off LLC Cairo Egypt Amer Univ Cairo Fac Econ Hlth Econ Cairo Egypt Selayang Hosp Batu Caves Selangor Malaysia Hosp Umum Sarawak Jalan Hosp Sarawak Malaysia Tuanku Jaafar Hosp Jalan Rasah Bukit Rasah Negeri Sembilan Malaysia AstraZeneca Petaling Jaya Selangor Malaysia Putrajaya Hosp Putrajaya Malaysia Amer Univ Cairo HTA Off LLC Hlth Econ 51 Helmy Hassan Aly St Cairo Egypt

IntroductionOur cost-of-illness (cOI) model adopted the perspective of both payer and society over a time horizon of 5 years to measure the economic burden of systemic lupus erythematosus (SLE) in *** cOI model utilized a prevalence-based model to estimate the costs and economic consequences of SLE in Malaysia. The clinical parameters were obtained from published literature and validated using the Delphi panel. Direct and indirect medical costs were measured, including disease management, transient events, and indirect costs. One-way sensitivity analysis was also *** number of target Malaysian patients with SLE in the cOI model was 18,121. At diagnosis, the numbers of SLE patients with mild, moderate, and severe phenotypes were 2,582, 13,897, and 1,642, respectively. The total SLE cost in Malaysia over 5 years from both payer and society perspectives was estimated at MYR 678 million and 2 billion, respectively. The results showed a considerable cost burden due to productivity losses resulting from SLE-related morbidity and mortality. Over a 5-year time horizon, the costs per patient per year from the payer and society perspectives were MYR 7,484 ($4766) and 24,281($15,465), *** study demonstrated the substantial economic burden of SLE in Malaysia over a time horizon of 5 years. It affects adults of working age, in addition to the costs of SLE management and its consequences, such as flares, infection, and organ damage. Our cOI model indicated that disease management costs among patients with higher disease severity were higher than those among patients with a mild phenotype. Hence, more attetion should be paid to limiting the progression of SLE and the occurrence of flares, with the need for further economic evaluation of novel treatments that could lead to better outcomes.

关键词： SLE Malaysia costs consequences burden c51 c5 c H51 H5 H

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