检索结果-内蒙古大学图书馆

Three new c21 steroidal glycosides isolated from Metaplexis japonica and their potential inhibitory effects on tyrosine protein kinases

引用

NATURAL PRODUcT RESEARcH 2022年第8期36卷 1988-1995页

作者： Wang, Xu Ma, Qing-Yun Liu, chen Yang, Jia Lv, Qing-Tao Tian, Zhen-Hua Jiang, Hai-Qiang Rong, Rong Shandong Univ Tradit Chinese Med Coll Pharmaceut Sci Jinan Peoples R China Shandong Univ Tradit Chinese Med Expt Ctr Jinan Peoples R China

Three new steroidal glycosides, metapregnoside A-c (II-IV), together with one known compound, byzantionoside B (I), were isolated from the fresh whole herb of Metaplexis japonica by using high-speed countercurrent chromatography and semi-preparative liquid chromatography. Their structures and relative configurations were elucidated by spectroscopic methods including 1D NMR, 2D NMR and HR-ESI-MS. The potential targets of compound I-IV were identified by virtual screening. And the potential inhibitory effects of these compounds on tyrosine protein kinases were compared by molecular docking. Byzantionoside B (I) was the first isolated compound from Metaplexis genus. The docking score of metapregnoside c (IV) was the highest. And the sugar chain residues at position c-20 in the pregn-4-en-3-one derivatives is the main factor affecting their docking scores on tyrosine protein kinases Fes/Fps.

关键词： Metaplexis japonica metapregnoside A– c molecular docking tyrosine protein kinases Fes Fps

来源：评论

学校读者我要写书评

暂无评论

c. Richard conti and chinese cardiology 1989-2022

引用

cLINIcAL cARDIOLOGY 2022年第11期45卷 1089-1093页

作者： Harold, John Gordon Cedars Sinai Smidt Heart Inst Dept Cardiol Cedars Sinai Med Off TowersSuite 750 Los Angeles CA 90048 USA

The death of c. Richard conti, MD, MAcc in February 2022 marked the passing of a global leader in cardiology who played a pivotal role in the history of the American college of cardiology and the college's outreac... 详细信息

关键词： c Richard conti china global leader in cardiology Great Wall International congress of cardiology

来源：评论

学校读者我要写书评

暂无评论

USP13 modulates the stability of the APc/c adaptor cDH1

引用

MOLEcULAR BIOLOGY REPORTS 2022年第5期49卷 4079-4087页

作者： Esposito, Mara Gutierrez, Gustavo J. Vrije Univ Brussel Fac Sci & Bioengn Sci Dept Biol Lab Pathophysiol Cell Signaling Pl Laan 2 B-1050 Brussels Belgium Univ Basel Biozentrum Spitalstr 41 CH-4056 Basel Switzerland Galapagos NV Generaal Wittelaan L11 A3 B-2800 Mechelen Belgium

Background The cell division cycle is a process that is exquisitely controlled by a complex interplay between E3 ubiquitin ligases and deubiquitinating enzymes (DUBs). We have previously reported that the DUB USP13 regulates Aurora B levels along the cell cycle. That observation prompted us to explore any possible connection between USP13 and the APc/c-cDH1, the major E3 controlling Aurora B levels in cells. Methods We performed immunoprecipitation assays followed by western-blotting to assess the interaction between USP13 and cDH1. The cellular effects of USP13 gain or loss of function were analyzed by transfection of FLAG-tagged USP13 plasmid or small interfering RNAs and short hairpin RNAs directed against USP13. The levels of cDH1 and other proteins were quantified in cell extracts by western-blotting. Results We found that USP13 binds to the APc/c adaptor cDH1. In addition, we report for the first time that USP13 controls cDH1 protein levels in cells: overexpression of USP13 increased cDH1 levels, whereas depletion of USP13 decreased cDH1 levels. conclusions We unveil the existing interplay between USP13 and cDH1: USP13 is capable of stabilizing cDH1 levels. We previously reported that USP13 stabilizes Aurora B in cells, a known substrate of the APc/c-cDH1 E3 ubiquitin ligase, before their entry into mitosis. Altogether, our data identify and establish the USP13-cDH1-Aurora B axis as a new regulatory module required for flawless cell cycle progression in mammalian cells, whose misfunction may be involved in the rewiring of cell cycle pathways linked to cancer development.

关键词： APc c cDH1 USP13 Aurora B E3 ubiquitin ligase Proteasome DUB

来源：评论

学校读者我要写书评

暂无评论

SUMOylation of the chromodomain factor MRG-1 in c. elegans affects chromatin-regulatory dynamics

引用

BIOTEcHNIQUES 2022年第1期73卷 15 - 17页

作者： Baytek, Guelkiz Blume, Alexander Demirel, Funda Gerceker Bulut, Selman Popp, Oliver Mertins, Philipp Tursun, Baris Max Delbruck Ctr Mol Med Helmholtz Assoc MDC D-13125 Berlin Germany Berlin Inst Med Syst Biol BIMSB D-10115 Berlin Germany Univ Hamburg Inst Cell & Syst Biol Anim Dept Biol D-20146 Hamburg Germany

Epigenetic mechanisms control chromatin accessibility and gene expression to ensure proper cell fate specification. Histone proteins are integral chromatin components, and their modification promotes gene expression regulation. Specific proteins recognize modified histones such as the chromodomain protein MRG-1. MRG-1 is the caenorhabditis elegans ortholog of mammalian MRG15, which is involved in DNA repair. MRG-1 binds methylated histone H3 and is important for germline maturation and safeguarding. To elucidate interacting proteins that modulate MRG-1 activity, we performed in-depth protein-protein interaction analysis using immunoprecipitations coupled with mass spectrometry. We detected strong association with the Small ubiquitin-like modifier SUMO, and found that MRG-1 is post-translationally modified by SUMO. SUMOylation affects chromatin-binding dynamics of MRG-1, suggesting an epigenetic regulation pathway, which may be conserved. MULTIDIScIPLINARY ABSTRAcT Epigenetic mechanisms control chromatin accessibility and gene expression to ensure proper cell fate specification. We describe in this study that in the nematode c. elegans, the epigenetic regulator MRG-1 is modified by the small ubiquitin-like modifier SUMO. Posttranslational modification by SUMO affects chromatin-binding dynamics of MRG-1, suggesting a modulation of epigenetic regulation. METHOD SUMMARY co-immunoprecipitation is in combination with single-pot, solid-phase-enhanced, sample preparation (SP3), followed by mass spectrometry (coIP-MS) and label-free quantification (LFQ). TWEETABLE ABSTRAcT SUMOylation of the mammalian epigenetic factor MRG15 ortholog MRG-1 in c. elegans affects chromatin-binding dynamics of MRG-1.

关键词： c elegans chromatin MRG-1 epigenetics MRG15 MORF4 protein interaction SUMO

来源：评论

学校读者我要写书评

暂无评论

Multi-suture craniosynostosis in c.1570c>T (***524Trp) mutated TRAF7: a case report

引用

cHILDS NERVOUS SYSTEM 2022年第4期38卷 843-846页

作者： chaisrisawadisuk, Sarut Taranath, Ajay Azzopardi, Jonathan Moore, Mark H. Womens & Childrens Hosp Cleft & Craniofacial South Australia Adelaide SA Australia Mahidol Univ Siriraj Hosp Dept Surg Div Plast SurgFac Med Bangkok Thailand Womens & Childrens Hosp Dept Med Imaging Adelaide SA Australia

craniosynostosis is a condition of premature fusion of the cranial sutures. Multi-suture craniosynostosis has been found to be associated with a number of syndromes and underlying gene mutations. Tumour necrosis factor receptor-associated factors (TRAFs) are a family of adaptor proteins interacting with cell surface receptors or other signalling molecules. TRAF7 is one of the factors involved in multiple biologic processes, including ubiquitination, myogenesis and toll-like receptor signalling. Here, we report a child who presented with multi-suture craniosynostosis and had the uncommon c.1570c>T (***524Trp) variant of TRAF7.

关键词： Arg524Trp craniosynostosis c 1570c>T TRAF7 mutation

来源：评论

学校读者我要写书评

暂无评论

Heterogeneous Pd/c-catalyzed, ligand free Suzuki-Miyaura coupling reaction furnishes newp-terphenyl derivatives

引用

NATURAL PRODUcT RESEARcH 2022年第2期36卷 566-570页

作者： Avula, Satya Kumar Rehman, Najeeb Ur Anwar, Muhammad U. Aalthani, Ghanim csuk, Rene Al-Harrasi, Ahmed Univ Nizwa Nat & Med Sci Res Ctr Nizwa Oman Martin Luther Univ Halle Wittenberg Organ Chem Halle Saale Germany

A series of newpara-terphenyls derivatives have been efficiently synthesized by a ligand-free heterogeneous Pd/c-catalyzed two-fold Suzuki-Miyaura coupling reaction. Methyl 5-bromo-2-iodobenzoate was selected to react with a variety of different aryl boronic acids (2a-i). Nine newp-terphenyl derivatives (3a-i) were prepared and the structures were confirmed by several analytical techniques including infrared, spectroscopy,H-1 and(13)c NMR spectroscopy, mass spectrometry, and in the case of compound3 b,by X-ray diffraction method. The new derivatives were obtained in very good yields (78-91%). This synthetic facile route is envisioned to improve the preparation ofp-terphenyl-based natural products.

关键词： Ligand-free catalysis aryl boronic acids Suzuki-Miyaura coupling reaction Pd c heterogeneous catalysis

来源：评论

学校读者我要写书评

暂无评论

comparative study of cUDA-based parallel programming in c and Python for GPU acceleration of the 4th order Runge-Kutta method

引用

NUcLEAR ENGINEERING AND DESIGN 2024年 421卷

作者： Fernandes, Davi F. Santos, Marcelo c. Silva, Adilson c. Lima, Alan M. M. Univ Fed Rio de Janeiro Nucl Engn Program COPPE CP 68509 BR-21941972 Rio De Janeiro RJ Brazil

In this paper, a comparative study is presented on the application of General-purpose computing on Graphics Processing Units for solving the point reactor kinetics equations through the utilization of the 4th Order RungeKutta (RK4) method using the programming languages c and Python. Sequential and parallel algorithms of the RK4 method were developed in c/c++ and Python, with parallel algorithms specifically designed to operate on Graphics Processing Units (GPUs) utilizing the NVIDIA compute Unified Device Architecture (cUDA) as the programming platform. As an experiment, the execution time for the sequential and parallel algorithms were compared for a reactivity value of rho = 0.003 and a simulation time of t = 100 s. The parallel c and Python algorithms achieved, respectively, speedups of 9.33 and 409.7 when comparing the execution time on the best GPU utilized (RTX 3070Ti) with the best cPU (3600XT), while still maintaining numerical precision.

关键词： GPU Point reactor kinetics equations Runge-Kutta Method Python c

来源：评论

学校读者我要写书评

暂无评论

c. elegans as a test system to study relevant compounds that contribute to the specific health-related effects of different cannabis varieties

引用

JOURNAL OF cANNABIS RESEARcH 2022年第1期4卷 53页

作者： Van Es-Remers, Monique Spadaro, Jesus Arellano Poppelaars, Eefje Kim, Hye Kyong van Haaster, Marieke de Wit, Marcel ILiopoulou, Eva Wildwater, Marjolein Korthout, Henrie Vivaltes BV Regulierenring 9 NL-3981 LA Bunnik Netherlands Fytagoras BV Sylviusweg 72 NL-2333 BE Leiden Netherlands Maripham BV Nieuw Mathenesserstr 33 NL-3029 AV Rotterdam Netherlands

Background The medicinal effects of cannabis varieties on the market cannot be explained solely by the presence of the major cannabinoids Delta(9)-tetrahydrocannabinol (THc) and cannabidiol (cBD). Evidence for putative entourage effects caused by other compounds present in cannabis is hard to obtain due to the subjective nature of patient experience data. caenorhabditis elegans (c. elegans) is an objective test system to identify cannabis compounds involved in claimed health and entourage effects. Methods From a medicinal cannabis breeding program by MariPharm BV, the Netherlands a set of 12 varieties were selected both THc rich varieties as well as cBD rich varieties. A consecutive extraction process was applied resulting in a non-polar (cannabinoid-rich) and polar (cannabinoid-poor) extract of each variety. The test model c. elegans was exposed to these extracts in a broad set of bioassays for appetite control, body oscillation, motility, and nervous system function. Results Exposing c. elegans to extracts with a high concentration of cannabinoids (> 1 mu g/mL) reduces the life span of c. elegans dramatically. Exposing the nematodes to the low-cannabinoid (< 0.005 mu g/mL) polar extracts, however, resulted in significant effects with respect to appetite control, body oscillation, motility, and nervous system-related functions in a dose-dependent and variety-dependent manner. Discussion c. elegans is a small, transparent organism with a complete nervous system, behavior and is due to its genetic robustness and short life cycle highly suitable to unravel entourage effects of cannabis compounds. Although c. elegans lacks an obvious cB1 and cB2 receptor it has orthologs of Serotonin and Vanilloid receptor which are also involved in (endo)cannabinoid signaling. conclusion By using c. elegans, we were able to objectively distinguish different effects of different varieties despite the cannabinoid content. c. elegans seems a useful test system for studying entourage effe

关键词： c elegans Medicinal cannabis Entourage effects Appetite Motility Body oscillation Nervous system Memory Endurance performance

来源：评论

学校读者我要写书评

暂无评论

A novel mutation in theZNF462gene c.3306dup;p.(Gln1103Thrfs*10) is associated to Weiss-Kruszka syndrome. A case report

引用

AcTA cLINIcA BELGIcA 2022年第1期77卷 118-121页

作者： Gonzalez-Tarancon, R. Salvador-Ruperez, E. Miramar Gallart, M. D. Barroso, E. Diez Garcia-Prieto, I Perez Delgado, R. Lopez Pison, J. Garcia Jimenez, M. c. Univ Hosp Miguel Servet Dept Clin Biochem Clin Genet Lab Zaragoza Spain NIMGenetics Madrid Spain Univ Hosp Miguel Servet Dept Pediat Neurometab Unit Zaragoza Spain

Background Weiss-Kruszka syndrome (WSKA) is a rare disorder caused by mutations in theZNF462gene or deletion of 9p31.2 chromosome region, involvingZNF462. The prevalence of WSKA is unknown as only 24 affected individuals have been described. This syndrome should be suspected in individuals presenting mild global developmental delay and common craniofacial abnormalities. case presentation We presented a case of an infant, 3 years and 4-month life who presented pondostatural and psychomotor retardation, generalized hypotonia with hypermobility, bilateral palpebral ptosis, epicanthal folds, and poorly expressive facies as the main clinical features. These characteristics lead to the realization of genetics studies that resulted in the identification of a novel mutation c.3306dup;p.(Gln1103Thrfs*10) inZNF462. conclusions WSKA should be suspected in individuals presenting mild global developmental delay, ptosis, downslanting palpebral fissures, exaggerated cupid's Bow, arched eyebrows, epicanthal folds and short upturned nose with a bulbous tip. Hypertrophy of the ventricular septum and severe OSA were described in our patient and should be considered in future reviews of the disease. This case is added to the reduced number of publications previously reported regarding WSKA and contributes to understanding the genetic characteristics, clinical features, and diagnosis of this syndrome.

关键词： WKSA ZNF462 c 3306dup p (Gln1103Thrfs*10) ptosis

来源：评论

学校读者我要写书评

暂无评论

An M/M/c/K queueing system in an inventory routing problem considering congestion and response time for post-disaster humanitarian relief: a case study

引用

JOURNAL OF HUMANITARIAN LOGISTIcS AND SUPPLY cHAIN MANAGEMENT 2022年第2期12卷 182-219页

作者： Masoumi, Mahdieh Aghsami, Amir Alipour-Vaezi, Mohammad Jolai, Fariborz Esmailifar, Behdad Univ Tehran Coll Engn Ind & Syst Engn Tehran Iran KN Toosi Univ Technol Tehran Iran

Purpose Due to the randomness and unpredictability of many disasters, it is essential to be prepared to face difficult conditions after a disaster to reduce human casualties and meet the needs of the people. After the disaster, one of the most essential measures is to deliver relief supplies to those affected by the disaster. Therefore, this paper aims to assign demand points to the warehouses as well as routing their related relief vehicles after a disaster considering convergence in the border warehouses. Design/methodology/approach This research proposes a multi-objective, multi-commodity and multi-period queueing-inventory-routing problem in which a queuing system has been applied to reduce the congestion in the borders of the affected zones. To show the validity of the proposed model, a small-size problem has been solved using exact methods. Moreover, to deal with the complexity of the problem, a metaheuristic algorithm has been utilized to solve the large dimensions of the problem. Finally, various sensitivity analyses have been performed to determine the effects of different parameters on the optimal response. Findings According to the results, the proposed model can optimize the objective functions simultaneously, in which decision-makers can determine their priority according to the condition by using the sensitivity analysis results. Originality/value The focus of the research is on delivering relief items to the affected people on time and at the lowest cost, in addition to preventing long queues at the entrances to the affected areas.

关键词： Humanitarian logistics Inventory-routing problem M M c K queueing systems

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：