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Buckling analysis of a cantilever single-walled carbon nanotube embedded in an elastic medium with an attached spring

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MIcRO & NANO LETTERS 2017年第4期12卷 255-259页

作者： Yayli, Mustafa Ozgur Uludag Univ Fac Engn Dept Civil Engn 16059 Gorukle Campus Bursa Turkey

The buckling analysis of a cantilever single-walled carbon nanotube embedded in an elastic medium with an attached spring is researched. The effects of axial compression load, attached spring, small size and surrounding elastic medium are taken into account at the same time. Theoretical formulation is carried out on the basis of the Bernoulli-Euler beam theory in conjunction with Eringen ' s non-local elasticity theory. Fourier sine series is selected for the simulation of single-walled carbon nanotube deflections. Winkler elastic foundation type is used to simulate the interaction between single-walled carbon nanotube and elastic medium. 2 x 2 coefficient matrix is derived with the aid of applying Stokes ' transformation to corresponding non-local boundary conditions. The critical buckling loads are calculated by using this coefficient matrix. Different validation studies are performed to endorse and corroborate the usefulness of the presented analytical method.

关键词： buckling single-wall carbon nanotubes elasticity nanomechanics cantilevers compressibility Fourier series buckling analysis cantilever single-walled carbon nanotube elastic medium attached spring axial compression load Bernoulli-Euler beam theory Eringen nonlocal elasticity theory Fourier sine series single-walled carbon nanotube deflections Winkler elastic foundation Stokes transformation nonlocal boundary conditions critical buckling loads coefficient matrix c

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上下通吃梅赛德斯-奔驰GL c v雷克萨斯RX

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汽车与运动 2016年第4期 126-131页

作者：马爽郝笑天

梅赛德斯-奔驰GLc 300 4MATIc和雷克萨斯RX 200t F-SPORT,这两辆本不在同一个级别的车型却因为相同的竞争策略以及互有交集的价格区间成为了直接的竞争对手。如果按照evo的评判标准谁能够最终胜出？我想你们一定很感兴趣错位竞争策略成... 详细信息

梅赛德斯-奔驰GLc 300 4MATIc和雷克萨斯RX 200t F-SPORT,这两辆本不在同一个级别的车型却因为相同的竞争策略以及互有交集的价格区间成为了直接的竞争对手。如果按照evo的评判标准谁能够最终胜出？我想你们一定很感兴趣错位竞争策略成为了众多企业的市场战略之一在我们眼前,这辆身形俊朗的梅赛德斯-奔驰GLc和它身边那辆拥有犀利眼神的雷克萨斯RX因为都刚刚完成车型的换代,所以都有着羡煞旁人的颜值。而且,它们在市场上逐渐走高的表现更是让人垂涎。除此之外它们还有一个共同点,那就是被赋予了一身＂上下通吃＂的武艺。

关键词：梅赛德斯 GL c v RX 雷克萨斯市场战略错位竞争车身长度 SPORT 涡轮增压发动机麦弗逊

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一种基于System c语言的模型检测方法

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广西民族大学学报（自然科学版） 2016年第3期22卷 80-85页

作者：吴丽佳于琼靳庆庚广西民族大学广西混杂计算与集成电路设计分析重点实验室广西南宁530006

System c语言在软硬件协同设计过程中被广泛用来建模和仿真.笔者提出了一种验证System c设计的方法,即通过把System c设计映射成为一个具有良好定义语义的UPPAAL时间自动机.System c设计的结构和非正式定义的行为在形成的UPPAAL时间自... 详细信息

System c语言在软硬件协同设计过程中被广泛用来建模和仿真.笔者提出了一种验证System c设计的方法,即通过把System c设计映射成为一个具有良好定义语义的UPPAAL时间自动机.System c设计的结构和非正式定义的行为在形成的UPPAAL时间自动机中得到了完整的保留.产生的UPPAAL模型允许使用UPPAAL模型检查器和其配套工具来进行验证.模型检查器用来验证设计的一些重要属性,比如活性,死锁问题和时间约束属性.通过对两个实例的活性、安全性和时间属性的验证来证明该方法的适用性.

关键词： System c 时间自动机模型检测

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Solvent Interface Trapping as an Effective Technique to Fabricate Graphite-Nanomaterial composite Thin Films

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MRS ADVANcES 2018年第1-2期3卷 19-23页

作者： Padmanabhan, Medini Meyen, Rachel Houghton, Kerri St John, Miles Rhode Isl Coll Dept Phys Sci Providence RI 02908 USA

Natural graphite can be exfoliated into thin films by trapping it at the interface between water and heptane [S. J Woltornist, A. J. Oyer, J-M. Y. carrillo, A.V. Dobrynin, and D.H. Adamson, AcS Nano 7, 7062 (2013)]. In this work, we add functional elements into these graphitic thin films by introducing additives into the water phase prior to exfoliation. We report the successful incorporation of ZnO nanoparticles thereby enabling the composite films to act as effective ultraviolet photodetectors. In a similar manner, integration of silver nanowires is achieved, which results in an enhancement of the electrical conductivity of graphite.

关键词： c composite thin film

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稳定沉默TIPE2后削弱PolyI:c诱导的人单核/巨噬细胞凋亡

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中国现代医生 2016年第16期54卷 1-5,F0003页

作者：江洁曙王珊珊方晶晶徐意叶小磊宁波大学医学院附属医院ICU 浙江宁波315020 宁波大学医学院附属医院急诊科浙江宁波315020 宁波市医学科学研究所浙江宁波315020

目的观察TIPE2稳定沉默后对TLR激动剂Poly I:c诱导THP-1凋亡的影响。方法以THP-1细胞为研究对象,使用不同TLR激活剂与THP-1细胞孵育后,采用荧光定量PcR检测TIPE2 m RNA表达。应用慢病毒技术稳定沉默TIPE2表达后,MTT法检测细胞增殖,Annex... 详细信息

目的观察TIPE2稳定沉默后对TLR激动剂Poly I:c诱导THP-1凋亡的影响。方法以THP-1细胞为研究对象,使用不同TLR激活剂与THP-1细胞孵育后,采用荧光定量PcR检测TIPE2 m RNA表达。应用慢病毒技术稳定沉默TIPE2表达后,MTT法检测细胞增殖,Annexin V/PI双染法检测细胞凋亡,免疫印迹分析TIPE2沉默后caspase-8表达水平变化。结果 TLRs激活剂中TLR3特异性激活剂Poly I:c可以显著上调TIPE2的表达(P<0.05),随作用时间延长,可显著抑制THP-1细胞增殖,并可诱导细胞凋亡。利用慢病毒技术稳定沉默THP-1细胞中TIPE2表达以后,可显著削弱Poly I:c诱导的TIPE2表达(P<0.05),TIPE2沉默后,Poly I:c抑制THP-1增殖和诱导细胞凋亡的效应显著削弱,随后免疫印迹的结果显示,caspase-8的活化形式,p41/42表达下调。结论Poly I:c通过上调TIPE2表达可抑制THP-1细胞增殖,并可诱导细胞凋亡,稳定沉默TIPE2后可一定程度削弱上述效应,可能与下调caspase-8的活性形式表达有关。

关键词： Voly I c TIPE2 免疫 TLR 凋亡

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Update on hepatitis c: Direct-acting antivirals

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World Journal of Hepatology 2015年第28期7卷 2829-2833页

作者： Leon L Seifert Ryan B Perumpail Aijaz Ahmed Department of Transplantation Medicine University Hospital Münster Division of Gastroenterology and Hepatology Stanford University School of Medicine

Hepatitis c virus(HcV) was discovered 26 years ago. For decades, interferon-based therapy has been the mainstay of treatment for HcV. Recently, several direct-acting antivirals(DAAs) have been approved for treatment of HcV-infected patients and to help combat the virus. These drugs have revolutionized the management of HcV as all-oral regimens with favorable side effect profiles and superior rates of sustained virological response. Emerging real-world data are demonstrating results comparable to registration trials for DAA agents. Suddenly, the potential for eradicating HcV is on the horizon.

关键词： Hepatitis c virus Direct-acting antivirals Sustained virologic response Management Treatment

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Dynamic regulation of nuclear architecture and mechanicsa rheostatic role for the nucleus in tailoring cellular mechanosensitivity

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NUcLEUS 2017年第3期8卷 287-300页

作者： Thorpe, Stephen D. Lee, David A. Queen Mary Univ London Sch Engn & Mat Sci Inst Bioengn London England

Nuclear architecture, a function of both chromatin and nucleoskeleton structure, is known to change with stem cell differentiation and differs between various somatic cell types. These changes in nuclear architecture are associated with the regulation of gene expression and genome function in a cell-type specific manner. Biophysical stimuli are known effectors of differentiation and also elicit stimuli-specific changes in nuclear architecture. This occurs via the process of mechanotransduction whereby extracellular mechanical forces activate several well characterized signaling cascades of cytoplasmic origin, and potentially some recently elucidated signaling cascades originating in the nucleus. Recent work has demonstrated changes in nuclear mechanics both with pluripotency state in embryonic stem cells, and with differentiation progression in adult mesenchymal stem cells. This review explores the interplay between cytoplasmic and nuclear mechanosensitivity, highlighting a role for the nucleus as a rheostat in tuning the cellular mechano-response.

关键词： chromatin differentiation embryonic stem cell lamin A c LINc complex mechanobiology mechanotransduction mesenchymal stem cell nucleus

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Effects of chlamydia trachomatis infection on sperm chromatin condensation and DNA integrity

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ANDROLOGIA 2018年第3期50卷 2018 Apr;50(3)页

作者： Marvast, L. Dehghan Talebi, A. R. Ghasemzadeh, J. Hosseini, A. Pacey, A. A. Univ Sheffield Acad Unit Reprod & Dev Med Dept Human Metab Sheffield S Yorkshire England Shahid Sadoughi Univ Med Sci Res & Clin Ctr Infertil Yazd Iran

The present study was performed to investigate the relation of chlamydia trachomatis infection to sperm chromatin/DNA integrity in a population of infertile men (male partner of infertile couples) from Iran. Blood, semen and first-void urine samples were obtained from 250 infertile men. Data were analysed with regard to the results of (i) serological analysis for specific antibodies to *** in serum;(ii) the presence of *** and DNA in first-void urine;and (iii) in the semen sample of the male partner, in addition to sperm analysis, four different tests (aniline blue, chromomycin A3, acridine orange and TUNEL) were used to detect sperm chromatin and DNA abnormalities. The main conclusions of the results were: (i) no evidence of *** infection in semen samples was found;(ii) sperm DNA fragmentation and chromatin studies were not correlated with *** diagnosis;(iii) the percentage of DNA fragmentation is positively correlated with the percentage of immotile sperm but negatively with semen volume, normal morphology;and (iv) in sperm chromatin evaluations, only the percentage of chromatin protamination was related to male age.

关键词： c trachomatis DNA infertility sperm chromatin

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Supplementation with high-dose docosahexaenoic acid increases the Omega-3 Index more than high-dose eicosapentaenoic acid

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PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY AcIDS 2017年 120卷 8-14页

作者： Allaire, Janie Harris, William S. Vors, cecile charest, Amelie Marin, Johanne Jackson, Kristina Harris Tchernof, Andre couture, Patrick Lamarche, Benoit Univ Laval INAF Pavillon ServHochelaga Blvd Quebec City PQ G1V 0A6 Canada Univ South Dakota Sanford Sch Med Sioux Falls SD USA OmegaQuant Analyt LLC Sioux Falls SD USA Univ Laval CHU Quebec Ctr Rech Quebec City PQ Canada IUCPQ Quebec City PQ Canada

Background: Recent studies suggest that eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids have distinct effects on cardiometabolic risk factors. The Omega-3 Index (030, which is calculated as the proportion of EPA and DHA in red blood cell (RBc) membranes, has been inversely associated with the risk of coronary heart diseases and coronary mortality. The objective of this study was to compare the effects of EPA and DHA supplementation on the 031 in men and women with abdominal obesity and subclinical inflammation. Methods: In a double-blind controlled crossover study, 48 men and 106 women with abdominal obesity and subclinical inflammation were randomized to a sequence of three-treatment phases: 1-2.7 g/d of EPA, 2-2.7 g/d of DHA, and 3-3 g/d of corn oil (0 g of EPA +DHA). All supplements were provided as 3 x 1 g capsules for a total of 3 g/d. The 10-week treatment phases were separated by nine-week washouts. RBc membrane fatty acid composition and 031 were assessed at baseline and the end of each phase. Differences in 031 between treatments were assessed using mixed models for repeated measures. Results: The increase in the 031 after supplementation with DHA (+ 5.6% compared with control, P < 0.0001) was significantly greater than after EPA (+ 3.3% compared with control, P < 0.0001;DHA vs. EPA, P < 0.0001). compared to control, DHA supplementation decreased (-0.8%, P < 0.0001) while EPA increased (+ 2.5%, P < 0.0001) proportion of docosapentaenoic acid (DPA) in RBcs (DHA vs. EPA, P < 0.0001). The baseline 031 was higher in women than in men (6.3% vs. 5.8%, P = 0.011). The difference between DHA and EPA in increasing the 031 tended to be higher in men than in women (+ 2.6% vs. + 2.2% respectively, P for the treatment by sex interaction = 0.0537). conclusions: The increase in the 031 is greater with high dose DHA supplementation than with high dose EPA, which is consistent with the greater potency of DHA to modulate cardiometabolic risk factors. The extent to whi

关键词： BMI body mass index cHD coronary heart disease cRP c-reactive protein cVD cardiovascular diseases c cholesterol DHA docosahexaenoic acid DPA docosapentaenoic acid ELOVL2 ELOVL fatty acid elongase 2 ELOVL5 ELOVL fatty acid elongase 5 EPA eicosapentaenoic acid FADS1 fatty acids desaturase 2 or delta-5 fatty acids desaturase FADS2 fatty acids desaturase 2 or delta-6 fatty acids desaturase GAPDH glyceraldehyde 3-phosphate dehydrogenase HDL high-density lipoprotein INAF Institute of nutrition and functional foods Lcn3-PUFA long-chain omega-3 polyunsaturated fatty acid LDL low-density lipoprotein MetS metabolic syndrome MUFA monounsaturated fatty acid O3I Omega-3 Index PUFA polyunsaturated fatty acid RBc red blood cell SFA saturated fatty acid TG triglyceride

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High-resolution imaging of muscle attachment structures in caenorhabditis elegans

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cYTOSKELETON 2017年第11期74卷 426-442页

作者： Qadota, Hiroshi Matsunaga, Yohei Nguyen, Ken c. Q. Mattheyses, Alexa Hall, David H. Benian, Guy M. Emory Univ Dept Pathol Whitehead Biomed Res BldgRoom 105E Atlanta GA 30322 USA Albert Einstein Coll Med Dept Neurosci Bronx NY 10461 USA Emory Univ Dept Cell Biol Atlanta GA 30322 USA

We used structured illumination microscopy (SIM) to obtain super-resolution images of muscle attachment structures in caenorhabditis elegans striated muscle. SIM imaging of M-line components revealed two patterns: PAT-3 (-integrin) and proteins that interact in a complex with the cytoplasmic tail of -integrin and localize to the basal muscle cell membrane [UNc-112 (kindlin), PAT-4 (ILK), UNc-97 (PINcH), PAT-6 (-parvin), and UNc-95], are found in discrete, angled segments with gaps. In contrast, proteins localized throughout the depth of the M-line (UNc-89 (obscurin) and UNc-98) are imaged as continuous lines. Systematic immunostaining of muscle cell boundaries revealed that dense body components close to the basal muscle cell membrane also localize at cell boundaries. SIM imaging of muscle cell boundaries reveal zipper-like structures. Electron micrographs reveal electron dense material similar in appearance to dense bodies located adjacent to the basolateral cell membranes of adjacent muscle cells separated by EcM. Moreover, by EM, there are a variety of features of the muscle cell boundaries that help explain the zipper-like pattern of muscle protein localization observed by SIM. Short dense bodies in atn-1 mutants that are null for -actinin and lack the deeper extensions of dense bodies, showed zipper-like structures by SIM similar to cell boundary structures, further indicating that the surface-proximal components of dense bodies form the zipper-like structures at cell boundaries. Moreover, mutants in thin and thick filament components do not have dot-like dense bodies, suggesting that myofilament tension is required for assembly or maintenance of proper dense body shape.

关键词： c elegans electron microscopy integrin adhesion sites muscle super resolution microscopy

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