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Submucosal Injection of Dexamethasone Reduces Postoperative Discomfort After Third-Molar Extraction: A Systematic Review and Meta-analysis (vol 148, pg 81, 2017)

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JOURNAL OF THE AMERIcAN DENTAL ASSOcIATION 2017年第5期148卷 287-287页

作者： chen, Qian Chongqing Med Univ Chongqing Municipal Key Lab Oral Biomed Engn High Coll Stomatol Chongqing Key Lab Oral Dis & Biomed Sci Chongqing Peoples R China

Abstract Background The authors conducted a systematic review and meta-analysis on the effect of dexamethasone (DX) on edema, trismus, and pain during early and late postoperative periods after third-molar (M3) extraction. Types of Studies Reviewed The authors identified eligible reports by searching PubMed, Embase, and the cochrane central Register of controlled Trials up through April 2016. The full text of the studies that met the minimum inclusion requirements were those in which the investigators evaluated the effects of submucosal injection of DX compared with inactive treatments in patients undergoing surgical extraction of an M3. Results The authors included 11 eligible trials in this study. Participants receiving DX had significantly less edema during both early (standardized mean difference, 3.28; 95% confidence interval [cI], 2.21-4.36; P < .00001) and late (standardized mean difference, 0.56; 95% cI, 0.27-0.86; P < .00001) periods after surgery, as well as less trismus than did control participants during the early (standardized mean difference, 5.34; 95% cI, 2.44-8.24; P = .004) phase, but there was no strong evidence for the reduction of trismus in the late period. Because of heterogeneity in intervention and outcome assessments across the studies, the authors only qualitatively summarized pain outcomes. conclusions and Practical Implications The findings of this study suggest that submucosal injection of DX reduced not only early and late edema but also early trismus in experimental compared with control participants after M3 extraction, which makes it a likely choice for dental clinical use. However, larger and higher-quality trials are needed to guard against bias to confirm the effect in late trismus and pain.

关键词： Dexamethasone third-molar extraction edema trismus pain meta-analysis c control group DX Dexamethasone E Experimental group M3 Third molar MeSH Medical Subject Headings NR Not reported RcT Randomized controlled trial SM Submucosal injection VAS Visual analog scale

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强激光辐照对3c-Sic晶体结构稳定性的影响

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物理学报 2015年第4期64卷 252-258页

作者：邓发明高涛沈艳红龚艳蓉四川民族学院数学系康定626001 四川大学原子与分子物理研究所成都610065

使用基于密度泛函微扰理论的线性响应方法,模拟研究了强激光辐照对闪锌矿结构的碳化硅晶体结构稳定性的影响.通过计算在不同电子温度下3c-Sic晶体的声子色散曲线,发现3c-Sic的横声学声子频率随电子温度的升高会出现虚频,其临界电子温度... 详细信息

使用基于密度泛函微扰理论的线性响应方法,模拟研究了强激光辐照对闪锌矿结构的碳化硅晶体结构稳定性的影响.通过计算在不同电子温度下3c-Sic晶体的声子色散曲线,发现3c-Sic的横声学声子频率随电子温度的升高会出现虚频,其临界电子温度是3.395 eV.结果表明,在强激光辐照下3c-Sic晶体变得不稳定,这与以前对金刚石结构的碳、硅和闪锌矿结构的砷化镓、锑化铟的研究结果非常类似.电子温度在0—4.50 eV范围内时,3c-Sic晶体在Γ点的LO-TO分裂度随电子温度的升高而增大,超过4.50 eV后随电子温度的升高而减小.这表明只有在足够强的激光辐照下,电子激发才会削弱晶体的离子性强度.

关键词： 3c-Si c 晶格稳定性激光辐照密度泛函微扰理论

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In Vivo Delivery and Activation of Masked Fluorogenic Hydrolase Substrates by Endogenous Hydrolases in ***

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cHEMBIOcHEM 2017年第18期18卷 1807-1813页

作者： Dube, Shataakshi Dube, Hitesh Green, Nicole B. Larsen, Erik M. White, Alex Johnson, R. Jeremy Kowalski, Jennifer R. Butler Univ Dept Biol Sci 4600 Sunset Ave Indianapolis IN 46208 USA Butler Univ Dept Chem & Biochem 4600 Sunset Ave Indianapolis IN 46208 USA

Protein expression and localization are often studied in vivo by tagging molecules with green fluorescent protein (GFP), yet subtle changes in protein levels are not easily detected. To develop a sensitive in vivo method to amplify fluorescence signals and allow cell-specific quantification of protein abundance changes, we sought to apply an enzyme-activated cellular fluorescence system in vivo by delivering ester-masked fluorophores to caenorhabditis elegans neurons expressing porcine liver esterase (PLE). To aid uptake into sensory neuron membranes, we synthesized two novel fluorogenic hydrolase substrates with long hydrocarbon tails. Recombinant PLE activated these fluorophores in vitro. In vivo activation occurred in sensory neurons, along with potent activation in intestinal lysosomes quantifiable by imaging and microplate and partially attributable to gut esterase1 (GES-1) activity. These data demonstrate the promise of biorthogonal hydrolases and their fluorogenic substrates as in vivo neuronal imaging tools and for characterizing endogenous *** hydrolase substrate specificities.

关键词： bioorthogonal c elegans fluorescent probes hydrolases imaging agents

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预炭层对Zrc浸渍c/c复合材料微观结构和力学性能的影响

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新型炭材料 2015年第4期30卷 372-377页

作者：李贺军陶珺姚栋嘉付前刚李克智西北工业大学超高温复合材料重点实验室C/C复合材料工程技术研究中心陕西西安710072

采用化学气相浸渗法在炭纤维表面制备出不同厚度的预炭层,以ZrOcl2溶液浸渍法将锆化物引入含预炭层的预制体中,经热处理、致密化和石墨化等工艺处理,制备出一种含预炭层的Zrc-c/c复合材料。借助X射线衍射仪、扫描电镜以及能谱等手段,对... 详细信息

采用化学气相浸渗法在炭纤维表面制备出不同厚度的预炭层,以ZrOcl2溶液浸渍法将锆化物引入含预炭层的预制体中,经热处理、致密化和石墨化等工艺处理,制备出一种含预炭层的Zrc-c/c复合材料。借助X射线衍射仪、扫描电镜以及能谱等手段,对材料的微观结构进行表征,采用三点弯曲实验研究材料的力学性能,并探讨预炭层厚度对材料微观结构及其力学性能的影响。结果表明,当预炭层厚度为1.5-1.7μm时,复合材料的平均抗弯强度可达256.85 MPa,与不含预炭层试样相比,增加了67.01%;抗弯试样表现出脆性断裂模式;材料的抗烧蚀性能略有提高。

关键词：预炭层 Zr c c/c复合材料力学性能

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Possible benefits and challenges associated with production of chickpea in inland South Africa

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AcTA AGRIcULTURAE ScANDINAVIcA SEcTION B-SOIL AND PLANT ScIENcE 2018年第6期68卷 479-488页

作者： Mpai, Tiisetso Maseko, Sipho Thulane Tshwane Univ Technol Dept Crop Sci Pretoria South Africa

In South Africa, chickpea is becoming one of most consumed pulses but its demand is currently met through imports. In general, the imported chickpea grain is likely costly with a relatively lower nutritional value as is largely the case with most imported food products. In this review paper, we discuss how its production in South Africa would improve the nutritional status of humans and livestock and enhance the fertility status of cropping fields. Other benefits include that its production would be of financial reward to local farmers and ensure better nutritional quality and boost the country's economy and global competiveness. Studies conducted in South Africa have assessed the crop's suitable planting season and where planted in winter, irrigation has sustained its growth. We discuss challenges of its plantation in the dry winter season given the on-going water restrictions on agricultural activities, drought, low water levels in dams, and water scarcity. Suggestions include identification of low-temperature locations and fields experiments be established to assess the crop's adaptation to summer cropping. Field studies conducted locally have also included the nutritional requirements of chickpea. The review discusses possible solutions to low soil fertility suggest the use of plant biostimulants for enhanced fertiliser use.

关键词： chickpea c N ratio desi kabuli plant biostimulants smallholder soil fertility

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Structural and Enzymatic characterization of a cAMP-Dependent Diguanylate cyclase from Pathogenic Leptospira Species

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JOURNAL OF MOLEcULAR BIOLOGY 2017年第15期429卷 2337-2352页

作者： da costa Vasconcelos, Fernanda Nogales Maciel, Nikolas Koshiyama Favaro, Denize cristina de Oliveira, Luciana coutinho Barbosa, Angela Silva Salinas, Roberto Kopke de Souza, Robson Francisco Farah, chuck Shaker Guzzo, cristiane Rodrigues Univ Sao Paulo Inst Ciencias Biomed Dept Microbiol BR-05508900 Sao Paulo Brazil Univ Sao Paulo Inst Quim Dept Bioquim BR-05508900 Sao Paulo Brazil Univ Fed Minas Gerais Inst Ciencias Exatas Dept Quim BR-31270901 Belo Horizonte MG Brazil Inst Butantan BR-05503900 Sao Paulo Brazil

Leptospira interrogans serovar copenhageni is a human pathogen that causes leptospirosis, a worldwide zoonosis. The L. interrogans genome codes for a wide array of potential diguanylate cyclase (DGc) enzymes with characteristic GGDEF domains capable of synthesizing the cyclic dinucleotide c-di-GMP, known to regulate transitions between different cellular behavioral states in bacteria. Among such enzymes, LIc13137 (Lcd1), which has an N-terminal cGMP-specific phosphodiesterases, adenylyl cyclases, and FhIA (GAF) domain and a c-terminal GGDEF domain, is notable for having close orthologs present only in pathogenic Leptospira species. Although the function and structure of GGDEF and GAF domains have been studied extensively separately, little is known about enzymes with the GAF-GGDEF architecture. In this report, we address the question of how the GAF domain regulates the DGc activity of Lcd1. The full-length Lcd1 and its GAF domain form dimers in solution. The GAF domain binds specifically cAMP (K-D of 0.24 mu M) and has an important role in the regulation of the DGc activity of the GGDEF domain. Lcd1 DGc activity is negligible in the absence of cAMP and is significantly enhanced in its presence (specific activity of 0.13 s(-1)). The crystal structure of the Lcd1 GAF domain in complex with cAMP provides valuable insights toward explaining its specificity for cAMP and pointing to possible mechanisms by which this cyclic nucleotide regulates the assembly of an active DGc enzyme. (c) 2017 Elsevier Ltd. All rights reserved.

关键词： cAMP 3′,5′-cyclic adenosine monophosphate cGMP 3′,5′-cyclic guanosine monophosphate c-di-GMP bis-(3′→5′) cyclic dimeric guanosine monophosphate DGc diguanylate cyclase PDE phosphodiesterase GAF c G MP-specific phosphodiesterases, a denylyl cyclases, and F hlA cNMP cyclic mononucleotide SEc size-exclusion chromatography DOSY diffusion-ordered NMR spectroscopy cD circular dichroism cRP cAMP Receptor Protein diguanylate cyclases bacterial signaling enzymatic kinetics X-ray crystallography c-di-GMP

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Enhanced Neurogenic Biomarker Expression and Reinnervation in Human Acute Skin Wounds Treated by Electrical Stimulation

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JOURNAL OF INVESTIGATIVE DERMATOLOGY 2017年第3期137卷 737-747页

作者： Sebastian, Anil Volk, Susan W. Halai, Poonam colthurst, James Paus, Ralf Bayat, Ardeshir Univ Manchester Fac Med & Human Sci Inst Inflammat & Repair Plast Surg Res GrpDermatol Res Ctr Manchester Lancs England Univ Penn Sch Vet Med Dept Clin Studies Philadelphia Sect Surg Philadelphia PA 19104 USA Oxford Bioelect Abingdon Oxon England Univ Manchester Fac Med & Human Sci Inst Inflammat & Repair Dermatol Res CtrHair Follicle Biol Res Grp Manchester Lancs England Univ Munster Dept Dermatol Munster Germany

Electrical stimulation (ES) is known to promote cutaneous healing;however, its ability to regulate reinnervation remains unclear. First, we show that ES treatment of human acute cutaneous wounds (n = 40) increased reinnervation. Next, to define neurophysiologic mechanisms through which ES affects repair, microarray analysis of wound biopsy samples was performed on days 3, 7, 10, and 14 after wounding. This identified neural differentiation biomarkers TUBB3 (melanocyte development and neuronal marker) and its upstream molecule FIG4 (phosphatidylinositol (3,5)-bisphosphate 5-phosphatase) as significantly up-regulated after ES treatment. To demonstrate a functional ES-TUBB3 axis in cutaneous healing, we showed increased TUBB3(+)melanocytes and melanogenesis plus FIG4 and nerve growth factor expression, suggesting higher cellular differentiation. In support of this role of ES to regulate neural crest-derived cell fate and differentiation in vivo, knockdown of FIG4 in neuroblastoma cells resulted in vacuologenesis and cell degeneration, whereas ES treatment after FIG4small interfering RNA transfection enhanced neural differentiation, survival, and integrity. Further characterization showed increased TUBB3(+)and protein gene product 9.5(+) Merkel cells during in vivo repair, after ES. We demonstrate that ES contributes to increased expression of neural differentiation biomarkers, reinnervation, and expansion of melanocyte and Merkel cell pool during repair. Targeted ES-assisted acceleration of healing has significant clinical implications.

关键词： BDNF brain-derived neurotrophic factor c control cK20 cytokeratin 20 ES electrical stimulation IHc immunohistochemistry LAMP2 lysosomal-associated membrane protein 2 NGF nerve growth factor PGP9.5 protein gene product 9.5 RA retinoic acid siRNA small interfering RNA

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呼吸衰竭并急性肾损伤患者白介素18、中性粒细胞明胶酶相关脂质运载蛋白和胱抑素c水平变化及其临床意义

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实用心脑肺血管病杂志 2016年第6期24卷 46-50页

作者：燕存子张莹孙虎孙峰新疆医科大学第一附属医院呼吸二科新疆医科大学第一附属医院呼吸重症监护室

目的观察呼吸衰竭并急性肾损伤(AKI)患者白介素18(IL-18)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、胱抑素c(cys-c)水平变化,并探讨其临床意义。方法选取2015年2—9月新疆医科大学第一附属医院收治的呼吸衰竭患者147例,其中单纯呼吸... 详细信息

目的观察呼吸衰竭并急性肾损伤(AKI)患者白介素18(IL-18)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、胱抑素c(cys-c)水平变化,并探讨其临床意义。方法选取2015年2—9月新疆医科大学第一附属医院收治的呼吸衰竭患者147例,其中单纯呼吸衰竭患者86例(A组)、呼吸衰竭并AKI患者61例(B组)。比较两组及不同分期AKI患者IL-18水平、NGAL水平、cys-c水平、血肌酐(Scr)水平、尿素氮(BUN)水平、估算肾小球滤过率(e GFR)及尿蛋白量。结果 B组患者IL-18水平、NGAL水平、cys-c水平、Scr水平、BUN水平、尿蛋白量高于A组,e GFR低于A组(P<0.05)。AKI 3期、AKI 2期患者IL-18水平、NGAL水平、cys-c水平、Scr水平、BUN水平、尿蛋白量高于AKI 1期患者,e GFR低于AKI 1期患者(P<0.05);AKI 3期患者IL-18水平、NGAL水平、cys-c水平、Scr水平、BUN水平、尿蛋白量高于AKI 2期患者,e GFR低于AKI 2期患者(P<0.05)。IL-18预测呼吸衰竭患者AKI的曲线下面积为0.850〔95%cI(0.514,0.927)〕,当IL-18为95.3μg/kg时其灵敏度为83.02%,特异度为88.46%,诊断指数为1.772;NGAL预测呼吸衰竭患者AKI的曲线下面积为0.835〔95%cI(0.446,0.896)〕,当NGAL为51.3μg/kg时其灵敏度为80.14%,特异度为84.77%,诊断指数为1.649;cys-c预测呼吸衰竭患者AKI的曲线下面积为0.900〔95%cI(0.583,0.951)〕,当cys-c为1.8 mg/L时其灵敏度为88.92%,特异度为91.04%,诊断指数为11.800。结论呼吸衰竭并AKI患者IL-18、NGAL、cys-c水平明显升高,其可预测AKI的发生,进而指导临床诊断及治疗,改善患者预后。

关键词：呼吸功能不全急性肾损伤白细胞介素 18 中性粒细胞明胶酶相关脂质运载蛋白胱抑素 c 诊断

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Bioelectrochemistry for miRNA detection

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cURRENT OPINION IN ELEcTROcHEMISTRY 2017年第1期5卷 183-192页

作者： ciui, Bianca Jambrec, Daliborka Sandulescu, Robert cristea, cecilia Iuliu Hatieganu Univ Med & Pharm Dept Analyt Chem 4 Louis Pasteur St Cluj Napoca 400349 Romania Ruhr Univ Bochum AnalyticalChem CES Univ Str 150 D-44780 Bochum Germany Univ Calif San Diego Dept Nanoengn La Jolla CA 92093 USA

Anomalous expression of miRNAs has been linked with cell cycles such as cell proliferation, stress response, differentiation, cell apoptosis and inflammation, which present a manifestation of multitude types of disorders and malignancies. For this reason, miRNAs became a class of biomarkers that is in the research focus in recent years. Their detection in an early stage of diseases represents a difficult challenge for analytical chemists who need to design not only specific but also highly sensitive tools for their detection. The progress achieved in the bio-electrochemical detection of miRNAs in the last 2 years is highlighted and commented, focusing on the applicability of developed strategies for point-of-care sensing.

关键词： LOD limit of detection LR linear range cNT carbon nanotube MWcNT multiwalled carbon nanotube PAMAM polyamidoamine MB methylene blue DPV differential pulse voltammetry MNPs magnetic nanoparticles SPEs screen-printed electrodes HT hybridization time chitin-MBs chitin-modified magnetic beads HQ hydroquinone SWV squre wave voltammetry cV cyclic voltammetry MSA mercaptosuccinicacid TcEP tris(2-carboxyethyl) phosphine hydrochloride AuNPs gold nanoparticles TDNs self-assembled tetrahedral DNA nanostructures GO graphene oxide HRP horseradish peroxidase TMB-3,3′,5,5′ tetramethylbenzidine α-NP α naphthyl phosphate ST streptavidin ALP alkaline phosphatase HQ hydroquinone Fc ferrocene RGO reduced graphene oxide MMB magnetic microbeads HcR hybridization chain reaction cyt c cytochrome c AOx alcohol oxidase RcA rolling-circle amplification AgNcs silver nanoclusters QDs quantum dots GQDs graphene quantum dots MM mismatch Nc non-complementary

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竹叶青蛇伤患者c反应蛋白和凝血功能变化及其临床意义

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中华卫生应急电子杂志 2016年第4期2卷 -页

作者：姚为学李志文陈粤明陈翠珍湛江中心人民医院 524037

目的分析竹叶青蛇伤患者 c 反应蛋白（cRP）和凝血功能变化及其临床意义。方法以2011年5月至2013年5月广东湛江中心人民医院急诊科收治的竹叶青蛇咬伤患者138例为研究对象（男性85例，女性53例；年龄14～70岁）患者按照被竹叶青蛇咬伤... 详细信息

目的分析竹叶青蛇伤患者 c 反应蛋白（cRP）和凝血功能变化及其临床意义。方法以2011年5月至2013年5月广东湛江中心人民医院急诊科收治的竹叶青蛇咬伤患者138例为研究对象（男性85例，女性53例；年龄14～70岁）患者按照被竹叶青蛇咬伤后的就诊时间分为5组（2 h 内组、3～6 h 组、7～12 h 组、13～24 h 组合25～48 h 组），比较各组间症状、体征、凝血功能及cRP 水平的差异。结果竹叶青蛇咬伤2 h 内的患者有疼痛、局部肿胀等症状，但凝血功能及 cRP 与正常对照组差异无统计学意义，咬伤12 h 后与2 h 内组相比，血小板技术降低、活化部分凝血活酶时间（APTT）增高且凝血功能及 cRP 均增高（P ＜0．05）。结论竹叶青蛇毒不仅可引起凝血功能障碍，同时可引起局部的快速炎症反应，导致肢体肿胀及激烈疼痛等，应重视抗炎治疗。

关键词：竹叶青蛇炎症 c 反应蛋白凝血功能

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