创意是一种投资,是你不同于竞争对手最大的资产,是表达自己时最重要的工具,也是品牌的重要力量!——迅销集团全球创意总裁John c Jay一直以创新傲立行业的优衣库,在打造极致线下体验的征途上,又推最新力作,和迪士尼合作的＂MAGIc FOR AL...
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创意是一种投资,是你不同于竞争对手最大的资产,是表达自己时最重要的工具,也是品牌的重要力量!——迅销集团全球创意总裁John c Jay一直以创新傲立行业的优衣库,在打造极致线下体验的征途上,又推最新力作,和迪士尼合作的＂MAGIc FOR ALL概念店＂于2015年9月27日,大家都在庆祝中国传统节日——中秋佳节之际,在淮海路的最大旗舰店优衣库上海全球首发,掀起一场全新的奇幻美妙购物体验。
The purpose of this study was to analyse specific molecular mechanisms involved in the intrinsic resistance of c. albicans biofilms to antifungals. We investigated the transcriptional profile of three genes (BGL2, SUN...
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The purpose of this study was to analyse specific molecular mechanisms involved in the intrinsic resistance of c. albicans biofilms to antifungals. We investigated the transcriptional profile of three genes (BGL2, SUN41, EcE1) involved in candida cell wall formation in response to voriconazole or anidulafungin after the production of intermediate and mature biofilms. c. albicans M61, a well-documented biofilm producer strain, was used for the development of intermediate (12 h and 18 h) and completely mature biofilms (48 h). After exposure of cells from each biofilm growth mode to voriconazole (128 and 512 mg l(-1)) or anidulafungin (0.25 and 1 mg l(-1)) for 12-24 h, total RNA samples extracted from biofilm cells were analysed by RT-PcR. The voriconazole and anidulafungin biofilm MIc was 512 and 0.5 mg l(-1) respectively. Anidulafungin caused significant up-regulation of SUN41 (3.7-9.3-fold) and BGL2 (2.2-2.8 fold) in intermediately mature biofilms;whereas, voriconazole increased gene expression in completely mature biofilms (SUN41 2.3-fold, BGL2 2.1-fold). Gene expression was primarily down-regulated by voriconazole in intermediately, but not completely mature biofilms. Both antifungals caused down-regulation of EcE1 in intermediately mature biofilms.
In this study, we report the complete mitochondrial genome sequence of western painted turtle, chrysemys picta bellii. The genome is found to be 16,875bp in length and has a base composition of A (34.4%), G (13.0%), c...
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In this study, we report the complete mitochondrial genome sequence of western painted turtle, chrysemys picta bellii. The genome is found to be 16,875bp in length and has a base composition of A (34.4%), G (13.0%), c (26.0%), and T (26.6%). Similar to other turtles, it contains a typically conserved structure including 13 protein-coding genes, 22 transfer RNA genes, 2 ribosomal RNA genes, and 1 control region (D-loop). Most of the genes are encoded on H-strand, except for the eight tRNA and ND6 genes. All protein-coding genes start with an ATN codon except for cOX1 and ND4, which initiate with GTG instead, and terminate with the typical stop codon (TAA/TAG) or a single T (T-) or an unexpected codon of AGG. The complete mitochondrial genome sequence provided here would be useful for further phylogenetic analysis and conservation genetic studies in c. p. bellii.
Globally 71 million people are living with hepatitis c virus (HcV) out which 7.1 million (10%) are present in Pakistan. Genotype 3 is the most common HcV type in the country. World Health Organization is working with ...
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Globally 71 million people are living with hepatitis c virus (HcV) out which 7.1 million (10%) are present in Pakistan. Genotype 3 is the most common HcV type in the country. World Health Organization is working with health authorities in different countries for effective control of HcV, to reduce its incidence by 90% and to reduce hepatitis related mortality by 65% by the year 2030. There are several challenges that hinder elimination of HcV from Pakistan including the lack of patient awareness about the causes and transmission of disease, lack of affordability for investigations and drug treatment and lack of experienced healthcare professionals. Other major contributors to achieve HcV elimination are lack of effective drugs and delayed regulatory approvals combined with compromised monitoring by health authorities and lack of robust epidemiological data. Efforts are needed to educate the public about the modes of transmission and prevention of HcV infection, and massively upscale screening along with treatment. There is a dire need to prevent more than 200,000 new infections that occur each year in Pakistan. Given the scale of the problem, it is very unlikely that the government alone can handle it.
Ernährungsumstellung – vor allem das Meiden arachidonsäurehaltiger Nahrungsmittel – hilft, entzündungsunterhaltende Faktoren zu minimieren. Ausleitende Verfahren wie Aderlass- und Blutegeltherapie wir...
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Ernährungsumstellung – vor allem das Meiden arachidonsäurehaltiger Nahrungsmittel – hilft, entzündungsunterhaltende Faktoren zu minimieren. Ausleitende Verfahren wie Aderlass- und Blutegeltherapie wirken ebenfalls antientzündlich sowie umstimmend. Die Behandlung der Darmdysbiose mit einem antimykotischen und einem mikrobiologischen Präparat wirkt sich positiv auf die Arthritis ***ährungsumstellung – vor allem das Meiden arachidonsäurehaltiger Nahrungsmittel – hilft, entzündungsunterhaltende Faktoren zu minimieren. Ausleitende Verfahren wie Aderlass- und Blutegeltherapie wirken ebenfalls antientzündlich sowie umstimmend. Die Behandlung der Darmdysbiose mit einem antimykotischen und einem mikrobiologischen Präparat wirkt sich positiv auf die Arthritis aus.
chronic hepatitis c(cHc) infection affects almost 3% of the global population and can lead to cirrhosis, liver failure, and hepatocellular carcinoma in a significant number of those infected. Until recently, the only ...
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chronic hepatitis c(cHc) infection affects almost 3% of the global population and can lead to cirrhosis, liver failure, and hepatocellular carcinoma in a significant number of those infected. Until recently, the only treatments available were pegylated interferon and ribavirin, which traditionally were not very effective and have considerable side effects. For this reason, interest in complementary and alternative medications(cAM) in the management of hepatitis c has been investigated. Some cAM has demonstrated therapeutic potential in chronic hepatitis c treatment. Unfortunately, some cAM has been shown to have the potential to cause drug-induced liver injury. This article will review and evaluate many of the natural molecules that interact with the hepatitis c virus(HcV) life cycle and discuss their potential use and safety in HcV therapy, as well as highlight some important interactions between medical and complementary treatments.
AIM: To investigate the impact of telaprevir-based triple therapy on the serum alpha-fetoprotein(AFP) level of chronic hepatitis c ***: A total of 210 patients with chronic hepatitis c genotype 1 of high viral load(ba...
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AIM: To investigate the impact of telaprevir-based triple therapy on the serum alpha-fetoprotein(AFP) level of chronic hepatitis c ***: A total of 210 patients with chronic hepatitis c genotype 1 of high viral load(baseline serum hepatitis c virus RNA > 5.0 log10 IU/m L) were divided into two groups by type of treatment: triple therapy with telaprevir, pegylated-interferon-α(PEGIFNα), and ribavirin(RBV) for 24 wk(n = 88), or dual therapy with PEG-IFNα and RBV for 48 wk(n = 122). The relationship between virological response and the change in the serum AFP level from baseline to 24 wk after the end of treatment was examined. RESULTS: No significant difference in mean baseline AFP level was found between the triple and dual therapy groups(8.8 ng/m L vs 7.8 ng/m L). Triple therapy produced significant declines in the AFP level in sustained virological response(SVR) and non-SVR patients(7.8 ng/m L at baseline to 3.5 ng/m L at 24 wk after the end of treatment, P < 0.001 and 14.3 ng/m L to 9.5 ng/m L, P = 0.004, respectively). In contrast, dual therapy resulted in a significant decline in AFP level only in SVR patients(4.7 ng/m L to 2.8 ng/m L, P< 0.001), but not in non-SVR patients(10.2 ng/m L to 10.1 ng/m L). Among patients with a high-baseline AFP level(≥ 10 ng/m L), the decline in the AFP level was significantly higher in the triple therapy than in the dual therapy group(15.9 ng/m L vs 1.6 ng/m L, P = 0.037). cONcLUSION: Regardless of virological response, telaprevir-based triple therapy reduced the serum AFP level.
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