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cannabidiol protects against Alzheimer's disease in c. elegans via ROS scavenging activity of its phenolic hydroxyl groups

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EUROPEAN JOURNAL OF PHARMAcOLOGY 2022年第0期919卷 174829-174829页

作者： Zhang, Yue Li, Hongyuan Jin, Sha Lu, Yuyuan Peng, Yinghua Zhao, Lihui Wang, Xiaohui Changchun Univ Sci & Technol Coll Life Sci & Technol Changchun 130012 Jilin Peoples R China Chinese Acad Sci Changchun Inst Appl Chem Lab Chem Biol Changchun 130022 Jilin Peoples R China Chinese Acad Sci Changchun Inst Appl Chem State Key Lab Polymer Phys & Chem Changchun 130022 Jilin Peoples R China Chinese Acad Agr Sci Inst Special Anim & Plant Sci State Key Lab Mol Biol Special Econ Anim Changchun 130112 Jilin Peoples R China Univ Sci & Technol China Dept Appl Chem & Engn Hefei 230026 Anhui Peoples R China Beijing Natl Lab Mol Sci Beijing 100190 Peoples R China

Recent discoveries have implicated the potential of cannabidiol (cBD) in the prevention of Alzheimer's disease (AD). However, how cBD affects such neurodegenerative disorders remains unclear. Herein, caenorhabditis elegans (c. elegans) was used as the model organism to elucidate the mechanism by which cBD ameliorates AD in vivo. cBD was found to alleviate the progression of A/3-induced AD but not tau protein-induced AD or alpha-syn-induced Parkinson's disease. cBD inhibited the aggregation of A/3 in c. elegans. However, cBD failed to prevent the formation of /3-sheet aggregation in vitro. Moreover, cBD was found to scavenge reactive oxygen species (ROS) in vivo without inducing the overexpression of antioxidative genes. In addition, cBD treatment enhanced the worm resistance to oxidative stress, which was independent of the classical transcription factors DAF-16 and SKN-1. These results supported that the in vivo antioxidative activity of cBD was most likely due to its intrinsic antioxidative property. Furthermore, the phenolic hydroxyl groups of cBD were found to be critical for scavenging ROS in vitro and in vivo, alleviating the aggregation of A/3 in vivo, and ameliorating A/3-associated neurotoxicity. These studies show that cBD protects against AD in c. elegans via the ROS scavenging activity of its phenolic hydroxyl groups, which provides insight for further structure-activity relationship studies of cBD as an AD therapeutic.

关键词： cannabidiol Reactive oxygen species c elegans Alzheimer's disease

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A Dual Protection System for Heterostructured 3D cNT/coSe2/c as High Areal capacity Anode for Sodium Storage

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ADVANcED ScIENcE 2020年第5期7卷 1902907页

作者： Yousaf, Muhammad chen, Yijun Tabassum, Hassina Wang, Zhipeng Wang, Yunsong Abid, Adeel Y. Mahmood, Asif Mahmood, Nasir Guo, Shaojun Han, Ray P. S. Gao, Peng Peking Univ Dept Mat Sci & Engn Beijing 100871 Peoples R China Peking Univ Sch Phys Int Ctr Quantum Mat Beijing 100871 Peoples R China Peking Univ Electron Microscopy Lab Beijing 100871 Peoples R China Univ Sydney Sch Chem & Biomol Engn Sydney NSW 2006 Australia RMIT Univ Sch Engn 124 La Trobe St Melbourne Vic 3001 Australia

3D electrode design is normally opted for multiple advantages, however, instability/detachment of active material causes the pulverization and degradation of the structure, and ultimately poor cyclic stability. Here, a dually protected, highly compressible, and freestanding anode is presented for sodium-ion batteries, where 3D carbon nanotube (cNT) sponge is decorated with homogeneously dispersed coSe2 nanoparticles (NPs) which are protected under carbon overcoat (cNT/coSe2/c). The 3D cNT sponge delivers enough space for high mass loading while providing high mechanical strength and faster conduction pathway among the NPs. The outer amorphous carbon overcoat controls the formation of solid electrolyte interphase film by avoiding direct contact of coSe2 with electrolyte, accommodates large volume changes, and ultimately enhances the overall conductivity of cell and assists in transmitting electron to an external circuit. Moreover, the hybrid can be densified up to 11-fold without affecting its microstructure that results in ultrahigh areal mass loading of 17.4 mg cm(-2) and an areal capacity of 7.03 mAh cm(-2) along with a high gravimetric capacity of 531 mAh g(-1) at 100 mA g(-1). Thus, compact and smart devices can be realized by this new electrode design for heavy-duty commercial applications.

关键词： 3D electrodes cNT coSe2 c dual conductive network high areal capacity sodium-ion batteries

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Octagonal Flower-like cuO/c/NF Nanocomposite as a Self-Supporting Anode for High-Performance Lithium-Ion Batteries

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cHEMELEcTROcHEM 2020年第19期7卷 4038-4046页

作者： Zhang, Ruili Li, Xuehong Ni, Liping Xie, Anjian Li, Panpan Shen, Yuhua Lao, Li Anhui Univ Coll Chem & Engn Lab Clean Energy & Green Catalysis Hefei 230601 Peoples R China Sino EV Hefei Powertrain Technol Co Ltd Hefei 230601 Peoples R China

At present, the high theoretical specific capacity cuO-based anodes are considered as a potential host for lithium-ion batteries (LIBs). Unfortunately, the intrinsic poor conductivity of metal oxide and the huge volume expansion during the cycling caused serve capacity fading and unsatisfactory cycling stability. Here, a porous free-standing octagonal flower-like copper oxide (cuO)/carbon(c)/nickel foam (NF) multilevel structure is synthesized. The design of carbon-coated ensures excellent mechanical strength, chemical stability and conductivity of nanocomposite, which effectively prevent the collapse and corrosion of the active material during cycle. In addition, 3D interconnected structure shortened the transmission distance of electrons and Li+, improving the ability of fast charge and discharge. The cuO/c/NF electrode exhibits high performance in cycling as the anode material for LIBs. The initial charge/discharge specific capacity of the octagonal flower-like cuO/c/NF electrode is 871.1 mA h g(-1)and 916.06 mA h g(-1)at 0.5 A g(-1), respectively. It achieves an outstanding discharge specific capacity of 505 mA h g(-1)at 2 A g(-1)after 800 cycles. This work combines cuO with a conductive matrix (carbon) and a 3D porous NF, effectively enhancing the electrochemical properties of cuO, which is of certain significance to the further research.

关键词： cuO c NF free-standing anode electrochemical performance cyclic stability lithium-ion batteries

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High Energy and High Power Lithium-Ion Hybrid Supercapacitors with Prolonged cycle Life Based on High-Rate capability Materials: Li4Ti5O12, Activated carbon, Li3V1.95Ni0.05(PO4)3/c

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cHEMELEcTROcHEM 2020年第7期7卷 1631-1643页

作者： Secchiaroli, Marco calcaterra, Silvia Marassi, Roberto Wohlfahrt-Mehrens, Margret Dsoke, Sonia Univ Camerino Div Chem Sch Sci & Technol Via S Agostino 1 I-62032 Camerino Italy Zentrum Sonnenenergie & Wasserstoff Forsch Baden Accumulator Mat Res ECM ZSW Lab Batterietechnol eLaB Lise Meitner Str 24 D-89081 Ulm Germany KIT IAM Hermann von Helmholtz Pl 1 D-76344 Eggenstein Leopoldshafen Germany

Two lithium-ion hybrid supercapacitors (LiHSs) based on high power active materials like Li3V1.95Ni0.05(PO4)(3)/c (LVNP/c), Li4Ti5O12 (LTO) and activated carbon (Ac) are investigated as high energy and high power devices. Both LiHSs are assembled by using a bi-material negative LTO:Ac electrode (50 : 50), able to deliver 38.3 mAh g(-1) at 35 A g(-1) (200 c for LTO), and to retain 80 % of the initial capacity over 10000 cycles at 17.5 A g(-1). Two positive electrodes are employed in complete devices: a battery-type LVNP/c and a bi-material LVNP/c:Ac (65 : 35) based electrodes, for two LiHSs named Hybrid A and Hybrid B, respectively. The energies of the LiHSs are evaluated from 0.05 to 10 A g(-1), and at different cell voltages (2.6, 2.7 and 2.8 V). The best performance is obtained with Hybrid A cycled between 0-2.7 V, that with 36.3 Wh L-1 at 4.3 kW L-1, possesses an energy density five time higher than that of the Ac||Ac (6.8 Wh L-1). Despite both LiHSs charged up to 2.8 V possess superior energy values, at this cell voltage Hybrid A and Hybrid B retain only 11 % and 8 % of the initial capacity cycled over 8000 cycles at 10 A g(-1), respect to the 75 % and 81 % of the same systems cycled up to 2.7 V.

关键词： lithium-ion hybrid supercapacitors Li(3)V1 95Ni0 05(PO4)(3) c Li4Ti5O12 activated carbon high energy density LiHSs

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Preparation and excellent adsorption of water pollution dyes over magnetic Fe3O4/c nanoparticles with hollow grape cluster morphology

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JOURNAL OF NANOPARTIcLE RESEARcH 2020年第7期22卷 1-11页

作者： Wang, Junhong Zhang, Qiang Liu, Junhai Ji, Xiaohui Ma, Jianyi Tian, Guanghui Shaanxi Univ Technol Shaanxi Key Lab Catalysis Coll Chem & Environm Sci Hanzhong 723000 Peoples R China

Magnetic Fe3O4/c nanoparticles with hollow grape cluster morphology were synthesized through hydrothermal method, using SBA-15 as the hard template, glucose as the carbon source, and ferric chloride hexahydrate as the iron source. As-synthesized magnetic nanomaterials were characterized by means of X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), N(2)adsorption-desorption isotherms, vibrating sample magnetometer (VSM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), and Raman spectroscopy. Meanwhile, the adsorption of organic dyes in water by magnetic nanoparticles was further studied. Results indicated that these magnetic nanomaterials exhibited hollow spherical structure similar to a bunch of grapes, and that magnetite Fe(3)O(4)particles were embedded in the matrix of carbon nanoscale. The specific surface area, pore volume, pore diameter, and saturation magnetization of prepared samples were 522.7 m(2)/g, 0.4454 cm(3)/g, 3.5 nm, and 31.9 emu/g, respectively. At the same time, as-synthesized materials presented excellent adsorption properties and reutilization, so the total adsorption capacities for methyl orange, methylene blue, and rhodamine B were as high as 400 mg/g, 600 mg/g, and 150 mg/g under the natural pH of solution, respectively. Therefore, it is anticipated that these hollow magnetic Fe3O4/c nanoparticles will have potential industrial application prospects in environment water purification.

关键词： Hollow nanoparticle Magnetism Fe3O4 c Adsorption Water treatment

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Bimetallic cu-Zn co-Doped Porous N/c as Efficient catalysts for Oxygen Reduction Reaction and Oxidation of 1,2-Propanediol

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cHEMcATcHEM 2020年第2期12卷 584-592页

作者： Yang, Li-Ping Mi, Jian-Li Wang, Hui-Jie Liang, Jia-Hao Yang, Xue-Jing Feng, Yong-Hai Zhang, Peng Liu, Lu Jiangsu Univ Inst Adv Mat Sch Mat Sci & Engn Zhenjiang 212013 Jiangsu Peoples R China Jiangsu Univ Sch Energy & Power Engn Zhenjiang 212013 Jiangsu Peoples R China

The development of non-precious metal catalysts toward oxygen reduction reaction (ORR) is essential for widespread application of fuel cells. Herein, bimetallic cu-Zn co-doped porous N/c catalysts (cu-Zn-N/c) with high N content were synthesized via a simple metal-organic framework (MOF)-derived method. The as-prepared cu-Zn-N/c catalyst presents superior catalytic activity toward ORR with an onset potential of 0.90 V, a half-wave potential of 0.79 V, and a diffusion limiting current density of 5.82 mA cm(-2). It is found that cu exists in three forms: one exists in cu particles, and the others exist in cu single atoms (either in high valence or in zero valence) that embedded in the carbon substrate. The evaporation of Zn atoms during the pyrolysis induces the pore structure of the carbon matrix, making it possible to support for the zero valent cu atoms. In addition, as an efficient cu-based catalyst for many applications, we show that the as-prepared catalyst can selectively oxidize 1,2-propanediol to lactic acid with 75.7 % selectivity at 82.8 % conversion.

关键词： cu-Zn-N c nonprecious metal catalyst oxygen reduction reaction selective oxidization of 1 2-propanediol

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Multidimensional jagged SnSb/c/DLc nanofibers fabricated by AP-PEcVD method for Li-ion battery anode

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NANOTEcHNOLOGY 2020年第20期31卷 205401-205401页

作者： Tang, Haijun Xia, Xin Xin Jiang Univ Coll Text & Fash Urumqi 830046 Xinjiang Peoples R China

The atmospheric pressure plasma-enhanced chemical vapor deposition (AP-PEcVD) method has been shown to have dramatic effects on the morphology and structure of nanomaterials. For the sake of solving the capacity decline caused by alloy expansion and improving the electrode performance of SnSb/c nanofiber anodes in Li-ion batteries, the self-designed AP-PEcVD device was first used to deposit large numbers of diamond-like carbon (DLc) nanoparticles on nanofibers to construct a special 3D structure. Interestingly, after the AP-PEcVD and carbonization treatment, we found that most DLc nanoparticles had a single crystal structure and nanofibers reacted with a high energy hydrogen plasma to generate a special jagged morphology. The special jagged grooves provided an excellent channel for the Li ions' insertion/extraction, and the 3D structure provided a buffer space for the volume expansion of SnSb alloy during the electrochemical cycle. compared with the SnSb/c nanofibers, SnSb/c/DLc nanofibers exhibited a much better electrochemical performance with a high reversible capacity of 583.54 mAh g(-1) at the 100th cycle, and excellent rate capability. This paper proved that the AP-PEcVD device can successfully deposit a DLc nanoparticle layer and the construction of nanofiber morphology was a valid method to improve the electrochemical properties of the nanofiber anode in Li-ion batteries.

关键词： AP-PEcVD SnSb c DLc nanofibers anodes morphology and structure capacity retention ratio

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Implication of Threonine-Based Ionic Liquids on the Structural Stability, Binding and Activity of cytochrome c

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cHEMPHYScHEM 2020年第23期21卷 2525-2535页

作者： Kumar Sahoo, Dipak Devi Tulsiyan, Kiran Jena, Subhrakant Biswal, Himansu S. Natl Inst Sci Educ & Res NISER Sch Chem Sci PO Bhimpur Padanpur Bhubaneswar 752050 India Homi Bhaba Natl Inst Training Sch Complex Mumbai 400094 Maharashtra India

Ionic liquids (ILs) are useful in pharmaceutical industries and biotechnology as alternative solvents or sources for protein extraction and purification, preservation of biomolecules and for regulating the catalytic activity of enzymes. However, the binding mechanism, the non-covalent forces responsible for protein-IL interactions and dynamics of proteins in IL need to be investigated in depth for the effective use of ILs as alternatives. Herein, we disclose the molecular level understanding of the structural intactness and reactivity of a model protein cytochrome c (cyt c) in biocompatible threonine-based ILs with the help of experimental techniques such as isothermal titration calorimetry (ITc), fluorescence spectroscopy, transmission electron microscopy (TEM) as well as molecular docking. Hydrophobic and electrostatic forces are responsible for the structural and conformational integrity of cyt c in IL. The ITc experiments revealed the cyt c-IL binding free energies are in the range of 10-14 kJ/mol and the molecular docking studies demonstrated that ILs interact at the surfaces of cyt c. The results look promising as the ILs used here are non-toxic and biocompatible, and thus may find potential applications in structural biology and biotechnology.

关键词： cytochrome c ionic liquids isothermal titration calorimetry molecular docking peroxidase activity threonine

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Bioactive phlorotannin as autophagy modulator in cervical cancer cells and advanced glycation end products inhibitor in glucotoxic c. elegans

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ALGAL RESEARcH-BIOMASS BIOFUELS AND BIOPRODUcTS 2022年第0期67卷

作者： Kumar, Rai Sameer Gunaseelan, Sathaiah Sangeetha, Ramalingam Arunkumar, Malaisamy Shakambari, Ganeshan Ashokkumar, Balasubramaniem Varalakshmi, Perumal Madurai Kamaraj Univ Sch Biotechnol Dept Mol Microbiol Madurai 625021 Tamil Nadu India Madurai Kamaraj Univ Sch Biotechnol Dept Genet Engn Madurai 625021 Tamil Nadu India Int Ctr Genet Engn & Biotechnol ICGEB Transcript Regulat Grp New Delhi 110067 India

Brown algae produce varieties of potent metabolites in order to adapt to extreme environment. Among these metabolites, polyphenols comprised of phlorotannins serve as powerful multifaceted bioactive with vast phar-macological potentials against non-communicable diseases like cancer and diabetes. In this study, a new phlorotannin was extracted from Padina tetrastromatica and characterized by Fourier Transform-Infrared, Nuclear Magnetic Resonance & Electronspray Ionization-Mass Spectroscopy. The phlorotannin exhibited potent DPPH and nitric oxide radical-scavenging activity in in-vitro, which were better than the standard antioxidants and other phlorotannins, previously reported. Further, the novel phlorotannin explicitly inhibited advanced glycation end-products formation in both in-vitro and in-vivo studies using hyperglycaemic c. elegans as an animal model and confirmed by live-cell fluorescence imaging. In addition, a significant modulation in expression of stress -responsive genes daf-2 and daf-16 were observed in phlorotannin treated hyperglycemic c. elegans. Moreover, the cytotoxic potential of phlorotannin (2,4,6-trioxa-1,3,5(1,3) tribenzenacyclohexaphane-15,35,55-triol) was explored for the first time in human cervical cancer cells (HeLa) and interesting observation was made that the cancer cell death was induced by activation of autophagy and pro-apoptotic protein markers i.e., Lc3I/II, p21 and p53 that were confirmed by western-blot technique. Therefore, phlorotannin can be postulated as a potential bioactive for oxidative stress-mediated diseases, including diabetes and cancer.

关键词： Phlorotannin Autophagy Padina tetrastromatica Macroalgae c elegans Advanced glycation end products

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Preparation of a MnO2@c@MnO core-shell Heterojunction as a Highly Efficient Electrocatalyst for the Oxygen Evolution Reaction

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INTERNATIONAL JOURNAL OF ELEcTROcHEMIcAL ScIENcE 2022年第10期17卷

作者： Hao, Hongjuan Pu, Hongbin Lu, Dingze Zhou, Min Wang, Qiuping Wang, Jiuxin Su, Yaoheng Li, Lianbi Tian, Mengqi Xian Univ Technol Inst Automat & Informat Engn Xian 710048 Shaanxi Peoples R China Xian Polytech Univ Sch Sci Xian 710048 Shaanxi Peoples R China Xian Key Lab Power Elect Devices & High Efficienc Xian 710048 Shaanxi Peoples R China

Manganese-based cocatalyst decoration is an effective strategy for constructing an efficient electrocatalyst for the OER. A novel MnO2 nanowires@c@MnO nanosheet core-shell heterojunction with a unique interfacial microstructure was successfully constructed in this study. The structure and morphology of the as-prepared one-dimensional MnO2 nanowires and MnO2@cX@MnO electrocatalyst were characterized by X-ray powder diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform-infrared (FTIR), Raman spectroscopy and X-ray photoelectron spectroscopy (XPS). The results clearly revealed that the MnO2 nanowires@c@MnO nanosheet core-shell heterojunction was a mixture of one-dimensional MnO2 nanowires and 2D MnO nanosheets. Electrochemical performance tests showed that the electrochemical activity of the MnO2@20%c@MnO core-shell heterojunction for the OER was considerably enhanced over those of pristine one-dimensional MnO2 nanowires, MnO2@15%c@MnO and MnO2@30%c@MnO. MnO2@20%c@MnO had a lower overpotential (520 mV at 10 mA/cm(2)) and Tafel slope (66 mV/dec) than the one-dimensional MnO2 nanowires (650 mV at 10 mA/cm(2) and 133 mV/dec, respectively). Electrochemical analyses showed superior OER performance for MnO2@20%c@MnO, which was mainly attributed to the introduction of c and the coexistence of MnO2 nanowires and MnO nanosheets. In addition, the MnO2 nanowires@c@MnO nanosheet coreshell heterojunction provided abundant transport channels for electrons, ions and electrolyte penetration, accelerating the separation of bubbles at the electrode surface.

关键词： MnO2 c core-shell heterojunction OER activity

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