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Recovery of Aliphatic Fatty Acids from Red Seaweed champia parvula (c. Agardh) and Its Antifungal Action

JOURNAL OF AQUATIc FOOD PRODUcT TEcHNOLOGY 2019年第9期28卷 922-932页

作者： Kumar, Vinoth R. Subbiah, Murugesan Ganesan, Abirami Ramu Pachaiyappas Coll Unit Algal Biotechnol & Bionanotechnol PG & Res Dept Bot Chennai Tamil Nadu India Fiji Natl Univ Dept Food Sci & Home Econ Sch Appl Sci CEST Suva Fiji

The aim of the present study was to evaluate the antifungal activity of seaweed champia parvula and identification of active compounds for this action. In this regard, c. parvula crude extracts were obtained from n-hexane, ethyl acetate, chloroform, methanol, and water used to study the antifungal action. Results showed that methanolic extract had potent action against c. albicans, c. tropicalis, T. mentagrophytes, and ***, with the highest inhibition of 16.7 mm found against c. tropicalis. Minimum inhibition concentration at 12.5 and minimum fungal concentration at 25 mu g/mL were found in the methanolic extract. Therefore, to identify the bioactive compound for this antifungal action in the methanolic extract, thin-layer chromatography (TLc) and reverse-phase high-performance liquid chromatography (RP-HPLc) were used. The RP-HPLc had three peaks with retention times at 3.30, 3.86, and 4.73 min, showing the presence of ester fatty acid compound. Further, these compounds were characterized by nuclear magnetic resonance (NMR), gas chromatography (Gc), and liquid chromatography-mass spectrometry (Lc-MS), which showed the presence of long-chain aliphatic fatty acid like eicosanoic acid with formation of oct-1-en-3-ol compounds attached.

关键词： Seaweed antifungal fatty acids eicosanoic acid c tropicalis

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Impact of hepatitis c virus genotype 3 on liver disease progression in a chinese national cohort

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chinese Medical Journal 2020年第3期133卷 253-261页

作者： Nan Wu Hui-Ying Rao Wei-Bo Yang Zhi-Liang Gao Rui-Feng Yang Ran Fei Ying-Hui Gao Qian Jin Lai Wei Peking University People’s Hospital Peking University Hepatology InstituteBeijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseaseBeijing 100044China Department of Infectious Diseases The First Affiliated Hospital of Kunming Medical CollegeKunmingYunnan 650032China Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510630China Hepatopancreatobiliary Center Beijing Tsinghua Changgung HospitalInstitute for Precision MedicineTsinghua UniversityBeijing 102218China

Background:Hepatitis c virus(HcV)genotype 3,particularly subtype 3b,is increasing in prevalence and distribution in *** study evaluated the prevalence,regional distribution,clinical characteristics,host factors,treatment outcomes,and disease progression of patients with HcV genotype 3 in ***:A 5-year follow-up was preceded by a cross-sectional *** choices were at the discretion of treating *** infection time to overall-disease-progression(defined by≥1 of:newly diagnosed cirrhosis;cirrhosis at baseline,child-Turcotte-Pugh score increased 2 points or more;progression from compensated cirrhosis to decompensated cirrhosis;hepatocellular carcinoma;liver transplantation;or death)was calculated using the Kaplan-Meier *** regression analyses were conducted to evaluate the risk factors for disease ***:The cross-sectional study enrolled 997 patients,including 91 with HcV genotype 3 *** them,subtype 3b(57.1%)was more dominant than subtype 3a(38.5%).Five hundred and twelve patients were included into the follow-up *** patients analyzed for estimated infection time to overall-disease-progression,52/304(17.1%)patients with HcV genotype 1 and 4/41(9.8%)with HcV genotype 3(4/26 with genotype 3b,0/13 with genotype 3a,and 0/2 with undefined subtype of genotype 3)experienced *** with HcV genotype 3 were younger than those with genotype 1(mean age:39.5±8.7 vs.46.9±13.6 years)and demonstrated more rapid disease progression(mean estimated infection time to overall-disease-progression 27.1 vs.35.6 years).conclusions:HcV genotype 3,specifically subtype 3b,is associated with more rapid progression of liver *** analysis to compare HcV subtype 3a and 3b is needed in high prevalence regions.

关键词： Hepatitis c virus genotype 3 chronic hepatitis c Disease progression

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MicroRNA-135a Modulates Hepatitis c Virus Genome Replication through Downregulation of Host Antiviral Factors

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Virologica Sinica 2019年第2期34卷 197-210页

作者： catherine Sodroski Brianna Lowey Laura Hertz T.Jake Liang Qisheng Li Liver Diseases Branch National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health

cellular microRNAs(miRNAs) have been shown to modulate HcV infection via directly acting on the viral genome or indirectly through targeting the virus-associated host factors. Recently we generated a comprehensive map of HcV–miRNA interactions through genome-wide miRNA functional screens and transcriptomics analyses. Many previously unappreciated cellular miRNAs were identified to be involved in HcV infection, including miR-135a, a human cancerrelated miRNA. In the present study, we investigated the role of miR-135a in regulating HcV life cycle and showed that it preferentially enhances viral genome replication. Bioinformatics-based integrative analyses and subsequent functional assays revealed three antiviral host factors, including receptor interacting serine/threonine kinase 2(RIPK2), myeloid differentiation primary response 88(MYD88), and c-X-c motif chemokine ligand 12(cXcL12), as bona fide targets of miR-135a. These genes have been shown to inhibit HcV infection at the RNA replication stage. Our data demonstrated that repression of key host restriction factors mediated the proviral effect of miR-135a on HcV propagation. In addition,miR-135a hepatic abundance is upregulated by HcV infection in both cultured hepatocytes and human liver, likely mediating a more favorable environment for viral replication and possibly contributing to HcV-induced liver *** results provide novel insights into HcV–host interactions and unveil molecular pathways linking miRNA biology to HcV pathogenesis.

关键词： Hepatitis c virus (HcV) Genome replication Virus-host interactions miR-135a Antiviral factors

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空心钉钛缆张力带内固定与克氏针钢丝张力带内固定对c型髌骨骨折的近远期疗效分析

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中国伤残医学 2022年第12期30卷 5-9页

作者：夏青盐城市第一人民医院创伤骨科江苏盐城224001

对比空心钉钛缆张力带内固定与克氏针钢丝张力带内固定对c型髌骨骨折的近远期疗效.方法:于2018年2月-2020年3月选择在本院进行手术治疗的c型髌骨骨折患者110例作为研究对象,根据随机信封抽签原则把患者分为观察组与对照组各55例.观察组... 详细信息

对比空心钉钛缆张力带内固定与克氏针钢丝张力带内固定对c型髌骨骨折的近远期疗效.方法:于2018年2月-2020年3月选择在本院进行手术治疗的c型髌骨骨折患者110例作为研究对象,根据随机信封抽签原则把患者分为观察组与对照组各55例.观察组给予空心钉钛缆张力带内固定治疗,对照组给予克氏针钢丝张力带内固定治疗,记录与随访2组的近远期疗效.结果:所有患者都顺利完成手术,2组手术时间、术中出血量对比差异无统计学意义(P>0.05);观察组的术后住院时间与术后骨折愈合时间少于对照组(P<0.05).2组术后7天的血清IGF-1、chemerin含量低于术前(P<0.05),观察组低于对照组(P<0.05).观察组术后6个月的疗效优良率为96.4%,高于对照组的81.8%(P<0.05).观察组随访1年的内固定松动、软组织炎症、关节粘连、切口感染等并发症发生率为3.6%,低于对照组的21.8%(P<0.05).结论:相对于克氏针钢丝张力带,空心钉钛缆张力带内固定治疗c型髌骨骨折能抑制IGF-1、chemerin的表达,促进患者近期康复,也能提高患者的远期疗效优良率,降低并发症的发生.

关键词：克氏针钢丝张力带空心钉钛缆 c 型髌骨骨折并发症

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基于灰色关联度分析的乙醇偶合制备c4烯烃的研究

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科技资讯 2022年第14期20卷 62-66页

作者：李三杰胡玉林汪太行郑州财经学院统计与大数据学院郑州财经学院信息工程学院河南郑州450044

利用灰色关联度分析法,分析不同催化剂组合及温度对乙醇转化率以及c;烯烃选择性大小的影响,确定参考序列,求出差序列,计算不同温度下各种催化剂组合的乙醇转化率和c;烯烃选择性的关联度大小,并对关联度进行量化分析,根据在不同温度下各... 详细信息

利用灰色关联度分析法,分析不同催化剂组合及温度对乙醇转化率以及c;烯烃选择性大小的影响,确定参考序列,求出差序列,计算不同温度下各种催化剂组合的乙醇转化率和c;烯烃选择性的关联度大小,并对关联度进行量化分析,根据在不同温度下各种催化剂组合下对乙醇转化率以及c;烯烃的选择性大小的影响关联度大小,探索乙醇催化偶合制备c;烯烃的工艺条件。

关键词：乙醇 c 烯烃灰色关联度分析法关联系数关联度

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Fiber orientations effect on process performance for wire cut electrical discharge machining (WEDM) of 2D c/Sic composite

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INTERNATIONAL JOURNAL OF ADVANcED MANUFAcTURING TEcHNOLOGY 2019年第1-4期102卷 507-518页

作者： He, Wenbin He, Shaotai Du, Jinguang Ming, Wuyi Ma, Jun cao, Yang Li, Xiaoke Zhengzhou Univ Light Ind Henan Prov Key Lab Intelligent Mfg Mech Equipment Zhengzhou 450002 Henan Peoples R China

Adopting orthogonal experiments, relevant machinability in wire cut electrical discharge machining (WEDM) of 2D c/Sic composite was studied. The effects of electrical machining parameters (namely pulse width, pulse interval, and the number of tubes) on machining speed and surface roughness were analyzed. In addition, the effect of fiber orientations on the machinability was also studied. The main effect and interaction of the selected electrical machining parameters were also discussed. The key results show that the fiber orientation effect on machining speed plays a weaker role in WEDM of this composite. For machining speed, the number of tubes and the pulse interval have no interaction in both of machining directions A and B. For surface roughness, the number of tubes and the pulse interval have obvious interaction in both of machining directions A and B. The fiber orientation has a larger effect on the surface roughness than that on machining speed in WEDM of this composite. After analyzing the material removal mechanism, some new significant results show that the carbon fibers are removed in the form of transverse and longitudinal fracture. Interfacial debonding between fiber carbon and Sic matrix, pit, and recast layer form on the machined surface. Micro cracks are observed in the carbon fiber, and a part of the micro cracks are cross.

关键词： c Sic composite Fiber orientation Wire cut electrical discharge machining Machining speed Surface roughness

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Dose-dependant acute or subacute disease caused by Burkholderia pseudomallei strain NcTc 13392 in a BALB/c aerosol model of infection

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JOURNAL OF APPLIED MIcROBIOLOGY 2019年第4期127卷 1224-1235页

作者： Funnell, S. G. P. Tree, J. A. Hatch, G. J. Bate, S. R. Hall, G. Pearson, G. Rayner, E. L. Roberts, A. D. G. Vipond, J. Publ Hlth England Natl Infect Serv Salisbury SP4 0GJ Wilts England

Aims The goal of this study was to examine, for the first time, the virulence and pathogenicity of aerosolized Burkholderia pseudomallei, strain NcTc 13392, in BALB/c mice in order to develop an animal model for testing novel medical countermeasures (McMs) for the treatment of human acute and subacute (a disease state between acute and chronic) melioidosis. Methods and Results BALB/c mice were exposed to varying doses of aerosolized bacteria. Acute disease was seen in animals exposed to a very-high dose (>= 10(3) cFU per animal) and death occurred 3-4 days postchallenge (pc). Bacteria were detected in the lungs, liver, kidney and spleen. In contrast, animals exposed to a low dose (<10 cFU per animal) survived to the end of the study (day 30 pc) but developed weight loss, a bacterial tissue burden and increasing clinical signs of infection from day 20 pc onwards, mimicking a subacute form of the disease. Pathological changes in the tissues mirrored these findings. conclusions This proof of concept study has shown that B. pseudomallei strain NcTc 13392 is virulent and pathogenic in BALB/c mice, when delivered by aerosol. By varying the doses of aerosolized bacteria it was possible to mimic characteristics of both human acute and subacute melioidosis, at the same time, within the same study. Significance and Impact of the Study Burkholderia pseudomallei, the aetiological agent of melioidosis, causes a serious and often fatal disease in humans and animals. Novel McMs are urgently needed for both public health and biodefense purposes. The present model provides a useful tool for the assessment and evaluation of new McMs (e.g. therapeutics and vaccines) and offers the potential for testing new treatments for both subacute to chronic and acute melioidosis prior to human clinical trials.

关键词： aerosol BALB c Burkholderia dose Melioidosis pseudomallei subacute

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On the security of biquadratic c public-key cryptosystems and its generalizations

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cRYPTOGRAPHY AND cOMMUNIcATIONS-DIScRETE-STRUcTURES BOOLEAN FUNcTIONS AND SEQUENcES 2019年第3期11卷 427-442页

作者： Felke, Patrick Univ Appl Sci Emden Leer Constantiapl 4 D-26723 Emden Germany

Public key cryptosystems based on multivariate polynomials have been studied since the eighties. One of them, called c, was introduced in 1988 by Imai and Matsumoto, and broken in 1993 by Dobbertin in classified work he did for the German Federal Office for Information Security and later by Patarin (see Dobbertin et al. 2005, Patarin 1995). Since then, the construction of multivariate systems sharing a great deal of the c properties have become of particular interest. Dobbertin introduced in a series of classified papers and later in a challenge of the MysteryTwister-competition hosted by the Horst-Gortz-Institute in 2005, (see Dobbertin et al. 2005) together with the author, a system where the central mapping is a power mapping of degree 4 and shares almost all the properties of c. It was therefore called biquadratic c. The challenge remained unbroken and the security of these systems an open problem. As its key size is rather large, the interest in such systems became low during the last years. Due to the initiative of the European Telecommunications Standards Institute and the National Institute for Standards and Technology in creating standards for post-quantum cryptography, systems with bigger key sizes have become of interest for practical applications. In this paper we will consider biquadratic c and more general systems based on hidden monomials of degree k called k-ary c. We will prove a lower bound for the running time of attacks based on Grobner basis algorithms like F-4 or F-5. We will compute the first fall degree for k-ary c and give a counterexample to the first fall degree assumption. We will derive an estimate for the complexity of breaking the above mentioned cryptochallenge and give parameter sizes for secure systems by taking into account all known types of attacks. It will turn out that the security requirements yield systems with impractical key sizes even for applications in post-quantum cryptography. Although k-ary c is not of practical inter

关键词： biquadratic c c First fall degree Degree of regularity Solving equations Grobner basis attacks Post-quantum cryptography Multivariate cryptography Dobbertin Imai-Matsumoto

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血清胱抑素c水平与2型糖尿病肾病的相关性研究

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中文科技期刊数据库（文摘版）医药卫生 2022年第8期 55-57页

作者：王洪光高海波北京市丰台区中医医院内分泌科北京100076

以确诊2型糖尿病且并发肾病并发症患者为对象,检测患者的血清胱抑素c,明确该指标水平和并发症的相关性。方法筛查医院确诊2型糖尿病的患者,以发生并发症-肾病患者为研究对象,共选取98例,单纯糖尿病共计40例,微量白蛋白尿患者共计28例... 详细信息

以确诊2型糖尿病且并发肾病并发症患者为对象,检测患者的血清胱抑素c,明确该指标水平和并发症的相关性。方法筛查医院确诊2型糖尿病的患者,以发生并发症-肾病患者为研究对象,共选取98例,单纯糖尿病共计40例,微量白蛋白尿患者共计28例、大量白蛋白尿患者共计30例,患者最早于2020年12月入院,最晚于2022年3月入院;结合研究对象入院时间,随机抽取同期在本院预约、实施健康体检且体检报告显示身体健康者为对照组对象,共选取98例;98例研究对象是疾病组,98例对照对象是对照组;两组患者入院后,均提供高质量血样,均进行血清学检查,检查指标较多,以胱抑素c为主要指标,其余指标为辅助指标。结果研究涉及指标是①血清胱抑素 c(cys-c)、②尿素氮(BUN)、③血肌酐(Scr)检出值、阳性率,在参与组别是对照组、疾病组(单纯性糖尿病、糖尿病肾病)时,对照组三项检出值最低、三项阳性率最小(P<0.05),但疾病组内部比较有差异,显示糖尿病肾病检出值高、阳性率大(P<0.05);在参与组别是微量白蛋白尿、大量白蛋白尿患者时,仅有①的检出值、阳性率比较有差异(P<0.05),显示分期越靠后,检出值越高,阳性率越大(P<0.05)。结论确诊2型糖尿病后,做好肾功能检查,及时筛查出肾病,在筛查过程中cys-c可发挥显著作用。

关键词： 2型糖尿病并发症健康体检入院时间血样检查指标血清胱抑素 c

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Effect of spray drying technological conditions on the performance of LiFePO4/c cathode materials with high energy density

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IONIcS 2019年第12期25卷 5633-5642页

作者： Ding, Ruqian Liu, Hao Wang, Li Liang, Guangchuan Hebei Univ Technol Inst Power Source & Ecomat Sci Tianjin 300130 Peoples R China Hebei Univ Technol Key Lab Special Funct Mat Ecol Environm & Informa Minist Educ Tianjin 300130 Peoples R China Hebei Univ Technol Key Lab New Type Funct Mat Hebei Prov Tianjin 300130 Peoples R China

Lithium iron phosphate/carbon (LiFePO4/c) composites with high energy density were synthesized by wet ball milling, spray drying, and carbothermal reduction method. The effect of spray drying technological conditions on the performance of LiFePO4/c composites was systematically investigated. The samples were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), electrochemical impedance spectroscopy (EIS), and galvanostatic charge/discharge tests, etc. The results show that all as-prepared LiFePO4/c composites have a well-ordered olivine structure and spherical morphology. compared with centrifugal spray drying technology, LiFePO4/c prepared by pressure spray has a smaller particle size and exhibits more uniform particle size distribution as well as better electrochemical performance. However, as the particle size of LiFePO4/c microspheres is decreased, the sphericity of particles becomes worse and tap density of materials steps down, resulting in poor processability in 14500 cylindrical battery.

关键词： LiFePO4 c Spray drying Particle size Electrochemical performance Processability

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