检索结果-内蒙古大学图书馆

Fistuloates A-c: New antioxidative aromatic compounds isolated from cassia fistula

JOURNAL OF cHEMIcAL RESEARcH 2019年第11-12期43卷 516-521页

作者： Aftab, Zahida Afzal, Masood Bushra Khan, Hidayatullah Badshah, Syed Khan, Dilfaraz Ullah, Hamid Khan, Shafiullah Gomal Univ Inst Chem Sci Dera Ismail Khan 29220 Khyber Pakhtunk Pakistan Univ Sci & Technol Bannu Dept Chem Bannu Pakistan BUITEMS FABS Dept Chem Quetta Pakistan

Three new aromatic compounds named fistuloates: A (3-butyl-6-ethylnonyl-3-(1-phenylethyl) benzoate), B (3-(6-tert-butyl-1-ethoxy-5-ethyl-4-methylnonyl)-5-ethylbenzoic acid isobutyl ester) and c (4,5-diethoxy-2-propylbenzoic acid 7-(6-pentyltetrahydropyran-2-yl)-heptyl ester) were isolated from the ethyl acetate soluble fraction of cassia fistula Linn. The structural formulae of the isolated compounds A-c were established through interpretation of their spectral data. compounds A-c exhibited significant antioxidant properties in 2,2-diphenyl-1-picrylhydrazyl, 2,2 '-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and superoxide anion radical scavenging assays that signifies that c. fistula carries potential anti-oxidant constituents and may assist to cure diseases associated with oxidative stress and others.

关键词： antioxidant activity c fistula characterization ethyl acetate fraction fistuloates A-c

来源：评论

学校读者我要写书评

暂无评论

MicroRNA transcriptome analysis of poly I:c-stimulated and PRRSV-infected porcine alveolar macrophages

引用

JOURNAL OF APPLIED GENETIcS 2019年第3-4期60卷 375-383页

作者： Wu, Junjing Ji, Ziyun Qiao, Mu Peng, Xianwen Wu, Huayu Song, Zhongxu Zhao, Haizhong Liu, Guisheng Li, Fenge Mei, Shuqi Hubei Prov Acad Agr Sci Inst Anim Husb & Vet Hubei Key Lab Anim Embryo & Mol Breeding Wuhan Hubei Peoples R China Huazhong Agr Univ Key Lab Pig Genet & Breeding Minist Agr Wuhan Hubei Peoples R China Huazhong Agr Univ Key Lab Agr Anim Genet Breeding & Reprod Minist Educ Wuhan Hubei Peoples R China

Porcine reproductive and respiratory syndrome virus (PRRSV) causes severe reproductive failure in sows, respiratory diseases, and high mortality in piglets, which results in serious economic losses to the swine industry worldwide. Previous studies have described that PRRSV could suppress the host immune system and had antiapoptotic activity in its initial phase of infection. Polyinosinic-polycytidylic acid (poly I:c), a synthesized analogue of viral double-strand RNA, activates innate immunity responses and induces apoptosis in cells. Therefore, we performed miRNA transcriptome analysis of poly I:c-stimulated and PRRSV-infected porcine alveolar macrophages (PAMs) using deep sequencing technology, to compare the different miRNA profiles between the statuses of innate immune activation and inactivation. After sequencing, 267 known mature miRNAs and 64 novel miRNAs were observed in PAMs, and a total of 197 miRNAs were significantly differently expressed in poly I:c-stimulated PAMs, compared with mock control cells. Thirty-three of them were also significantly alerted in PRRSV-infected PAMs. This indicated that PRRSV only slightly alerted the miRNA expression profile of host cells compared with poly I:c-stimulated PAMs, which confirmed that PRRSV could suppress host innate immune responses during the early stages of infection. Among the differentially expressed miRNAs, we found that ssc-miR-27b-3p could significantly inhibit PRRSV RNA and protein replication in MARc-145 cells and PAMs. Its antiviral mechanism needs further research in the future.

关键词： PRRSV Poly I c Innate immune Apoptosis miR-27b

来源：评论

学校读者我要写书评

暂无评论

Ombitasvir/paritaprevir/ritonavir + dasabuvir +/-ribavirin in real world hepatitis c patients

引用

World Journal of Gastroenterology 2019年第18期25卷 2229-2239页

作者： Nicole Loo Eric Lawitz Naim Alkhouri Jennifer Wells carmen Landaverde Angie coste Rossalynn Salcido Michael Scott Fred Poordad Academic and Clinical Affairs Texas Liver Institute

BAcKGROUND The hepatitis c virus(HcV) NS5A inhibitor ABT-267(ombitasvir, OBV), the HcV NS4/4A protease inhibitor ABT-450(paritaprevir, PTV), the cYP3A inhibitor ritonavir(r) and the non-nucleoside NS5B polymerase inhibitor ABT-333(dasabuvir, DSV)(OBV/PTV/r + DSV) with or without ribavirin(RBV) is a direct-acting antiviral regimen approved in the United States and other major countries for the treatment of HcV in genotype 1(GT1) infected patients. Patients with HcV who are considered "hard-to-cure" have generally been excluded from registration trials due to rigorous study inclusion criteria, presence of comorbidities and previous treatment *** To investigate the efficacy of this regimen in HcV G1-infected patients historically excluded from clinical *** Patients were ≥ 18 years old and chronically infected with HcV GT1(GT1a, GT1b or GT1a/1b). Patients were treatment-na?ve or previously failed a regimen including pegylated interferon/RBV +/-telaprevir, boceprevir, or *** hundred patients were treated with the study drug regimen, which was administered for 12 or 24 wk +/-RBV according to GT1 subtype and presence/absence of cirrhosis. Patients were evaluated every 4 wk from treatment day 1 and at 4 and 12 wk after *** Many of the patients studied had comorbidities(44.2% hypertensive, 33.7%obese, 20.2% cirrhotic) and 16% previously failed HcV treatment. Ninety-six patients completed study follow-up and 99% achieved 12-wk sustained virologic response. The majority(88.4%) of patients had undetectable HcV RNA by week 4. The most common adverse events were fatigue(12%), headache(10%),insomnia(9%) and diarrhea(8%); none led to treatment discontinuation. Physical and mental patient reported outcomes scores significantly improved after treatment. Almost all(98%) patients were treatment *** In an all-comers HcV GT1 population, 12 or 24-wk of OBV/PTV/r + DSV +/-RBV is highly effective and tolerable and results

关键词： Hepatitis c Ombitasvir Paritaprevir Ritonavir Dasabuvir Genotype 1

来源：评论

学校读者我要写书评

暂无评论

Association of the human aryl hydrocarbon receptor repressor (AhRR)-c.565c>G transversion with male infertility: A case-control study from Iran

引用

JOURNAL OF cELLULAR BIOcHEMISTRY 2019年第6期120卷 8999-9005页

作者： Mohammad-Hasani, Azadeh colagar, Abasalt Hosseinzadeh Fallah, Ali Univ Mazandaran Fac Basic Sci Dept Mol & Cell Biol Babol Sar *** Iran

Dioxins (eg, 2,3,7,8-tetrachlorodibenzo-p-dioxin/TcDD), as environmental endocrine disruptors and toxic carcinogens, can affectmale reproductive health. The influence of dioxins is mediated via the aryl hydrocarbon receptor (AhR) pathway and its repressor (AhRR). In this study, we investigated the association of AhRR-c.565c>G transversion polymorphism with male infertility. In a hospital-based case-control study, 221 semen samples (111 infertile and 110 healthy controls) based onWorld Health Organization guidelines were collected from in vitro fertilization centers of Babol, Iran. The AhRR-c.565c>G (rs2292596) polymorphism was genotyped using a polymerase chain reaction-restriction fragment length polymorphism analysis. The difference in the allele frequency of AhRR-c.565c>G transversion polymorphism did not reach a significant level. The genotype frequency was statistically significantly different between fertile and infertile men. We found that polymorphism rs2292596 (Pro185Ala) was statistically significantly associated with the risk of male infertility. In addition, the statistical difference became more significant when the frequency was compared between the Pro/Pro genotype and the Pro/Ala plus Ala/Ala genotype. The 185 Pro wild-type alleles of AhRR may be associated with the risk of male infertility. The proallele also may diminish inhibition of AhR-mediated signaling of exposure to environmental pollutants.

关键词： AhRR c 565c > G dioxin male infertility reproductive health toxic carcinogen

来源：评论

学校读者我要写书评

暂无评论

Hepatocellular carcinoma in the post-hepatitis c virus era: Should we change the paradigm?

引用

World Journal of Gastroenterology 2019年第29期25卷 3929-3940页

作者： Hadar Meringer Oren Shibolet Liat Deutsch Department of Gastroenterology and Hepatology Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine Tel Aviv University

Hepatocellular carcinoma (Hcc) is a common and deadly malignancy. The disease usually develops on a background of chronic liver disease. Until recently, the most common etiology was infection with the hepatitis c virus (HcV). The advent of direct-acting antiviral (DAA) therapies has been a major breakthrough in HcV treatment. Sustained virologic response can now be achieved in almost all treated patients, even in patients with a high risk for the development of Hcc, such as the elderly or those with significant fibrosis. Early reports raised concerns of a high risk for Hcc occurrence after DAA therapy both in patients with previous resection of tumors and those without previous tumors. As the World Health Organization’s goals for eradication of HcV are being endorsed worldwide, the elimination of HcV seems feasible. Simultaneous to the decrease in the burden of cirrhosis from HcV, non-alcoholic fatty liver disease (NAFLD) incidence has been increasing dramatically including significant increased incidence of cirrhosis and Hcc in these patients. Surprisingly, a substantial proportion of patients with NAFLD were shown to develop Hcc even in the absence of cirrhosis. Furthermore, Hcc treatment and potential complications are known to be influenced by liver steatosis. These changes in etiology and epidemiology of Hcc suggest the beginning of a new era: The post–HcV era. changes may eventually undermine current practices of early detection, surveillance and management of Hcc. We focused on the risk of Hcc occurrence and recurrence in the post–HcV era, the surveillance needed after DAA therapy and current studies in Hcc patients with NAFLD.

关键词： Hepatocellular carcinoma Hepatitis c virus Direct-acting antivirals Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis

来源：评论

学校读者我要写书评

暂无评论

Using c-elegans notch mutants in an undergraduate cancer biology laboratory course to demonstrate oncogenic effects on cell proliferation

引用

JOURNAL OF BIOLOGIcAL EDUcATION 2019年第3期53卷 265-273页

作者： Groth, Amy c. Eastern Connecticut State Univ Dept Biol Willimantic CT 06226 USA

Undergraduate laboratory exercises addressing aspects of cancer biology such as increased cell proliferation, gain-of-function signaling mutations and tumour formation often rely on tissue culture or even small mammal models. Many departments have limited or no access to these tools, and even well-equipped departments face logistical problems when incorporating these models into laboratory classes. I have developed a laboratory exercise using the microscopic worm, c. elegans, to demonstrate the effects of Notch receptor mutations on cell proliferation. Notch, which is activated by juxtacrine signaling, is mutated in many human cancers. In this exercise, students compare the germline phenotypes of worms that have a loss-of-function Notch mutation (no cells in the germline) or a gain-of-function Notch mutation (over-proliferation resulting in a germline tumour). Students also genotype the worms and perform sequence analysis to determine the effects of the mutations on the protein sequence. This laboratory exercise demonstrates oncogenic proliferation, correlates genotype to phenotype, exposes students to model organisms and introduces sequence databases and analysis. In addition to cancer biology courses, this exercise could be incorporated in courses with a focus on genetics, cell biology or developmental biology.

关键词： Mutation cancer c elegans laboratory exercise development

来源：评论

学校读者我要写书评

暂无评论

Addendum to: “The Friedrichs angle and alternating projections in Hilbert c ⁎ -modules” [J. Math. Anal. Appl. 516 (2022) 126474]

引用

Journal of Mathematical Analysis and Applications 2023年第1期522卷

作者： Koen van den Dungen Bram Mesland Adam Rennie Mathematical Institute of the University of Bonn Germany Mathematisch Instituut Universiteit Leiden Netherlands School of Mathematics and Applied Statistics University of Wollongong Wollongong Australia

We show by (counter)example that the intersection of complemented submodules in a Hilbert c ⁎ -module is not necessarily complemented, answering the last open question from [1] .

关键词： Two projections Von Neumann's alternating projection theorem Friedrichs angle Hilbert c ⁎ -module Local-global principle

来源：评论

学校读者我要写书评

暂无评论

Hepatitis c virus core protein modulates several signaling pathways involved in hepatocellular carcinoma

引用

World Journal of Gastroenterology 2019年第1期25卷 42-58页

作者： Shahab Mahmoudvand Somayeh Shokri Reza Taherkhani Fatemeh Farshadpour Department of Virology School of Medicine Ahvaz Jundishapur University of Medical Sciences Department of Medical Virology School of MedicineHamadan University of Medical Sciences The Persian Gulf Tropical Medicine Research Center Bushehr University of Medical Sciences

Hepatocellular carcinoma(Hcc) is the fifth most common cancer, and hepatitis c virus(HcV) infection plays a major role in Hcc development. The molecular mechanisms by which HcV infection leads to Hcc are varied. HcV core protein is an important risk factor in HcV-associated liver pathogenesis and can modulate several signaling pathways involved in cell cycle regulation, cell growth promotion, cell proliferation, apoptosis, oxidative stress and lipid metabolism. The dysregulation of signaling pathways such as transforming growth factor β(TGF-β), vascular endothelial growth factor(VEGF), Wnt/β-catenin(WNT), cyclooxygenase-2(cOX-2) and peroxisome proliferator-activated receptor α(PPARα) by HcV core protein is implicated in the development of Hcc. Therefore, it has been suggested that this protein be considered a favorable target for further studies in the development of Hcc. In addition, considering the axial role of these signaling pathways in Hcc, they are considered druggable targets for cancer therapy. Therefore, using strategies to limit the dysregulation effects of core protein on these signaling pathways seems necessary to prevent HcV-related Hcc.

关键词： Hepatitis c virus core protein Transforming growth factorβ Vascular endothelial growth factor Wnt/β-catenin cyclooxygenase-2 Peroxisome proliferatoractivated receptorα Hepatocellular carcinoma

来源：评论

学校读者我要写书评

暂无评论

Study of the synthesis of c:H coating by PEcVD for protecting Mg-based nano-objects

引用

PLASMA PROcESSES AND POLYMERS 2020年第11期17卷 2000083-2000083页

作者： Liang, Hui Panepinto, Adriano Prince, Loic Olivier, Marjorie cossement, Damien Bousser, Etienne Geng, Xi Li, Wenjiang chen, Minfang Snyders, Rony Thiry, Damien Tianjin Univ Technol Sch Mat Sci & Engn Tianjin Peoples R China Univ Mons Chim Interact Plasma Surface 20 Pl Parc B-7000 Mons Belgium Univ Mons Mat Sci Dept Mons Belgium Mat Nova Res Ctr Mons Belgium Ecole Polytech Montreal Funct Coating & Surface Engn Lab Montreal PQ Canada Minist Educ Key Lab Display Mat & Photoelect Device Tianjin Peoples R China

In the context of protecting Mg-based nano-objects for potential hydrogen storage applications, the potential of c:H layer as a barrier polymer material deposited by the plasma-enhanced chemical vapor deposition process is examined. corrosion tests reveal (a) good barrier properties of the c:H layer and (b) suggest an increase in the internal stress with the power dissipated in the plasma. The latter is attributed to an increase in the cross-linking density of the coatings accompanied by an increase in the stiffness as shown by nanoindentation measurements. Finally, for a given set of plasma parameters, Mg-based nanowires were successfully enrobed by the c:H coatings as evidenced by scanning electron microscopy measurements.

关键词： c H plasma polymer films corrosion barrier hydrogen storage Mg nanowires

来源：评论

学校读者我要写书评

暂无评论

Dendritic cells modulate c-kit expression on the edge between activation and death

引用

EUROPEAN JOURNAL OF IMMUNOLOGY 2019年第4期49卷 534-545页

作者： Simonetti, Sonia Seijas, Amairelys B. Barroeta Natalini, Ambra Vitale, Sara Runci, Daniele Soriani, Alessandra Di Virgilio, Antonio Arico, Eleonora Gabriele, Lucia Santoni, Angela Di Rosa, Francesca CNR Inst Mol Biol & Pathol Rome Italy Univ Rome Sapienza Dept Mol Med Rome Italy Fdn Cenci Bolognetti Ist Pasteur Italia Rome Italy Ist Super Sanita BENA Ctr Nazl Sperimentaz & Benessere Anim Rome Italy Ist Super Sanita Dept Oncol & Mol Med Rome Italy

Dendritic cells (Dcs) are key players in immunity and tolerance. Some Dcs express c-kit, the receptor for stem cell factor (ScF), nevertheless c-kit functional role and the regulation of its expression in Dcs are incompletely defined. We recently demonstrated that autocrine ScF sustains a pro-survival circuit, and that ScF increases phospho-AKT in c-kit+ mouse bone marrow-derived Dcs (BMdDcs). Herein we observed that cpG and PolyI:c, two stimuli mimicking bacterial and viral nucleic acids respectively, strongly inhibited c-kit expression by BMdDcs and spleen Dcs in vitro and in vivo. Experiments in IFNARI(-/-) mice showed that IFN-I pathway was required for c-kit down-regulation in cDc1s, but only partially supported it in cDc2s. Furthermore, cpG and PolyI:c strongly inhibited c-kit mRNA expression. In agreement with the reduced c-kit levels, ScF pro-survival activity was impaired. Thus in the presence of exogenously provided ScF, either PolyI:c or cpG induced spleen Dc death in 2 days, while at earlier times IL-6 and IL-12 production were slightly increased. In contrast, ScF improved survival of unstimulated spleen Dcs expressing high c-kit levels. Our studies suggest that c-kit down-modulation is a previously neglected component of Dc response to cpG and PolyI:c, regulating Dc survival and ultimately tuning immune response.

关键词： conventional dendritic cell subsets dendritic cell survival cpG PolyI c Stem cell factor

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：