检索结果-内蒙古大学图书馆

common and Specific Effects of Selank, Noopept, and Semax on the Glycine Site of the NMDA Receptor in BALB/c and c57Bl/6 Mice Brains

引用

NEUROcHEMIcAL JOURNAL 2023年第2期17卷 211-218页

作者： Vasil'eva, E. V. Abdullina, A. A. Kovalev, G. I. Zakusov Res Inst Pharmacol Moscow Russia Ul Baltiiskaya 8 Moscow 125315 Russia

We have examined the effects of the nootropic peptides Selank (300 mg/kg), Noopept (1 mg/kg), and Semax (0.6 mg/kg) after subchronic intraperitoneal (i.p.) and intranasal (i.n.) administration on the binding of [H-3]-MDL105,51 to NMDA glycine site in BALB/c and c57Bl/6 mouse brain. It was found that in c57Bl/6 mice in comparison with BALB/c the number of glycine binding sites (B-max) at baseline was 15% higher in the cortex and 47% lower in the hippocampus. In the cortex, i.n. administration of Selank, Noopept, and Semax resulted in 18, 19, and 66% decreases in the number of glycine binding sites in BALB/c mice, and in 53, 49, and 66% in c57Bl/6 mice, respectively. In the hippocampus, i.n. administration of Selank, Noopept, and Semax resulted in 15, 63, and 95% increase in the number of glycine binding sites in BALB/c mice, respectively, while in c57Bl/6 mice all three peptides were not effective. I.p. administration of Selank and Semax decreased glycine binding sites by 24 and 40% in the cortex and by 11 and 19% in the hippocampus in BALB/c mice, while in c57Bl/6 mice the reduction was 15 and 47% in the cortex and 45 and 24% in the hippocampus, respectively. Noopept did not affect binding under these conditions. These patterns observed in the cortex after i.n. and i.p. administration appear to be common to the both mice strains, suggesting an engagement of the cortical NMDA glycine site in some common pharmacological effects of the selected peptides. Whereas the specific effect of Selank, Noopept, and Semax after i.n. administration in the BALB/c hippocampi may be associated with the mechanisms of peptides nootropic and anxiolytic activities manifested specifically in this mouse strain.

关键词： selank noopept semax mice BALB c c57Bl 6 prefrontal cortex hippocampus NMDA-receptor glycine site [H-3]-MDL105 519

来源：评论

学校读者我要写书评

暂无评论

Revisiting T. c. Schneirla's "Interrelationships of the 'Innate' and the 'Acquired' in Instinctive Behavior" (1956)

引用

BIOLOGIcAL THEORY 2024年第2期19卷 84-93页

作者： Kohn, Gregory M. Univ North Florida Dept Psychol Anim Social Interact Lab Jacksonville FL 32224 USA

During the postwar period, the concept of instinct came to encapsulate the debate around the importance of nature versus nurture. The fact that animals show highly organized behavior early in development suggested the presence of an underlying fixity where behavior was "inbuilt" into an animal's biology despite an individual's experiences. This placed a discrete and exhaustive line between the innate and acquired that became a foundation for the European-dominated field of ethology. Across the Atlantic, a group of comparative psychologists led by the American Museum of Natural History's T. c. Schneirla contested this approach, proposing that the study of animal behavior should avoid abstract dichotomies with a renewed focus on developmental processes. While Schneirla's theoretical and empirical work shaped the modern study of animal behavior, his legacy requires revisiting in an era where the nature versus nurture debate is regaining prominence. In this article, I revisit Schneirla's approach to behavior with a focus on his paper "Interrelationships of the 'Innate' and the 'Acquired' in Instinctive Behavior" (published in M. Autuori et al. (1956) L'instinct dans le comportement des animaux et de l'homme;Masson, Paris, pp. 387-452) for the journal's "classics in Biological Theory" collection;the paper is available as supplementary material in the online version of this article. A companion article (this issue;G. M. Kohn (2024) "A Discussion on Instinct, Paris, 1954") presents the commentary that was published with it.

关键词： Animal behavior classics Development Ethology History Innatenes Nativism T c Schneirla

来源：评论

学校读者我要写书评

暂无评论

c/Sb Superlattice-Like Films with High Thermal Stability and Low Power consumption for Phase-change Memory

引用

JOURNAL OF ELEcTRONIc MATERIALS 2022年第10期51卷 5594-5600页

作者： Zeng, Xiaotian Zhu, Xiaoqin Hu, Yifeng Song, Zhitang Jiangsu Univ Technol Sch Math & Phys Changzhou 213001 Jiangsu Peoples R China Chinese Acad Sci Shanghai Inst Microsyst & Informat Technol State Key Lab Funct Mat Informat Shanghai 200050 Peoples R China

The physical properties and device electrical properties of superlattice-like c/Sb phase change films are investigated. compared with Sb monolayer films, the superlattice-like c/Sb films have preferable thermal stability, including higher crystallization temperature, longer data life, and larger crystallization activation energy. As the thickness of the carbon layer increases, the band gap gradually increases. X-ray photoelectron spectroscopy results show that c-Sb bonds exist in the c/Sb superlattice-like films. X-ray diffraction and atomic force microscope results show that the addition of carbon inhibits the grain growth, making the grain size smaller and inhibiting the crystallization of Sb materials. Phase-change memory devices based on [c(6nm)/Sb(4nm)](8) superlattice-like films have smaller threshold voltages and lower power consumption compared to Sb films. In conclusion, c/Sb superlattice-like films have high thermal stability and low power consumption.

关键词： Phase-change memory c Sb superlattice-like film high thermal stability low power consumption

来源：评论

学校读者我要写书评

暂无评论

core-shell structured c/SiO2 composites derived from Si-rich biomass as anode materials for lithium-ion batteries

引用

IONIcS 2022年第1期28卷 151-160页

作者： Li, Yixin Liu, Li Liu, Xiaoyang Feng, Yi Yu, Liyun He, Zhongyu cui, Xinying Zhang, Minzhe Zhu, Yanchao Wang, Xiaofeng Jilin Univ Coll Chem State Key Lab Inorgan Synth & Preparat Chem 2699 Qianjin St Changchun 130012 Peoples R China Northeast Normal Univ Dept Chem Changchun 130024 Peoples R China

Lignin and ash are the main factors to limit integrated utilization of Si-rich biomass. In this study, core-shell structured lignin-SiO2 composites are prepared from rice husks (RHs) by alkali extraction and acid precipitation and applied as the precursors of anode materials to achieve efficient application. Alkaline lignin is employed to supplement carbon to improve electrochemical performance of c/SiO2 composites. The optimal sample c/SiO2-6 possesses integrated coating shells and appropriate carbon content (38.27%), resulting in stable cycling performance and high capacity retention of 534 mA h g(-1) at 1 A g(-1) after 1000 cycles, close to 574 mA h g(-1) of the c/SiO2 composite synthesized by commercial raw materials. Meanwhile, c/SiO2-6 has superior rate performance and lower impedance, because the carbon coating improves conductivity and kinetic performance. The method provides a strategy for integrated utilization of Si-rich biomass and preparation of c/SiO2 anode materials with desirable electrochemical properties.

关键词： Si-rich biomass Alkaline lignin c SiO2 composites core-shell structure Anode materials

来源：评论

学校读者我要写书评

暂无评论

Multi-walled carbon nanotubes induce transgenerational toxicity associated with activation of germline long non-coding RNA linc-7 in c. elegans

引用

cHEMOSPHERE 2022年 301卷 134687页

作者： Zhao, Yingyue Xu, Ruoran Hua, Xin Rui, Qi Wang, Dayong Nanjing Agr Univ Coll Life Sci Nanjing 210095 Peoples R China Southeast Univ Med Sch Nanjing 210009 Peoples R China

With the increase in application, multi-walled carbon nanotubes (MWcNTs) are potentially bioavailable to environmental organisms. However, the potential transgenerational effect of MWcNTs and underlying mechanisms remains still unclear. Here, we examined transgenerational MWcNT toxicity and the underlying mechanism mediated by germline long non-coding RNAs (lncRNAs) in caenorhabditis elegans. Exposure to 0.1-10 mu g/L MWcNT caused transgenerational toxicity reflected by endpoints of brood size and locomotion behavior. Meanwhile, among germline lncRNAs, expression of 5 lncRNAs were dysregulated by MWcNT exposure. Among these 5 dysregulated lncRNAs, only germline RNAi of linc-7 affected MWcNT toxicity. Increase in germline linc-7 expression was observed transgenerationally, and transgenerational MWcNT toxicity was prevented in linc-7 (RNAi) nematodes. Moreover, germline linc-7 controlled transgenerational MWcNT toxicity by activating downstream DAF-12, a transcriptional factor. Therefore, our data indicated the association between induction of transgenerational MWcNT toxicity and increase in germline linc-7 expression in organisms.

关键词： Multi-walled carbon nanotubes Germline linc-7 Transgenerational toxicity c elegans

来源：评论

学校读者我要写书评

暂无评论

construction of sandwich-structured c/c-Sic and c/c-Sic-Zrc composites with good mechanical and anti-ablation properties

引用

JOURNAL OF THE EUROPEAN cERAMIc SOcIETY 2022年第4期42卷 1219-1226页

作者： Zhao, Rida Hu, chenglong Wang, Yuanhong Pang, Shengyang Li, Jian Tang, Sufang cheng, Hui-Ming Chinese Acad Sci Inst Met Res Shenyang 110016 Peoples R China Univ Sci & Technol China Sch Mat Sci & Engn Hefei 230026 Peoples R China China Aerosp Sci & Ind Corp Res Inst 31 Beijing 100074 Peoples R China Chinese Acad Sci Inst Met Res Shenyang Natl Lab Mat Sci Shenyang 110016 Peoples R China

Four kinds of sandwich-structured c/c-Sic and c/c-Sic-Zrc composites with or without a Sic interphase deposited by isothermal chemical vapor infiltration (IcVI), were designed and fabricated by a joint process of electromagnetic coupling chemical vapor infiltration (EcVI) and precursor infiltration and pyrolysis (PIP). The fabricated composites are macroscopically nonhomogeneous materials with low density, high strength and low ablation rate. The interphase and matrix constituents had remarkable effects on the mechanical and ablation properties of these composites. The c/c-Sic composites with an IcVI-Sic interphase exhibited the highest flexural strength of 306.5 MPa. While the c/c-Sic-Zrc composites with the interphase showed the best antiablation performance with low linear and mass ablation rates of 0.37 mu m/s and 0.04 mg/cm2.s, respectively, after the ablation for 500 s under an oxyacetylene flame test at around 2000 degrees c.

关键词： Sandwich-structure c c-Sic-Zrc Flexural property Ablation behavior

来源：评论

学校读者我要写书评

暂无评论

Fabrication of porous Sic nanostructured coatings on c/c composite by laser chemical vapor deposition for improving the thermal shock resistance

引用

cERAMIcS INTERNATIONAL 2022年第9期48卷 12450-12459页

作者： Wang, chongjie Guo, Bingjian Lu, Pengjian Xu, Qingfang Tu, Rong Kosinova, Marina Zhang, Song Wuhan Univ Technol State Key Lab Adv Technol Mat Synth & Proc 122 Luoshi Rd Wuhan 430070 Peoples R China Chem & Chem Engn Guangdong Lab Chaozhou Branch Chaozhou 521000 Peoples R China Wuhan Univ Technol Sch Mat Sci & Engn 122 Luoshi Rd Wuhan 430070 Peoples R China Zhejiang MTCN Technol Co Ltd 59 Luhui RdTaihu St Changxing 311103 Zhejiang Peoples R China Wuhan Tuocai Technol Co Ltd 147 Luoshi Rd Wuhan 430070 Peoples R China Russian Acad Sci Siberian Branch Nikolaev Inst Inorgan Chem 3 Acad Lavrerntiev Pr Novosibirsk 630090 Russia

Recently, fabricating one-dimensional (1D) nanomaterials on c/c composite has been recognized effective to improve the thermal shock resistance of the coated composites. However, the remaining metal catalyst in cVD process and the week bond of 1D nanomaterials with substrate limit the strengthening effect. Herein, laser chemical vapor deposition (LcVD) was proposed for fabricating porous Sic nanostructured coating on c/c composite without metal catalyst. The laser heating resulted in a temperature gradient between the top and bottom of the coating, providing an external driving force for the vertical growth of whiskers with side-branches, forming a porous network nanostructure. The porous nanostructure was beneficial to reduce cTE and effectively relieve thermal stress. After 10 times of thermal shock test from RT to 1723 K, the porous Sic nanostructured coating remained intact. This work provides a novel methodology to produce functional coating on c/c composite with outstanding thermal shock resistance.

关键词： Sic coating Laser chemical vapor deposition (LcVD) c c composite Porous nanostructure Thermal shock resistance

来源：评论

学校读者我要写书评

暂无评论

Boron-doped rice husk-derived c/SiOx composites as high-property anode for Li-ion batteries

引用

IONIcS 2022年第9期28卷 4159-4167页

作者： Zhang, Haibang Yang, Zexu Zhang, Ning Qiao, Kaiyuan Liu, Yunying He, Wenxiu cui, Jinlong Sun, Juncai Dalian Maritime Univ Inst Mat & Technol Linghai Rd 1 Dalian 116026 Peoples R China Inner Mongolia Univ Sci & Technol Aerogel Funct Nanomat Lab Aerding Rd 7 Kundulun Dist 014010 Baotou Peoples R China

For conversion of renewable biomass, boron (B)-doped porous c/SiOx composites (B@c/SiOx) were prepared from rice husks and H3BO3 via a simple annealing process. The introduction of B induces the extrinsic defects and additional active sites, tunes the chemistry of carbon skeleton, and improves electrochemical performance of composites. The B-doped c skeleton substantially relieves volume change of SiOx and enhances the electronic conductivity of composites. The unique porous structure, large specific surface area, and B-doping endow B@c/SiOx with the high cycling capacity, excellent rate property, and exceptional cycling stability. Moreover, B doping can significantly decrease the Li+ migration barrier in c matrix of c/SiOx. When applied as Li-ion batteries anode, the optimized electrode harvests a cycling capacity of 1040 mAh g(-1) under 0.1 A g(-1) after 100 cycles with an elevated initial coulombic efficiency (cE) of 70.2%, and long cycle life up to 1000 cycles with a capacity of 610 mAh g(-1) under 1.0 A g(-1). This research sheds light on the thoughts of biomass-derived materials for sustainable energy storage devices.

关键词： c SiOx composites B-doped Rice husks High-property Anodes

来源：评论

学校读者我要写书评

暂无评论

SafeOSL: Ensuring memory safety of c via ownership-based intermediate language

引用

SOFTWARE-PRAcTIcE & EXPERIENcE 2022年第5期52卷 1114-1142页

作者： Yin, Xiaohua Huang, Zhiqiu Kan, Shuanglong Shen, Guohua chen, Zhe Liu, Yang Wang, Fei Nanjing Univ Aeronaut & Astronaut Coll Comp Sci & Technol Nanjing 211106 Peoples R China Collaborat Innovat Ctr Novel Software Technol & I Nanjing Peoples R China Minist Ind & Informat Technol Key Lab Safety Crit Software Nanjing Peoples R China TU Kaiserslautern Dept Comp Sci Kaiserslautern Germany Nanyang Technol Univ Sch Comp Sci & Engn Singapore Singapore Suzhou Univ Sci & Technol Sch Elect & Informat Engn Suzhou Peoples R China

The unsafe features of c make it a big challenge to ensure memory safety of c programs, and often lead to memory errors that can result in vulnerabilities. Various formal verification techniques for ensuring memory safety of c have been proposed. However, most of them either have a high overhead, such as state explosion problem in model checking, or have false positives, such as abstract interpretation. In this article, by innovatively borrowing ownership system from Rust, we propose a novel and sound static memory safety analysis approach, named SafeOSL. Its basic idea is an ownership-based intermediate language, called ownership system language (OSL), which captures the features of the ownership system in Rust. Ownership system specifies the relations among variables and memory locations, and maintains invariants that can ensure memory safety. The semantics of OSL is formalized in K-framework, which is a rewriting-logic based tool. c programs to be checked are first transformed into OSL programs and then detected by OSL semantics. Experimental results have demonstrated that SafeOSL is effective in detecting memory errors of c. Moreover, the translations and experiments indicate that the intermediate language OSL could be reused by other programming languages to detect memory errors.

关键词： c memory errors memory safety ownership system Rust

来源：评论

学校读者我要写书评

暂无评论

Brazing of c/c composite and TiAl Alloy Using TiNiSi Filler Metal Added cu Interlayer

引用

JOURNAL OF MATERIALS ENGINEERING AND PERFORMANcE 2022年第2期31卷 1277-1284页

作者： Li, Shengnan Du, Dong Jiu, Yongtao Qin, Jian Liu, Quanming Long, Weimin Tsinghua Univ Dept Mech Engn Beijing 100084 Peoples R China Zhengzhou Res Inst Mech Engn Co Ltd State Key Lab Adv Brazing Filler Met & Technol Zhengzhou 450001 Peoples R China China Innovat Acad Intelligent Equipment Ningbo C Ningbo 315700 Peoples R China

A novel Ti-Ni-Si brazing filler metal was designed and fabricated to braze the c/c composite and c/c composite, and c/c composite and TiAl intermetallic alloy at 1060 degrees c for 10 min. The interfacial microstructures and mechanical properties were investigated, and the enhancing mechanism of the joint strength was elucidated. The results showed that a perfect interface joint was achieved by using TiNiSi to braze the c/c composite. Ductile Ti3Sic2 carbide was formed at the interface, which is beneficial to the joint bonding effect. The direct joining between the c/c composite and TiAl alloy using TiNiSi filler metal was unsuccessful, which was attributed to the high content of intermetallic compounds and hard-brittle phases in the brazed joint. The addition of a cu interlayer to the joint can adjust the interfacial structure and reduce the content of brittle compounds, leading to a complete connection between the c/c composite and TiAl alloy. The interfacial transition layer on the c/c composite side mainly consisted of Ti3Sic2, Ti3Alc ductile ceramic phases, and Tic phase, which enhanced the performance of the brazed joint. The average shear strength at room temperature was 18.8 MPa, with the maximum value of 23.6 MPa, and the average shear strength at 600 degrees c was 25.8 MPa.

关键词： c c composite interlayer TiAl intermetallic compound Ti3Sic2 ductile ceramic phase

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：