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Veterinary bacteriology in Denmark from the 1880s to 2022

APMIS 2024年第1期132卷 31-42页

作者： Leisner, Jorgen J. Larsen, Jens Laurits Univ Copenhagen Fac Hlth & Med Sci Dept Vet & Anim Sci Copenhagen Denmark Abildgaard Soc Fredensborg Denmark Univ Copenhagen Fac Hlth & Med Sci Dept Vet & Anim Sci Gronnegardsvej 15 DK-1870 Frederiksberg C Denmark

This paper gives an account of the history of veterinary bacteriology including clinical veterinary bacteriology as well as the area of veterinary public health in Denmark from the 1880s to 2022. We describe key persons, including B. Bang, c.O. Jensen, K.A. Jensen and others who made important contributions to the development of these areas of microbiological expertise, and we discuss how challenges ranging from bovine tuberculosis to bacterial antimicrobial resistance have been met. Further, we describe progress in research on important bacterial pathogens both with regard to animal clinical aspects and zoonotic food-related aspects. Finally, we describe current issues in relation to One Health and research organization.

关键词： Antimicrobial resistance Bernhard Bang c O Jensen Mycobacterium bovis Mycoplasma pathogen Salmonella Serum Laboratory veterinary microbiology

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Estimated impact and value of blood-based colorectal cancer screening at varied adherence compared with stool-based screening

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JOURNAL OF MEDIcAL EcONOMIcS 2024年第1期27卷 746-753页

作者： Kisiel, John B. Fendrick, A. Mark Ebner, Derek W. Ozbay, A. Burak Vahdat, Vahab Estes, chris Limburg, Paul J. Mayo Clin Div Gastroenterol & Hepatol Rochester MN USA Univ Michigan Div Gen Med North Campus Res Complex2800 Plymouth RdBldg 16 Ann Arbor MI 48109 USA Exact Sci Corp Madison WI USA

ObjectiveThis analysis estimated the outcomes of triennial blood-based colorectal cancer (cRc) screening at various adherence, including perfect adherence, compared with triennial multi-target stool DNA (mt-sDNA) screening at the reported real-world adherence *** validated cRc-AIM model simulated a US cohort of average-risk individuals receiving triennial screening with mt-sDNA or blood-based test from ages 45 to 75 years. Modeled specificity and sensitivity were based on reported data. Adherence was set at a real-world rate of 65.6% for mt-sDNA and at 65.6%, relative 10% incremental increases from 65.6%, or 100% for the blood-based test. costs of mt-sDNA and the blood-based test were based on prices for clinically available tests ($508.87 and $895, respectively). Value-based pricing was estimated at a willingness-to-pay threshold of $100,*** tests resulted in life-years gained (LYG), reduced cRc cases, and reduced deaths versus no screening. With adherence for mt-sDNA set at 65.6% and for blood-based test set at 100%, mt-sDNA resulted in 30% more LYG, 52% more averted cRc cases, and 32% more averted cRc deaths. At reported sensitivity and specificity rates, mt-sDNA at 65.6% adherence dominates (is more effective and less costly) the blood-based test at any adherence. There was no price at which triennial screening with the blood-based test at any adherence was cost-effective compared with mt-sDNA at 65.6% *** screening with mt-sDNA resulted in better clinical outcomes at a lower cost compared with the modeled blood-based test even at perfect adherence, supporting application of blood-based tests only as a secondary screening option. Blood-based colorectal cancer screening has lower diagnostic accuracy, lower clinical and health outcomes, and is more expensive than mt-sDNA, even with perfect blood-based screening participation. Although better than no screening at all, blood-based testing is unlikely to exceed perfo

关键词： Liquid biopsy colorectal neoplasms computer simulation early detection of cancer feces/chemistry I10 I1 I c31 c3 c

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Light changes Promote Distinct Responses of Plastid Protein Acetylation Marks

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MOLEcULAR & cELLULAR PROTEOMIcS 2024年第11期23卷 100845页

作者： Eirich, Juergen Boyer, Jean-Baptiste Armbruster, Laura Ivanauskaite, Aiste De La Torre, carolina Meinnel, Thierry Wirtz, Markus Mulo, Paula Finkemeier, Iris Giglione, carmela Univ Munster Inst Plant Biol & Biotechnol Plant Physiol Munster Germany Univ Paris Saclay Inst Integrat Biol Cell I2BC CEA CNRS Gif Sur Yvette France Heidelberg Univ Ctr Organismal Studies Heidelberg Heidelberg Germany Univ Turku Dept Life Technol Mol Plant Biol Turku Finland Heidelberg Univ Med Fac Mannheim NGS Core Facil Mannheim Germany

Protein acetylation is a key co- and post-translational modification. However, how different types of acetylation respond to environmental stress is still unknown. To address this, we investigated the role of a member of the newly discovered family of plastid acetyltransferases (GNAT2), which features both lysine- and N-terminal acetyltransferase activities. Our study aimed to provide a holistic multi-omics acetylation-dependent view of plant acclimation to short-term light changes. We found that both the yield and coverage of the N-terminal acetylome remained unchanged in WT and gnat2-KO backgrounds after 2 h of exposure to high light or darkness. Similarly, no differences in transcriptome or adenylate energy charge were observed between the genotypes under the tested light conditions. In contrast, the lysine acetylome proved to be sensitive to the changes in light conditions, especially in the gnat2 background. This suggests unique strategies of plant acclimation for quick responses to environmental changes involving lysine, but not N-terminal, GNAT2-mediated acetylation activity.

关键词： acetyltransferase acetylation quantitative proteomics light acclimation Arabidopsis thaliana acK acetylation of lysine side chains c control light cV compensation voltage D darkness GNAT GcN5 family HL high light HSP heat shock protein KAT lysine acetyltransferase LcH light harvesting complex NAT N-terminal acetyltransferase NTA acetylation of N-termini PS photosystem TMT tandem mass tags UPLc ultra-performance liquid chromatography

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Executability and connexivity in an Interpretation of Griss

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STUDIA LOGIcA 2024年第1-2期112卷 459-509页

作者： Ferguson, Thomas M. M. Univ Amsterdam ILLC Amsterdam Netherlands Czech Acad Sci Inst Philosophy & Comp Sci Prague Czech Republic

Although the work of G.F.c. Griss is commonly understood as a program of negationless mathematics, close examination of Griss's work suggests a more fundamental feature is its executability, a requirement that mental constructions are possible only if corresponding mental activity can be actively carried out. Emphasizing executability reveals that Griss's arguments against negation leave open several types of negation-including D. Nelson's strong negation-as compatible with Griss's intuitionism. Reinterpreting Griss's program as one of executable mathematics, we iteratively develop a pair of bilateral constructive logics and argue for their adequacy as accounts of the propositional basis of Griss's work. We conclude by observing connexive features exhibited by the two bilateral logics and by investigating the difficulties connexive principles reveal for the development of executable mathematics.

关键词： connexive logic constructive logic G F c Griss Executable logic

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cell division machinery drives cell- specific gene activation during differentiation in Bacillus subtilis

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PROcEEDINGS OF THE NATIONAL AcADEMY OF ScIENcES OF THE UNITED STATES OF AMERIcA 2024年第13期121卷 e2400584121页

作者： chareyre, Sylvia Li, Xuesong Anjuwon, Brandon R. Updegrove, Taylor B. clifford, Sarah Brogan, Anna P. Su, Yijun Zhang, Lixia chen, Jiji Shroff, Hari Ramamurthia, Kumaran S. NCI Mol Biol Lab NIH Bethesda MD 20892 USA Natl Inst Biomed Imaging & Bioengn Lab High Resolut Opt Imaging NIH Bethesda MD 20892 USA HHMI Ashburn VA 20147 USA NIH Adv Imaging & Microscopy Resource Bethesda MD 20892 USA

When faced with starvation, the bacterium Bacillus subtilis transforms itself into a dormant cell type called a "spore". Sporulation initiates with an asymmetric division event, which requires the relocation of the core divisome components FtsA and FtsZ, after which the sigma factor aF is exclusively activated in the smaller daughter cell. compartment- specific activation of aF requires the SpoIIE phosphatase, which displays a biased localization on one side of the asymmetric division septum and associates with the structural protein DivIVA, but the mechanism by which this preferential localization is achieved is unclear. Here, we isolated a variant of DivIVA that indiscriminately activates aF in both daughter cells due to promiscuous localization of SpoIIE, which was corrected by overproduction of FtsA and FtsZ. We propose that the core components of the redeployed cell division machinery drive the asymmetric localization of DivIVA and SpoIIE to trigger the initiation of the sporulation program.

关键词： c difficile E coli | RacA MincD

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Economic burden of systemic lupus erythematosus in Malaysia

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JOURNAL OF MEDIcAL EcONOMIcS 2024年第SUP1期27卷 46-55页

作者： Elsisi, Gihan Hamdy Joe, Ang Yu Zain, Mollyza Mohd Yusoof, Habibah Mohd Teh, cheng Lay Mohd, Asmah Binti Khor, Xiang Ting Isa, Liza Binti Mohd HTA Off LLC Cairo Egypt Amer Univ Cairo Fac Econ Hlth Econ Cairo Egypt Selayang Hosp Batu Caves Selangor Malaysia Hosp Umum Sarawak Jalan Hosp Sarawak Malaysia Tuanku Jaafar Hosp Jalan Rasah Bukit Rasah Negeri Sembilan Malaysia AstraZeneca Petaling Jaya Selangor Malaysia Putrajaya Hosp Putrajaya Malaysia Amer Univ Cairo HTA Off LLC Hlth Econ 51 Helmy Hassan Aly St Cairo Egypt

IntroductionOur cost-of-illness (cOI) model adopted the perspective of both payer and society over a time horizon of 5 years to measure the economic burden of systemic lupus erythematosus (SLE) in *** cOI model utilized a prevalence-based model to estimate the costs and economic consequences of SLE in Malaysia. The clinical parameters were obtained from published literature and validated using the Delphi panel. Direct and indirect medical costs were measured, including disease management, transient events, and indirect costs. One-way sensitivity analysis was also *** number of target Malaysian patients with SLE in the cOI model was 18,121. At diagnosis, the numbers of SLE patients with mild, moderate, and severe phenotypes were 2,582, 13,897, and 1,642, respectively. The total SLE cost in Malaysia over 5 years from both payer and society perspectives was estimated at MYR 678 million and 2 billion, respectively. The results showed a considerable cost burden due to productivity losses resulting from SLE-related morbidity and mortality. Over a 5-year time horizon, the costs per patient per year from the payer and society perspectives were MYR 7,484 ($4766) and 24,281($15,465), *** study demonstrated the substantial economic burden of SLE in Malaysia over a time horizon of 5 years. It affects adults of working age, in addition to the costs of SLE management and its consequences, such as flares, infection, and organ damage. Our cOI model indicated that disease management costs among patients with higher disease severity were higher than those among patients with a mild phenotype. Hence, more attetion should be paid to limiting the progression of SLE and the occurrence of flares, with the need for further economic evaluation of novel treatments that could lead to better outcomes.

关键词： SLE Malaysia costs consequences burden c51 c5 c H51 H5 H

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A Nitrogen-specific Interactome Analysis Sheds Light on the Role of the SnRK1 and TOR Kinases in Plant Nitrogen Signaling

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MOLEcULAR & cELLULAR PROTEOMIcS 2024年第10期23卷 100842页

作者： Persyn, Freya Smagghe, Wouter Eeckhout, Dominique Mertens, Toon Smorscek, Thomas De Winne, Nancy Persiau, Geert van de Slijke, Eveline crepin, Nathalie Gadeyne, Astrid Van Leene, Jelle De Jaeger, Geert Univ Ghent Dept Plant Biotechnol & Bioinformat Ghent Belgium VIB Ctr Plant Syst Biol Ghent Belgium

Nitrogen (N) is of utmost importance for plant growth and development. Multiple studies have shown that N signaling is tightly coupled with carbon (c) levels, but the interplay between c/N metabolism and growth remains largely an enigma. Nonetheless, the protein kinases Sucrose Non- fermenting 1 (SNF1)-Related Kinase 1 (SnRK1) and Target Of Rapamycin (TOR), two ancient central metabolic regulators, are emerging as key integrators that link c/N status with growth. Despite their pivotal importance, the exact mechanisms behind the sensing of N status and its integration with c availability to drive metabolic decisions are largely unknown. Especially for SnRK1, it is not clear how this kinase responds to altered N levels. Therefore, we first monitored N-dependent SnRK1 kinase activity with an in vivo Separation of Phase-based Activity Reporter of Kinase (SPARK) sensor, revealing a contrasting N-dependency in Arabidopsis thaliana (Arabidopsis) shoot and root tissues. Next, using affinity purification (AP) and proximity labeling (PL) coupled to mass spectrometry (MS) experiments, we constructed a comprehensive SnRK1 and TOR interactome in Arabidopsis cell cultures during N-starved and N-repleted growth conditions. To broaden our understanding of the N-specificity of the TOR/SnRK1 signaling events, the resulting network was compared to corresponding c-related networks, identifying a large number of novel, N-specific interactors. Moreover, through integration of N-dependent transcriptome and phosphoproteome data, we were able to pinpoint additional Ndependent network components, highlighting for instance SnRK1 regulatory proteins that might function at the crosstalk of c/N signaling. Finally, confirmation of known and identification of novel SnRK1 interactors, such as Inositol-Requiring 1 (IRE1A) and the RAB GTPase RAB18, indicate that SnRK1, present at the ER, is involved in N signaling and autophagy induction.

关键词： nitrogen signaling Snf-related protein kinase 1 (SnRK1) target of rapamycin (TOR) Arabidopsis thaliana protein interactome AP-MS proximity labeling unfolded protein response (UPR) inositol-requiring enzyme 1 (IRE1) AMPK AMP-activated protein kinase AP-MS affinity purification coupled to mass spectrometry ASP AMPK substrate peptide ATI1 ATG8-interacting 1 BSK brassinosteroid-signaling kinase c carbon ER endoplasmic reticulum FLZ FcS-like zinc finger GFP green fluorescent protein GO Gene Ontology HOTag homo-oligomerizing peptide-tag IRE1 inositol-requiring 1 LFQ label-free quantitation LST8 Lethal with Sec Thirtheen-8 MS Murashige & Skoog MSMO Murashige & Skoog Minimal Organics N nitrogen NLP NIN-like protein NSAF normalized spectral abundance factor PANK2 pantothenate kinase 2 Pcc Pearson correlation coefficient PNR primary nitrate response PL-MS proximity labeling coupled to mass spectrometry PPI protein–protein interaction RAB18 RAB GTPase homolog B18 RT-qPcR reverse transcription quantitative PcR S6K ribosomal S6 kinase SEM standard error of mean SNF1 sucrose non-fermenting 1 SEc12 Sec12p-like protein SnRK1 SNF1-related kinase 1 SPARK separation of phase-based activity reporter of kinase SPPIER separation of phase-based protein interaction reporter TPS trehalose-6-phosphate synthase TOR target of rapamycin WT wild type

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comparative evaluation of organic waste composting rate with urea and KOH application: Environment Development and Sustainability

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ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY 2024年第2期26卷 3889-3910页

作者： Mirzababaei, Nilougfar Hassani, Akbar Univ Zanjan Coll Agr Dept Soil Sci Zanjan Iran

composting degradable organic matters with chemical fertilizers produces stable material with the aid of organisms and makes nutrients readily available to plants. A field study was carried out for incorporation of the urea and KOH treatments on composting fresh cattle manure, wheat straw, sawdust, and dried leaves to evaluate the decomposition rate during four months. The mineralization of the organic wastes as increased in microbial biomass carbon (MBc) and organic matter (OM) loss was higher in urea treatments, in contrast with KOH treatments which need more time for optimum decomposition. Lac case activity reduced in the manure but increased in other organic wastes and in the urea treatments. Water-soluble carbon (WSc) decreased in all organic wastes, particularly in urea-treated manure. The fluctuation of pH and electrical conductivity (Ec) were observed for four months but increased at the end of the experiment. Total organic carbon (TOc) reduced, and total nitrogen (TN) has risen, especially in the presence of urea treatments;so, the c/N ratio significantly decreased and the trend of composting progressed overtime. Insufficient technical planning in composting has led to changed approaches to increase elements availability with the management of existing plantations. The successive applications of urea were observed to enhance the rate of organic wastes decomposition than KOH treatments. This study further recommends application of urea and KOH with degradable organic materials in which this method should be improved with the ability to mineralize nutrients rapidly, which could make them advantageous to crop growth.

关键词： composting rate Wastes Urea KOH MBc c N ratio

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DcE attribute development investigating public policy for the provision of medicinal cannabis

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JOURNAL OF MEDIcAL EcONOMIcS 2024年第1期27卷 1232-1244页

作者： Gething, Katrina Erku, Daniel Scuffham, Paul Griffith Univ Ctr Appl Hlth Econ Sch Med & Dent Nathan Australia Griffith Univ Menzies Hlth Inst Queensland Southport Australia

BackgroundDefining attributes and attribute levels for a discrete choice experiment (DcE) poses a significant challenge for practitioners exploring preferences for new or unfamiliar products due to the dearth of available information and limits in stakeholder knowledge. This study outlines a comprehensive process for identifying attributes and levels in a DcE aimed at gauging public preferences for health policies related to medicinal cannabis (Mc).MethodsA rigorous four-stage attribute development process was utilized and included i) the formulation of a preliminary attribute list from a scoping review and document analysis, ii) reduction of attributes via focus groups, iii) removal of inappropriate attributes using Delphi studies and research team knowledge, and iv) refinement of attribute language based on the feedback from think-aloud *** base attribute list formed from the scoping review and document analysis served as effective discussion stimuli in focus groups, especially for participants with limited subject knowledge. Structured focus group activities proved more effective than open-ended discussions in engaging naive participants. Delphi studies were found to be overcomplex for expert-led attribute prioritization. Think-aloud interviews during a pilot DcE were essential for assessing attribute language and clarity and understanding participants' decision-making *** development of DcE attributes measuring preferences for an unfamiliar health product requires a multi-method approach. Evaluating the outcomes from various methods of attribute development yielded a refined list of attributes that were significant to stakeholders, allowed for meaningful trade-offs, and were presented in language accessible to the target population.

关键词： Medicinal cannabis public preferences attribute development c90 c9 c I18 I1 I

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Assessing the anti-collagenase activity and phytochemical evaluation of eight plants cultivated in Egypt;developing a validation method for the ellagic acid content in chrysophyllum oliviforme using HPLc-DAD

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NATURAL PRODUcT RESEARcH 2024年第11期38卷 1929-1937页

作者： Abdelrahim, Nariman Ali Noshy Saad, Marina Zaghloul, Martina Ashraf Neaz, Ossama Samueal EVA Cosmet Co Res & Dev Dept Giza Egypt

Preventing aging signs is a vast cosmetic quest hence;the authors felt the necessity to focus on emerging new plant extracts by the evaluation of anti-aging potential of eight plants cultivated in Egypt. Total phenolics (TPc), total flavonoids content (TFc) and collagenase assay were performed;only four plants were subjected to (ORAc) assay, ferrozine iron metal chelation assay and (HPLc) analysis against polyphenolic standard;validation method according to IcH guidelines for ellagic acid content in c. oliviforme by HPLc-DAD was performed, molecular docking simulation was implemented by (MOE) module. c. oliviforme exhibited the highest anti-collagenase with the lowest (Ic50), (TPc = 299.70 +/- 16.97 mg/GAE), method of validation of c. oliviforme extract following the IcH guidelines of ellagic acid content (147.446 +/- 0.00041 mg/g);c. oliviforme was the most potent extract and was standardized to be reproducible for the industrial scale.

关键词： c oliviforme ellagic acid HP Lc standardization MOE module MMP-1 Anti-collagenase assay

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