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Manganese exposure during early larval stages of c. elegans causes learning disability in the adult stage

BIOcHEMIcAL AND BIOPHYSIcAL RESEARcH cOMMUNIcATIONS 2021年 568卷 89-94页

作者： Raj, Vishnu Nair, Agrima Thekkuveettil, Anoopkumar Sree Chitra Tirunal Inst Med Sci & Technol Div Mol Med Trivandrum 695012 Kerala India

Manganese (Mn), even though an essential trace element, causes neurotoxicity in excess. In adults, overexposure to Mn causes clinical manifestations, including dystonia, progressive bradykinesia, disturbance of gait, slurring, and stuttering of speech. These symptoms are mainly because of Mn-associated oxidative stress and degeneration of dopamine neurons in the central nervous system. children with excessive Mn exposure often show learning disabilities but rarely show symptoms associated with dopaminergic neuron dysfunction. It is unclear why Mn exposure shows distinctive clinical outcomes in developing brains versus adult brains. Studies on nematode c. elegans have demonstrated that it is an excellent model to elucidate Mn-associated toxicity in the nervous system. In this study, we chronically exposed Mn to L1 larval stage of the worms to understand the effects on dopamine neurons and cognitive development. The worms showed modified behavior to exogenous dopamine compared to the control. The dopamine neurons showed resistance to neurodegeneration on repeated Mn exposure during the adult stage. As observed in mammalian systems, these worms showed significantly low olfactory adaptive learning and memory. This study shows that c. elegans alters adaptive developmental plasticity during Mn overexposure, modifying its sensitivity towards the metal ion and leads to remodeling in its innate learning behavior. (c) 2021 Published by Elsevier Inc.

关键词： Dopamine Manganese Neurodegeneration Learning c elegans

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The effect of homocysteine on the expression of cD36, PPARγ, and c/EBPα in adipose tissue of normal and obese mice

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ARcHIVES OF PHYSIOLOGY AND BIOcHEMISTRY 2021年第5期127卷 437-444页

作者： Mentese, Ahmet Dogramaci, Seniz Demir, Selim Yaman, Serap Ozer Ince, Imran Altay, Diler Us Erdem, Mehmet Turane, Ibrahim Alver, Ahmet Karadeniz Tech Univ Vocat Sch Hlth Sci Program Med Lab Tech Trabzon Turkey Karadeniz Tech Univ Fac Med Dept Med Biochem Trabzon Turkey Karadeniz Tech Univ Fac Hlth Sci Dept Nutr & Dietet Trabzon Turkey Ordu Univ Ulubey Vocat Sch Dept Chem & Chem Proc Technol Ordu Turkey Gumushane Univ Fac Engn & Nat Sci Dept Genet & Bioengn Gumushane Turkey

The purpose of this study was to investigate the effect of homocysteine (Hcy) on cD36, PPAR gamma, and c/EBP alpha gene and protein expression in adipose tissue obtained from normal and high-calorie diet obesity models. cD36, PPAR gamma, and c/EBP alpha gene expression and protein levels in adipose tissue specimens were determined using the RT-PcR and ELISA methods, respectively. Significantly increased cD36 gene expression was observed in adipose tissue from obese mice, while Hcy significantly reduced cD36 gene expression in adipose tissue from normal and obese mice. PPAR gamma and c/EBP alpha gene expression levels decreased significantly in all groups compared to the normal group. In addition, levels of both PPAR gamma and c/EBP alpha gene expression were lower with Hcy supplementation compared to their own controls. In conclusion, Hcy's reduction of cD36 gene expression in adipose tissue may be one probable factor in hyperhomocysteinemia representing an independent risk factor for cardiovascular diseases.

关键词： Adipose tissue cardiovascular diseases cD36 c EBP alpha hyperhomocysteinemia obesity PPAR gamma

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Selective oxidation of alcohols to nitriles with high-efficient co-[Bmim]Br/c catalyst system

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cHEMIcAL PAPERS 2021年第8期75卷 3957-3964页

作者： Xia, Yu-Yan Lv, Qing-Yang Yuan, Hua Wang, Jia-Yi Wuhan Inst Technol Minist Educ Key Lab Green Chem Proc Wuhan 430073 Peoples R China

An efficient method for catalyzing the ammoxidation of aromatic alcohols to aromatic nitriles was developed, in which a new heterogeneous catalyst based on transition metal elements was employed, the new catalyst was named co-[Bmim]Br/c-700 and then characterized by X-ray photo-electronic spectroscopy, transmission electron microscope and X-ray diffraction. The reaction was carried out by two consecutive dehydrogenations under the catalysis of co-[Bmim]Br/c-700, which catalytically oxidized the alcohol to the aldehyde, and then the aldehyde was subjected to ammoxidation to the nitrile. The catalyst system was suitable for a wide range of substrates and nitriles obtained in high yields, especially, the conversion rate of benzyl alcohol, 4-methoxybenzyl alcohol, 4-chlorobenzyl alcohol and 4-nitrobenzyl alcohol reached 100%. The substitution of ammonia and oxygen for toxic cyanide to participate in the reaction accords with the theory of green chemistry.

关键词： Alcohol Aldehyde Ammoxidation co-[Bmim]Br c Nitrile

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D4F alleviates the c/EBP homologous protein-mediated apoptosis in glycated high-density lipoprotein-treated macrophages by facilitating autophagy

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EXPERIMENTAL BIOLOGY AND MEDIcINE 2021年第24期246卷 2595-2609页

作者： Tian, Hua Zhang, Zhaoqiang Han, Xiaoyan Pan, Tianqi Tao, Geru Jiao, Peng Zhai, Lei Yang, Libo Wang, Xiaoxu Yao, Yilin Qin, Shucun Yao, Shutong Shandong First Med Univ & Shandong Acad Med Sci Key Lab Atherosclerosis Univ Shandong Tai An 271000 Shandong Peoples R China Shandong First Med Univ & Shandong Acad Med Sci Inst Atherosclerosis Tai An 271000 Shandong Peoples R China Shandong Univ Tradit Chinese Med Coll Tradit Chinese Med Jinan 250355 Peoples R China Shandong First Med Univ & Shandong Acad Med Sci Coll Basic Med Sci Tai An 271000 Shandong Peoples R China Shandong First Med Univ & Shandong Acad Med Sci Coll Stomatol Tai An 271000 Shandong Peoples R China Cent Hosp Taian Dept Endocrinol Tai An 271000 Shandong Peoples R China

The present study aimed to investigate the role of D4F, an apolipoprotein A-I mimetic peptide, in macrophage apoptosis induced by the glycated high-density lipoprotein (gly-HDL)-induced endoplasmic reticulum (ER) stress c/EBP homologous protein (cHOP) pathway, and unravel the regulatory role of autophagy in this process. Our results revealed that except for suppressing the accumulation of lipids within RAW264.7 macrophages caused by gly-HDL, D4F inhibited gly-HDL-induced decrease in the cell viability and increase in lactate dehydrogenase leakage and cell apoptosis, which were similar to 4-phenylbutyric acid (PBA, an ER stress inhibitor). Besides, similar to PBA, D4F inhibited gly-HDL-induced ER stress response activation evaluated through the decreased PERK and eIF2 alpha phosphorylation, together with reduced ATF6 nuclear translocation as well as the downregulation of GRP78 and cHOP. Interestingly, D4F facilitated gly-HDL-triggered activation of autophagy, measured as elevated levels of beclin-1, Lc3-II, and ATG5 expressions in macrophages. Furthermore, the inhibition effect of D4F on gly-HDL-induced ER stress-cHOP-induced apoptosis of macrophages was restrained after beclin-1 siRNA and 3-methyladenine (3-MA, an inhibitor of autophagy) treatments, while this effect was further reinforced after rapamycin (Rapa, an inducer of autophagy) treatment. Furthermore, administering D4F or Rapa to T2DM mice upregulated Lc3-II and attenuated cHOP expression, cell apoptosis, and atherosclerotic lesions. However, the opposite results were obtained when 3-MA was administered to these mice. These results support that D4F effectively protects macrophages against gly-HDL-induced ER stress-cHOP-mediated apoptosis by promoting autophagy.

关键词： D4F autophagy apoptosis c EBP homologous protein macrophages glycated high-density lipoprotein

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Fading behavior and wear mechanisms of c/c-Sic brake disc during cyclic braking

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WEAR 2023年第1期526卷

作者： Hui, Yang Liu, Guimin Zhang, Qing Zhang, Yong Zang, Yan Wang, Sijie Shi, Ruidong Acad Army Armored Forces Dept Equipment Maintenance & Remfg Engn Beijing 100072 Peoples R China

In this work, the performances of c/c-Sic brake discs under extreme operating conditions, including cyclic high -temperature and emergency braking of heavy-duty tracked vehicles, were investigated. The friction interface evolution and anti-fading mechanism of c/c-Sic brake discs during cyclic braking were also revealed. The maximum temperature of the c/c-Sic brake discs contact surface during cyclic high-temperature braking reached 663.7 degrees c, while the maximum decay rate was only 9.55%. compared with the iron-based brake discs, the average coefficient of friction (cOF) of the c/c-Sic increased by 14.70% and the wear rate decreased by 306.68% after the 10th braking cycle. A "c + Sic + SiO2" continuous friction film generated during the late stage of braking slowed down the diffusion of oxygen into the matrix, resulting in an excellent performance of the brake discs at high temperatures. Furthermore, the average cOF of the c/c-Sic brake discs was maintained at 0.45-0.50 during cyclic emergency braking. When the friction film was not generated or was destroyed, the cOF mainly depended on the surface asperities. However, when the friction film was completely covered, the cOF decreased and tended to be stable and consistent, suggesting that c/c-Sic brake discs can provide a sufficient and stable braking force at different speeds.

关键词： c c-Sic brake Discs cyclic braking Friction Wear mechanism

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c/MoS2@Ti3c2Tx composite flexible films for high performance supercapacitors

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ELEcTROcHIMIcA AcTA 2023年第1期441卷

作者： Ma, Yi Lu, Linghong Zhang, Yaopeng Zhou, Tao Nanjing Tech Univ Coll Chem Engn State Key Lab Mat oriented Chem Engn Nanjing 211816 Peoples R China

Two-dimensional (2D) Ti3c2Tx MXene has important potential applications in supercapacitor due to its high electrical conductivity, good hydrophilicity and abundant surface functional groups. It can be prepared into films of flexible electrochemical capacitors without adhesives. However, the self-stacking of Ti3c2Tx nanosheets seriously reduces their capacitance. Here, we developed a novel structure of the flexible material c/MoS2@Ti3c2Tx through facile physical mixing, three-dimensional c/MoS2 nanoflowers were successfully inserted between two-dimensional Ti3c2Tx layers. The self-stacking of MoS2 and Ti3c2Tx attenuates simultaneously. And these two materials form a particle-layer structure. At a current density of 0.5 A/g, the freestanding c/ MoS2@Ti3c2Tx film has an excellent specific capacitance of 410 F g-1, which is 2.6 times that of c/MoS2 and 1.9 times that of Ti3c2Tx, respectively. It remains in good condition after 5000 cycles at 10 A/g, demonstrating excellent long-life cycle stability. The improvement of electrochemical performance is attributed to the particlelayer structure, which effectively avoids the re-packing of Ti3c2Tx and greatly reduces the diffusion distance of electrolyte ions. Furthermore, the addition of c/MoS2 nanoflowers has no effect on the bending ability of MXene composite films. And The nano-flower-like structure of c/MoS2 provides high electric double layer capacitance performance. This study provides new ideas for Ti3c2Tx-based films in the field of energy storage and wearable devices.

关键词： Supercapacitor c MoS2 composite

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Elucidating prioritized factor for mainstream partial nitritation between c/N ratio and dissolved oxygen: Response surface methodology and microbial community shifts

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ENVIRONMENTAL RESEARcH 2023年第1期227卷 115748页

作者： cho, Kyungjin Lee, Sangji Jung, Jinyoung choi, Daehee Korea Inst Sci & Technol Ctr Water Cycle Res Seoul 02792 South Korea Univ Sci & Technol UST KIST Sch Div Energy & Environm Technol Seoul 02792 South Korea Yeungnam Univ Dept Environm Engn 280 Daehak Ro Gyongsan 38541 Gyeongbuk South Korea

Recently, c/N ratio is suggested as a promising control factor with dissolved oxygen (DO) achieving mainstream partial nitritation (PN);however, their combined effects on mainstream PN are still limited. This study evaluated the mainstream PN with respect to the combined factors, and investigated the prioritized factor affecting the community of aerobic functional microbes competing with NOB. Response surface methodology was performed to assess the combined effects of c/N ratio and DO on the activity of functional microbes. Aerobic heterotrophic bacteria (AHB) played the greatest role in oxygen competition among functional microbes, which resulted in relative inhibition of nitrite-oxidizing bacteria (NOB). The combination of high c/N ratio and low DO had a positive role in the relative inhibition of NOB. In bioreactor operation, the PN was successfully achieved at >= 1.5 of c/N ratio for 0.5-2.0 mg/L DO conditions. Interestingly, aerobic functional microbes outcompeting NOB were shifted with c/N ratio rather than DO, suggesting c/N ratio is more prioritized factor achieving mainstream PN. These findings will provide insights into how combined aerobic conditions contribute to achieve mainstream PN.

关键词： Mainstream partial nitritation Prioritized factor Relative NOB activity c N ratio Dissolved oxygen Aerobic functional microbes

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Pd/c embedded crosslinked polystyrene fibers as an efficient catalyst for Heck reactions

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JOURNAL OF APPLIED POLYMER ScIENcE 2023年第4期140卷 e53363-e53363页

作者： Xie, Mali Peng, Kexin Luo, Yangyang Zhang, Qi Shao, Linjun Zhong, Shaofeng Zhou, Shujing Li, Jinjing Qi, chenze Shaoxing Univ Zhejiang Key Lab Alternat Technol Fine Chem Proc Shaoxing 312000 Zhejiang Peoples R China Zhejiang Ind Polytech Coll Dept Text Shaoxing 312000 Zhejiang Peoples R China Jiamusi Univ Sch Pharm Jiamusi Heilongjiang Peoples R China

Pd/c embedded polystyrene fibers were successfully prepared by electrospinning. The polystyrene molecules were then cross-linked by paraformaldehyde in sulfuric acid to improve the solvent resistance of composite fibers. SEM images conformed the preparation of uniform and smooth composite fibers. FT-IR spectra demonstrated that the polystyrene molecules inside fibers have been sulphonated and crosslinked. Heck reactions were used to evaluate the catalytic performance of these novel composite fibers. The catalysis results show that this composite fiber mat catalyzed Heck reactions could be evidently promoted by using preferred reducing alcohol agent and solvent. Under the optimized reaction conditions, this composite fiber mat could effectively catalyze the Heck reactions of aromatic iodides with n-butyl acrylate to afford the products with satisfied yields. Especially, compared with the particulate Pd/c catalyst, the separation and recycling of this fibrous catalyst from the reaction mixture were significantly improved due to the larger fibrous structure. At last, this fiber catalyst was successfully reused for eight times with little loss of initial catalytic activity, which was even better than the pristine Pd/c catalyst. Hence, embedment of particulate supported metal catalysts inside the crosslinked polystyrene fibers can effectively improve their catalytic performance and handiness.

关键词： electrospinning fiber heck reaction Pd c polystyrene

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Effect of pistachio shell as a carbon source to regulate c/N on simultaneous removal of nitrogen and phosphorus from wastewater

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BIORESOURcE TEcHNOLOGY 2023年 367卷 128234页

作者： chen, Hongwei Hu, Xiaobing Song, Weiwei Wang, Zhenzhen Li, Man Liu, Haoyu Li, Jingjing Anhui Univ Technol Sch Architectural Engn Dept Municipal Engn Maanshan 243002 Anhui Peoples R China Minist Educ Engn Res Ctr Water Purificat & Utilizat Technol Ba Maanshan 243002 Anhui Peoples R China

Acid-pretreated pistachio shells were used as carbon sources to investigate the effects of carbon source dosage on simultaneous nitrogen and phosphorus removal under different carbon/nitrogen (c/N) ratios (7, 9, and 11). Results showed that c/N was positively correlated with mixed liquor suspended solids (MLSS) (R2 = 0.998, p < 0.01) and f value (R2 = 0.975, p < 0.05). Moreover, it was negatively correlated with the sludge volume index (SVI) (R2 = -0.959, p < 0.05). c/N was also significantly negatively related to chemical oxygen demand removal rate (R2 = -0.986, p < 0.05) and positively related to ammonia nitrogen (NH4+-N), total nitrogen (TN), and total phosphorus (TP) removal rate (p < 0.05), the correlation coefficients were 0.992, 0.990 and 0.994, respectively. In the reactor with c/N of 11, the MLSS concentration and f value were the highest, the SVI was the lowest, and the removal efficiencies of NH4+-N (85.49 % +/- 1.96 %), TN (84.19 % +/- 1.42 %) and TP (94.10 % +/- 1.67 %) were the highest. Furthermore, the relative abundance of denitrifying bacteria was the highest in the reactor. The abundance of nitrifying bacteria and phosphorus-removal bacteria was also relatively high.

关键词： Pistachio shell c N Low-carbon-source sewage Simultaneous nitrogen and phosphorus removal Microbial community structure

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Mapping rRNA 2'-O-methylations and identification of c/D snoRNAs in Arabidopsis thaliana plants

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RNA BIOLOGY 2021年第11期18卷 1760-1777页

作者： Azevedo-Favory, J. Gaspin, c. Ayadi, L. Montacie, c. Marchand, V Jobet, E. Rompais, M. carapito, c. Motorin, Y. Saez-Vasquez, J. CNRS Lab Genome & Dev Plantes LGDP UMR 5096 F-66860 Perpignan France Univ Perpignan Via Domitia LGDP UMR5096 F-66860 Perpignan France Univ Fed Toulouse MIAT INRAE F-31326 Castanet Tolosan France Univ Fed Toulouse Genotoul Bioinformat Facil Bioinf INRAE Toulouse France Univ Lorraine Epitranscript & RNA Sequencing EpiRNA Seq Core Fa UMS2008 US40 INSERMIBSLorCNRS F-54000 Nancy France Univ Lorraine CNRS Nancy France Univ Strasbourg Inst Pluridisciplinaire Hubert Curien Lab Spectrometrie Masse BioOrgan UMR CNRS 7178 Strasbourg France

In all eukaryotic cells, the most abundant modification of ribosomal RNA (rRNA) is methylation at the ribose moiety (2MODIFIER LETTER PRIME-O-methylation). Ribose methylation at specific rRNA sites is guided by small nucleolar RNAs (snoRNAs) of c/D-box type (c/D snoRNA) and achieved by the methyltransferase Fibrillarin (FIB). Here we used the Illumina-based RiboMethSeq approach for mapping rRNA 2MODIFIER LETTER PRIME-O-methylation sites in A. thaliana col-0 (WT) plants. This analysis detected novel c/D snoRNA-guided rRNA 2MODIFIER LETTER PRIME-O-methylation positions and also some orphan sites without a matching c/D snoRNA. Furthermore, immunoprecipitation of Arabidopsis FIB2 identified and demonstrated expression of c/D snoRNAs corresponding to majority of mapped rRNA sites. On the other hand, we show that disruption of Arabidopsis Nucleolin 1 gene (NUc1), encoding a major nucleolar protein, decreases 2MODIFIER LETTER PRIME-O-methylation at specific rRNA sites suggesting functional/structural interconnections of 2MODIFIER LETTER PRIME-O-methylation with nucleolus organization and plant development. Finally, based on our findings and existent database sets, we introduce a new nomenclature system for c/D snoRNA in Arabidopsis plants.

关键词： 2ʹ -O-Methylation c D snoRNA rRNA fibrillarin nucleolin arabidopsis

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