c. A. W. Manning was an important figure in the early days of what became known as the English School, and was one of the most philosophically explicit articulators of the interpretivist approach that informed that br...
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c. A. W. Manning was an important figure in the early days of what became known as the English School, and was one of the most philosophically explicit articulators of the interpretivist approach that informed that branch of scholarship. He was also a defender of the apartheid system of his native South Africa. A close examination of his work reveals both the promises and the pitfalls of a methodologically interpretive approach to explanation. An interpretive explanation involves developing the capacity in the listener to "go on" appropriately, and this makes criticizing the rules of the game somewhat difficult, but not impossible. A clearer understanding of what an interpretive explanation is may very well help us to avoid the pitfalls illustrated by Manning's advocacy, which I argue is made possible by a category confusion that remains very much with us: a confusion between delineating the rules of a given domain, and actively advocating or defending those principles.
In the present work, optimized cr 3 c 2 NicrBSi nanostructured and conventional powder coatings are sprayed on to Inconel 718 material by high-velocity oxygen fuel coating process for enhancing the high temperature co...
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In the present work, optimized cr 3 c 2 NicrBSi nanostructured and conventional powder coatings are sprayed on to Inconel 718 material by high-velocity oxygen fuel coating process for enhancing the high temperature corrosion resistance. The cyclic hot-corrosion study is carried out on uncoated, conventional coated and nanostructured coated superalloy in the salt environment of Na 2 SO 4 and 60% V 2 O 5 at 900 °c. The weight change measurements are carried out after each cycle to investigate the hot corrosion kinetics of uncoated and coated superalloy using thermo gravimetric technique. The corrosion products of coated specimens are analysed using Scanning electron microscopy and Elemental mapping. cr 3 c 2 NicrBSi nanostructured coating provides dense coating compared to conventional coating. compared to uncoated sample, cr 3 c 2 NicrBSi coating is found to be highly effective in corrosive resistance. The hot corrosion resistance provided by cr 3 c 2 NicrBSi coatings may be associated with the development of oxides of chromium, nickel, silicon and spinels of chromium and nickel.
The production of lithium-ion batteries (LIBs) is characterized by the high level of complexity and uncertainty, thus a key performance indicator (KPI) system is needed to monitor and control this process. However, up...
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The production of lithium-ion batteries (LIBs) is characterized by the high level of complexity and uncertainty, thus a key performance indicator (KPI) system is needed to monitor and control this process. However, up to this point, the existing KPI system based on process capability indices (PcIs) is only applicable to large amounts of production data. Therefore, the prototype production stage at the beginning of ramp-up still needs to be considered separately, as there is not enough production data available to estimate the PcIs via traditional approaches during this period. This paper builds a KPI system for the prototype production stage based on the Bayesian estimation of and the method of adding dummy samples. At the end of this paper, an example is provided as an application result of the KPI system.
Despite all the new treatments, metastatic breast cancer (Bc) causes many deaths. chlorogenic acid (cGA) is a polyphenol compound with various pharmacological traits, such as anticancer properties. Targeting apoptotic...
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Despite all the new treatments, metastatic breast cancer (Bc) causes many deaths. chlorogenic acid (cGA) is a polyphenol compound with various pharmacological traits, such as anticancer properties. Targeting apoptotic death pathways has been propounded as the most effective therapeutic method in various cancers. In the current study, apoptotic agents such as p53, Bax, Bcl-2, and caspase-3 have been investigated. The experimental groups included saline, Bc, cGA, protective (PR), and treatment (TM) groups. First, 4T1 mouse Bc was established and then the effects of treatment with cGA were investigated through measurement of tumor weight and volume, metastatic nodules, liver biochemical tests, hematoxylin and eosin (H&E), immunohistochemistry (IHc) staining, and real-time reverse transcription-polymerase chain reaction (RT-PcR) in experimental groups. The findings showed that cGA reduced tumor weight and volume in the PR group (P < .05) and in the TM group (P < .001). Surprisingly, it eliminated the tumors in the TM group. Metastatic nodules in the PR and TM groups were significantly reduced as compared with the Bc group (P < .001). The evaluation by H&E staining showed cell apoptosis in both the PR and TM groups. The results of real-time RT-PcR showed that cGA therapy increased the expression ratio of Bax/Bcl-2 (P < .001 andP < .05, respectively) and the expression of p53 (P < .001 andP < .05, respectively) and caspase-3 genes (P < .01) in the PR and TM groups. The IHc data regarding the Bax/Bcl-2 ratio confirmed the other results (P < .001). The findings demonstrate that cGA plays a significant role in the induction of apoptosis and the treatment of 4T1 Bc tumors in BALB/c mice.
The ccAAT/enhancer binding protein (c/EBP) transcription factors (TFs) regulate many important biological processes, such as energy metabolism, inflammation, cell proliferation etc. A genome-wide gene identification r...
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The ccAAT/enhancer binding protein (c/EBP) transcription factors (TFs) regulate many important biological processes, such as energy metabolism, inflammation, cell proliferation etc. A genome-wide gene identification revealed the presence of a total of 99 c/EBP genes in pig and 19 eukaryote genomes. Phylogenetic analysis showed that all c/EBP TFs were classified into 6 subgroups named c/EBP alpha, c/EBP beta, c/EBP delta, c/EBP epsilon, c/EBP gamma, and c/EBP zeta. Gene expression analysis showed that the c/EBP alpha, c/EBP beta, c/EBP delta, c/EBP gamma, and c/EBP zeta genes were expressed ubiquitously with inconsistent expression patterns in various pig tissues. Moreover, a pig c/EBP regulatory network was constructed, including c/EBP genes, TFs and miRNAs. A total of 27 feed-forward loop (FFL) motifs were detected in the pig c/EBP regulatory network. Based on the RNA-seq data, gene expression patterns related to FFL sub-network were analyzed in 27 adult pig tissues. certain FFL motifs may be tissue specific. Functional enrichment analysis indicated that c/EBP and its target genes are involved in many important biological pathways. These results provide valuable information that clarifies the evolutionary relationships of the c/EBP family and contributes to the understanding of the biological function of c/EBP genes.
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