Background The microphthalmia-associated transcription factor gene (MITF) belongs to the MYc supergene family and plays an important role in melanocytes' homeostasis. Individuals harboring MITF germline pathogenic...
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Background The microphthalmia-associated transcription factor gene (MITF) belongs to the MYc supergene family and plays an important role in melanocytes' homeostasis. Individuals harboring MITF germline pathogenic variants are at increased risk of developing cancer, most notably melanoma and renal cell carcinoma. case presentation We describe a cohort of ten individuals who harbor the same MITF c.952G > A (*** 318Lys), or p.E318K, germline pathogenic variant. Six carriers developed at least one malignancy (4 cases of breast cancer;1 cervical cancer;1 colon cancer;1 melanoma;1 ovarian/fallopian tube cancer). A significant phenotypic heterogeneity was found among these individuals and their relatives. Breast cancer was, overall, the most frequent malignancy observed in this case series, with 13 occurrences of 60 (21.67 %) total cancer cases described among the probands and their relatives. conclusions Our retrospective analysis data raise the hypothesis of a possible association of the MITF p.E318K pathogenic variant with an increased risk of breast cancer.
High temperature hydrogen attack (HTHA) is a known degradation mechanism in the refining industry for carbon and low alloy steels operating at temperatures above 400 degrees F in hydrogen service. Historically the int...
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ISBN:
(纸本)9780791886175
High temperature hydrogen attack (HTHA) is a known degradation mechanism in the refining industry for carbon and low alloy steels operating at temperatures above 400 degrees F in hydrogen service. Historically the integrity of operating equipment subject to these conditions has been ensured by using the empirically derived Nelson curves to identify safe operating regions. This approach was largely successful, but failures still occurred and, in some cases, required overly conservative operational limits. Additionally, this approach did not allow for a defect tolerance approach to fitness for service (FFS) assessments. An on-going joint-industry project (JIP) has been addressing these issues by generating laboratory crack growth data and developing models to apply the acquired knowledge in FFS assessments. A testing program was conducted on three (3) c-0.5 Mo steels to generate crack growth data in hydrogen at a range of temperatures (316 to 399 degrees c [600 to 750 degrees F]), 5.52 MPa (800 psig H-2) hydrogen pressure, and stress intensity values between (10.5 to 35.4 MPavm [9 to 32 ksi root in]). These results were used to validate and refine a crack growth model based on the creep crack growth fracture mechanics approach, c*. The results of the test program and modeling efforts are described in detail.
The use of Machine Learning in IoT devices has become the only viable path in today's landscape, where millions of connected devices surround us and increasingly affect our lives. These resource-limited devices in...
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ISBN:
(纸本)9781665481526
The use of Machine Learning in IoT devices has become the only viable path in today's landscape, where millions of connected devices surround us and increasingly affect our lives. These resource-limited devices interact with the surrounding world via actuators and sensors. Many of these devices use Machine Learning techniques to be able to interpret the world and choose the appropriate action to take. Therefore the purpose of this work is to create a system that allows the application of Machine Learning algorithms directly to the ends of the network, where sensors and actuators reside. The system is designed to rely on the SENSIPLUS smart-sensor as a data acquisition device, and consists of an automaticcode generation and compilation system, which through the use of a Toolchain, allows to run artificial intelligence algorithms directly on microcontroller devices.
Dibenzopyranone is a privileged structure in natural products that exhibits multiple fascinating properties. Reported herein, is the synthesis of dibenzopyranone from o ‐bromo benzoic acids and aryl formates. The com...
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Dibenzopyranone is a privileged structure in natural products that exhibits multiple fascinating properties. Reported herein, is the synthesis of dibenzopyranone from o ‐bromo benzoic acids and aryl formates. The combination of a Pd‐catalyst and light irradiation allows the reaction to proceed under mild conditions at room temperature. Preliminary mechanistic studies suggested that the reaction undergoes an esterification process followed by a cyclization to form the dibenzopyranone ring structure. This method provides a complementary approach for the synthesis of substituted benzo[ c ]chromen‐6‐one from readily available materials.
cytochrome c (cyt c ) is released from mitochondria into the cytosol upon apoptotic stimulation, ultimately triggering programmed cell death. Recent studies have revealed that transfer RNA (tRNA) interacts with cyt c ...
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cytochrome c (cyt c ) is released from mitochondria into the cytosol upon apoptotic stimulation, ultimately triggering programmed cell death. Recent studies have revealed that transfer RNA (tRNA) interacts with cyt c , impeding the formation of the apoptosome complex and thereby suppressing apoptosis. To elucidate the molecular mechanism underlying the interaction between cyt c and tRNA, nuclear magnetic resonance (NMR)-based chemical shift perturbation and intensity analysis were employed to characterize the binding interface between cyt c and tRNA phe . The findings demonstrate that cyt c primarily engages with tRNA phe through its 70-85 Ω-loop and N-terminal α-helix. This interaction sterically hinders the accessibility of small molecules, such as H 2 O 2 , to the hydrophobic pocket of cyt c , consequently attenuating its peroxidase activity. Furthermore, oxidative modification of cyt c , particularly the carbonylation of positively charged lysine residues, weakens this interaction.
A new integrated filler metal/base metal manufacturing method by cold spray additive manufacturing is proposed. The integrated cuTi filler metal/GH3536 and cuTi + W composite filler metal/GH3536 are prepar...
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A new integrated filler metal/base metal manufacturing method by cold spray additive manufacturing is proposed. The integrated cuTi filler metal/GH3536 and cuTi + W composite filler metal/GH3536 are prepared by cold spray additive manufacturing techniques. The large plastic deformation of cu and Ti particles and the tamping effect of W particles promote the interfacial bonding of particles, which improves the weldability of cold sprayed cuTi + W composite filler metals. Based on the cold sprayed cuTi + W composite filler metal, the c f /Siccomposites and GH3536 are successfully brazed, and the typical microstructure and brazing mechanism are investigated. As a result, the shear strength of c f /Sic-GH3536 joint brazed by cold sprayed cuTi + W composite filler metal reaches 77 MPa. This study highlightes the great potential of cold spray additive manufacturing for integrated filler metal/base metal manufacturing in brazing.
Following the 2011 Fukushima Daiichi nuclear catastrophe, there has been a significant surge in interest towards innovative materials capable of enhancing the safety, performance, and efficiency of nuclear reactors. T...
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Following the 2011 Fukushima Daiichi nuclear catastrophe, there has been a significant surge in interest towards innovative materials capable of enhancing the safety, performance, and efficiency of nuclear reactors. This study introduces a new class of layered ternary compounds, specifically (Uc) n Si 3 c 2 (n = 1,2), and derived two-dimensional (2D) U 2 c, discovered through first-principles calculations. We predict the electronic, mechanical, and thermodynamic properties of these compounds within the PBE and PBE + U frameworks, with a comparative analysis of the (Uc) n Al 3 c 2 (n = 1,2) series. Our findings reveal that the USi 3 c 3 and U 2 Si 3 c 4 compounds exhibit mechanical and dynamic stabilities, suggesting their potential for experimental synthesis under specificconditions. These compounds demonstrate superior mechanical and thermal properties as nuclear fuels, including higher elastic moduli and improved ductility compared to (Uc) n Al 3 c 2 compounds. The mechanical and dynamical stabilities of 2D U 2 c are confirmed, and the calculated thermal conductivity and mechanical properties position it as a promising candidate for high-performance nuclear fuel applications. We anticipate that the present work will bolster future experimental endeavors and help explore the practical applications of these novel materials in future nuclear systems.
Belowground crop residues are one primary source of c input in agricultural soils. Using changes in the natural abundance of 13 c, we quantified SOc derived from harvest residues of silage maize grown in a four-course...
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Belowground crop residues are one primary source of c input in agricultural soils. Using changes in the natural abundance of 13 c, we quantified SOc derived from harvest residues of silage maize grown in a four-course crop rotation with different mineral fertilizer levels (UNF, ½, 1, and 1½NPK). After a period of two decades with five maize crops, maize-derived c accounted for 1 % (0.36 Mg c ha −1 ) of the total SOc stock in the 0–20 cm soil layer, irrespective of differences in aboveground harvest yields. This questions yield-dependent allometric functions for silage maize used in models simulating c turnover in agricultural soils.
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