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1st International conference on Nanoscience and Nanotechnology (IcNAN)

作者： Yu, Hong-Wei Zhang, Ze Shen, Tao Jiang, Jing-Hui chang, Dong Pan, Hong-Zhi Fudan Univ Shanghai Pudong Hosp Dept Clin Lab Pudong Med Ctr 2800 Gongwei Rd Shanghai 201399 Peoples R China Fudan Univ Shanghai Pudong Hosp Dept Outpatient Dept Pudong Med Ctr 2800 Gongwei Rd Shanghai 201399 Peoples R China Harbin Med Univ Affiliated Hosp 1 23 Youzheng St Harbin 150001 Heilongjiang Peoples R China Shanghai Univ Med & Hlth Sci 279 Zhouzhu Rd Shanghai 201318 Peoples R China

A novel strategy for highly sensitive electrochemical detection of uric acid (UA) was proposed based on graphene quantum dots (GQDs), GQDs were introduced as a suitable substrate for enzyme immobilisation. Uric oxidase (UOx) was immobilised on GQDs modified glassy carbon electrode (GcE). Transmission electron microscope, scanning electron microscopy, cyclic voltammetry and electrochemical impedance spectroscopy techniques were used for characterising the electrochemical biosensor. The developed biosensor responds efficiently to UA presence over the concentration linear range 1-800M with the detection limit 0.3M. This novel biosensing platform based on UOx/GQDs electrode responded even more sensitively than that based on GcE modified by UOx alone. The inexpensive, reliable and sensitive sensing platform based on UOx/GQDs electrode provides wide potential applications in clinical.

关键词： organic compounds graphene devices quantum dots enzymes biosensors biochemistry electrochemical electrodes electrochemical sensors transmission electron microscopy scanning electron microscopy voltammetry (chemical analysis) electrochemical impedance spectroscopy nanomedicine molecular biophysics sensitive uric acid determination graphene quantum dots uric oxidase immobilisation electrochemical detection GQD enzyme immobilisation glassy carbon electrode GcE transmission electron microscope scanning electron microscopy cyclic voltammetry electrochemical impedance spectroscopy electrochemical biosensor c

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Pharmaceutical management of hepatitis B and c in liver and kidney transplant recipients

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2015年第4期6卷 105-110页

作者： chrysoula Pipili Evangelos cholongitas Division of Nephrology Royal Infirmary of Edinburgh 4th Department of Internal Medicine Medical School of Aristotle University Hippokration General Hospital of Thessaloniki

The combination of hepatitis B immune globulin with entecavir or tenofovir(at least for a certain period of time) seems to be the most reasonable prophylaxis against recurrent hepatitis B after liver transplantation. Entecavir represents an attractive option for treatment of na?ve kidney transplant recipients, because of its high efficacy and the low rates of resistance. However antiviral treatment should be individualized in the view of kidney function and the previous resistance. To date, new captivating therapeutic strategies could make interferon-free regimens viable for treatment of hepatitis c virus positive liver transplant recipients. The recent combinations of sofosbuvir with simeprevir or daclatasvir or ledipasvir plus/minus ribavirin have boosted the on treatment and sustained virological response to rates approaching 100% within liver transplant recipients with recurrent chronic hepatitis c(cHc). Preliminary data showed that the second generation direct oral antivirals could result to high treatment rates of recurrent cHc in kidney transplant recipients as well. Ongoing studies will clarify the optimal treatment of recurrent cHc in kidney transplant recipients.

关键词： Viral hepatitis Hepatitis c recurrence Hepatitis B

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Assessment of Usual Fruit, Vegetable and Vitamin c Intakes in a Sample of Egyptian children: Pilot Study

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Food and Nutrition Sciences 2015年第10期6卷 923-934页

作者： Laila Hussein Nehad Hassan Mahmoud Mohamad Sahar Abdel Aziz Department of Nutrition National Research Center Giza Egypt

The objective was to create an Egyptian database on the contributors of fruit and vegetables in the diets of preschool children and to estimate the usual daily intakes of fruits, vegetables and vitamin c. A total of 59 healthy boys and girls aged 2.5 - 6 years attending day care centers in urban Giza governorate completed the study by interviewing their mothers on 6x non-consecutive days using the 24 h dietary recall. Participants were classified according to age, gender and socioeconomic class. Prevalence of daily consumptions of fruits and vegetables amounted to 22% and 54%, respectively of the total children. The daily intakes of fruits and vegetables averaged 117.5 and 56.4 g, respectively. The consumption of different types of fruits and vegetables was unevenly distributed by different personal and social variables. Estimated daily vitamin c supply from the diet was 38 mg per child, which satisfied the respective recommended nutrient intake (RNI) of 30 mg for the first six years of life. However, the diet of 15% of the children covered less than 75% of RNI. Top fruits contributing to vitamin c were oranges, guava, watermelon, pears and grapes. Extra foods such as chipsy was consumed by 81% of the children, contributed 18% to daily vitamin c supply and also 58.6 mg sodium. A multilevel intervention strategy is warranted for promoting daily fruit and vegetable intake and healthy eating in early childhood.

关键词： children Aged 2.5 - 6 Years Fruit & Vegetable Intakes Vitamin c Intake Health Problems & Vit c Deficiency

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Mechanical and thermal physical properties, and thermal shock behavior of (ZrB 2 + Sic) reinforced Zr 3 [Al(Si)] 4 c 6 composite prepared by in situ hot-pressing

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Journal of Alloys and compounds 2015年 619卷 338-344页

作者： Lei Yu Yongbao Feng Jian Yang Tai Qiu Limei Pan College of Materials Science and Engineering Nanjing Tech University Nanjing 210009 China

The mechanical and thermal physical properties, as well as thermal shock behavior of in situ hot-pressed 30 vol.% (ZrB 2 + Sic)/Zr 3 [Al(Si)] 4 c 6 composite have been investigated and compared with monolithic Zr 3 [Al(Si)] 4 c 6 ceramic. The composite shows superior hardness (Vickers hardness of 17.5 GPa), stiffness (Young’s modulus of 418 GPa), strength (room-temperature bending strength of 648 MPa, and high-temperature bending strength of 439 MPa at 1300 °c in air), and toughness (fracture toughness of 7.69 MPa m 1/2 ) compared with Zr 3 [Al(Si)] 4 c 6 . The composite can retain a high modulus of 362 GPa at 1350 °c (87% of that at ambient temperature). In addition, the composite exhibits higher specific heat capacity and thermal conductivity but slightly lower coefficient of thermal expansion compared with Zr 3 [Al(Si)] 4 c 6 . The critical thermal shock temperature difference (Δ T c ) increases from 225 °c for Zr 3 [Al(Si)] 4 c 6 to 345 °c for the composite, and the calculation results of thermal shock resistance parameters also indicate a much improved thermal shock resistance of the composite.

关键词： (ZrB 2 + Sic)/Zr 3 [Al(Si)] 4 c 6 Mechanical properties Thermal conductivity Thermal shock resistance Ultra high-temperature ceramics (UHTcs)

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Variables Associated with cirrhosis Diagnosis in Patients with chronic Hepatitis c: A case-control Study

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Health 2015年第12期7卷 1634-1641页

作者： Gilmar Amorim de Sousa Iris do céu clara costa Dyego Leandro Bezerra de Souza Fabia Barbosa de Andrade Lívia Medeiros Soares celani Ranna Santos Pessoa Marlon césar de Souza Filho Daniel Fernandes Mello de Oliveira Luana Lopes de Medeiros Lucila Samara Dantas de Oliveira Maria Flávia Monteiro The Integrated Department of Medicine Federal University of Rio Grande do Norte UFRN Natal Brazil The Post-Graduate Program in Collective Health of UFRN Natal Brazil Gastroenterology Program of the University Hospital Onofre Lopes/UFRN Natal Brazil The Medical School of UFRN Natal Brazil

The diagnosis of liver cirrhosis in patients with chronic hepatitis c has not always been easy, since the gold standard method is the liver biopsy, which is an invasive procedure with interobserver accuracy problems and there have been reports of complications including records of deaths due to hemoperitoneum. cirrhosis changes the prognosis of the subject with hepatitis c and requires a different clinical management. This study aimed to identify clinical and laboratory variables associated with the diagnosis of cirrhosis in the ultrasonography of patients infected with hepatitis c. In a case-control study, we evaluated 70 cirrhotic patients with chronic hepatitis c compared to a control group of 70 non-cirrhotic people with positive HcV. The results showed, through logistic regression analysis, that the variables blood donor and professional athlete, adjusted for alcohol consumption, showed OR 0.24 and 0.18, with p values of 0.044 and 0.035, respectively. We conclude that the diagnosis of cirrhosis in patients with chronic hepatitis c remains challenging, but the patients with the condition of blood donor or professional athlete prove to be less likely to cirrhosis in ultrasonography in the initial consultation.

关键词： cirrhosis Biomakers Fibrosis Hepatitis c Virus clinical Diagnosis Biopsy Non-Invasive Methods Scores Ultrasonography

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New biomarkers for clinical management of hepatitis c virus infected patients

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World Journal of clinical Infectious Diseases 2015年第4期5卷 59-66页

作者： Alessandra Biasiolo Andrea Martini Patrizia Pontisso Department of Medicine University of Padua

Hepatocellular carcinoma(Hcc) is the third most frequent oncological cause of death worldwide, principally a consequence of hepatitis c virus(HcV) infection and its prognosis is mostly poor. For early identification and surveillance of HcV patients with liver disease progression, the availability of suitable diagnostic and prognostic biomarkers is still an unmet clinical need. Alfa-fetoprotein together with imaging techniques is commonly used, however its specificity and sensitivity are not satisfactory. Several clinical and serological data have been proposed to define the risk of disease progression in HcV infected patients and new biomarkers have been proposed, including post-transcriptionally modified molecules and genetic biomarkers. The present editorial article attempts to summarize the current knowledge on the new promising tools for effective early diagnosis of HcV-related liver disease progression and for the surveillance of Hcc.

关键词： Hepatitis c virus infection Biomarkers Liver disease progression Hepatocellular carcinoma

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Antiproliferative Activity of Acerogenin c, a Macrocyclicdiarylheptanoid, on PDGF-Induced Human Aortic Smooth Muscle cells Proliferation

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Pharmacology & Pharmacy 2015年第2期6卷 47-55页

作者： Byung-Yoon cha Wen Lei Shi Kotaro Watanabe Takayuki Yonezawa Toshiaki Teruya Kiyotake Kiyotake Yuichi Ishikawa Shigeru Nishiyama Kazuo Nagai Je-Tae Woo Research Institute for Biological Functions Chubu University Matsumoto Japan Department of Biological Chemistry Chubu University Matsumoto Japan Department of Chemistry Faculty of Science and Technology Keio University Yokohama Japan

Platelet-derived growth factor (PDGF)-BB is one of the most potent factors in the development and progression of various vascular disorders, such as atherosclerosis and restenosis. PDGF is a major stimulant for vascular smooth muscle cells (VSMcs) proliferation via the mitogenesis signaling pathway. In the present study, we investigated the effect of acerogenin c, a macrocyclicdiarylhep-tanoid, on PDGF-BB-stimulated human aortic smooth muscle cells (HASMcs) proliferation. Acer-ogenin c significantly inhibited PDGF (20 ng/mL)-BB-induced [3H]-thymidine incorporation into DNA at concentrations of 0.1, 1 and 10 μM without any cytotoxicity. Acerogenin c also blocked PDGF-BB-stimulated phosphorylation of PLcγ1 and Akt but had no effect on extracellular signal-regulated kinase 1/2 (ERK1/2) and PDGF beta-receptor (Rβ) activation. In addition, acerogenin c (0.1 - 10 μM) induced cell-cycle arrest in the G1 phase, which was associated with the down-regulation of cyclins and the up-regulation of p27kip1. These results suggest that acerogenin c blocks PDGF-BB-stimulated HASMcs proliferation via G0/G1 arrest in association with the induction of p27kip1 and the suppression of PLcγ1 and phosphatidylinositol 3-kinase (PI3-K)/Akt signaling pathways. Furthermore, acerogenin c may be used for prevention and treatment of atherosclerosis during restenosis after coronary angioplasty.

关键词： HASMcs Acerogenin c PDGF-BB p27kip1 cell cycle

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c-Terminal Modification of Fully Unprotected Peptide Hydrazides

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Synfacts 2016年第6期12卷 0584-0584页

作者： Timothy M. Swager Vera Schröder

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Facile one-pot hydrothermal synthesis of stable and biocompatible fluorescent carbon dots from lemon grass herb

Facile one-pot hydrothermal synthesis of stable and biocompa...

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1st International conference on Nanoscience and Nanotechnology (IcNAN)

作者： Thota, Sai Praneeth Thota, Sai Manohar Bhagavatham, Saikrishna Srimadh Manoj, Kaja Sai Muthukumar, Vijaya Sayee Sai Venketesh, Sivaramakrishnan Vadlani, Praveen V. Belliraj, Siva Kumar Sri Sathya Sai Inst Higher Learning Dept Chem Res Mol Modelling Lab Prasanthinilayam 515134 Andhra Pradesh India Sri Sathya Sai Inst Higher Learning Dept Biosci Prasanthinilayam 515134 Andhra Pradesh India Sri Sathya Sai Inst Higher Learning Dept Phys Prasanthinilayam 515134 Andhra Pradesh India Kansas State Univ Dept Grain Sci & Ind Bioproc & Renewable Energy Lab Manhattan KS 66506 USA Kansas State Univ Dept Chem Engn Bioproc & Renewable Energy Lab Durland Hall Manhattan KS 66506 USA

Luminescent carbon-based nanomaterials hold great promise due to their stable photo-physical behaviour, biocompatibility and lower toxicity. This work involves economic and facile one-pot green synthesis of water-soluble nanostructures from lemon grass (LGNS) [cymbopogon citratus (Dc) Stapf] as carbon source. High-resolution transmission electron microscopy confirmed the formation of LGNS with lattice spacing of 0.23nm matching low-dimensional graphitic structures. The strong absorption exhibited at 278nm could be attributed to ?-states of sp(2)/sp(3) hybridisation in carbon nanostructures. Fluorescence spectroscopy of LGNS exhibited strong excitation-dependent emission properties over a broad range of wavelengths from 300 to 600nm. Quantitatively, these LGNS were estimated to have quantum yield of 23.3%. Biomass derived LGNS could be potentially exploited for wide variety of applications like bioimaging, up-conversion, drug delivery and optoelectronic devices. To this extent, synthesised LGNS were used to image yeast cells via multicolour/multi-excitation fluorescence imaging.

关键词： fluorescence carbon nanofabrication photoluminescence toxicology transmission electron microscopy cellular biophysics biomedical optical imaging nanomedicine biomedical materials microorganisms liquid phase deposition one-pot hydrothermal synthesis biocompatible fluorescent carbon dots lemon grass herb luminescent carbon-based nanomaterials stable photophysical behaviour toxicity water-soluble nanostructures carbon source high-resolution transmission electron microscopy low-dimensional graphitic structures hybridisation carbon nanostructures fluorescence spectroscopy excitation-dependent emission properties biomass derived LGNS bioimaging drug delivery optoelectronic devices yeast cell image multicolour-multiexcitation fluorescence imaging c

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A comparison of SOFA and NOVAS astrometric software libraries 5

A comparison of SOFA and NOVAS astrometric software librarie...

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conference on Software and cyberinfrastructure for Astronomy V

作者： Piascik, Andrzej S. copperwheat, christopher M. Lam, Marco c. Leckngam, Apichat Prasit, Apirat Prasit, Pakawat Smith, Robert J. Steele, Lain A. Liverpool John Moores Univ Astrophys Res Inst Liverpool L3 5RF Merseyside England Natl Astron Res Inst Thailand 260 Moo 4 Chiang Mai 50180 Thailand

ISBN: (数字)9781510619685

ISBN: (纸本)9781510619685

The preferred programming languages and operating systems used in writing and running astrometric software have changed over time. The Python language is now well supported by the scientific community which provides open-source standard libraries for astronomical calculation including Astropy(1), SciPy(2) and NumPy(3). We surveyed available open source astrometric libraries and compare IcRS coordinate to observation transforms using recent releases of c source code and Python wrappers from the IAU Standard of Fundamental Astronomy(4) (SOFA), against those using the US Naval Observatory Vector Astrometry Software(5) (NOVAS). The selection of an underlying operating system with long term support is also an important aspect of maintaining a working telescope control system. The installation and operation of the libraries under both Linux Ubuntu LTS (Long Term Support) and Windows 10 are explored.

关键词： Astrometry Software Transforms Programming Python c

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