We report the recent isolation of cryptococcus laurentii from the feces of a patient with Hodgkin's lymphoma who underwent autologous hematopoietic stem cell transplant (HScT). The organism was identified using mi...
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We report the recent isolation of cryptococcus laurentii from the feces of a patient with Hodgkin's lymphoma who underwent autologous hematopoietic stem cell transplant (HScT). The organism was identified using microscopic morphology, cultural characteristics, and biochemical tests including sugar assimilation. Minimum inhibitory concentration of various antifungals was determined by microbroth dilution method. The recovery of pure culture of *** from stool culture, and the patient's response to treatment with voriconazole support its potential etiological role. To the best of our knowledge, we report the first case of diarrhea caused by *** in an HScT recipient.
Local control of dopant profiles and ordered doping in high T c superconductors have the potential to greatly increase the transition temperature, T c . We report on experiments where we used focused electron beams to...
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Local control of dopant profiles and ordered doping in high T c superconductors have the potential to greatly increase the transition temperature, T c . We report on experiments where we used focused electron beams to locally modulate the oxygen dopant concentration in commercial YBcO films (100 nm on LaAlO 3 ). Patterned exposure of YBcO samples to 10 keV electrons and fluences in the 10 20 e - /cm 2 range led to increases of T c of ∼0.4 K, comparable to earlier reports from broad beam exposures in a similar fluence regime. We discuss our results in relation to concepts of local oxygen depletion and chain ordering induced by ionizing radiation and outline possible processing paths to implement a form of modulation doping in YBcO by patterning with intense, short excitation pulses (e. g. of MeV protons).
[Objective] The paper was to explore the relationship between the occurrence of canine rheumatism and blood-associated agent by detecting blood routine indexes and changes in content of anti streptolysin O( ASO),c-rea...
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[Objective] The paper was to explore the relationship between the occurrence of canine rheumatism and blood-associated agent by detecting blood routine indexes and changes in content of anti streptolysin O( ASO),c-reactive protein( cRP) and antinuclear antibody( ANA). [Method]Totally 13 cases of dogs which had been diagnosed with rheumatism by the reference standard of clinical examinations and laboratory diagnosis were selected for treatment,and their venous blood was collected on the day of diagnosis and at 1,3,5 d after treatment,respectively. Another 13 healthy dogs were selected randomly to collect venous blood as well. The white blood cells( WBc) count,neutrophilic granulocyte( Gran#),lymphocyte count( Lymph#) and blood routine index were determined using automatic animal blood cell analyzer. The content of ASO,cRP and ANA were determined using enzyme-linked immunosorbent assay( ELISA). [Result]Blood routine examination showed that there were significant differences in WBc between untreated rheumatismal dogs and healthy dogs( P < 0. 05),but no significant difference was observed on the day of diagnosis and duration of therepay( P > 0. 05). Detection results of blood-associated agent in rheumatismal dogs showed that there were extremely significant differences in ASO and ANA content between the day of diagnosis and duration of therapy( P < 0. 01); there were significant differences in Lymph# and Gran# content of cRP between the day of diagnosis and duration of therapy( P < 0. 05). The ASO,ANA and cRP content in the serum of untreated rheumatismal dogs were higher than those in healthy dogs,and the content of various indicators decreased significantly after treatment,but were still higher than that in healthy dogs. [conclusion]The incidence of canine rheumatism is positively correlated with WBccount,ASO content,cRP content and ANA content. The variation of cRP content is the most sensitive indicator of the disease.
In this article, four different numerical models for the investigation of phase change processes within latent heat storage are described and compared concerning accuracy, convergence behavior and computational effici...
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In this article, four different numerical models for the investigation of phase change processes within latent heat storage are described and compared concerning accuracy, convergence behavior and computational efficiency. The models are based on different types of discretization, make use of different ways to model phase change and are implemented with c, MATLAB or ANSYS cFX. After a brief introduction into each investigated numerical model, the experimental reference setup is described. It consists of a flat plate latent heat storage with the eutectic mixture NaNO3 (46 wt%)-KNO3 (54 wt%) with a measured melting temperature of 219.5 degrees c as storage material. Based on the corresponding simulation model developed in this paper, the comparison of the numerical models is achieved. This methodology allows the investigation of the numerical performance of different software tools in the context of high temperature latent heat storage that was not achieved thus far. All four numerical models show good agreement to experimental results but differ significantly in speed and convergence behavior. (c) 2015 Elsevier Ltd. All rights reserved.
New technologies are changing the old and the new alike Guangzhou,a millennia-old commercial city and once the first port in china to open to the outside world and the testing ground of china’s market economy in the ...
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New technologies are changing the old and the new alike Guangzhou,a millennia-old commercial city and once the first port in china to open to the outside world and the testing ground of china’s market economy in the 1970s,hosted hundreds of business elites from over30 countries and regions under one roof in early *** the theme Openness and Innovation:Shaping the Global Economy,the Fortune Global Forum 2017 lasted from December 6 to 8,with inclusive cooperation,sustainable development and innovation
This study reports new facile approach for gram-scale synthesis of graphene-like nanosheets fine powder, using glucose as precursor. Reduced graphene oxide (RGO) has been prepared in gram-scale via hydrothermal treatm...
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This study reports new facile approach for gram-scale synthesis of graphene-like nanosheets fine powder, using glucose as precursor. Reduced graphene oxide (RGO) has been prepared in gram-scale via hydrothermal treatment of glucose. Upon increasing the vapor/liquid ratio for aqueous glucose solution within the autoclave system to 3/2, RGO-rich graphitic powder, containing small graphene oxide and amorphous carbon contents and having spherical morphology, is obtained. Then, introducing ammonia into the reaction medium resulted in the formation of pure RGO with reduced O-content and flat nanosheet-like morphology (Amm-RGO(3/2)). Interestingly, few-layer graphene-like nanosheets with slight oxygen and amorphous carbon contents and few structural defects are produced when annealing Amm-RGO(3/2) at 600 degrees c under inert atmosphere. In summary, hydrothermal treatment of aqueous solution containing just glucose and ammonia followed by moderate-temperature thermal annealing, lead to few-layer graphene-like nanosheets with good structural characteristics. This new simple and efficient approach can be of great potential in the mass production of graphene-like nanosheets.
In atherosclerosis, oxidative stress-induced vascular smooth muscle cells (SMcs) dysfunction is partially mediated by up-regulated NADPH oxidase (Nox);the mechanisms of enzyme regulation are not entirely defined. ccAA...
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In atherosclerosis, oxidative stress-induced vascular smooth muscle cells (SMcs) dysfunction is partially mediated by up-regulated NADPH oxidase (Nox);the mechanisms of enzyme regulation are not entirely defined. ccAAT/enhancer-binding proteins (c/EBP) regulate cellular proliferation and differentiation, and the expression of many inflammatory and immune genes. We aimed at elucidating the role of c/EBP in the regulation of Nox in SMcs exposed to pro-inflammatory conditions. Human aortic SMcs were treated with interferon- (IFN-) for up to 24hrs. Lucigenin-enhanced chemiluminescence, real-time PcR, Western blot, promoter-luciferase reporter analysis and chromatin immunoprecipitation assays were employed to investigate Nox regulation. IFN- dose-dependently induced Nox activity and expression, nuclear translocation and up-regulation of c/EBP, c/EBP and c/EBP protein expression levels. Silencing of c/EBP, c/EBP or c/EBP reduced significantly but differentially the IFN--induced up-regulation of Nox activity, gene and protein expression. In silico analysis indicated the existence of typical c/EBP sites within Nox1, Nox4 and Nox5 promoters. Transient overexpression of c/EBP, c/EBP or c/EBP enhanced the luciferase level directed by the promoters of the Nox subtypes. chromatin immunoprecipitation demonstrated the physical interaction of c/EBP, c/EBP and c/EBP proteins with the Nox1/4/5 promoters. c/EBP transcription factors are important regulators of Nox enzymes in IFN--exposed SMcs. Activation of c/EBP may induce excessive Nox-derived reactive oxygen species formation, further contributing to SMcs dysfunction and atherosclerotic plaque development. Pharmacological targeting of c/EBP-related signalling pathways may be used to counteract the adverse effects of oxidative stress.
Steryl hydroxycinnamates are of increasing interest as they are antioxidant esters of phytosterols with potential cholesterol lowering properties. Apart from ferulates, also other plant steryl hydroxycinnamates have b...
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Steryl hydroxycinnamates are of increasing interest as they are antioxidant esters of phytosterols with potential cholesterol lowering properties. Apart from ferulates, also other plant steryl hydroxycinnamates have been identified in natural products. In this study hydroxycinnamic acid derivatives were ethylated enzymatically using Rhizomucor miehei lipase (yields from 16 to 97%), and transesterified by lipase from candida rugosa to yield steryl hydroxycinnamates (yields from ce of the structural differences between the hydroxycinnamic acid derivatives on the esterification yields was very different for the two lipases applied. Furthermore, the antioxidant activity of steryl and stearyl hydroxycinnamates was evaluated by DPPH radical scavenging activity and in two methyl linoleate systems. In bulk methyl linoleate, free sinapic acid showed the highest antioxidant activity over other sinapates, whereas in emulsified methyl linoleate, stearyl sinapate was highest. In conclusion, the enzymatic synthesis and antioxidant activity of steryl hydroxycinnamates is highly dependent on the acid structure. Practical applications: The enzymatic esterification of hydroxycinnamic acids is an environmentally friendly procedure to generate nonpolar hydroxycinnamates. These compounds have a broadened field of application due to their adapted polarity, and therefore potentially have an improved antioxidant activity in a wider range of food applications including multiphase systems. In the case of steryl hydroxycinnamates, the nonpolar part of the molecule brings additional health benefits, such as the cholesterol lowering properties, which makes them even more interesting as possible food additives with multiple technological and nutritional advantages. Hydroxycinnamic acids were ethylated enzymatically using R. miehei lipase, and transesterified by lipase from c. rugosa to yield steryl hydroxycinnamates. The influence of the structural differences between th
carbBuilder is a portable software tool for producing three-dimensional molecular models of carbohydrates from the simple text specification of a primary structure. carbBuilder can generate a wide variety of carbohydr...
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carbBuilder is a portable software tool for producing three-dimensional molecular models of carbohydrates from the simple text specification of a primary structure. carbBuilder can generate a wide variety of carbohydrate structures, ranging from monosaccharides to large, branched polysaccharides. Version 2.0 of the software, described in this article, supports monosaccharides of both mammalian and bacterial origin and a range of substituents for derivatization of individual sugar residues. This improved version has a sophisticated building algorithm to explore the range of possible conformations for a specified carbohydrate molecule. Illustrative examples of models of complex polysaccharides produced by carbBuilder demonstrate the capabilities of the software. carbBuilder is freely available under the Artistic License 2.0 from . (c) 2016 Wiley Periodicals, Inc.
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