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SUMOylation of the chromodomain factor MRG-1 in c. elegans affects chromatin-regulatory dynamics

BIOTEcHNIQUES 2022年第1期73卷 15 - 17页

作者： Baytek, Guelkiz Blume, Alexander Demirel, Funda Gerceker Bulut, Selman Popp, Oliver Mertins, Philipp Tursun, Baris Max Delbruck Ctr Mol Med Helmholtz Assoc MDC D-13125 Berlin Germany Berlin Inst Med Syst Biol BIMSB D-10115 Berlin Germany Univ Hamburg Inst Cell & Syst Biol Anim Dept Biol D-20146 Hamburg Germany

Epigenetic mechanisms control chromatin accessibility and gene expression to ensure proper cell fate specification. Histone proteins are integral chromatin components, and their modification promotes gene expression regulation. Specific proteins recognize modified histones such as the chromodomain protein MRG-1. MRG-1 is the caenorhabditis elegans ortholog of mammalian MRG15, which is involved in DNA repair. MRG-1 binds methylated histone H3 and is important for germline maturation and safeguarding. To elucidate interacting proteins that modulate MRG-1 activity, we performed in-depth protein-protein interaction analysis using immunoprecipitations coupled with mass spectrometry. We detected strong association with the Small ubiquitin-like modifier SUMO, and found that MRG-1 is post-translationally modified by SUMO. SUMOylation affects chromatin-binding dynamics of MRG-1, suggesting an epigenetic regulation pathway, which may be conserved. MULTIDIScIPLINARY ABSTRAcT Epigenetic mechanisms control chromatin accessibility and gene expression to ensure proper cell fate specification. We describe in this study that in the nematode c. elegans, the epigenetic regulator MRG-1 is modified by the small ubiquitin-like modifier SUMO. Posttranslational modification by SUMO affects chromatin-binding dynamics of MRG-1, suggesting a modulation of epigenetic regulation. METHOD SUMMARY co-immunoprecipitation is in combination with single-pot, solid-phase-enhanced, sample preparation (SP3), followed by mass spectrometry (coIP-MS) and label-free quantification (LFQ). TWEETABLE ABSTRAcT SUMOylation of the mammalian epigenetic factor MRG15 ortholog MRG-1 in c. elegans affects chromatin-binding dynamics of MRG-1.

关键词： c elegans chromatin MRG-1 epigenetics MRG15 MORF4 protein interaction SUMO

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Multi-suture craniosynostosis in c.1570c>T (***524Trp) mutated TRAF7: a case report

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cHILDS NERVOUS SYSTEM 2022年第4期38卷 843-846页

作者： chaisrisawadisuk, Sarut Taranath, Ajay Azzopardi, Jonathan Moore, Mark H. Womens & Childrens Hosp Cleft & Craniofacial South Australia Adelaide SA Australia Mahidol Univ Siriraj Hosp Dept Surg Div Plast SurgFac Med Bangkok Thailand Womens & Childrens Hosp Dept Med Imaging Adelaide SA Australia

craniosynostosis is a condition of premature fusion of the cranial sutures. Multi-suture craniosynostosis has been found to be associated with a number of syndromes and underlying gene mutations. Tumour necrosis factor receptor-associated factors (TRAFs) are a family of adaptor proteins interacting with cell surface receptors or other signalling molecules. TRAF7 is one of the factors involved in multiple biologic processes, including ubiquitination, myogenesis and toll-like receptor signalling. Here, we report a child who presented with multi-suture craniosynostosis and had the uncommon c.1570c>T (***524Trp) variant of TRAF7.

关键词： Arg524Trp craniosynostosis c 1570c>T TRAF7 mutation

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Heterogeneous Pd/c-catalyzed, ligand free Suzuki-Miyaura coupling reaction furnishes newp-terphenyl derivatives

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NATURAL PRODUcT RESEARcH 2022年第2期36卷 566-570页

作者： Avula, Satya Kumar Rehman, Najeeb Ur Anwar, Muhammad U. Aalthani, Ghanim csuk, Rene Al-Harrasi, Ahmed Univ Nizwa Nat & Med Sci Res Ctr Nizwa Oman Martin Luther Univ Halle Wittenberg Organ Chem Halle Saale Germany

A series of newpara-terphenyls derivatives have been efficiently synthesized by a ligand-free heterogeneous Pd/c-catalyzed two-fold Suzuki-Miyaura coupling reaction. Methyl 5-bromo-2-iodobenzoate was selected to react with a variety of different aryl boronic acids (2a-i). Nine newp-terphenyl derivatives (3a-i) were prepared and the structures were confirmed by several analytical techniques including infrared, spectroscopy,H-1 and(13)c NMR spectroscopy, mass spectrometry, and in the case of compound3 b,by X-ray diffraction method. The new derivatives were obtained in very good yields (78-91%). This synthetic facile route is envisioned to improve the preparation ofp-terphenyl-based natural products.

关键词： Ligand-free catalysis aryl boronic acids Suzuki-Miyaura coupling reaction Pd c heterogeneous catalysis

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comparative study of cUDA-based parallel programming in c and Python for GPU acceleration of the 4th order Runge-Kutta method

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NUcLEAR ENGINEERING AND DESIGN 2024年 421卷

作者： Fernandes, Davi F. Santos, Marcelo c. Silva, Adilson c. Lima, Alan M. M. Univ Fed Rio de Janeiro Nucl Engn Program COPPE CP 68509 BR-21941972 Rio De Janeiro RJ Brazil

In this paper, a comparative study is presented on the application of General-purpose computing on Graphics Processing Units for solving the point reactor kinetics equations through the utilization of the 4th Order RungeKutta (RK4) method using the programming languages c and Python. Sequential and parallel algorithms of the RK4 method were developed in c/c++ and Python, with parallel algorithms specifically designed to operate on Graphics Processing Units (GPUs) utilizing the NVIDIA compute Unified Device Architecture (cUDA) as the programming platform. As an experiment, the execution time for the sequential and parallel algorithms were compared for a reactivity value of rho = 0.003 and a simulation time of t = 100 s. The parallel c and Python algorithms achieved, respectively, speedups of 9.33 and 409.7 when comparing the execution time on the best GPU utilized (RTX 3070Ti) with the best cPU (3600XT), while still maintaining numerical precision.

关键词： GPU Point reactor kinetics equations Runge-Kutta Method Python c

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c. elegans as a test system to study relevant compounds that contribute to the specific health-related effects of different cannabis varieties

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JOURNAL OF cANNABIS RESEARcH 2022年第1期4卷 53页

作者： Van Es-Remers, Monique Spadaro, Jesus Arellano Poppelaars, Eefje Kim, Hye Kyong van Haaster, Marieke de Wit, Marcel ILiopoulou, Eva Wildwater, Marjolein Korthout, Henrie Vivaltes BV Regulierenring 9 NL-3981 LA Bunnik Netherlands Fytagoras BV Sylviusweg 72 NL-2333 BE Leiden Netherlands Maripham BV Nieuw Mathenesserstr 33 NL-3029 AV Rotterdam Netherlands

Background The medicinal effects of cannabis varieties on the market cannot be explained solely by the presence of the major cannabinoids Delta(9)-tetrahydrocannabinol (THc) and cannabidiol (cBD). Evidence for putative entourage effects caused by other compounds present in cannabis is hard to obtain due to the subjective nature of patient experience data. caenorhabditis elegans (c. elegans) is an objective test system to identify cannabis compounds involved in claimed health and entourage effects. Methods From a medicinal cannabis breeding program by MariPharm BV, the Netherlands a set of 12 varieties were selected both THc rich varieties as well as cBD rich varieties. A consecutive extraction process was applied resulting in a non-polar (cannabinoid-rich) and polar (cannabinoid-poor) extract of each variety. The test model c. elegans was exposed to these extracts in a broad set of bioassays for appetite control, body oscillation, motility, and nervous system function. Results Exposing c. elegans to extracts with a high concentration of cannabinoids (> 1 mu g/mL) reduces the life span of c. elegans dramatically. Exposing the nematodes to the low-cannabinoid (< 0.005 mu g/mL) polar extracts, however, resulted in significant effects with respect to appetite control, body oscillation, motility, and nervous system-related functions in a dose-dependent and variety-dependent manner. Discussion c. elegans is a small, transparent organism with a complete nervous system, behavior and is due to its genetic robustness and short life cycle highly suitable to unravel entourage effects of cannabis compounds. Although c. elegans lacks an obvious cB1 and cB2 receptor it has orthologs of Serotonin and Vanilloid receptor which are also involved in (endo)cannabinoid signaling. conclusion By using c. elegans, we were able to objectively distinguish different effects of different varieties despite the cannabinoid content. c. elegans seems a useful test system for studying entourage effe

关键词： c elegans Medicinal cannabis Entourage effects Appetite Motility Body oscillation Nervous system Memory Endurance performance

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A novel mutation in theZNF462gene c.3306dup;p.(Gln1103Thrfs*10) is associated to Weiss-Kruszka syndrome. A case report

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AcTA cLINIcA BELGIcA 2022年第1期77卷 118-121页

作者： Gonzalez-Tarancon, R. Salvador-Ruperez, E. Miramar Gallart, M. D. Barroso, E. Diez Garcia-Prieto, I Perez Delgado, R. Lopez Pison, J. Garcia Jimenez, M. c. Univ Hosp Miguel Servet Dept Clin Biochem Clin Genet Lab Zaragoza Spain NIMGenetics Madrid Spain Univ Hosp Miguel Servet Dept Pediat Neurometab Unit Zaragoza Spain

Background Weiss-Kruszka syndrome (WSKA) is a rare disorder caused by mutations in theZNF462gene or deletion of 9p31.2 chromosome region, involvingZNF462. The prevalence of WSKA is unknown as only 24 affected individuals have been described. This syndrome should be suspected in individuals presenting mild global developmental delay and common craniofacial abnormalities. case presentation We presented a case of an infant, 3 years and 4-month life who presented pondostatural and psychomotor retardation, generalized hypotonia with hypermobility, bilateral palpebral ptosis, epicanthal folds, and poorly expressive facies as the main clinical features. These characteristics lead to the realization of genetics studies that resulted in the identification of a novel mutation c.3306dup;p.(Gln1103Thrfs*10) inZNF462. conclusions WSKA should be suspected in individuals presenting mild global developmental delay, ptosis, downslanting palpebral fissures, exaggerated cupid's Bow, arched eyebrows, epicanthal folds and short upturned nose with a bulbous tip. Hypertrophy of the ventricular septum and severe OSA were described in our patient and should be considered in future reviews of the disease. This case is added to the reduced number of publications previously reported regarding WSKA and contributes to understanding the genetic characteristics, clinical features, and diagnosis of this syndrome.

关键词： WKSA ZNF462 c 3306dup p (Gln1103Thrfs*10) ptosis

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An M/M/c/K queueing system in an inventory routing problem considering congestion and response time for post-disaster humanitarian relief: a case study

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JOURNAL OF HUMANITARIAN LOGISTIcS AND SUPPLY cHAIN MANAGEMENT 2022年第2期12卷 182-219页

作者： Masoumi, Mahdieh Aghsami, Amir Alipour-Vaezi, Mohammad Jolai, Fariborz Esmailifar, Behdad Univ Tehran Coll Engn Ind & Syst Engn Tehran Iran KN Toosi Univ Technol Tehran Iran

Purpose Due to the randomness and unpredictability of many disasters, it is essential to be prepared to face difficult conditions after a disaster to reduce human casualties and meet the needs of the people. After the disaster, one of the most essential measures is to deliver relief supplies to those affected by the disaster. Therefore, this paper aims to assign demand points to the warehouses as well as routing their related relief vehicles after a disaster considering convergence in the border warehouses. Design/methodology/approach This research proposes a multi-objective, multi-commodity and multi-period queueing-inventory-routing problem in which a queuing system has been applied to reduce the congestion in the borders of the affected zones. To show the validity of the proposed model, a small-size problem has been solved using exact methods. Moreover, to deal with the complexity of the problem, a metaheuristic algorithm has been utilized to solve the large dimensions of the problem. Finally, various sensitivity analyses have been performed to determine the effects of different parameters on the optimal response. Findings According to the results, the proposed model can optimize the objective functions simultaneously, in which decision-makers can determine their priority according to the condition by using the sensitivity analysis results. Originality/value The focus of the research is on delivering relief items to the affected people on time and at the lowest cost, in addition to preventing long queues at the entrances to the affected areas.

关键词： Humanitarian logistics Inventory-routing problem M M c K queueing systems

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Rapid Synthesis and Microenvironment Optimization of Hierarchical Porous Fe―N―c catalysts for Enhanced ORR in Microbial Fuel cells

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ADVANcED ScIENcE 2024年第31期11卷 e2402610页

作者： Jiang, Bolong Jiang, Nan cui, Yanyan Wang, Huan Zhang, Geng Li, Jiayou Zhang, Yuhan Qingdao Univ Technol Innovat Inst Sustainable Maritime Architecture Res Qingdao 266000 Shandong Peoples R China Qingdao Univ Technol Inst Environm & Municipal Engn Qingdao 266000 Shandong Peoples R China Northeast Petr Univ Coll Chem & Chem Engn Daqing 163318 Heilongjiang Peoples R China

Here, an approach to produce a hierarchical porous Fe-N-c@TABOH catalyst with densely accessible high intrinsic active FeNx sites is proposed. The method involves a single-step pyrolysis of Zn/Fe-zeolitic imidazolate framework (Zn/Fe-ZIF-H) with tetrabutylammonium hydroxide (TABOH) micelles, which is obtained by utilizing TABOH as a structural template and electronic mediator at room temperature for a brief duration of 16 min. Notably, the yield of Zn/Fe-ZIF-H is 3.5 times that of Zn/Fe-ZIF-N prepared by conventional method. Results indicate that in addition to expediting synthesis and increasing yield of the Zn/Fe-ZIF-H, the TABOH induces a hierarchical porous structure and fosters the formation of more and higher intrinsic active FeNx moieties in Fex-N-c@TABOH, showing that TABOH is a multifunctional template. crucially, the increased mesoporosity/external surface area and optimized microenvironment of Fe-N-c@TABOH significantly enhance ORR activity by facilitating the formation of high intrinsic active FeNx sites, increasing accessible FeNx sites, and reducing mass transfer resistance. Through structure tailoring and microenvironment optimization, the resulting Fe-N-c@TABOH exhibits superior ORR performance. DFT calculation further validates that the synergistic effect of these two factors leads to low ORR barrier and optimized *OH adsorption energy. This study underscores the importance of structure and electronic engineering in the development of highly active ORR catalysts. A simple rapid strategy to fabricate a hierarchical porous Fe-N-c@TABOH catalyst with densely accessible high intrinsic active FeNx sites is proposed. Benefit from structure tailoring and microenvironment optimization, the resulting Fe-N-c@TABOH showed superior ORR performance, offering an exceptionally high MFc power density of 830.1 +/- 5.2 mWm-2, which is comparable to that of the Pt/c catalyst. image

关键词： Fe & horbar N & horbar c hierarchical porous microbial fuel cells microenvironment oxygen reduction reaction

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Development of nanostructured Ge/c anodes with a multistacking layer fabricated via Ar high-pressure sputtering for high-capacity Li⁺-ion batteries

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APPLIED PHYSIcS EXPRESS 2024年第2期17卷 026001-026001页

作者： Omae, Tomoki Yamada, Teruya Fujikake, Daiki Kozawa, Takahiro Uchida, Giichiro Meijo Univ Fac Sci & Technol Nagoya Aichi 4688502 Japan Osaka Univ Joining & Welding Res Inst Ibaraki Osaka 5670047 Japan

To realize high-capacity Ge anodes for next-generation Li+-ion batteries, a multilayer anode with a c(top)/Ge(middle)/c(bottom) structure wasdeveloped, where nanostructured amorphous Ge (a-Ge) and amorphous-like carbon films with a grain size of 10-20 nm were depositedsequentially by high-pressure Ar sputtering at 500 mTorr. compared with the a-Ge anode, the c(top)/a-Ge(middle)/c(bottom) multistacking layeranode showed improved capacity degradation for repeated lithiation/delithiation reactions and achieved a high capacity of 910 mAh g(-1)with nocapacity fading after 90 cycles at a c-rate of 0.1.(c) 2024 The Author(s). Published on behalf of The Japan Society of Applied Physics by IOPPublishing Ltd

关键词： low temperature plasma process Li ion battery Ge c

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S-Block Metal Mg-Mediated co―N―c as Efficient Oxygen Electrocatalyst for Durable and Temperature-Adapted Zn-Air Batteries

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ADVANcED ScIENcE 2024年第34期11卷 e2403865页

作者： Wang, Henan Niu, Xinxin Liu, Wenxian Yin, Ruilian Dai, Jiale Guo, Wei Kong, chao Ma, Lu Ding, Xia Wu, Fangfang Shi, Wenhui Deng, Tianqi cao, Xiehong Zhejiang Univ Technol Pinghu Inst Adv Mat Coll Mat Sci & Engn Hangzhou 310014 Peoples R China Zhejiang Univ Technol Coll Chem Engn Hangzhou 310014 Peoples R China Zhejiang Univ Technol Coll Chem Engn Ctr Membrane & Water Sci & Technol Hangzhou 310014 Peoples R China Zhejiang Univ State Key Lab Silicon & Adv Semicond Mat Hangzhou 310027 Peoples R China Zhejiang Univ Sch Mat Sci & Engn Hangzhou 310027 Peoples R China Zhejiang Univ Inst Adv Semicond Hangzhou 311215 Peoples R China Zhejiang Univ Hangzhou Global Sci & Technol Innovat Ctr Zhejiang Prov Key Lab Power Semicond Mat & Devices Hangzhou 311215 Peoples R China

In the quest to enhance Zn-air batteries (ZABs) for operating across a wide spectrum of temperatures, synthesizing robust oxygen electrocatalysts is paramount. conventional strategies focusing on orbital hybridization of d-d and p-d aim to moderate the excessive interaction between the d-band of the transition metal active site and oxygen intermediate, yet often yield suboptimal performance. Herein, an innovative s-block metal modulation is reported to refine the electronic structure and catalytic behavior of co & horbar;Nc catalysts. Employing density functional theory (DFT) calculations, it is revealed that incorporating Mg markedly depresses the d-band center of co sites, thereby fine-tuning the adsorption energy of the oxygen reduction reaction (ORR) intermediate. consequently, the Mg-modified co & horbar;Nc catalyst (Mgco & horbar;Nc) unveils remarkable intrinsic ORR activity with a significantly reduced activation energy (Ea) of 10.0 kJ mol(-1), outstripping the performance of both co & horbar;Nc (17.6 kJ mol(-1)), benchmark Pt/c (15.9 kJ mol(-1)), and many recent reports. Moreover, ZABs outfitted with the finely tuned Mg0.1co0.9 & horbar;Nc realize a formidable power density of 157.0 mW cm(-2), paired with an extremely long cycle life of 1700 h, and an exceptionally minimal voltage gap decay rate of 0.006 mV h(-1). Further, the Mg0.1co0.9 & horbar;Nc-based flexible ZAB presents a mere 2% specific capacity degradation when the temperature fluctuates from 25 to -20 degrees c, underscoring its robustness and suitability for practical deployment in diverse environmental conditions.

关键词： metal & horbar N & horbar c oxygen reduction reaction s-block temperature-adapted Zn-air batteries

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