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焊接技术 2019年第5期48卷 43-46页

作者：张伟光郭璟田卉莘曾黎罗震蔡养川中国机械工程学会北京100048 天津大学材料科学与工程学院天津300350 天津市津猫电线电缆集团股份有限公司天津301721 大庆油田第三采油厂规划设计研究所黑龙江大庆163113

Tic陶瓷颗粒硬度高,可以作为外加硬质相颗粒,提高熔覆层金属的耐磨损性能。文中以钴基合金熔覆层为金属基体,加入Ti c陶瓷颗粒,研究Tic陶瓷颗粒微观形貌与耐磨损性能的关系。结果表明:小尺寸陶瓷颗粒、花瓣状陶瓷颗粒和花草状陶瓷颗粒... 详细信息

Tic陶瓷颗粒硬度高,可以作为外加硬质相颗粒,提高熔覆层金属的耐磨损性能。文中以钴基合金熔覆层为金属基体,加入Ti c陶瓷颗粒,研究Tic陶瓷颗粒微观形貌与耐磨损性能的关系。结果表明:小尺寸陶瓷颗粒、花瓣状陶瓷颗粒和花草状陶瓷颗粒可以有效提高熔覆层的耐磨损性能,而大尺寸未熔化陶瓷颗粒在外力作用下容易碎化脱落,恶化熔覆层的耐磨损性能。

关键词： Ti c 钴基合金熔覆层耐磨损性能

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comparisons of field and laboratory estimates of risk of DDTs from contaminated sediments to humans that consume fish in Palos Verdes, california, USA

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ScIENcE OF THE TOTAL ENVIRONMENT 2017年 601卷 1139-1146页

作者： coffin, Scott Gan, Jay Schlenk, Daniel Univ Calif Riverside Dept Environm Sci Riverside CA 92521 USA

calculating risk from sea food exposure to persistent organic pollutants continues to be problematic as estimates of exposure from diet require extensive monitoring of fish species and limited assessments of bioavailability from sediments where the contaminants tend to reside. Previous studies in our laboratory utilized a laboratory-based isotope dilution method (IDM) to estimate the bioavailability of DDT [1,1,1-trichloro-2, 2-bis(p-chlorophenyl) ethane] and its metabolites from sediment to biota froma superfund site on the shelf of the Palos Verdes (PVS) Peninsula in california (USA). Using a biota-sediment accumulation factor (BSAF) derived from IDM and biomagnification factors (BMF) calculated from previous studies as well as seafood-consumption data specific to anglers in the PVS area, we estimated cancer and non-cancer risks for anglers and nursing infants representing sensitive groups. Predicted cancer risks from consumption of White croaker (Genyonemus lineatus) to the 50th and 95th percentile to all shore mode anglers were, respectively, 2 x 10(-7) and 7 x 10(-7), which were similar (t)o field studies using fish concentrations of all DDT isomers and their environmental degradates (SDDT) from collected animals. The calculated non-cancer hazard quotient values for the 50th and 95th percentile shore mode anglers consuming White croaker from this study (0.008 and 0.023, respectively) were also of similar magnitude as those obtained from studies based on samples obtained solely from fish. For nursing infants, similar results were also observed. These results indicate that estimates of bioavailability using IDM from sediment could be used accurately to determine risk to SDDT in humans from fish consumption. (c) 2017 Elsevier B. V. All rights reserved.

关键词： DDT 1,1,1-trichloro-2, 2-bis ( p -chloro-phenyl) ethane PVS Palos Verdes Shelf HOcs hydrophobic organic contaminants USEPA United States Environmental Protection Agency IDM Isotope Dilution Method LAcSD Los Angeles county Sanitation District ΣDDT total bioavailable DDT BSAF biota-sediment accumulation factor BMF biomagnification factor c f concentration of ΣDDT in White croaker V f lipid fraction in the tissue of White croaker c s ΣDDT concentration in sediment TOc total organic carbon content c p concentration of ΣDDT in polychaete V p lipid fraction in polychaete tissue OEHHA california Environmental Protection Agency Office of Environmental Health Hazard Assessment BLMc breast milk lipid concentration of ΣDDT ADD average daily dose of ΣDDT from fish BMI bw body weight-normalized breast milk ingestion rate during the first year of life cAPcOA california Air Pollution control Officers Association Ifish sport fish ingestion rate GI gastrointestinal absorption fraction EF exposure frequency ASF age slope factor cSF cancer slope factor SQO sediment quality objective USAcE US Army corps of Engineers

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Is Resistance to Mountain Pine Beetle Associated with Genetic Resistance to White Pine Blister Rust in Limber Pine?

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FORESTS 2018年第10期9卷

作者： Holtz, christine T. Schoettle, Anna W. Mt Studies Inst 1315 Snowden StSuite 305 Silverton CO 81433 USA US Forest Serv USDA Rocky Mt Res Stn 240 West Prospect Rd Ft Collins CO 80526 USA

Limber pine (Pinus flexilis James) co-evolved with the mountain pine beetle (Dendroctonus ponderosae Hopkins;MPB) and is now also challenged by the non-native pathogen cronartium ribicola (J.c. Fisch.) that causes the lethal disease white pine blister rust (WPBR). Previous research suggests that trees infected with WPBR can be preferred hosts for MPB. Using resin duct traits associated with MPB resistance, we tested for a relationship between resistance to MPB and WPBR in limber pine, in the absence of either biological agent. These analyses will help evaluate if MPB historically may have contributed to natural selection for WPBR resistance in advance of WPBR invasion, and could help explain the unusually high frequency of the dominant cr4 allele for complete resistance to WPBR in limber pine populations of the Southern Rocky Mountains. Resin duct production, density and relative duct area did not differ between healthy trees previously inferred to carry the dominant cr4 allele and trees that lack it at 22 sites, though some duct traits varied with elevation. MPB resistance does not appear to have played an evolutionary role in contributing to the high frequency of cr4 in naive populations, however, MPB may affect the future evolution of resistance to WPBR in the pines where the two pests coincide and WPBR will affect forest recovery after MPB epidemics. MPB-WPBR interactions in a changing climate will affect the future trajectory of limber pine.

关键词： Pinus flexilis James Dendroctonus ponderosae Hopkins cronartium ribicola J c Fisch resistance resin ducts major gene resistance natural selection elevation plant defense

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硫辛酸对不同时期糖尿病肾病患者尿微量白蛋白及炎症的影响

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中华临床医师杂志（电子版） 2019年第4期13卷 241-245页

作者：石锋吴豫梅曾黄辉吴永新王红梅梅州市人民医院内分泌科

目的探讨硫辛酸对不同时期糖尿病肾病患者尿微量白蛋白和炎症的影响。方法选取2015年7月至2017年12月在梅州市人民医院内分泌科住院治疗的2型糖尿病患者90例,根据24 h尿微量白蛋白排泄率(UAER)分为3组,即正常白蛋白尿组(NA,UAER<30 m... 详细信息

目的探讨硫辛酸对不同时期糖尿病肾病患者尿微量白蛋白和炎症的影响。方法选取2015年7月至2017年12月在梅州市人民医院内分泌科住院治疗的2型糖尿病患者90例,根据24 h尿微量白蛋白排泄率(UAER)分为3组,即正常白蛋白尿组(NA,UAER<30 mg/24 h)、微量白蛋白尿组(MA,30 mg/24 h≤UAER<300 mg/24 h)和临床肾病组(cN,UAER≥300 mg/24 h);同时随机选取同期健康体检者30名作为正常对照组(Nc)。再将3组糖尿病患者按随机数字表法随机分为等样本量的观察组和对照组,对照组给予常规治疗,观察组在常规治疗基础上给予注射用硫辛酸0.45 g加入0.9 %氯化钠注射液250 ml中避光缓慢静滴,1次/d,共2周。观察各组患者UAER、血清肌酐(Scr)、血糖、血清超敏c反应蛋白(hs-cRP)、血清肿瘤坏死因子α(TNF-α)水平的变化。结果2型糖尿病肾病患者血清hs-cRP、TNF-α水平明显高于正常对照组[(5.98±1.54)mg/L vs (6.49±1.84)mg/L vs(7.02±1.75)mg/L vs(2.95±0.86)mg/L;(17.19±5.05)ng/L vs(19.61±5.42)ng/L vs (20.25±6.23)ng/L vs (10.24±3.16)ng/L],差异具有统计学意义(F=15.63、25.22,P均<0.01),但糖尿病肾病不同时期比较差异无统计学意义;观察组经硫辛酸治疗后与对照组治疗后比较,其hs-cRP、TNF-α、Scr、UAER水平明显降低[(5.01±0.93)mg/L vs (3.89±0.72)mg/L,(5.51±1.23)mg/L vs (4.25±0.88)mg/L,(6.15±1.32)mg/L vs (4.78±1.01)mg/L;(15.59±4.19)ng/L vs (12.04±3.45)ng/L,(18.02±4.42)ng/L vs (14.43±4.22)ng/L,(18.67±4.88)ng/L vs (15.09±4.47)ng/L;(83.5±9.4)μmol/L vs (67.3±6.2)μmol/L,(85.6±16.0)μmol/L vs (61.3±16.7)μmol/L,(98.5±20.4)μmol/L vs (69.4±16.8)μmol/L;(16.5±7.4)mg/24 h vs(13.3±6.2)mg/24 h,(145.6±66.0)mg/24 h vs (106.3±56.7)mg/24 h,(805.5±166.4)mg/24 h vs(612.3±110.8)mg/24 h],差异具有统计学意义(t=3.689、3.227、3.192、2.526、2.275、2.095、5.572、4.069、4.265、5.597、2.051、3.742,P均<0.05)。结论2型糖尿病肾病患者存在炎症反应,硫辛酸可改善2型糖尿病肾病炎症状态,减少尿微量白蛋白排泄和降低血肌酐水平,从而达到肾保护作用。

关键词：硫辛酸糖尿病肾病炎症因子超敏 c 反应蛋白肿瘤坏死因子α

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J. Heyrovsky's Oscillographic Polarography. Roots of Present chronopotentiometric Analysis of Biomacromolecules

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ELEcTROANALYSIS 2018年第7期30卷 1259-1270页

作者： Palecek, Emil Heyrovsky, Michael Dorcak, Vlastimil CAS Inst Biophys Kralovopolska 135 Brno 61265 Czech Republic CAS J Heyrovsky Inst Phys Chem Dolejskova 2155-3 Prague 18223 8 Czech Republic

In 1941J. Heyrovsky invented Oscillographic Polarography (OP) with controlled alternating current (a.c.). The method was developed during the World War and the first commercially available instruments for OP were produced in czechoslovakia at the beginning of the 1950's. Such instruments offered derivative and cyclic OP curves allowing simple analysis of various compounds and stimulated the publication of hundreds of papers. Thanks to OP, electrochemical analysis of DNA started already in 1958. According to the present nomenclature, OP can be denominated as a.c. chronopotentiometry. Surprisingly, authors who later described derivative and cyclic chronopotentiometry did not consider J. Heyrovsky's OP methodology in their work. Present electrochemical studies of biomacromolecules take advantage of modern instruments for constant current chronopotentiometric stripping, allowing DNA and protein structure-sensitive analysis. Recent progress in these studies is reviewed.

关键词： Oscillographic polarography with controlled a c constant current chronopotentiometric stripping catalytic hydrogen evolution in biomacromolecules at mercury electrodes Protein structure-sensitive analysis Intrinsic electrocatalysis in DNA

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嗜酸性粒细胞性哮喘小鼠相关体液中3-溴酪氨酸水平的研究

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精准医学杂志 2019年第5期34卷 405-407,411页

作者：刘昭管仁政金蓉林荣军青岛大学附属医院崂山院区综合儿科

目的探讨3-溴酪氨酸在嗜酸性粒细胞性哮喘小鼠相关体液中含量的变化及与哮喘的关系。方法BABL/c雌性小鼠48只,随机分为实验组和对照组各24只,实验组使用鸡卵蛋白(OVA)诱导建立嗜酸性粒细胞性哮喘小鼠模型,采用酶联免疫吸附试验方法检测... 详细信息

目的探讨3-溴酪氨酸在嗜酸性粒细胞性哮喘小鼠相关体液中含量的变化及与哮喘的关系。方法BABL/c雌性小鼠48只,随机分为实验组和对照组各24只,实验组使用鸡卵蛋白(OVA)诱导建立嗜酸性粒细胞性哮喘小鼠模型,采用酶联免疫吸附试验方法检测两组小鼠血液、尿液及肺泡灌洗液中3-溴酪氨酸的含量,并进行分析比较。结果实验组小鼠肺泡灌洗液及尿液中3-溴酪氨酸的含量明显高于对照组,差异具有统计学意义(t=4.25、4.56,P<0.05)。实验组血液中的3-溴酪氨酸含量略高于对照组,但差异无统计学意义(P>0.05)。实验组肺泡灌洗液和尿液中3-溴酪氨酸含量与肺泡灌洗液中嗜酸性粒细胞数呈正相关(r=0.89、0.46,P<0.05)。结论通过检测肺泡灌洗液及尿液中3-溴酪氨酸的水平有可能为哮喘的诊断提供帮助。

关键词：哮喘疾病模型,动物酪氨酸嗜酸细胞小鼠,近交BALB c

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chitinase-3-like protein 1 as a predictor for the progression or regression of liver fibrosis

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Hepatoma Research 2018年第8期4卷 81-86页

作者： Biaoyang Lin Shengjun Wu Yunhua Liu Longgen Liu Saadiya Mushtaq Zhejiang-California International Nanosystems Institute(ZCNI)Proprium Research Center Zhejiang UniversityHangzhou310058Zhejiang ProvinceChina Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Af.liated HospitalSchool ofMedicineZhejiang UniversityHangzhou310058Zhejiang ProvinceChina University of Washington School of Medicine SeattleWA98195USA Sir Run Run Shaw Hospital School of MedicineZhejiang UniversityHangzhou310020Zhejiang ProvinceChina Department of Liver Diseases The Second Hospital of Yunnan ProvinceKunming650000Yunnan ProvinceChina The Third People’s Hospital hospital of Changzhou Changzhou213001Jiangsu ProvinceChina Virology Department Armed Forces Institute of PathologyBlock E-16New Cob LaneJaved Sultan Shaheed ColonyRawalpindiCanttRawalpindiPakistan

Liver fibrosis is a wound-healing response of liver cells to chronic injuries caused by viral infections, including hepatitis B virus (HBV), hepatitis c virus (HcV), toxins, and alcohol abuse. The ability to stage diseases for treatment na?ve patients to initiate proper medical procedures and predict the clinical causes of the disease or the treatment response is important given the increased prevalence of liver fibrosis caused by HBV, HcV and fatty liver diseases. cHI3L1 (chitinase-3-like protein 1, also known as YKL-40), which belongs to the chitinase family but lacks chitinolytic activity and is highly expressed in the liver, seems to fulfill this role. cHI3L1 is a non-invasive staging marker for liver fibrosis caused by HBV, HcV and non-alcoholic fatty liver disease as well as a predictor of the clinical causes and fibrotic changes after treatments. cHI3L1 predicts histological progression of liver fibrosis and fibrosis progression rate (fibrosis unit/year), rapid fibrosis progression after liver transplantation and response to interferon and recent direct acting antiviral therapy in chronic HcV patients. cHI3L1 also predicts response to antiviral therapy in chronic HBV patients.

关键词： cHI3L1 liver fibrosis progression regression hepatitis B virus hepatitis c virus treatment response

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一测多评法测定皿培式培养牛樟芝中3种樟芝酸类成分的含量

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中国中药杂志 2018年第21期43卷 4283-4287页

作者：吴雨田文静林佩欣罗吉孟林挺陈海峰厦门大学药学院福建厦门361102 台湾工业技术研究院台湾新竹30011

建立皿培式培养牛樟芝Antrodia camphorate中3种樟芝酸类成分(25S)-antcin K,(25R)-antcin K,(25S)-antcin c的一测多评法,该研究优化了皿培式培养牛樟芝质量控制的HPLc指纹图谱条件,实现其主含成分(25R)-antcin K和(25S)-antcin K的基线分离。以(25S)-antcin c为内参物,测定(25S)-antcin K和(25R)-antcin K的相对校正因子,计算皿培式培养牛樟芝中难以大量制备的这一对差向异构体的含量,实现一测多评。同时,采用外标法测定皿培式培养牛樟芝中3种樟芝酸类成分的含量,并将其含量测定结果与一测多评法测定结果进行比较,结果显示一测多评法与外标法测定结果无显著差异。因此,以(25S)-antcin c为内参物,利用一测多评法测定(25S)-antcin K和(25R)-antcin K可应用于皿培式培养牛樟芝的定量分析。

关键词：皿培式培养牛樟芝一测多评 (25S)-antcin K (25R)-antcin K (25S)-antcin c 相对矫正因子

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Thermodynamic analysis of steam gasification of municipal solid waste

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ENERGY SOURcES PART A-REcOVERY UTILIZATION AND ENVIRONMENTAL EFFEcTS 2018年第6期40卷 623-629页

作者： Xu, Pengcheng Hu, Ming Shao, Zheru cheng, Yi Tsinghua Univ Dept Chem Engn Beijing Peoples R China Everbright Envirotech Nanjing Ltd Nanjing Jiangsu Peoples R China China Everbright Grp Postdoctoral Sci Res Workstn Beijing Peoples R China

The main objective of this work is to understand steam gasification performance of municipal solid wastes (MSWs). The thermodynamic analysis was carried out by using seven different kinds of MSWs as the feedstock with the temperature ranging from 773 to 1773 K and steam to MSW ratio ranging from 0.5 to 1.5. It is summarized that temperature and the effective mole ratio of H/c (R-H/c) are two key factors, and lower temperature and/or larger R-H/c result in a larger mole ratio of H-2/cO. The model predictions agree very well with the referenced experimental results, which can predict steam gasification performance of MSWs.

关键词： Effective mole ratio of H c municipal solid waste Steam gasification thermodynamic analysis waste treatment

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30 years of advances in functionalization of carbon nanomaterials for biomedical applications: a practical review

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JOURNAL OF MATERIALS RESEARcH 2017年第1期32卷 107-127页

作者： Bardhan, Neelkanth M. MIT Dept Mat Sci & Engn Dept Biol Engn Koch Inst Integrat Canc Res Cambridge MA 02139 USA

carbon-based nanomaterials (cANOMATs), including fullerenes, carbon nanotubes, graphene, and their derivatives, are widely considered to be the next-generation materials for a broad range of biomedical applications, owing to their unique opto-electronic, chemical, and mechanical properties. However, for bio-applications, cANOMATs need to be surface-functionalized, to render them passive, non-toxic, and water-soluble. Here, we review the current state-of-the-art in the methods of functionalization of cANOMATs. In contrast to other Reviews, we present an objective analysis of the various approaches reported in the literature, using metrics such as the agent of functionalization, number of steps, and time required, the need for special instruments, effect on properties, scalability, reproducibility, and applications. Our Review offers a way for researchers to make a rational selection of the process of functionalization to best suit their desired application. This opens up new opportunities for developing targeted functionalization strategies, based on the need to excel at the above metrics.

关键词： c nanostructure biomedical

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