检索结果-内蒙古大学图书馆

Routine measurement of serum calcitonin in patients with nodular thyroid disorders?

Nuklearmedizin - NuclearMedicine 2018年第2期47卷 65-72页

作者： M. Dietlein H. Wieler M. Schmidt R. Schwab P. E. Goretzki H. Schicha

In spite of the fact that the German Society of Endocrinology has recommended calcitonin as screening-parameter the majority of physicians in Germany do not routinely use calcitonin in patients with thyroid nodules to exclude medullary thyroid cancer (MTc). The future revision of the recommendation should describe reference values for each commercially available assay, separately for men and women (basal and after pentagastrin-stimulation), and should define sonomorphological inclusion criteria. The epidemiological database of the prevalence of MTc is controversial and the specificity of basal elevated calcitonin levels is limited up to the 5-fold of the upper reference level. If renal insufficiency, bacterial infection, and an alcohol- or druginduced stimulation of calcitonin is excluded, hypercalcitoninaemia should be confirmed by a second measurement (if necessary using another assay). Stimulation of calcitonin by use of pentagastrin is mandatory prior to the decision on thyroidectomy. A stimulated calcitonin level <100 pg/ ml justifies “wait and see”. If stimulated calcitonin levels range between 100 and 200 pg/ml or higher, the differentiation between c-cell hyperplasia and MTc remains uncertain, especially in men. The implementation of calcitonin- screening requires the definition of sonographic inclusion criteria and validation of each assay. Additional prerequisites are excellent logistic (short period between blood sampling and start of the laboratory test), knowledge of differential diagnoses, knowledge of the consumption of drugs and alcohol, availability of pentagastrin-testing and of moleculargenetic testing with full information to the patients and sufficient time before the decision on surgery is made. All this and the choice of a skilled surgeon, experienced in thyroidectomy and lymphadenectomy with a low rate of local complications are the rationale to recommend calcitonin-screening primarily in centers for thyroid disorders.

关键词： calcitonin screening thyroid nodule medullary thyroid cancer c cell hyperplasia calcitonin Screening Schilddrüsenknoten medulläres Schilddrüsenkarzinom c Zell Hyperplasie

来源：评论

学校读者我要写书评

暂无评论

Partial purification of a polygalacturonase from a new Aspergillus sojae mutant and its application in grape mash maceration

引用

INTERNATIONAL JOURNAL OF FOOD ScIENcE AND TEcHNOLOGY 2017年第3期52卷 834-842页

作者： Yildiz, Semanur Mata-Gomez, Marco A. Tari, canan Rito-Palomares, Marco Tecnol Monterrey Sch Sci & Engn Ave Eugenio Garza Sada 2501 Sur Monterrey 64849 Nuevo Leon Mexico Izmir Inst Technol Fac Engn Dept Food Engn TR-35430 Izmir Turkey

The use of polygalacturonase (PG) preparations in winemaking promotes the release of phenolic compounds. A PG from a new source, Aspergillus sojae mutant, was semi-purified and tested for grape mash maceration. crude extract (cE), a commercial pectinase, and two high PG activity semi-purified preparations, F-I and F-II,F- were applied for maceration at PG activity of 3.5Ug(-1) of grape for 46h. Enzyme-assisted maceration significantly (P < 0.05) increased the total phenolic content from 255.8 to 916.3 +/- 5.2, 5732.9 +/- 9.9, 563.4 +/- 6.7 and 620.6 +/- 18.4mgL(-1) for cE, commercial pectinase, F-I and F-II, respectively. The content of individual phenolics such as gallic, protocatechuic, chlorogenic and p-coumaric acids was improved. Principal component and hierarchical clustering analyses suggested that cE has a better performance upon the release of phenols. Semi-purified preparations acted similar to commercial pectinase. These findings open an opportunity for the potential use of PG from the mutant strain as an alternative macerating enzyme.

关键词： Aspergillus sojae c Sauvignon maceration phenolic compounds polygalacturonase purification

来源：评论

学校读者我要写书评

暂无评论

聚一氯对二甲苯涂层材料防护性能的研究

引用

山东化工 2019年第15期48卷 8-11页

作者：李东高彩云北方民族大学材料科学与工程学院宁夏银川750021 北方民族大学化学与化学工程学院宁夏银川750021

聚对二甲基苯类(Parylene)涂层是一种具有优异防护性的高分子材料。本文以一氯对二甲基苯二聚体为原料,利用真空气相沉积法制备了聚一氯对二甲苯涂层(Parylene c)。利用接触角测定仪测得Parylene c涂层与H2O的接触角为114.04°,表明... 详细信息

聚对二甲基苯类(Parylene)涂层是一种具有优异防护性的高分子材料。本文以一氯对二甲基苯二聚体为原料,利用真空气相沉积法制备了聚一氯对二甲苯涂层(Parylene c)。利用接触角测定仪测得Parylene c涂层与H2O的接触角为114.04°,表明Parylene c涂层有着较优异的防水特性。以涂覆Parylene c涂层的铜片为工作电极,通过对电极的电化学交流阻抗谱(EIS)、开路电位(OcP)和塔菲尔(Tafel)曲线对涂层的电化学性能进行分析,结果表明cl元素的存在有效地的阻止氧气和其它腐蚀性气体的通过,使得Parylene c涂层对铜片具有优异的防腐蚀性能,腐蚀电流密度降低到了10-7.5A/cm^-2。

关键词： Parylene c 涂层防护性能

来源：评论

学校读者我要写书评

暂无评论

Guidelines for Authors

引用

chinese Physics c 2019年第8期43卷 I0001-I0002页

*** and scope chinese Physics c (cPc) publishes original research papers, letters and reviews, covering theory and experiments in the fields of particle physics, nuclear physics, particle and nuclear astrophysics, and cosmology. *** Manuscripts must be submitted through the online submission system at http://***. Submissions by email will not be accepted. By submitting a paper for publication in cPc, the authors imply that the material has not been published previously nor has been submitted for publication elsewhere.

关键词： chinese Physics c (cPc) particle physics covering theory

来源：评论

学校读者我要写书评

暂无评论

Interaction of immunosuppressants with HcV antivirals daclatasvir and asunaprevir: combined effects with mycophenolic acid

引用

World Journal of Transplantation 2018年第5期8卷 156-166页

作者： Petra E de Ruiter Yashna Gadjradj Robert J de Knegt Herold J Metselaar Jan NM Ijzermans Luc JW van der Laan Department of Surgery Erasmus MC-University Medical Center Department of Gastroenterology and Hepatology Erasmus MC-University Medical Center

AIM To investigate the specific effects of immunosuppressants on the antiviral action of daclatasvir and *** The antiviral activity of daclatasvir(DcV) and asunaprevir(ASV) combined with immunosuppressants was tested using two in vitro models for hepatitis c virus(HcV) *** Tacrolimus, rapamycin and cyclosporine did not negatively affect the antiviral action of DcV or ASV. Mycophenolic acid(MPA) showed additive antiviral effects combined with these direct acting antivirals(DAAs). MPA induces interferon-stimulated genes(ISGs) and is a potent GTP synthesis inhibitor. DcV or ASV did not induce ISGs expression nor affected ISG induction by MPA. Rather, the combined antiviral effect of MPA with DcV and ASV was partly mediated via inhibition of GTP *** Immunosuppressants do not negatively affect the antiviral activity of DAAs. MPA has additive effect on the antiviral action of DcV and ASV. This combined benefit needs to be confirmed in prospective clinical trials.

关键词： Immunosuppressant Hepatitis c Daclatasvir Asunaprevir Liver Transplantation

来源：评论

学校读者我要写书评

暂无评论

Ultrathin Poly(glycidyl ether) coatings on Polystyrene for Temperature-Triggered Human Dermal Fibroblast Sheet Fabrication

引用

AcS BIOMATERIALS ScIENcE & ENGINEERING 2017年第9期3卷 2155-2165页

作者： Stoebener, Daniel David Uckert, Melanie cuellar-camacho, Jose Luis Hoppensack, Anke Weinhart, Marie Free Univ Berlin Inst Chem & Biochem Takustr 3 D-14195 Berlin Germany

The fabrication of cell sheets is a major requirement for bottom-up tissue engineering purposes (e.g., cell sheet engineering) and regenerative medicine. Employing thermoresponsive polymer coatings as tissue culture substrates allows for the mild, temperature-triggered detachment of intact cell sheets along with their extracellular matrix (EcM). It has been shown before that biocompatible, thermoresponsive poly(glycidyl ether) monolayers on gold substrates can be utilized to harvest confluent cell sheets by simply reducing the temperature to 20 degrees c. Herein, we report on the first poly(glycidyl ether)-based coating on an application-relevant tissue culture plastic substrate. We devised a simple, substrate-geometry-independent method to functionalize polystyrene (PS) surfaces from dilute ethanolic solution via the physical adsorption process of a thermoresponsive poly(glycidyl ether) block copolymer (PGE) bearing a short, hydrophobic, and photoreactive benzophenone (BP) anchor block. Subsequently, the PGE-coated PS is UV-irradiated for covalent photoimmobilization of the polymer on the PS substrate. Online monitoring of the adsorption process via QcM-D measurements and detailed characterization of the resulting coatings via AFM, ellipsometry, and water contact angle (cA) measurements revealed the formation of an ultrathin PGE layer with an average dry thickness of 0.7 +/- 0.1 nm. Adhesion and proliferation of human dermal fibroblasts on PGE-coated PS and tissue culture PS (TcPS) were comparable. For temperature-triggered detachment, fibroblasts were cultured in PGE-coated PS culture dishes at 37 degrees c for 24 h until they reached confluency. Intact cell sheets could be harvested from the thermoresponsive substrates within 51 +/- 17 min upon cooling to 20 degrees c, whereas sheets could not be harvested from uncoated PS and TcPS control dishes. Live/dead staining and flow cytometry affirmed a high viability of the fibroblasts within the cell sheets. Hence, ult

关键词： thermoresponsive polymer coating cell sheet detachment photoimmobilization physical adsorption c H-insertion

来源：评论

学校读者我要写书评

暂无评论

Investigation of graphene-on-metal substrates for SPR-based sensor using finite-difference time domain

引用

IET NANOBIOTEcHNOLOGY 2017年第8期11卷 981-986页

作者： Said, Fairus Atida Menon, Pulliyaseri Susthitha Rajendran, Venkatachalam Shaari, Sahbudin Majlis, Burhanuddin Y. Natl Univ Malaysia UKM Inst Microengn & Nanoelect IMEN Ukm Bangi 43600 Selangor Malaysia KS Rangasamy Coll Technol Ctr Nano Sci & Technol Ksr Kalvi Nagar 637215 Tamil Nadu India

In this study, the authors investigated the effects of a single layer graphene as a coating layer on top of metal thin films such as silver, gold, aluminum and copper using finite-difference time domain method. To enhance the resolution of surface plasmon resonance (SPR) sensor, it is necessary to increase the SPR reflectivity and decrease the full-width-half maximum (FWHM) of the SPR curve so that there is minimum uncertainty in the determination of the resonance dip. Numerical data was verified with analytical and experimental data where all the data were in good agreement with resonance angle differing in <10% due to noise present in components such as humidity and temperature. In further analysis, reflectivity and FWHM were compared among four types of metal with various thin film thicknesses where graphene was applied on top of the metal layers, and data was compared against pure conventional metal thin films. A 60nm-thick Au thin film results in higher performance with reflectivity of 92.4% and FWHM of 0.88 degrees whereas single layer graphene-on-60nm-thick Au gave reflectivity of 91.7% and FWHM of 1.32 degrees. However, a graphene-on-40nm-thick Ag also gave good performance with narrower FWHM of 0.88 degrees and reflection spectra of 89.2%.

关键词： graphene surface plasmon resonance finite difference time-domain analysis reflectivity metallic thin films silver gold aluminium copper chemical sensors biological techniques graphene-on-metal substrates SPR-based sensor finite-difference time domain metal thin films surface plasmon resonance sensor SPR curve resonance angles reflectivity c Ag Au Al cu

来源：评论

学校读者我要写书评

暂无评论

Influence of partial substitution for cB with MWNTs on performance of cB-filled NR composites

引用

MIcRO & NANO LETTERS 2017年第2期12卷 117-122页

作者： Zhang, Huan Wei, Yintao Kang, Zhenran Zhao, Guizhe Liu, Yaqing Tsinghua Univ State Key Lab Automot Safety & Energy Beijing 100084 Peoples R China North Univ China Shanxi Key Lab Nano Funct Composite Mat Taiyuan 030051 Peoples R China

The effects of substituting carbon black (cB) with multiwall carbon nanotubes (MWNTs) on the structure and properties of natural rubber (NR)/cB composites is explored. compared with NR/cB composites, NR/MWNTs/cB presents better filler dispersity and dynamic properties of the MWNT up to a certain concentration, as confirmed by scanning electron microscope, dynamic mechanical analyser and rubber processing analyser. Sample with 1 phr MWNTs shows obviously the highest tensile strength, 28.60 MPa, and almost the lowest heat build-up, only 9.6 degrees c, and it is attributed to that not only large cross-link density and better filler dispersity but also high effective elasticity and large filler-rubber interaction. However, when the concentration is much higher, MWNTs tend to aggregate and lead to the poor efficiency to enhance the dynamic properties of rubber composites or even deteriorate the properties.

关键词： rubber multi-wall carbon nanotubes scanning electron microscopy tensile strength elasticity aggregates (materials) nanocomposites nanofabrication c pressure 28.60 MPa MWNT aggregate filler-rubber interaction elasticity large cross-link density tensile strength rubber processing analysis dynamic mechanical analysis scanning electron microscopy filler dispersity natural rubber-cB composites multiwall carbon nanotubes substituting carbon black effects cB-filled NR composites partial substitution

来源：评论

学校读者我要写书评

暂无评论

Adsorption of Pb (II) from aqueous solution by cassia fistula seed carbon: Kinetics, equilibrium, and desorption studies

引用

ENVIRONMENTAL PROGRESS & SUSTAINABLE ENERGY 2017年第1期36卷 138-146页

作者： Senniappan, Sasireka Palanisamy, Shanmughaprabha Shanmugam, Sabarathinam Gobalsamy, Selvakumari Bharathiar Univ Ctr Res & Dev Coimbatore 641046 Tamil Nadu India Pk Coll Engn & Technol Dept Chem Coimbatore 641659 Tamil Nadu India Bharathiar Univ Dept Microbial Biotechnol Coimbatore 641046 Tamil Nadu India Coimbatore Inst Technol Dept Chem Coimbatore 641014 Tamil Nadu India

Thermal activation of cassia fistula seed carbon and its subsequent adsorption of Pb (II) has been studied by batch adsorption technique. The main objectives of this study were to: 1) investigate the lead adsorption from aqueous solution using c. fistula seed carbon, 2) study the influence of contact time, adsorbent dose, pH and initial metal ion concentration on adsorption process performance and 3) determine the appropriate adsorption isotherm and kinetic parameters of lead adsorption on c. fistula seed carbon. The experimental adsorption data fitted reasonably well with Freundlich adsorption isotherms. The maximum Langmuir adsorbent capacity (Q(0)) was 47.62 mg/g. Kinetic evaluation of the experimental data showed that the adsorption process followed pseudo-second order kinetics. The present study showed that thermally activated carbon prepared from c. fistula seed was capable of removing lead from aqueous solutions. The cost of removal is expected to be quite low, as the adsorbent is cheap and easily available in large quantities. (c) 2016 American Institute of chemical Engineers Environ Prog, 36: 138-146, 2017

关键词： adsorption lead c fistulaseed carbon kinetics isotherms

来源：评论

学校读者我要写书评

暂无评论

Attenuation ofβ-Amyloid Toxicity In Vitro and In Vivo by Accelerated Aggregation

引用

Neuroscience Bulletin 2017年第4期33卷 405-412页

作者： Aihua Yang chenxuan Wang Baomin Song Wendi Zhang Yuanyuan Guo Rong Yang Guangjun Nie Yanlian Yang chen Wang National Center for Nanoscience and Technology Beijing 100190China

Accumulation and aggregation of β-amyloid（Aβ） peptides result in neuronal death, leading to cognitive dysfunction in Alzheimer＇s disease. The self-assembled Aβ molecules form various intermediate aggregates including oligomers that are more toxic to neurons than the mature aggregates, including fibrils. Thus, one strategy to alleviate Aβ toxicity is to facilitate the conversion of Aβ intermediates to larger aggregates such as fibrils. In this study, we designed a peptide named A3 that significantly enhanced the formation of amorphous aggregates of Aβ by accelerating the aggregation kinetics. Thioflavin T fluorescence experiments revealed an accelerated aggregation of Aβ monomers, accompanying reduced Aβ cytotoxicity. Transgenic caenorhabditis elegans over-expressing amyloid precursor protein exhibited paralysis due to the accumulation of Aβ oligomers, and this phenotype was attenuated by feeding the animals with A3 peptide. These findings suggest that the Aβ aggregation-promotion effect can potentially be useful for developing strategies to reduce Aβ toxicity.

关键词： Aβ Alzheimer＇s disease Aggregation Aβ oligomer Amorphous aggregate cell death c elegans b-sheet

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：