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新型炭材料 2015年第4期30卷 372-377页

作者：李贺军陶珺姚栋嘉付前刚李克智西北工业大学超高温复合材料重点实验室C/C复合材料工程技术研究中心陕西西安710072

采用化学气相浸渗法在炭纤维表面制备出不同厚度的预炭层,以ZrOcl2溶液浸渍法将锆化物引入含预炭层的预制体中,经热处理、致密化和石墨化等工艺处理,制备出一种含预炭层的Zrc-c/c复合材料。借助X射线衍射仪、扫描电镜以及能谱等手段,对... 详细信息

采用化学气相浸渗法在炭纤维表面制备出不同厚度的预炭层,以ZrOcl2溶液浸渍法将锆化物引入含预炭层的预制体中,经热处理、致密化和石墨化等工艺处理,制备出一种含预炭层的Zrc-c/c复合材料。借助X射线衍射仪、扫描电镜以及能谱等手段,对材料的微观结构进行表征,采用三点弯曲实验研究材料的力学性能,并探讨预炭层厚度对材料微观结构及其力学性能的影响。结果表明,当预炭层厚度为1.5-1.7μm时,复合材料的平均抗弯强度可达256.85 MPa,与不含预炭层试样相比,增加了67.01%;抗弯试样表现出脆性断裂模式;材料的抗烧蚀性能略有提高。

关键词：预炭层 Zr c c/c复合材料力学性能

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Structural and Enzymatic characterization of a cAMP-Dependent Diguanylate cyclase from Pathogenic Leptospira Species

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JOURNAL OF MOLEcULAR BIOLOGY 2017年第15期429卷 2337-2352页

作者： da costa Vasconcelos, Fernanda Nogales Maciel, Nikolas Koshiyama Favaro, Denize cristina de Oliveira, Luciana coutinho Barbosa, Angela Silva Salinas, Roberto Kopke de Souza, Robson Francisco Farah, chuck Shaker Guzzo, cristiane Rodrigues Univ Sao Paulo Inst Ciencias Biomed Dept Microbiol BR-05508900 Sao Paulo Brazil Univ Sao Paulo Inst Quim Dept Bioquim BR-05508900 Sao Paulo Brazil Univ Fed Minas Gerais Inst Ciencias Exatas Dept Quim BR-31270901 Belo Horizonte MG Brazil Inst Butantan BR-05503900 Sao Paulo Brazil

Leptospira interrogans serovar copenhageni is a human pathogen that causes leptospirosis, a worldwide zoonosis. The L. interrogans genome codes for a wide array of potential diguanylate cyclase (DGc) enzymes with characteristic GGDEF domains capable of synthesizing the cyclic dinucleotide c-di-GMP, known to regulate transitions between different cellular behavioral states in bacteria. Among such enzymes, LIc13137 (Lcd1), which has an N-terminal cGMP-specific phosphodiesterases, adenylyl cyclases, and FhIA (GAF) domain and a c-terminal GGDEF domain, is notable for having close orthologs present only in pathogenic Leptospira species. Although the function and structure of GGDEF and GAF domains have been studied extensively separately, little is known about enzymes with the GAF-GGDEF architecture. In this report, we address the question of how the GAF domain regulates the DGc activity of Lcd1. The full-length Lcd1 and its GAF domain form dimers in solution. The GAF domain binds specifically cAMP (K-D of 0.24 mu M) and has an important role in the regulation of the DGc activity of the GGDEF domain. Lcd1 DGc activity is negligible in the absence of cAMP and is significantly enhanced in its presence (specific activity of 0.13 s(-1)). The crystal structure of the Lcd1 GAF domain in complex with cAMP provides valuable insights toward explaining its specificity for cAMP and pointing to possible mechanisms by which this cyclic nucleotide regulates the assembly of an active DGc enzyme. (c) 2017 Elsevier Ltd. All rights reserved.

关键词： cAMP 3′,5′-cyclic adenosine monophosphate cGMP 3′,5′-cyclic guanosine monophosphate c-di-GMP bis-(3′→5′) cyclic dimeric guanosine monophosphate DGc diguanylate cyclase PDE phosphodiesterase GAF c G MP-specific phosphodiesterases, a denylyl cyclases, and F hlA cNMP cyclic mononucleotide SEc size-exclusion chromatography DOSY diffusion-ordered NMR spectroscopy cD circular dichroism cRP cAMP Receptor Protein diguanylate cyclases bacterial signaling enzymatic kinetics X-ray crystallography c-di-GMP

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Bioelectrochemistry for miRNA detection

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cURRENT OPINION IN ELEcTROcHEMISTRY 2017年第1期5卷 183-192页

作者： ciui, Bianca Jambrec, Daliborka Sandulescu, Robert cristea, cecilia Iuliu Hatieganu Univ Med & Pharm Dept Analyt Chem 4 Louis Pasteur St Cluj Napoca 400349 Romania Ruhr Univ Bochum AnalyticalChem CES Univ Str 150 D-44780 Bochum Germany Univ Calif San Diego Dept Nanoengn La Jolla CA 92093 USA

Anomalous expression of miRNAs has been linked with cell cycles such as cell proliferation, stress response, differentiation, cell apoptosis and inflammation, which present a manifestation of multitude types of disorders and malignancies. For this reason, miRNAs became a class of biomarkers that is in the research focus in recent years. Their detection in an early stage of diseases represents a difficult challenge for analytical chemists who need to design not only specific but also highly sensitive tools for their detection. The progress achieved in the bio-electrochemical detection of miRNAs in the last 2 years is highlighted and commented, focusing on the applicability of developed strategies for point-of-care sensing.

关键词： LOD limit of detection LR linear range cNT carbon nanotube MWcNT multiwalled carbon nanotube PAMAM polyamidoamine MB methylene blue DPV differential pulse voltammetry MNPs magnetic nanoparticles SPEs screen-printed electrodes HT hybridization time chitin-MBs chitin-modified magnetic beads HQ hydroquinone SWV squre wave voltammetry cV cyclic voltammetry MSA mercaptosuccinicacid TcEP tris(2-carboxyethyl) phosphine hydrochloride AuNPs gold nanoparticles TDNs self-assembled tetrahedral DNA nanostructures GO graphene oxide HRP horseradish peroxidase TMB-3,3′,5,5′ tetramethylbenzidine α-NP α naphthyl phosphate ST streptavidin ALP alkaline phosphatase HQ hydroquinone Fc ferrocene RGO reduced graphene oxide MMB magnetic microbeads HcR hybridization chain reaction cyt c cytochrome c AOx alcohol oxidase RcA rolling-circle amplification AgNcs silver nanoclusters QDs quantum dots GQDs graphene quantum dots MM mismatch Nc non-complementary

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Enhanced Neurogenic Biomarker Expression and Reinnervation in Human Acute Skin Wounds Treated by Electrical Stimulation

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JOURNAL OF INVESTIGATIVE DERMATOLOGY 2017年第3期137卷 737-747页

作者： Sebastian, Anil Volk, Susan W. Halai, Poonam colthurst, James Paus, Ralf Bayat, Ardeshir Univ Manchester Fac Med & Human Sci Inst Inflammat & Repair Plast Surg Res GrpDermatol Res Ctr Manchester Lancs England Univ Penn Sch Vet Med Dept Clin Studies Philadelphia Sect Surg Philadelphia PA 19104 USA Oxford Bioelect Abingdon Oxon England Univ Manchester Fac Med & Human Sci Inst Inflammat & Repair Dermatol Res CtrHair Follicle Biol Res Grp Manchester Lancs England Univ Munster Dept Dermatol Munster Germany

Electrical stimulation (ES) is known to promote cutaneous healing;however, its ability to regulate reinnervation remains unclear. First, we show that ES treatment of human acute cutaneous wounds (n = 40) increased reinnervation. Next, to define neurophysiologic mechanisms through which ES affects repair, microarray analysis of wound biopsy samples was performed on days 3, 7, 10, and 14 after wounding. This identified neural differentiation biomarkers TUBB3 (melanocyte development and neuronal marker) and its upstream molecule FIG4 (phosphatidylinositol (3,5)-bisphosphate 5-phosphatase) as significantly up-regulated after ES treatment. To demonstrate a functional ES-TUBB3 axis in cutaneous healing, we showed increased TUBB3(+)melanocytes and melanogenesis plus FIG4 and nerve growth factor expression, suggesting higher cellular differentiation. In support of this role of ES to regulate neural crest-derived cell fate and differentiation in vivo, knockdown of FIG4 in neuroblastoma cells resulted in vacuologenesis and cell degeneration, whereas ES treatment after FIG4small interfering RNA transfection enhanced neural differentiation, survival, and integrity. Further characterization showed increased TUBB3(+)and protein gene product 9.5(+) Merkel cells during in vivo repair, after ES. We demonstrate that ES contributes to increased expression of neural differentiation biomarkers, reinnervation, and expansion of melanocyte and Merkel cell pool during repair. Targeted ES-assisted acceleration of healing has significant clinical implications.

关键词： BDNF brain-derived neurotrophic factor c control cK20 cytokeratin 20 ES electrical stimulation IHc immunohistochemistry LAMP2 lysosomal-associated membrane protein 2 NGF nerve growth factor PGP9.5 protein gene product 9.5 RA retinoic acid siRNA small interfering RNA

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Genetic and Morphological Differentiation of the Semiterrestrial crab Armases angustipes (Brachyura: Sesarmidae) along the Brazilian coast

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BIOLOGIcAL BULLETIN 2017年第1期232卷 30-44页

作者： Marochi, Murilo Zanetti Masunari, Setuko Schubart, christoph D. Univ Fed Parana Dept Zool Programa Posgrad Zool BR-81531970 Curitiba Parana Brazil Univ Regensburg Zool & Evolutionary Biol D-93040 Regensburg Germany

The genetic and morphometric population structures of the semiterrestrial crab Armases angustipes from along the Brazilian coast were examined. The influence of the central South Equatorial current on larval dispersal of A. angustipes also was evaluated. Six populations were sampled from estuarine areas in Sao Luis do Maranhao, Maranhao;Natal, Rio Grande do Norte;Maceio, Alagoas;Ilheus, Bahia;Aracruz, Espirito Santo;and Guaratuba, Parana. Patterns of genetic differentiation were assessed using DNA sequence data corresponding to parts of the mitochondrial cytochrome c oxidase subunit 1. Geometric morphometric techniques were used to evaluate morphological variation in shape and size of the carapace and right cheliped propodus. Our results revealed low genetic variability and lack of phylogeographic structure;geometric morphometrics showed statistically significant morphological differentiation and geographic structuring. Our data indicate the absence of possible barriers to gene flow for this mobile species, and no clear correlation of morphological or genetic variation with ocean currents and/or geographic distance. Our results also suggest that historical geological and climatological events and/or possible bottleneck effects influenced the current low genetic variability among the populations of A. angustipes.

关键词： AL, Maceió (city), Alagoas (state of Brazil) AMOVA, analysis of molecular variance BA, Ilhéus, Bahia (Brazil) cox1, cytochrome c oxidase subunit 1 cSEc, central South Equatorial current ES, Aracruz, Espírito Santo (Brazil) GPA, generalized procrustes analysis MA, São Luiz do Maranhão, Maranhão (Brazil) MANOVA, multivariate analysis of variance NBc, North Brazil current PcA, principal component analysis PR, Guaratuba, Paraná (Brazil) RN, Natal, Rio Grande do Norte (Brazil) SBc, South Brazil current UPGMA, unweighted pair group method with arithmetic mean

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Pegylated interferon α/ribavirin therapy enhances bone mineral density in children with chronic genotype 4 HcV infection

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World Journal of Pediatrics 2017年第4期13卷 346-352页

作者： Ahmed Megahed Nanees Salem Abeer Fathy Tarik Barakat Mona Abd El Latif Alsayed Suzy Abd El Mabood Khaled R Zalata Ahmed F Abdalla Pediatric Gastroenterology and Hepatology Unit Mansoura University Children's HospitalFaculty of MedicineMansoura UniversityEgypt Pediatric Endocrinology Unit Mansoura University Children's HospitalFaculty of MedicineMansoura UniversityEgypt Pediatric Hematology&Oncology Unit Mansoura University Children's HospitalFaculty of MedicineMansoura UniversityEgypt Pathology Department Faculty of MedicineMansoura UniversityEgypt

Background:The impact of chronic hepatitis c (cHc) on bone mineral density (BMD) has been well studied in adults with a relative paucity of data in children,especially concerning effect of treatment with pegylated interferon (PEG-IFN) plus ribavirin (RV).In the current work,we assessed prospectively changes in BMD in children with cHc before,during,and after ***:Forty-six consecutive children with noncirrhotic genotype 4 cHc were subjected to dual-energy X-ray absorptiometry at baseline,24 weeks,48 weeks of therapy and 24 weeks after ***,bone mineral content (BMc),and Z score of lumbar spine (L2-L4) were *** pubertal stage,viral load,liver function tests,serum calcium,phosphorus,alkaline phosphatase,parathyroid hormone,and liver histopathology were assessed in all included ***:Thirty (65.2%) patients had normal BMD,10 (21.7%) were at risk for low BMD,and 6 (13.1%) had low BMD for chronological *** with low BMD were significantly older (P=0.001),with higher frequency of delayed puberty than other groups (P=0.002).Baseline densitometric parameters (BMD & BMc) were significantly positively correlated with patients' age,weight,height,body mass index and hemoglobin level;while they were insignificantly correlated with basal viral load,histopathology activity index and fibrosis *** parameters improved significantly on PEG-IFN plus RV treatment,this improvement was found to be sustainable 24 weeks after ***:Low BMD is detectable in a proportion of cHc *** therapy leads to a sustainable increase in BMD.

关键词： bone mineral density chronic hepatitis c pegylated interferon ribavirin

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呼吸衰竭并急性肾损伤患者白介素18、中性粒细胞明胶酶相关脂质运载蛋白和胱抑素c水平变化及其临床意义

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实用心脑肺血管病杂志 2016年第6期24卷 46-50页

作者：燕存子张莹孙虎孙峰新疆医科大学第一附属医院呼吸二科新疆医科大学第一附属医院呼吸重症监护室

目的观察呼吸衰竭并急性肾损伤(AKI)患者白介素18(IL-18)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、胱抑素c(cys-c)水平变化,并探讨其临床意义。方法选取2015年2—9月新疆医科大学第一附属医院收治的呼吸衰竭患者147例,其中单纯呼吸... 详细信息

目的观察呼吸衰竭并急性肾损伤(AKI)患者白介素18(IL-18)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、胱抑素c(cys-c)水平变化,并探讨其临床意义。方法选取2015年2—9月新疆医科大学第一附属医院收治的呼吸衰竭患者147例,其中单纯呼吸衰竭患者86例(A组)、呼吸衰竭并AKI患者61例(B组)。比较两组及不同分期AKI患者IL-18水平、NGAL水平、cys-c水平、血肌酐(Scr)水平、尿素氮(BUN)水平、估算肾小球滤过率(e GFR)及尿蛋白量。结果 B组患者IL-18水平、NGAL水平、cys-c水平、Scr水平、BUN水平、尿蛋白量高于A组,e GFR低于A组(P<0.05)。AKI 3期、AKI 2期患者IL-18水平、NGAL水平、cys-c水平、Scr水平、BUN水平、尿蛋白量高于AKI 1期患者,e GFR低于AKI 1期患者(P<0.05);AKI 3期患者IL-18水平、NGAL水平、cys-c水平、Scr水平、BUN水平、尿蛋白量高于AKI 2期患者,e GFR低于AKI 2期患者(P<0.05)。IL-18预测呼吸衰竭患者AKI的曲线下面积为0.850〔95%cI(0.514,0.927)〕,当IL-18为95.3μg/kg时其灵敏度为83.02%,特异度为88.46%,诊断指数为1.772;NGAL预测呼吸衰竭患者AKI的曲线下面积为0.835〔95%cI(0.446,0.896)〕,当NGAL为51.3μg/kg时其灵敏度为80.14%,特异度为84.77%,诊断指数为1.649;cys-c预测呼吸衰竭患者AKI的曲线下面积为0.900〔95%cI(0.583,0.951)〕,当cys-c为1.8 mg/L时其灵敏度为88.92%,特异度为91.04%,诊断指数为11.800。结论呼吸衰竭并AKI患者IL-18、NGAL、cys-c水平明显升高,其可预测AKI的发生,进而指导临床诊断及治疗,改善患者预后。

关键词：呼吸功能不全急性肾损伤白细胞介素 18 中性粒细胞明胶酶相关脂质运载蛋白胱抑素 c 诊断

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前清蛋白、心肌酶、c 反应蛋白检测在重症手足口病合并心肌损伤患儿诊治中的意义

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中国基层医药 2016年第22期23卷 3500-3503页

作者：敖小艳浙江省长兴县人民医院儿科 313100

目的：探讨前清蛋白（PA）、心肌酶、c 反应蛋白（cRP）检测在重症手足口病（HFMD）合并心肌损伤患儿诊治中的应用价值。方法选取183例手足口病患儿作为观察组，其中重症患儿54例，普通患儿129例，另选取100例同期健康体检儿童作为对照... 详细信息

目的：探讨前清蛋白（PA）、心肌酶、c 反应蛋白（cRP）检测在重症手足口病（HFMD）合并心肌损伤患儿诊治中的应用价值。方法选取183例手足口病患儿作为观察组，其中重症患儿54例，普通患儿129例，另选取100例同期健康体检儿童作为对照组，检测所有研究对象血清 PA、α-丁酸脱氮酶（α-HBDH），肌酸激酶（cK），肌酸激酶同工酶（cK-MB）、cRP 的水平并进行比较。结果观察组血清 PA 水平为（194．37±42．86）mg／L，对照组为（267．15±52．04）mg／L，观察组血清 PA 水平明显低于对照组（t ＝5．942， P ＜0．05）；观察组血清α-HBDH、cK、cK-MB 及 cRP 分别为（261．58±61．40）U ／L、（124．80±67．51）U ／L、（38．79±16．26）U ／L 和（18．06±5．27）mg／L，对照组血清α-HBDH、cK、cK-MB 及 cRP 分别为（112．93±28．56）U ／L、（103．94±60．86）U ／L、（15．17±9．34）U ／L 和（4．82±0．95）mg／L，观察组α-HBDH、cK、cK-MB及 cRP 均明显高于对照组（t ＝8．356、5．087、9．446、10．755，均 P ＜0．05）。重症组血清 PA 水平为（144．92±40．36）mg／L，普通组为（230．89±46．27）mg／L，重症组血清 PA 水平明显低于普通组（t ＝7．035，P ＜0．05）；重症组血清α-HBDH、cK、cK-MB 及 cRP 分别为（301．58±71．40）U ／L、（145．31±67．84）U ／L、（43．66±18．95）U ／L 和（21．86±6．55）mg／L，普通组血清α-HBDH、cK、cK-MB 及 cRP 分别为（162．93±28．56）U ／L、（116．05±61．37）U ／L、（24．75±12．04）U ／L 和（7．25±3．82）mg／L，重症组患儿血清α-HBDH、cK、cK-MB 及cRP 均明显高于普通组（t ＝9．440、6．204、11．038、13．118，均 P ＜0．05）。重症 HFMD 合并心肌损伤患儿血清PA 水平为（131．02±36．54）mg／L，重症组为（149．73±42．81）mg／L，重症 HFMD 合并心肌损伤组血清 PA 水平明显低于重症组（t ＝7．801，P ＜0．05）；重症 HFMD 合并心肌损伤患儿血清α-HBDH、cK、cK-MB 及 cRP 分别为（327．84±74．95）U ／L、（152．92±68．75）U ／L、（45．17±20．68）U ／L 和（23．07±7．46）mg／L，重症组血清α-HBDH、cK、cK-MB 及 cRP 分别为（286．30±70．16）U ／L、（134．80±66．31）U ／L、（41．08±17．23）U ／L 和（20．95±6．20）mg／L，重症 HFMD 合并心肌损伤患儿血清α-HBDH、cK、cK-MB 及 cRP 均明显高于重症HFMD 组（t ＝4．394、5．938、4．077、4．165，均 P ＜0．05）。结论前清蛋白、心肌酶、cRP 检测利于手足口病患儿病情严重程度的判断，且利于患儿心肌损伤的早期诊断。

关键词：手足口病心肌损伤前清蛋白心肌酶 c 反应蛋白质

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Genetic biomarkers for hepatocellular cancer risk in a caucasian population

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World Journal of Gastroenterology 2017年第36期23卷 6674-6684页

作者： Elena De Mattia Erika cecchin Jerry Polesel Alessia Bignucolo Rossana Roncato Francesco Lupo Marina crovatto Angela Buonadonna claudio Tiribelli Giuseppe Toffoli Clinical and Experimental Phar-macology “Centro di Riferimento Oncologico”-National Cancer Institute Unit of Cancer Epidemiology “Centro di Riferimento Oncologico”-National Cancer Institute General Surgery 2U and Liver Transplantation Center A.O.U.Cittàdella Salute e della Scienza di TorinoUniversity of Torino Cytogenetics and Molecular Biology Unit Santa Maria degli Angeli Hospital Pordenone Medical Oncology Unit “Centro di Riferimento Oncologico”-National Cancer Institute Fondazione Italiana Fegato AREA Science Park

AIM To uncover novel genetic markers that could contribute to predicting hepatocellular carcinoma(Hcc)susceptibility in caucasians. METHODS The present retrospective case-control study compared genotype frequencies between a cohort of Hcc cases and two,independent,Hcc-free,age/sex-matched control *** Hcc cohort comprised 192 homogeneous patients that had undergone orthotopic liver *** first control group comprised167 patients that were matched to the Hcc cohort for the percentage of hepatitis B(HBV)and/or hepatitis c(HcV)infections.A second control group included192 virus-free,healthy individuals that were used to evaluate the generalizability of the identified predictive *** cases and controls were *** three study populations were characterized with a panel of 31 markers derived from 21 genes that encoded key proteins involved in hepatocarcinogenesis-related *** study end-point was to assess the association between genetic variants and Hcc onset. RESULTS Five genetic markers were identified as risk factors for Hcc in high-risk patients infected with HBV/*** to a dominant model,reduced Hcc risk was associated with three polymorphisms:ERcc1rs3212986(OR=0.46,95%cI:0.30-0.71,P=0.0005),GST-P1 rs1138272(OR=0.41,95%cI:0.21-0.81,P=0.0097),and cYP17A1 rs743572(OR=0.50,95%cI:0.31-0.79,P=0.0032).conversely,according to a recessive model,increased Hcc risk was associated with two polymorphisms:XRcc3 rs1799794(OR=3.70,95%cI:1.02-13.39,P=0.0461)and ABcB1 rs1128503(OR=2.06,95%cI:1.18-3.61,P=0.0111).These associations remained significant in a subgroup analysis,where patients were stratified according to viral status(HBV-or HcV-positive serology).Two variants exhibited a serology-specific effect:ABcB1 rs1128503(OR=4.18,95%cI:1.55-11.29,P=0.0048)showed an effect in the HBV-positive subgroup;and ERcc1 rs3212986(OR=0.33,95%cI:0.18-0.60,P=0.0003)showed an effect in the HcV-positive *** the five markers identified,E

关键词： ERcc1 XRcc3 GST-P1 cYP17A1 MDR-1 Polymorphisms Hepatocellular carcinoma risk Early diagnosis Antiviral therapy Hepatitis B viral/hepatitis c viral

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cysc、Hcy、HbA1c、hs-cRP在糖尿病早期肾损伤中的应用价值

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中国继续医学教育 2016年第14期8卷 32-33页

作者：云绍丽董彩霞河南省临颍县人民医院检验科河南临颍462600

目的分析cys c、Hcy、Hb A1c、hs-cRP在糖尿病早期肾损伤中的应用价值。方法将我院2012年4月－2014年9月收治的62例糖尿病早期肾损伤患者作为研究组;将同期62例健康体检者作为对照组,检测两组Hb A1c、hs-cRP、cys c、Hcy等指标水平。... 详细信息

目的分析cys c、Hcy、Hb A1c、hs-cRP在糖尿病早期肾损伤中的应用价值。方法将我院2012年4月－2014年9月收治的62例糖尿病早期肾损伤患者作为研究组;将同期62例健康体检者作为对照组,检测两组Hb A1c、hs-cRP、cys c、Hcy等指标水平。统计两组研究对象Hb A1c、hs-cRP、cys c、Hcy水平,比较研究组相关指标联合检测阳性率及单独检测阳性率。结果研究组Hb A1c、hs-cRP、cys c、Hcy等指标水平均高于对照组,两组差异显著（P〈0.05）;研究组相关指标单独检测阳性率显著低于联合检测阳性率,差异显著（P〈0.05）。结论 Hb A1c、hs-cRP、cys c、Hcy均可作为糖尿病早期肾损伤的检测指标,且四项指标联合检测可有效提高其诊断的阳性率及准确率,在糖尿病早期肾损伤患者的早期诊断与治疗中具有重要意义。

关键词： cys c Hcy HbA1c hs-cRP 糖尿病早期肾损伤

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