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Acta Pharmaceutica Sinica B 2016年第1期6卷 26-31页

作者： Xingquan Zhang Division of Infectious Diseases University of CaliforniaSan Diego School of Medicine

Unlike human immunodeficiency virus(HIV)and hepatitis B virus(HBV),hepatitis c virus(HcV)infection is a curable *** direct antiviral agent(DAA)targets are focused on HcV NS3/4A protein(protease),NS5 B protein(polymerase)and NS5 A *** first generation of DAAs includes boceprevir and telaprevir,which are protease inhibitors and were approved for clinical use *** cure rate for genotype 1 patients increased from 45% to 70% when boceprevir or telaprevir was added to standard PEG-IFN/*** effective and less toxic second generation DAAs supplanted these drugs by *** second generation of DAAs includes sofosbuvir(Sovaldi),simeprevir(Olysio),and fixed combination medicines Harvoni and Viekira *** drugs increase cure rates to over 90%without the need for interferon and effectively treat all HcV *** these drugs the "cure HcV"goal has become a *** remain about drug resistance mutations and the high cost of these *** investigation of new HcV drugs is progressing rapidly;fixed dose combination medicines in phase III clinical trials include Viekirax,asunaprevirtdaclatasvirtbeclabuvir,grazoprevirtelbasvir and others.

关键词： Hepatitis c virus cure HcV Sustained virologic response Direct antiviral agents NS3/4A protease inhibitor

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Impact of source/drain doping concentration on graphene nanoribbon field effect transistor performance

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IET cIRcUITS DEVIcES & SYSTEMS 2016年第6期10卷 457-462页

作者： Kaur, Jasleen Kumari, Anita Lovely Profess Univ Sch Elect Engn Jalandhar India

Graphene nanoribbon field effect transistor is considered as a next-generation device. In this study, effect on device performance parameters such as on and off state currents, cut-off frequency, delay and transconductance at different source and drain (S/D) doping concentrations is investigated. It is observed that changing the S/D doping concentrations has an impact on band-to-band tunnelling which affects the device performance. This study also reveals that the minimum conductivity point, i.e. Dirac point decreases with increase in doping concentration. The obtained results are based on non-equilibrium Green's function formalism, along with p(z) orbital band model. Poisson's equation solver is used to calculate the electrostatic potential. The results obtained show that the device performance greatly depends on the S/D doping concentration.

关键词： nanoribbons graphene devices field effect transistors graphene semiconductor doping tunnelling Green's function methods Poisson equation electrostatics source-drain doping concentration graphene nanoribbon field effect transistor next-generation device S-D doping concentration band-to-band tunnelling minimum conductivity point Dirac point nonequilibrium Green function formalism p(z) orbital band model Poisson equation solver electrostatic potential calculation c

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Phospholipase c from Pseudomonas aeruginosa and Bacillus cereus:characterization of catalytic activity

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Asian Pacific Journal of Tropical Medicine 2014年第11期7卷 860-866页

作者： Nooran Sherif Elleboudy Mohammad Mabrouk Aboulwafa Nadia Abdel-Haleem Hassouna Department of Microbiology and Immunology Faculty of PharmacyAin Shams University

Objective:To study characteristics of phospholipases c(PLcs),their importance for producing microorganisms us well us the potential of their use for industrial ***:PLc from Bacillus cereus(***) D101 was selected as an example of Gram-positive PLcs and PLc from Pseudomanas aeruginosa(***) D183 of Gram-negative *** were partially purified by ammonium sulfate precipitation followed by membrane *** purified preparations were used to study effect of different factors on activities as well as in substrate specificity tests which were conducted using a turbidimetric assay ***:Maximum activity was at pH 7 and 8 and 40 ℃ for *** PLc,and pH 8-10 and 37 ℃ for *** *** PLcs were inhibited by Pi at 5 mM or higher,whereas,PLc from *** only was inhibited by *** of *** PLc was not affected by removing Zn^(2+) ions from reaction mixture or their replacement with ca^(2+),Ba^(2+),Mg^(2+) or Mn^(2+)***-a-vis,activity of *** PLc was found to be metal ion dependent PLcs from both isolates were relatively thermostable and showed maximum affinity toward *** and phosphatidylethanolamine were not good substrates and phosphatidylinositol,phosphatidylserine,phosphatidylglycerol and cardiolipin could be considered ***:Human body physiological conditions could favor activity of *** and *** *** enzymes may participate in phosphate scavenging and virulence of producing isolates but not in *** from both isolates are potential candidates for industrial use.

关键词： Phospholipase c Pseudomonas aeruginosa Bacillus cereus catalytic activity Substrate specificity

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Hollow carbon microfibres fabricated using coaxial centrifugal spinning

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MIcRO & NANO LETTERS 2016年第2期11卷 74-76页

作者： Xu, Wei Xia, Lei Zhou, Xing-hai Xi, Peng cheng, Bo-wen Liang, Yu-xia Tianjin Polytech Univ Sch Text Tianjin 300387 Peoples R China Minist Educ Key Lab Adv Text Composites Tianjin 300387 Peoples R China Tianjin Polytech Univ Tianjin Multicipal Kay Lab Fiber Modificat & Func Tianjin 300387 Peoples R China Tianjin Normal Univ Sch Math Sci Tianjin 300387 Peoples R China

A novel method for preparing coaxial polyacrylonitrile (PAN)/polyvinyl pyrrolidone (PVP) microfibres is proposed. Further, the obtained composite fibres are subsequently processed using pre-oxidation and carbonisation treatments in order to obtain hollow carbon microfibres. The effects of different respective PVP and PAN concentrations in the inner and outer solutions (the solutions injected into the inner and outer centrifugal tubes, respectively) on the product morphology are discussed. It is found that hollow carbon microfibres can only be fabricated for concurrent inner PVP and outer PAN solution concentrations of 14-17 and 13-16 wt%, respectively. If either of the solution concentrations is too low, droplets are formed, whereas the spinneret becomes blocked and cannot spin if either of these concentrations is too high. The diameters of the coaxial fibres and hollow carbon fibres can be controlled between 3 and 10 mu m. This novel coaxial centrifugal spinning strategy can potentially be applied in the rapid fabrication of coaxial and hollow fibres.

关键词： carbon fibres oxidation materials preparation hollow carbon microfibres coaxial centrifugal spinning coaxial polyacrylonitrile-polyvinyl pyrrolidone microfibres composite fibres preoxidation treatment carbonisation treatment product morphology solution concentrations size 3 mum to 10 mum c

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Q-switched thulium-doped fibre ring lasers operating at 1.9 μm using multi-walled carbon nanotubes in UV-curing resin

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ELEcTRONIcS LETTERS 2016年第1期52卷 63-U123页

作者： Sakata, H. Kimpara, K. Takahashi, N. Shizuoka Univ Grad Sch Engn Dept Elect & Elect Engn Hamamatsu Shizuoka 4328561 Japan

The passively Q-switched operation of all-fibre thulium fibre lasers using UV-curing resin doped with multi-walled carbon nanotubes as a saturable absorber is demonstrated. A single-mode thulium-doped silica fibre is pumped by a laser diode emitting at 1.63 mu m through a wavelength-division multiplexing coupler. Unidirectional laser output from the fibre ring resonator is attained by using the retroreflector at the counter-directional output port. The fibre laser exhibits 1.9 mu m wavelength pulsed oscillation at a repetition rate of 7.2 kHz. When the pump power is increased to 161 mW, the output pulse power is measured by 150 mW with a pulse width of 3.2 mu s.

关键词： Q-switching curing fibre lasers laser cavity resonators multi-wall carbon nanotubes optical fibre couplers optical pumping optical saturable absorption oscillations resins ring lasers silicon compounds thulium wavelength division multiplexing c Q-switched thulium-doped fibre ring lasers SiO2:Tm UV-curing resin all-fibre thulium fibre lasers counter-directional output port fibre ring resonator frequency 7.2 kHz laser diode multiwalled carbon nanotubes output pulse power passively Q-switched operation pump power repetition rate retroreflector saturable absorber single-mode thulium-doped silica fibre unidirectional laser output wavelength 1.9 mum to 1.63 mum wavelength pulsed oscillation wavelength-division multiplexing coupler

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Acoustofluidic Rotational Manipulation of cells and Organisms Using Oscillating Solid Structures

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SMALL 2016年第37期12卷 5120-5125页

作者： Ozcelik, Adem Nama, Nitesh Huang, Po-Hsun Kaynak, Murat McReynolds, Melanie R. Hanna-Rose, Wendy Huang, Tony Jun Duke Univ Dept Mech Engn & Mat Sci Durham NC 27708 USA Penn State Univ Dept Engn Sci & Mech 227 Hammond Bldg University Pk PA 16802 USA Penn State Univ Dept Biochem & Mol Biol University Pk PA 16802 USA

A polydimethylsiloxane microchannel featuring sidewall sharp-edge structures and bare channels, and a piezoelement transducer is attached to a thin glass slide. When an external acoustic field is applied to the microchannel, the oscillation of the sharp-edge structures and the thin glass slide generate acoustic streaming flows which in turn rotate single cells and c. elegans in-plane and out-of-plane.

关键词： acoustofluidics c elegans microfluidics rotational manipulations

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Influence of carbon black with different concentration on dynamic properties and heat buildup of semi-efficient natural rubber composites

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MIcRO & NANO LETTERS 2016年第7期11卷 402-406页

作者： Zhang, Huan Zhang, Zhiyi Zhao, Guizhe Liu, Yaqing North Univ China Shanxi Key Lab Nano Funct Composite Mat Taiyuan 030051 Peoples R China North Univ China Coll Mat Sci & Engn Taiyuan 030051 Peoples R China

High abrasion furnace black (HAF) filler has long been recognised as reinforcing filler, but the impact of concentration on dynamic mechanics performance and heat buildup of vulcanisates is rarely reported. Therefore, natural rubber (NR) composites filled by N330 with different concentration were prepared. Payne effect and heat buildup of HAF/NR composites increases with an increase of HAF loadings during to that filler network structure become stronger with an increase of HAF loadings. Moreover, tensile strength, tear strength as well as modulus increase with an increase of HAF loadings is attributed to better dispersion and improved interfacial interaction between HAF and NR matrices. The results reveal that composites with 60 per hundreds of rubber (phr) of HAF exhibit better overall mechanical properties and lower heat buildup.

关键词： carbon filled polymers rubber tensile strength abrasion carbon black dynamic properties heat buildup semiefficient natural rubber composites high abrasion furnace black filler dynamic mechanics vulcanisates tensile strength tear strength tear modulus interfacial interaction mechanical properties c

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Molecular dynamics study of bio-manipulation in aqueous media

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MIcRO & NANO LETTERS 2016年第1期11卷 9-14页

作者： Kheirodin, Mohsen Pishkenari, Hossein Nejat Mahboobi, Seyed Hanif Sharif Univ Technol Sch Mech Engn Nano Robot Lab Tehran Iran Univ Calif Berkeley Dept Bioengn Berkeley CA 94720 USA

Nano-manipulation is one of the most important aspects of nano-robotics and nano-assembly. The positioning process is considered by many researches to be one of the most important parts of nano-assembly, but has been poorly investigated, particularly for biologic samples. This Letter is devoted to modelling the process of positioning a biomolecule with atomic force microscopy (AFM) in an aqueous media using molecular dynamics simulations. carbon nanotube (cNT) and graphite sheet are selected as AFM tip and substrate, respectively. To consider the effects of the medium on the manipulation, several models for decreasing the calculations including implicit, coarse grained, and all-atom methods have been investigated. They examined several parameters which may affect the quality of the manipulation process such as the cNT initial position with respect to the sample and substrate, its diameter and positioning strategies (pushing or pulling). The results demonstrate that despite of the implicit solvent methods, coarse-grained model can simulate the aqueous media accurately with lower computational cost. Furthermore, pulling method with a cNT which has a larger diameter and a smaller gap with respect to the substrate is the most appropriate setting for manipulation.

关键词： molecular dynamics method atomic force microscopy carbon nanotubes nanopositioning graphite biomanipulation aqueous media nanomanipulation nanorobotics nanoassembly atomic force microscopy molecular dynamics simulations carbon nanotube graphite sheet pushing pulling c

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Synthesis of carbon nanostructures from coal by chemical solid synthesis method

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MIcRO & NANO LETTERS 2016年第8期11卷 450-453页

作者： Fathabadi, Motahare Vakili Rafsanjani, Hasan Hashemipour Danafar, Firouze Shahid Bahonar Univ Dept Chem Engn Kerman Iran

carbon nanofibres (cNFs) and carbon spheres (cSs) are successfully synthesised using coal particles (<44 micron) in solid phase. coal and ferrocene as catalyst were fed to the reactor in the solid form. The reaction is carried out in a tubular reactor. The as-synthesised samples have been characterised through Raman spectroscopy, X-ray diffraction, scanning and transmission electron microscopy. The results show cNFs formed in 25-40 nm and mono dispersed cSs in 200-300 nm are amorphous. A feasible mechanism of cNFs and cSs formation from coal described here with the help of coal structure.

关键词： carbon fibres nanofibres catalysts Raman spectra X-ray diffraction scanning electron microscopy transmission electron microscopy amorphous state nanofabrication carbon nanostructures chemical solid synthesis method carbon nanofibres coal particles solid phase ferrocene catalyst tubular reactor Raman spectroscopy X-ray diffraction scanning electron microscopy transmission electron microscopy coal structure amorphous structure monodispersed carbon spheres c

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Graphene-based THz modulator analysed by equivalent circuit model

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MIcRO & NANO LETTERS 2016年第8期11卷 439-442页

作者： Xiao, Binggang chen, Jing Xie, Zhiyi Xiao, Sanshui Ji Liang Univ China Coll Informat Engn Hangzhou 310018 Zhejiang Peoples R China Tech Univ Denmark Dept Photon Engn DK-2800 Lyngby Denmark

A terahertz (THz) modulator based on graphene is proposed and analysed by use of equivalent transmission line of a homogeneous medium and the local anisotropic model of the graphene conductivity. The result calculated by the equivalent circuit is consistent with that obtained by Fresnel transfer matrices. For the modulator proposed here, when the frequency of carrier wave is 0.6 THz, the theoretical analysis indicates that the modulation bandwidth is 55.5 kHz and the modulation depth is 81.3% for voltage change from 0 to 50 V.

关键词： terahertz wave devices equivalent circuits modulators graphene graphene based THz modulator equivalent circuit model equivalent transmission line graphene conductivity Fresnel transfer matrices bandwidth 55 5 kHz c

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