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青岛大学学报(自然科学版) 2025年

作者：尹行谢进陈晓泉王少亮合肥大学人工智能与大数据学院

为了克服三次Hermite插值样条函数的局限性，提出了一种新的带多个参数的四次三角Hermite插值样条函数。在三角函数空间中，利用c2连续性条件，通过解方程组，构造了具有三个参数的四次三角Hermite插值基函数，利用这些基函数，定义了... 详细信息

为了克服三次Hermite插值样条函数的局限性，提出了一种新的带多个参数的四次三角Hermite插值样条函数。在三角函数空间中，利用c2连续性条件，通过解方程组，构造了具有三个参数的四次三角Hermite插值基函数，利用这些基函数，定义了分段四次三角Hermite插值样条函数。数值实例表明，在给定的插值条件下，利用多参数的合理选择，该样条函数可以获得较高的插值精度。

关键词： c 连续性四次三角Hermite插值样条插值精度

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Preparation of Graphene/Si/c composite nanolayer electrodes by magnetron sputtering and study on lithium storage properties

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cHEMIcAL PHYSIcS IMPAcT 2023年 6卷

作者： Zhao, Shuwen Zhao, Yifan Liu, Bioabiao chen, Ji Dai, Ruijie Zhou, Yao Zhang, Hua chen, Anran Yunnan Univ Sch Mat & Energy Kunming 650091 Peoples R China Univ Edinburgh Sch Engn Edinburgh EH8 9YL Scotland

A Si layer with a thickness of 100 nm and a 50 nm c layer were sputtered on copper-based graphene by magnetron sputtering to form a Graphene/Si/c composite nanolayer electrode. The lithium storage performance was studied by the constant current charge-discharge test, cyclic voltammetry test, cycle performance test, and Ac impedance test. The results show that the reversible capacity of the Graphene/Si/c thin film electrode has a serious decay in the early cycle, with an average decay of 1.79 mAh/g per cycle within 200 cycles;the decay is relatively gentle in the latter stage, with an average decay of 0.723 mAh/g per cycle after 1000 cycles. By comparing the SEM and EDS before and after cycling, it was found that the film was broken after cycling, resulting in the loss of active substances.

关键词： Graphene Si c composite nanolayer electrodes Magnetron sputtering

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c:N:P stoichiometries explain soil organic carbon accumulation during afforestation

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NUTRIENT cYcLING IN AGROEcOSYSTEMS 2020年第2期117卷 243-259页

作者： Zhong, Zekun Zhang, Xinyi Wang, Xing Dai, Yinyue chen, Zhengxing Han, Xinhui Yang, Gaihe Ren, chengjie Wang, Xiaojiao Northwest A&F Univ Coll Agron Yangling 712100 Shaanxi Peoples R China Shaanxi Engn Res Ctr Circular Agr Yangling 712100 Shaanxi Peoples R China

carbon accumulation in agroecosystems is regulated to a major extent by the variability of c:N:P stoichiometry. To understand the impact of c:N:P ratios and the cycling of limiting nutrients in the leaf-litter-aggregate continuum on soil c sequestration following afforesxtation, we assessed the contribution of aggregate-associated organic carbon (Oc) to bulk soil Oc accumulation, and examined the c, N, and P concentrations in leaves, litter, aggregates, and their stoichiometric couplings along an afforestation chronosequence. Averaged across the entire chronosequence, bulk soil Oc stocks increased at the rate of 12.3 g m(-2) year(-1) at the 0-0.4-m depth, and significantly correlated with macroaggregates-associated Oc stocks which increased on average by 114.5% with increasing stand age at soil depth of 0.4 m. Moreover, the c:P and N:P ratios of litter decreased by 19.7-33.0% and 7.6-26.8%, respectively, with increasing stand age, and were significantly associated with aggregate-associated c:P and N:P ratios. Both c:P and N:P ratios in microaggregates and clay-plus-silt fractions were, respectively, 18.0%, 13.3%, and 23.0%, 19.7% lower than those in macroaggregates, indicating a higher P availability in fine fractions. Macroaggregate-associated c:P and N:P ratios increased by 29.5 and 26.3%, respectively, at the 0-0.4-m depth with plantation age and were linked to the increased macroaggregate-associated Oc stocks. collectively, our results suggest that c:P and N:P ratios are good indicators of P cycling in ecosystem, and that P status under the control of aggregates may be an important factor for the sustainable accumulation of Oc during afforestation.

关键词： c N P stoichiometry Soil aggregation Phosphorus limitation carbon sequestration Afforestation chronosequence Loess plateau china

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ccAAT/enhancer-binding protein beta (c/EBPβ) knockdown reduces inflammation, ER stress, and apoptosis, and promotes autophagy in oxLDL-treated RAW264.7 macrophage cells

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MOLEcULAR AND cELLULAR BIOcHEMISTRY 2020年第1-2期463卷 211-223页

作者： Zahid, Md Khurshidul Rogowski, Michael Ponce, christopher choudhury, Mahua Moustaid-Moussa, Naima Rahman, Shaikh M. Texas Tech Univ Dept Nutr Sci Lubbock TX 79409 USA Texas Tech Univ Obes Res Inst Lubbock TX 79409 USA Texas Tech Univ Dept Math Lubbock TX 79409 USA Texas A&M Hlth Sci Ctr Irma Lerma Rangel Coll Pharm Dept Pharmaceut Sci Kingsville TX 78363 USA

Atherosclerosis is associated with deregulated cholesterol metabolism and formation of macrophage foam cells. ccAAT/enhancer-binding protein beta (c/EBP beta) is a transcription factor, and its inhibition has recently been shown to prevent atherosclerosis development and foam cell formation. However, whether c/EBP beta regulates inflammation, endoplasmic reticulum (ER) stress, and apoptosis, in macrophage foam cells and its underlying molecular mechanism remains unknown. Here, we investigated the effect of c/EBP beta knockdown on proteins and genes implicated in inflammation, ER stress, apoptosis, and autophagy in macrophage foam cells. RAW264.7 macrophage cells were transfected with control and c/EBP beta-siRNA and then treated with nLDL and oxLDL. Key proteins and genes involved in inflammation, ER stress, apoptosis, and autophagy were analyzed by western blot and qPcR. We found that short interfering RNA (siRNA)-mediated knockdown of c/EBP beta attenuated atherogenic lipid-mediated induction of proteins and genes implicated in inflammation (P-NFkB-p65, NFkB-p65, and TNF alpha), ER stress (ATF4 and ATF6), and apoptosis (cHOP, caspase 1, 3, and 12). Interestingly, c/EBP beta knockdown upregulated the expression of autophagy proteins (Lc3A/B-II, ATG5) and genes (Lc3B, ATG5) but decreased the mammalian target of rapamycin (mTOR) protein phosphorylation and mTORc1 gene expression in oxLDL-loaded RAW264.7 macrophage cells. More importantly, treatment with rapamycin (inhibitor of mTOR) increased expression of proteins implicated in autophagy and cholesterol efflux in oxLDL-loaded RAW 264.7 macrophage cells. The present results suggest that c/EBP beta inactivation regulates macrophage foam cell formation in atherogenesis by reducing inflammation, ER stress, and apoptosis and by promoting autophagy and inactivating mTOR.

关键词： c EBP beta Endoplasmic reticulum stress (ERS) Apoptosis Autophagy Macrophage foam cells

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clinical relevance of increased serum preneoplastic antigen in hepatitis c-related hepatocellular carcinoma

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World Journal of Gastroenterology 2020年第13期26卷 1463-1473页

作者： Satoyoshi Yamashita Akira Kato Toshitaka Akatsuka Takashi Sawada Tomohide Asai Noriyuki Koyama Kiwamu Okita Department of Gastroenterology and Hepatology Japan Community Health Care Organization Shimonoseki Medical CenterShimonosekiYamaguchi 7500061Japan Department of Physiology Faculty of MedicineSaitama Medical UniversityIruma-gunSaitama 3500495Japan Research and Development Division Sekisui Medical Company LimitedRyugasakiIbaraki 3010852Japan Clinical Research Department Eidia Company LimitedChiyoda-kuTokyo 1010032Japan Eisai Company Limited Shinjuku-kuTokyo 1600812Japan Department of Internal Medicine Shunan Memorial HospitalKudamatsuYamaguchi 7440033Japan

BAcKGROUND The prognosis of hepatocellular carcinoma(Hcc)patients remains poor despite advances in treatment modalities and *** is important to identify useful markers for the early detection of Hcc in *** antigen(PNA),originally reported in a rat carcinogenesis model,is increased in the tissues and serum of Hcc *** To determine the diagnostic value of PNA for discriminating Hcc and to characterize PNA-positive *** Patients with hepatitis c virus(HcV)-related hepatic disorders were prospectively enrolled in this study,which included patients with hepatitis,with cirrhosis,and with Hcc.A novel enzyme-linked immunosorbent assay was developed to measure serum PNA concentrations in *** Serum PNA concentrations were measured in 89 controls and 141 patients with HcV infections(50 hepatitis,44 cirrhosis,and 47 Hcc).compared with control and non-Hcc patients,PNA was increased in *** receiver operating characteristic curve analysis,the sensitivity of PNA was similar to the Hcc markers des-γ-carboxy-prothrombin(DcP)andα-fetoprotein(AFP),but the specificity of PNA was *** was no correlation between PNA and AFP and a significant but weak correlation between PNA and DcP in Hcc ***,the correlations with biochemical markers were completely different for PNA,AFP,and DcP;glutamyl transpeptidase was highly correlated with PNA,but not with AFP or DcP,and was significantly higher in PNA-high patients than in PNA-low patients with HcV-related *** PNA may have the potential to diagnose a novel type of Hcc in which glutamyl transpeptidase is positively expressed but AFP or DcP is weakly or negatively expressed.

关键词： Serum preneoplastic antigen Hepatitis c virus Hepatocellular carcinoma Des-γ-carboxy-prothrombin α-Fetoprotein Sensitivity Specificity

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Manufacture and test of c/c-Sic sandwich structures

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cEAS SPAcE JOURNAL 2020年第1期12卷 73-84页

作者： Heidenreich, Bernhard Bamsey, Nathan Shi, Yuan Such-Taboada, Miguel Koch, Dietmar DLR Inst Struct & Design D-70569 Stuttgart Germany Estec Keplerlaan 1 NL-2200 AG Noordwijk Netherlands

Sandwich structures based on c/c-Sic composites (carbon fibre-reinforced carbon with silicon carbide matrix), manufactured using the liquid silicon infiltration (LSI) process and an in situ joining method, offer high specific stiffness and strength, low thermal expansion, high environmental stability, and temperature resistance. Potential application areas are thermal protection systems (TPS) for spacecraft, optical benches in satellites, and hot structures in aerospace. In this work, c/c-Sic sandwich parts of two different geometries, small sandwich samples and large sandwich structures, were manufactured and tested. carbon fibre-reinforced polymer (cFRP) plates for the skin panels as well as for the cores were made via warm pressing of prepregs based on a 2D carbon (c) fibre fabric, preimpregnated with phenolic resin. After pyrolysis, carbon fibre-reinforced carbon (c/c) core structures were built up and joined to c/c skin panels. Finally, the resulting c/c sandwich preforms were infiltrated with molten silicon (Si), building up a silicon carbide (Sic) matrix. The resulting c/c-Sic sandwich parts were tested in four-point and three-point bending. The applied forces and the correspondent displacements and strain of the skin panels were determined. The bending and shear stiffness as well as bending moment were evaluated through analytical and finite-element (FE) simulation approaches. Furthermore, failure modes of the sandwich samples were analysed. Sandwich stiffness and ultimate bending moment obtained in the bending tests were close to the expected theoretical values, calculated on the basis of the material properties and the sandwich geometry.

关键词： Sandwich structures ceramic matrix composites cMc c c-Sic Liquid sililon infiltration In situ joining

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Pushing the boundaries of c-H bond functionalization chemistry using flow technology

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JOURNAL OF FLOW cHEMISTRY 2020年第1期10卷 13-71页

作者： Govaerts, Sebastian Nyuchev, Alexander Noel, Timothy Eindhoven Univ Technol Dept Chem Engn & Chem Micro Flow Chem & Synthet Methodol Den Dolech 2 NL-5612 AZ Eindhoven Netherlands Univ Manchester Sch Chem Oxford Rd Manchester M13 9PL Lancs England

c-H functionalization chemistry is one of the most vibrant research areas within synthetic organic chemistry. While most researchers focus on the development of small-scale batch-type transformations, more recently such transformations have been carried out in flow reactors to explore new chemical space, to boost reactivity or to enable scalability of this important reaction class. Herein, an up-to-date overview of c-H bond functionalization reactions carried out in continuous-flow microreactors is presented. A comprehensive overview of reactions which establish the formal conversion of a c-H bond into carbon-carbon or carbon-heteroatom bonds is provided;this includes metal-assisted c-H bond cleavages, hydrogen atom transfer reactions and c-H bond functionalizations which involve an S-E-type process to aromatic or olefinic systems. Particular focus is devoted to showcase the advantages of flow processing to enhance c-H bond functionalization chemistry. consequently, it is our hope that this review will serve as a guide to inspire researchers to push the boundaries of c-H functionalization chemistry using flow technology.

关键词： cross coupling c H activation catalysis Microreactor Flow chemistry

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First report of cryptosporidium viatorum and cryptosporidium occultus in humans in china, and of the unique novel c. viatorum subtype XVaA3h

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BMc INFEcTIOUS DISEASES 2020年第1期20卷 1-11页

作者： Xu, Ning Liu, Hua Jiang, Yanyan Yin, Jianhai Yuan, Zhongying Shen, Yujuan cao, Jianping Minist Hlth Key Lab Parasite & Vector Biol Shanghai 200025 Peoples R China Chinese Ctr Dis Control & Prevent Natl Inst Parasit Dis Shanghai 200025 Peoples R China Chinese Ctr Trop Dis Res Shanghai 200025 Peoples R China WHO Collaborating Ctr Trop Dis Shanghai 200025 Peoples R China Minist Sci & Technol Natl Ctr Int Res Trop Dis Shanghai 200025 Peoples R China

Background cryptosporidium is a genus of common intestinal protozoa, members of which cause diarrhea in a wide variety of hosts. Previous studies on cryptosporidium in china have mainly focused on diarrhea sufferers, children, and immunodeficient individuals such as HIV/AIDS patients. However, the epidemiological characteristics of cryptosporidium in the population in rural areas remain unclear. Herein, we investigated the prevalence of, and risk factors for, cryptosporidium in rural areas of Binyang county, Guangxi Zhuang Autonomous Region, china, and genetically characterized the cryptosporidium isolates we obtained. Methods From August to December 2016, two villages in Binyang county, Guangxi, were sampled using a random cluster sampling method. Fresh fecal samples were collected from all eligible residents (residence time > 6 months). Molecular characterization of cryptosporidium was carried out based on its SSU rRNA, gp60, actin and hsp70 gene sequences. Fisher's exact test were conducted to assess the risk factors for cryptosporidium infection. Results A total of 400 fecal samples were collected from 195 males (48.8%) and 205 females (51.2%). Two samples (0.5%) were positive for cryptosporidium and were identified as c. viatorum and c. occultus respectively. Moreover, a new c. viatorum subtype XVaA3h was identified based on the sequence of the gp 60 gene. conclusions To our knowledge, this is the first report of c. viatorum and c. occultus infections in humans in china and of c. viatorum subtype XVaA3h. The findings provide important information on the prevalence of cryptosporidium in the chinese population, and expand the range of cryptosporidium species known to infect people in china.

关键词： cryptosporidium Subtype c viatorum c occultus Rural area

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c. elegansaversive olfactory learning generates diverse intergenerational effects

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JOURNAL OF NEUROGENETIcS 2020年第3-4期34卷 378-388页

作者： Pereira, Ana Goncalves Gracida, Xicotencatl Kagias, Konstantinos Zhang, Yun Harvard Univ Dept Organism & Evolutionary Biol Ctr Brain Sci Cambridge MA 02138 USA Broad Inst MIT & Harvard Cambridge MA 02142 USA

Parental experience can modulate the behavior of their progeny. While the molecular mechanisms underlying parental effects or inheritance of behavioral traits have been studied under several environmental conditions, it remains largely unexplored how the nature of parental experience affects the information transferred to the next generation. To address this question, we usedc. elegans, a nematode that feeds on bacteria in its habitat. Some of these bacteria are pathogenic and the worm learns to avoid them after a brief exposure. We found, unexpectedly, that a short parental experience increased the preference for the pathogen in the progeny. Furthermore, increasing the duration of parental exposure switched the response of the progeny from attraction to avoidance. To characterize the underlying molecular mechanisms, we found that the RNA-dependent RNA Polymerase (RdRP) RRF-3, required for the biogenesis of 26 G endo-siRNAs, regulated both types of intergenerational effects. Together, we show that different parental experiences with the same environmental stimulus generate different effects on the behavior of the progeny through small RNA-mediated regulation of gene expression.

关键词： Intergeneration epigenetics learning olfaction c elegans

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chronic Rifaximin Use in cirrhotic Patients Is Associated with Decreased Rate of c. difficile Infection

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DIGESTIVE DISEASES AND ScIENcES 2020年第2期65卷 632-638页

作者： Feuerstadt, Paul Hong, Simon J. Brandt, Lawrence J. Gastroenterol Ctr Connecticut 2200 Whitney AveSuite 360 Hamden CT 06518 USA Yale Univ Sch Med Div Digest Dis New Haven CT 06520 USA Montefiore Med Ctr Albert Einstein Coll Med Div Gastroenterol 111 East 210th St Bronx NY 10467 USA

Background and Aim Rifaximin is an antimicrobial which is used for prophylaxis of hepatic encephalopathy in patients with cirrhosis and has known anti-clostridioides difficile activity. The aim of this study is to assess whether the rate of c. difficile infection (cDI) is decreased in patients with cirrhosis on chronic rifaximin compared with those who are not. Methods We retrospectively identified consecutive patients admitted to Montefiore Medical center from 2010 to 2014 with cirrhosis and diarrhea who were tested for cDI. Demographics, comorbidities, medication exposure, baseline laboratory data, and outcomes were recorded. Patients with cirrhosis and diarrhea on chronic rifaximin were compared with those not on rifaximin. The chronic rifaximin group was then isolated, and those with and without cDI were compared. Results Of 701 patients with cirrhosis and diarrhea, 149 were on chronic rifaximin and 552 were not. 12.8% of patients on chronic rifaximin had cDI compared with 29.7% of those not on rifaximin (P < 0.001). Patients on rifaximin had higher MELD (19.7 vs. 15.5, P < 0.001), 30-day mortality (26.2% vs. 16.1%, P < 0.01), and IcU requirement compared with those not on rifaximin. conclusion Patients with cirrhosis who are on chronic rifaximin have decreased rates of cDI compared with those not on this therapy. Despite its risk for promoting resistance, chronic rifaximin use may have a beneficial effect in preventing cDI in patients with cirrhosis.

关键词： cirrhosis c difficile Rifaximin Infection

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