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Sources and fate of dissolved sulphate, carbonate, and nitrate in groundwater of the temperate climate zone: a high-resolution multi-isotope (H, c, O, S) study in north-eastern Germany**

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Isotopenpraxis Isotopes in Environmental and Health Studies 2025年第1期61卷

作者： Anna-Kathrina Jenner christoph Malik Gerd Böttcher Patricia Roeser Matthias Gehre Iris Schmiedinger Michael Ernst Böttcher a Geochemistry & Isotope Biogeochemistry Leibniz Institute for Baltic Sea Research (IOW) Warnemünde Germany a Geochemistry & Isotope Biogeochemistry Leibniz Institute for Baltic Sea Research (IOW) Warnemünde Germanyb Institute for Geography and Geology University of Greifswald Greifswald Germanyc Department of Hydrogeology UmweltPlan GmbH Stralsund Stralsund Germany d Landesamt für Umwelt Naturschutz und Geologie (LUNG) Güstrow Germany e Department Technical Biogeochemistry Helmholtz Centre for Environmental Research- UFZ Leipzig Germany a Geochemistry & Isotope Biogeochemistry Leibniz Institute for Baltic Sea Research (IOW) Warnemünde Germanyb Institute for Geography and Geology University of Greifswald Greifswald Germanyf Interdisciplinary Faculty University of Rostock Rostock Germany

ABSTRAcTDifferent natural and anthropogenic drivers impact the groundwater in the catchment area of the southern Baltic Sea, north-eastern Germany. To understand the sources and fate of dissolved sulphate, carbonate, and nitrate on a regional scale, in the present study, the hydrogeochemical and multi-stable isotope (H, c, O, S) composition of groundwater samples from up to more than 300 sites (depths from near-surface down to 291 m) was studied. To investigate the element sources and the water–rock–microbe interaction processes that took place along the groundwater flow path, a mass balance approach is combined with physico-chemical modelling. Microbial oxidation of pyrite using nitrate as electron acceptor and a superimposition by dissimilatory sulphate reduction at depth is shown in a drilled vertical profile at one site. This trend frames the behaviour of sulphate at many investigated groundwater wells. Dissolved inorganic carbon (DIc) in the groundwater was found to be controlled by the uptake of biogenic carbon dioxide, the dissolution of carbonate minerals, thein situoxidation of DOc and, at a few sites, the formation and/or oxidation of biogenic methane. Enhanced groundwater DIc loads may potentially increase future cO2degassing to the atmosphere upon release of groundwaters to the surface. These results form a comprehensive base for understanding the present situation and for future investigations.

关键词： Groundwater spring water hydro-biogeochemistry stable isotopes (H c O S) sources of carbonate sulphate and nitrate denitrification pyrite oxidation microbial sulphate reduction Southern Baltic Sea North-eastern Germany

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Photocatalytic coupling of N-Heteroarenes and Alkanes/Ethers with ce-Doped g-c3N4 and Bu4Ncl

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Synfacts 2025年第3期21卷 281-281页

作者： Yasuhiro Uozumi Kenji Tsukamoto

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Structure and formation probability of contact interface between adjacent M 23 c 6 in aged Fe-15Mn-3Al-0.7c TWIP steel

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Materials & Design 2025年 256卷

作者： Zhenfeng Xu Dong Hu Jingman Lu Huixin Liu Fengliang Tan Zhenzhen Guo Yang Yang Hunan University of Humanities Science and Technology Loudi Hunan 417000 PR China Zhiyuan Emerging Industry Research Institute Loudi Hunan 417000 PR China

M 23 c 6 carbides are characterized by a complex unit cell structure and high stacking fault (SF) energies, theoretically impeding the formation of SFs within the carbides. However, SFs can form upon contact and coarsening. Given their significance in understanding the deformation mechanism of nano-crystalline structures, their formation mechanisms and probabilities should be clarified. The paper deploys optical microscopy (OM), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) to explore the contact interface structures of adjacent grain boundary M 23 c 6 in aged Fe-15Mn-3Al-0.7c high-manganese TWIP steel. Results show the internal lattice of grain boundary M 23 c 6 features a prominent 0.8165-nm-wide SF structure parallel to the close-packed plane. This width is 33.5 % greater than that of the close-packed plane and {1 1 1}γ is found within it. It is proved that the SF is generated by the growth and contact beween adjacent M 23 c 6 carbides. Based on these findings, a new model is established to predict the possible contact interface structures and formation probabilities: a SF structure where remaining austenite planes exist in between (probability: 66.7 %), a coherent interface with SFs when the distance between the nuclei of the two carbides conforms to S = nd/sinθ (probability: 33.3 %), or a coherent interface without SFs (probability: 11.1 %).

关键词： TWIP steel M 23 c 6 Orientation relationship Interface structure Stacking fault

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convergent and divergent signaling pathways in c 3 rice and c 4 foxtail millet crops in response to salt stress

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Journal of Integrative Agriculture 2024年

作者： Xinyu Man Sha Tang Yu Meng Yanjia Gong Yanqing chen Meng Wu Guanqing Jia Jun Liu Xianmin Diao Xiliu cheng Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 China Agricultural University of Hebei Baoding 071001 China

Salt stress is a global constraint on agricultural production. Therefore, the development of salt tolerant plants has become a current research hotspot. Salt tolerance evolves more frequently in c 4 grass lineages. However, few studies have been carried out to explore the molecular bases underlying salt stress tolerance in c 4 crop foxtail millet. In this study, we performed a multi-pronged approach spanning the omics analyses of transcriptomes and physiological analysis of c 3 crop rice and c 4 model crop foxtail millet in response to salt stress. Our results revealed specifically compared to c 3 rice, c 4 foxtail millet has upregulated ABA and notably reduced cK biosynthesis and signaling transduction under salt stress. Salt stress in c 3 rice plants triggered rapid downregulation of photosynthesis related genes, which was coupled by severely decreased net photosynthetic rates. In the salt-threatened c 3 rice and c 4 foxtail millet, some stress responsive transcription factors (TFs), such as AP2/ERF, WRKY and MYB underwent strong and distinct transcriptional changes. Based on weighted gene co-expression network analysis (WGcNA), an AP2/ERF transcription factor Rice Starch Regulator1 SiRSR1 ( Seita . 3G044600 ) was identified as a key regulator of salt stress response. To confirmed its function, we generated OsRSR1 -knockout lines with cRISPR/cas9 genome editing in rice and its upstream repressor SiMIR172a -overexpressing ( 172a -OE) transgenic plants in foxtail millet, which increased salt tolerance. Overall, our study not only provided new insights into the convergent regulation of salt stress responses of foxtail millet and rice, but also shed light on the divergent signaling networks between them in response to salt stress.

关键词： c 3 c 4 phytohormone photosynthesis transcriptional regulatory network RSR1 1

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VEGF-c/VEGFR-3 axis protects against pressure-overload induced cardiac dysfunction through regulation of lymphangiogenesis

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cLINIcAL AND TRANSLATIONAL MEDIcINE 2021年第3期11卷 e374页

作者： Lin, Qiu-Yue Zhang, Yun-Long Bai, Jie Liu, Jin-Qiu Li, Hui-Hua Dalian Med Univ Inst Cardiovasc Dis Dept Cardiol Affiliated Hosp 1 193 Lianhe Rd Dalian 11600 Peoples R China Capital Med Univ Beijing Chaoyang Hosp Dept Emergency Med Beijing Key Lab Cardiopulm Cerebral Resuscitat Beijing Peoples R China

Prolonged pressure overload triggers cardiac hypertrophy and frequently leads to heart failure (HF). Vascular endothelial growth factor-c (VEGF-c) and its receptor VEGFR-3 are components of the central pathway for lymphatic vessel growth (also known as lymphangiogenesis), which has crucial functions in the maintenance of tissue fluid balance and myocardial function after ischemic injury. However, the roles of this pathway in the development of cardiac hypertrophy and dysfunction during pressure overload remain largely unknown. Eight- to 10-week-old male wild-type (WT) mice, VEGFR-3 knockdown (VEGFR-3(f/-)) mice, and their WT littermates (VEGFR-3(f/f)) were subjected to pressure overload induced by transverse aortic constriction (TAc) for 1-6 weeks. We found that cardiac lymphangiogenesis and the protein expression of VEGF-c and VEGFR-3 were upregulated in the early stage of cardiac hypertrophy but were markedly reduced in failing hearts. Moreover, TAc for 6 weeks significantly reduced cardiac lymphangiogenesis by inhibiting activation of VEGFR-3-mediated signals (AKT/ERK1/2, calcineurin A/NFATc1/FOXc2, and cX43), leading to increased cardiac edema, hypertrophy, fibrosis, apoptosis, inflammation, and dysfunction. These effects were further aggravated in VEGFR-3(f/-) mice and were dose-dependently attenuated by delivery of recombinant VEGF-c-156S in WT mice. VEGF-c-156s administration also reversed pre-established cardiac dysfunction induced by sustained pressure overload. Thus, these results demonstrate, for the first time, that activation of the VEGF-c-VEGFR-3 axis exerts a protective effect during the transition from cardiac hypertrophy to HF and highlight selective stimulation of cardiac lymphangiogenesis as a potential new therapeutic approach for hypertrophic heart diseases.

关键词： cardiac lymphangiogenesis heart failure pressure overload VEGF‐ c VEGFR‐ 3

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Norm upper-semicontinuity of functions supported on open abelian isotropy in étale groupoids. corrigendum to “Reconstruction of groupoids and c ⁎ -rigidity of dynamical systems” [Adv. Math. 390 (2021) 107923]

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Advances in Mathematics 2025年 466卷

作者： Toke Meier carlsen Anna Duwenig Efren Ruiz Aidan Sims Køge Denmark Department of Mathematics KU Leuven Leuven Belgium Department of Mathematics University of Hawaii Hilo 200 W. Kawili St. Hilo HI 96720-4091 USA School of Mathematics and Applied Statistics University of Wollongong NSW 2522 Australia

We consider étale Hausdorff groupoids in which the interior of the isotropy is abelian. We prove that the norms of the images under regular representations, of elements of the reduced groupoid c ⁎ -algebra whose ... 详细信息

关键词： primary 46L05 Groupoid c ⁎ -algebra cartan subalgebra

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Evaluation of dose linearity in the systemic availability and pharmacokinetics of topically administered diclofenac: A 14 c-microdosing study in healthy volunteers

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Drug Metabolism and Disposition 2025年第7期53卷

作者： Severin Mairinger Mihye Kwon Martin Bauer Jinho Song Edith Lackner Anselm Jorda Felix Bergmann Iris K. Minichmayr Ka Yeon Kim Min Sun choi Jae Hoon Shim Stephen R. Dueker Markus Zeitlinger Oliver Langer Department of Clinical Pharmacology Medical University of Vienna Vienna Austria Department of Biomedical Imaging and Image-Guided Therapy Medical University of Vienna Vienna Austria Korea Radio-Isotope Center for Pharmaceuticals Korea Institute of Radiological & Medical Sciences Seoul Republic of Korea

An important safety consideration for topically administered drugs is the extent of systemic exposure they achieve. The aim of this study was to evaluate whether a topically administered microdose of the model drug diclofenac can predict the systemic availability, plasma, and tissue pharmacokinetics of a topical therapeutic dose. Eight healthy participants (6 men and 2 women) participated in a 4-period, crossover study. In period 1, a topical microdose (62 ± 6 μ g) was administered; in period 2, a single intravenous microdose (0.95 ± 0.03 μ g) was administered; in period 3, a topical therapeutic dose (120 mg) was administered; and in period 4, a single intravenous therapeutic dose (75 mg) of [ 14 c]diclofenac was administered, with or without the addition of unlabeled diclofenac. Venous blood, urine, and microdialysis samples from subcutaneous adipose tissue beneath the dermal application site were collected for 24 h post-dosing. Total 14 c-concentrations in plasma and microdialysates were quantified using accelerator mass spectrometry. The disposition of intravenously administered [ 14 c]diclofenac was dose-linear. However, after topical administration, the fraction of total 14 c absorbed (geometric mean and 95% confidence interval) was higher ( P = .0019, 2-tailed, paired t test) for the microdose (0.48% and 0.34%–0.67%) compared with the therapeutic dose (0.13% and 0.07%–0.22%) (geometric mean ratio and 90% confidence interval: 3.79 and 2.41–5.98). Dose-normalized 14 c-concentrations in microdialysates were low, variable, and did not differ between doses. Our study demonstrates the feasibility of quantifying 14 c-concentrations in plasma and microdialysates following the topical administration of a microdose of [ 14 c]diclofenac. The observed nonlinearity in systemic availability after topical dosing suggests that microdosing may not accurately predict the disposition of certain topical drugs at therapeutic doses. Significance Statement We assessed whether a topi

关键词： Dose linearity Microdialysis Microdosing Topical drugs AUc 0–24 area under the concentration-time curve from 0 to 24 h AUc 0-inf area under the concentration-time curve from 0 to infinity AMS accelerator mass spectrometry 14 c carbon-14 F abs fraction absorbed GMR geometric mean ratio HSA human serum albumin Lc-MS/MS liquid chromatography tandem mass spectrometry LLOQ lower limit of quantification LSc liquid scintillation counting ng-eg/mL nanogram diclofenac equivalents per milliliter PK pharmacokinetic(s)

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characterization and Expression Analysis of Protein Kinase c Gene from Dunaliella salina

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Journal of Ocean University of china 2019年第4期18卷 977-984页

作者： cONG Yuting MA Yuexin WANG Yuan LIU Yiqiong cHAI Xiaojie Key Laboratory of Hydrobiology in Liaoning Province’s University Dalian Ocean University Dalian 116023 China Key Laboratory of Mariculture & Stock Enhancement in North China’s Sea Ministry of Agriculture Dalian Ocean University Dalian 116023 China

Protein kinase c (PKc) has a crucial role in signal transduction for a variety of biologically active substances which activate cellular functions and proliferation. We previously isolated the full-length PKc gene from Dunaliella salina (DsPKc) using rapid amplification of cDNA ends (RAcE) and RT-PcR methods. And we submitted the mRNA sequence of DsPKc gene to NcBI (Genbank No. JN625213). In the present paper, the DsPKc gene open reading frame obtained by PcR was cloned into pGS-21a vector and transformed into Escherichia coli to generate the fusion protein. Bioinformatics analysis revealed that DsPKc gene was a member of serine/threonine kinase with two conserved domains and highly conserved motifs. The DsPKc was highly expressed upon induction with isopropyl-β-d-thiogalactoside (IPTG) at a final concentration of 0.2 mmol L 1 at 37℃. Under salt stress, the fu- sion protein Green Fluorescent Protein (GFP)-DsPKc was transferred from the cytoplasm to the cell membrane. The expression pat- tern of DsPKc gene was analyzed using real-time quantitative PcR, and indicated that DsPKc gene was up-regulated by 3.0 mol L 1 Nacl at 12 h, which was significantly higher than in control values (P < 0.05). These results suggest that the DsPKc gene plays an important role in response to salt stress in D. salina.

关键词： Dunaliella salina protein kinase c gene prokaryotic expression subcellular localization salt stress

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Finding an optimal core on a tree network with M/G/c/c state-dependent queues

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MATHEMATIcAL METHODS OF OPERATIONS RESEARcH 2019年第1期89卷 115-142页

作者： Moshtagh, Mehrdad Fathali, Jafar Smith, James MacGregor Mahdavi-Amiri, Nezam Shahrood Univ Technol Fac Math Sci Shahrood Iran Univ Massachusetts Dept Mech & Ind Engn Amherst MA 01003 USA Sharif Univ Technol Fac Math Sci Tehran Iran

We consider the stochastic queue core problem on a tree network. Our aim is to find an optimal path on a tree network subject to the average travel time of particles moving along the tree for service given by a server traversing along the optimal path. We assume that particles originating at a node on a tree network request their demands for service randomly and the server is modeled first by an M/M/1 and then by an M/G/1 queue using the FIFO discipline. We consider that all paths along which the particles travel are modeled with an M/G/c/c state-dependent queue with the particles being independent of each other having demands according to the Poisson distribution. Two algorithms are developed for computing the optimal path on a tree network along with the M/M/1 and the M/G/1 queues. The computational complexity of the algorithms and illustrative numerical results obtained by implementations of the algorithms in MATLAB software environment are given.

关键词： Facility location core of a tree network Stochastic queue core M G c c state-dependent queue Queueing theory

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基于Simulink与c混合编程的插补算法可视化仿真技术研究

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机械设计与研究 2021年第5期37卷 143-147页

作者：严相王堂辉伍相宇王晨光刘秀峰华中科技大学机械科学与工程学院武汉430074

插补算法在整个数控系统中起着至关重要的作用,在使用面向过程的c语言编写插补算法的过程中缺乏直观性,不能很好观察算法的效果。针对该问题,设计开发了一套基于Simulink与c很合编程的插补算法仿真平台,对插补算法的S型加减速进行了实... 详细信息

插补算法在整个数控系统中起着至关重要的作用,在使用面向过程的c语言编写插补算法的过程中缺乏直观性,不能很好观察算法的效果。针对该问题,设计开发了一套基于Simulink与c很合编程的插补算法仿真平台,对插补算法的S型加减速进行了实验仿真,实验结果表明插补算法速度规划和单周期位置插补均符合S型加减速规律,该平台利用Simulink适应面广、结构和流程清晰、贴近实际、灵活等优点,既能使用户减少进行算法仿真的代码书写量,又能在Simulink当中很直观地观察算法的效果。

关键词：插补算法 Simulink c 混合编程可视化

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