Hepatitis c virus(HcV) infection is a major global health *** by the HcV can cause acute and chronic liver diseases and may lead to cirrhosis,hepatocellular carcinoma or liver *** World Health Organization estimates t...
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Hepatitis c virus(HcV) infection is a major global health *** by the HcV can cause acute and chronic liver diseases and may lead to cirrhosis,hepatocellular carcinoma or liver *** World Health Organization estimates that approximately 3% of the world population have been infected with HcVand the worldwide prevalence is between 1% and 8% in pregnant women and between 0.05% and 5% in *** the introduction of blood product screening,vertical transmission becomes the leading cause of childhood HcV *** prevalence of pediatric HcV infection varies from 0.05% to 0.36% in developed countries and between 1.8% and 5% in the developing *** children born to women with antiHcV antibodies should be checked for HcV *** universal screening is controversial,selective antenatal HcV screening on high-risk populations is highly recommended and should be tested *** risk factors were shown to increase the possibility of HcV vertical transmission,including coinfections with human immunodeficiency virus,intravenous drug use and elevated maternal HcV viral load,while breastfeeding and HcV genotypes have been studied to have little *** present,no clinical intervention has been clearly studied and proved to reduce the HcV vertical transmission *** section should not be recommended as a procedure to prevent vertical transmission,however,breastfeeding is generally not *** high prevalence of global HcV infection necessitates renewed efforts in primary prevention,including vaccine development,as well as new approaches to reduce the burden of chronic liver *** researches should focus on the interruption of vertical transmission,developments of HcV vaccine and directacting antivirals in infancy and early childhood.
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