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ZIF-8-derived ZnO/c decorated hydroxyl-functionalized multi-walled carbon nanotubes as a new composite electrode for supercapacitor application

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cOLLOID AND INTERFAcE ScIENcE cOMMUNIcATIONS 2022年 47卷

作者： Otun, Kabir O. Xaba, Morena S. Zong, Shuang Liu, Xinying Hildebrandt, Diane El-Bahy, Salah M. Alotaibi, Mohammed T. El-Bahy, Zeinhom M. Univ South Africa Coll Sci Engn & Technol Inst Dev Energy African Sustainabil Private Bag X6 Florida South Africa Kwara State Univ Dept Chem & Ind Chem PMB 1530 Ilorin Nigeria Hebei Univ Sci & Technol Int Joint Lab New Energy Shijiazhuang 050018 Hebei Peoples R China Univ Witwatersrand African Energy Leadership Ctr Wits Business Sch ZA-2193 Johannesburg South Africa Univ Witwatersrand Sch Chem Mol Sci Inst ZA-2050 Johannesburg South Africa Taif Univ Turabah Univ Coll Dept Chem POB 11099 At Taif 21944 Saudi Arabia Al Azhar Univ Fac Sci Dept Chem Cairo 111884 Egypt

Due to the poor conductivity of metal-organic frameworks (MOFs), it is challenging to directly employ MOFs as electrode materials for supercapacitors. Herein, hydroxyl-functionalized multi-walled carbon nanotube (f-MWcNT) was used to decorate ZnO/c obtained from the prior calcination of pristine zeolitic imidazolate framework-8 (ZIF-8) and applied as electrode material for supercapacitor application. The resulting ZnO/c@f-MWcNT electrode exhibits excellent storage performance, as confirmed by the specific capacitance of 650 F/g at 1 A/g and a superior energy/power density compared to the single electrode. Additionally, the composite electrode displayed remarkable cycling stability of 70% after 5000 cycles and retained 75% of its initial capacitance at 10 A/g, demonstrating good rate cyclability. The exceptional performance of ZnO/c@f-MWcNT was attributed to the synergistic effects offered by f-MWcNT which improved its electrical conductivity and ZnO/c that provided sufficient redox-active sites and structural stability. This work may promote the design of advanced MOF-based nanocomposites for energy storage application.

关键词： carbon nanotube Energy storage Metal-organic frameworks ZnO c Nanocomposite

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Foundations for a Rust-Like Borrow checker for c 25

Foundations for a Rust-Like Borrow Checker for C

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25th AcM SIGPLAN/SIGBED International conference on Languages, compilers, and Tools for Embedded Systems (LcTES)

作者： Silva, Tiago Bispo, Joao carvalho, Tiago Univ Porto Porto Portugal INESC TEC Porto Portugal Polytech Inst Porto Sch Engn Porto Portugal

ISBN: (纸本)9798400706165

Memory safety issues in c are the origin of various vulnerabilities that can compromise a program's correctness or safety from attacks. We propose a different approach to tackle memory safety, the replication of Rust's Mid-level Intermediate Representation (MIR) Borrow checker, through the usage of static analysis and successive source-to-source code transformations, to be composed upstream of the compiler, thus ensuring maximal compatibility with most build systems. This allows us to approximate a subset of c to Rust's core concepts, applying the memory safety guarantees of the rustc compiler to c. In this work, we present a survey of Rust's efforts towards ensuring memory safety, and describe the theoretical basis for a c borrow checker, alongside a proof-of-concept that was developed to demonstrate its potential. This prototype correctly identified violations of the ownership and aliasing rules, and accurately reported each error with a level of detail comparable to that of the rustc compiler.

关键词： c Rust Source-to-Source Memory Safety Static analysis Borrow checker Lifetimes Ownership Transpiler code transformations

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Identification and analysis of differentially expressed microRNAs in gibel carp carassius auratus gibelio responding to polyinosinic-polycytidylic acid (poly I:c) stimulation

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FISH AND SHELLFISH IMMUNOLOGY REPORTS 2023年 4卷

作者： Zhang, Jialin Sun, Shanling Mao, Yiyang Qiao, Guo Li, Qiang Yancheng Inst Technol Coll Marine & Bioengn Yancheng 224051 Peoples R China

Polyinosinic-polycytidylic acid (poly I:c) is a synthesized analogue of viral double-strand RNA and considered as a potential immunostimulant in aquaculture. MicroRNAs (miRNAs) have been reported to play important roles in the development of the immune system and in regulation of host antiviral responses. In our earlier study, it was found that poly I:c pre-treatment could stimulate the resistance against cyprinid herpesvirus 2 (cyHV-2) infection and enhance the antiviral immune response in gibel carp. To understand the role of miRNAs in regulating the host response to poly I:c treatment, we investigated the expression profiles of miRNAs in the head kidney of poly I:c-treated gibel carp with small RNA sequencing technology. When compared with the untreated group, a total of 24 differentially expressed miRNAs were identified in the poly I:c-stimulated fish, among which, 7 and 17 miRNAs were upregulated and downregulated, respectively. Analysis of target genes of these differentially expressed miRNAs found that most targeted mRNAs were involved in catalytic activity, peptidase activity and endopeptidase activity, and were enriched in the metabolic, protein processing in endoplasmic reticulum and oxidative phosphorylation signaling pathways, suggesting that poly I:c could alter the expression of metabolism-related miRNAs in the kidney of gibel carp. Besides, it was noted that some immune-related miRNAs, including inflammation-related miRNAs (miR-192 and miR-731) and interferon-related miRNAs (miR-194a and miR-122), were downregulated after poly I:c treatment. In summary, it was found that poly I:c could regulate the cellular levels of specific miRNAs involved in metabolism and immune responses in the head kidney of gibel carp, which may increase the capacity of the immune cells to fight against pathogens infection.

关键词： Gibel carp Poly I c MicroRNA Transcriptome Immune response

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Imaging of lipid droplets using coumarin fluorophores in live cells and c. elegans

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JOURNAL OF PHOTOcHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 2022年 237卷 112589页

作者： Singh, Deepmala Regar, Ramprasad Soppina, Pushpanjali Soppina, Virupakshi Kanvah, Sriram Indian Inst Technol Gandhinagar Dept Chem Gandhinagar 382055 Gujarat India Indian Inst Technol Gandhinagar Dept Biol Engn Gandhinagar 382055 Gujarat India Sambalpur Univ Dept Biotechnol & Bioinformat Sambalpur 768019 Orissa India

Fluorescent probes offer incredibly effective tools for visualizing the dynamic morphology of lipid droplets (LDs) and investigating their physiological interactions. In this work, we have utilized solvatochromic coumarin probes bearing nitrile and ester substituents for live-cell imaging. The fluorescence probes are characterized by a donor (diethylamino) and acceptor (nitrile and/or ester) substituents and a rotatable double bond. The designed ar-chitecture allows investigation of environmental sensitivity apart from providing excellent ability to target sub -cellular organelles. The synthesized fluorophores showed low cytotoxicity and excellent localization within the lipid droplets. Further, the fluorophores were also utilized to study viscosity changes within the LDs induced by Nystatin. More importantly, we also demonstrate imaging of LDs in multi-cellular animal models such as c. elegans.

关键词： Viscosity sensing Visualization Fluorescence Sub-cellular organelles Lipid droplets c elegans coumarin-fluorophores

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Stable carbon isotope evidence for the origin of c 28 steranes in lacustrine source rocks from the Qikou Sag, Bohai Bay Basin, Eastern china

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ORGANIc GEOcHEMISTRY 2020年 145卷

作者： Zhang, Yongdong Sun, Yongge chen, Jianping South China Normal Univ Sch Geog Guangzhou 510631 Peoples R China Zhejiang Univ Sch Earth Sci Hangzhou 310027 Peoples R China China Natl Petr Corp Res Inst Petr Explorat & Dev Beijing 100083 Peoples R China

c 27 –c 29 steranes are common constituents of crude oils and hydrocarbon source rocks and are usually dominated by either c 27 or c 29 compounds. In the current study, however, steranes dominated by c 28 components were detected in eight lacustrine source rock samples in the first member of the Shahejie Formation in the Qikou Sag, Bohai Bay Basin of Eastern china. Ratios of c 28 /(c 27  + c 28  + c 29 ) ααα 20R steranes in four samples can exceeded 50%. Furthermore, c 27 triaromatic steroids, presumably originating from c 28 steranes, were also observed at high levels, relative to c 26 and c 28 homologues. Stable carbon isotope compositions of a c 28 ααα 20R sterane and c 27 20R triaromatic steroid were found to be similar, with δ 13 c at −37‰ and −36‰ respectively, much lower than values for pristane (by ∼7‰) and total organic carbon (by ∼10‰). The abnormally low δ 13 c values of the steroids suggest that c 28 ααα 20R sterane was biosynthesized by algae blooming in the water column during phases of overturn and mixing, such as in autumn, during which recycled cO 2 and nutrients welling up from hypolimnion to the epilimnion are assimilated, contributing to a high algal productivity and low δ 13 c in algal organic matter.

关键词： c 28 steranes compound-specific carbon isotope algae recycled cO 2 Qikou Sag Bohai Bay Basin

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A perspective on c. elegans neurodevelopment: from early visionaries to a booming neuroscience research

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JOURNAL OF NEUROGENETIcS 2020年第3-4期34卷 259-272页

作者： Rapti, Georgia European Mol Biol Lab Unit Dev Biol Heidelberg Germany

The formation of the nervous system and its striking complexity is a remarkable feat of development. c. elegans served as a unique model to dissect the molecular events in neurodevelopment, from its early visionaries to the current booming neuroscience community. Soon after being introduced as a model, c. elegans was mapped at the level of genes, cells, and synapses, providing the first metazoan with a complete cell lineage, sequenced genome, and connectome. Here, I summarize mechanisms underlying c. elegans neurodevelopment, from the generation and diversification of neural components to their navigation and connectivity. I point out recent noteworthy findings in the fields of glia biology, sex dimorphism and plasticity in neurodevelopment, highlighting how current research connects back to the pioneering studies by Brenner, Sulston and colleagues. Multifaceted investigations in model organisms, connecting genes to cell function and behavior, expand our mechanistic understanding of neurodevelopment while allowing us to formulate emerging questions for future discoveries.

关键词： Neurodevelopment c elegans glia neurons pathfinding synapses plasticity dimorphism

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changes in phosphorus pools in the detritusphere induced by removal of P or switch of residues with low and high c/P ratio

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BIOLOGY AND FERTILITY OF SOILS 2020年第1期56卷 1-10页

作者： Erinle, Kehinde O. Doolette, Ashlea Marschner, Petra Univ Adelaide Sch Agr Food & Wine Adelaide SA 5005 Australia

The effect of the addition of crop residues to soil has been extensively studied;however, little is known about their effect on P pools in the detritusphere and how these pools change if the residue is replaced by another residue with similar or different P concentration. An experiment was conducted to determine the influence of a change of residue types on P pools in the detritusphere. Detritusphere soil was generated by placing 20 g kg(-1) of either mature barley straw (H;high c/P 255) or young faba bean residue (L;low c/P 38) between two fine nylon meshes which were then sandwiched between two PVc caps filled with loamy sand maintained at 50% water holding capacity throughout the experiment. Then, the open ends of the caps were pressed together and held in place with rubber bands. After 2 weeks of moist incubation, the residues were replaced with either a H or L, resulting in four residue treatments: high-high (HH), high-low (HL), low-low (LL), or low-high (LH) which were incubated another 14 days. A control without residues between the caps was unamended throughout. The following P pools were measured in soil at 0-1 mm from the surface 14 days after the first (day 14) and second (day 28) residue addition: readily available P (cacl2 and anion exchange P);P bound to soil particles (citrate and Hcl-P);and microbial biomass P (MBP). On day 14, P pools and available N were higher, but MBP and microbial biomass N (MBN) were lower in L than in H. On day 28, P pools and available N followed the order LL > HL > LH > HH, whereas MBN and MBP were highest in HL. In a second experiment, the effect of crop residue removal and replacement with anion exchange membrane (AEM) on P pools in the detritusphere was assessed. Detritusphere soil was generated using faba bean residue as described above. The control had no residues between the caps. After 2-week moist incubation, the residues and the meshes were removed and either replaced with three AEM strips (approximately 6 x 2 cm ea

关键词： c nutrient ratio Detritusphere Nutrient availability Residues

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Efficient Detection of Test Interference in c Projects 24

Efficient Detection of Test Interference in C Projects

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39th AcM/IEEE International conference on Automated Software Engineering (ASE)

作者： Eder, Florian Winter, Stefan Ludwig Maximilians Univ Munchen Munich Germany Ulm Univ Ulm Germany

ISBN: (数字)9798400712487

ISBN: (纸本)9798400712487

During test execution, automated software tests can interfere, i.e., their results can deviate depending on their (possibly interleaved) execution order. Such interference imposes severe restrictions on regression testing, when execution order is not or cannot be controlled for, as they can lead to non-deterministic deviations of test results giving false indication of regressions in the code base. While the phenomenon has been extensively studied for Java and Python projects, it remains unclear if or how the obtained results apply for other languages with different testing practices. Our study contributes to filling that gap by reporting results from a large-scale study on test interference in 134 c projects. To cope with the combinatorial explosion of test execution counts when testing with all possible test orders, we propose and evaluate four novel dynamic reduction strategies for test permutations, which yield massive reductions in the number of test sequences to execute. As these strategies are specific to the resources that tests interfere on, rather than the language in which the code is written, we expect them to be useful for the study of test interference in other languages beyond c. Based on the results obtained with these reductions, our results indicate that test order dependencies are far less common in c projects, compared to Java or Python, and that other aspects (concurrency, cPU time) more frequently threaten test result stability.

关键词： Test interference flaky tests c

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c80E型敞车热轴原因分析及改进措施

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铁道车辆 2025年

作者：姚海徐世锋禹海燕周国东张钊中车齐齐哈尔车辆有限公司大连研发中心

自2020年10月起，经第3次段修的c80E型敞车在龙马、红旗渠等THDS探测站频繁出现轴承内探温升预报。经深入研究分析，发现c80E型通用敞车轮径变小，致使车轮热容量降低，在经过瓦日线蒲县站到龙马站12‰的长大下坡道连续制动后，车轮温... 详细信息

自2020年10月起，经第3次段修的c80E型敞车在龙马、红旗渠等THDS探测站频繁出现轴承内探温升预报。经深入研究分析，发现c80E型通用敞车轮径变小，致使车轮热容量降低，在经过瓦日线蒲县站到龙马站12‰的长大下坡道连续制动后，车轮温升显著；同时，轮径变小使得c80E型通用敞车固定杠杆与支点相对位置改变，易造成制动状态下基础制动装置受力不均，进而引发闸瓦受力不均，导致个别车轮温度进一步攀升。当车辆第3次段修后换装新造轴承，因其在使用初期运转热较高，多种因素综合作用引发了THDS热轴预报。针对制动系统制定了优化升级方案，通过改进闸瓦压力均匀性以及提升车轮散热性能，大幅降低了轮温峰值。2021年3月，76辆c80E型敞车完成了制动系统改造并投入瓦日线运用考验。试验数据表明，优化后的试验列车轮温超过300℃的占比为0～2.25%，远低于未优化列车的占比（0.77%～8.05%），验证了优化方案的有效性。2024年9月，依据机辆货检函[2024]116号《关于既有c80E系列敞车制动系统改造有关事宜的通知》，对所有c80E型车辆开展了优化提升改造。

关键词： c 型敞车制动系统热轴优化升级轮温 THDS探测

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c-Fos separation from Lamin A/c by GDF15 promotes colon cancer invasion and metastasis in inflammatory microenvironment

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JOURNAL OF cELLULAR PHYSIOLOGY 2020年第5期235卷 4407-4421页

作者： Ding, Youxiang Hao, Kun Li, Zhaohe Ma, Rong Zhou, You Zhou, Zhou Wei, Mian Liao, Yan Dai, Yao Yang, Yue Zhang, Xiaobo Zhao, Li China Pharmaceut Univ State Key Lab Nat Med Jiangsu Key Lab Carcinogenesis & Intervent Tongjiaxiang 24 Nanjing 210009 Jiangsu Peoples R China China Pharmaceut Univ Key Lab Drug Metab & Pharmacokinet Nanjing Jiangsu Peoples R China Nanjing Med Univ Affiliated Hosp 1 Dept Anesthesiol Nanjing Jiangsu Peoples R China Univ Florida Dept Radiat Oncol Gainesville FL USA

Inflammatory microenvironment is an important factor for promoting cancer invasion and metastasis, but the underlying molecular mechanisms remain unclear. Here, we mimicked an inflammatory microenvironment both in vitro and in vivo and investigated its effects on the invasion and metastasis of colon cancer. Moreover, colon cancer patient samples were also analyzed statistically. conditioned medium from the differentiated macrophages induced invasion and migration of colon cancer cells in vitro, which could be reversed by the treatment of a neutralizing anti-growth differentiation factor 15 (GDF15) antibody, indicating GDF15 involvement in inflammation-induced invasiveness. Also, we observed similar effects of human recombinant GDF15 on colon cancer cells. Mechanistically, GDF15 activated c-Fos by separating it from Lamin A/c, increasing transcriptional activity of c-Fos and regulating EMT gene expressions. However, c-Fos knockdown using lentivirus shRNA plasmid inhibited GDF15-triggered invasion and migration in vitro. In vivo, inflammation caused by lipopolysaccharides obviously increased GDF15 secretion, and c-Fos knockdown reduced the lung metastasis of colon cancer cells in mice model. In addition, c-Fos expressions in patient samples were found to be associated with colon cancer metastasis and TNM stages. Taken together, GDF15 in inflammatory microenvironment induces colon cancer invasion and metastasis by regulating EMT genes by activating c-Fos, which might be a potential therapeutic target for metastatic colon cancer.

关键词： EMT Erk1 2 Lamin A c c-Fos signaling axis macrophages-derived cytokine

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