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Social and sexual behaviors in c. elegans: the first fifty years

JOURNAL OF NEUROGENETIcS 2020年第3-4期34卷 389-394页

作者： Portman, Douglas S. Univ Rochester Del Monte Inst Neurosci Dept Biomed Genet 601 Elmwood AveBox 633 Rochester NY 14642 USA Univ Rochester Del Monte Inst Neurosci Dept Neurosci 601 Elmwood AveBox 633 Rochester NY 14642 USA Univ Rochester Del Monte Inst Neurosci Dept Biol 601 Elmwood AveBox 633 Rochester NY 14642 USA

For the first 25 years after the landmark 1974 paper that launched the field, most c. elegans biologists were content to think of their subjects as solitary creatures. c. elegans presented no shortage of fascinating biological problems, but some of the features that led Brenner to settle on this species-in particular, its free-living, self-fertilizing lifestyle-also seemed to reduce its potential for interesting social behavior. That perspective soon changed, with the last two decades bringing remarkable progress in identifying and understanding the complex interactions between worms. The growing appreciation that c. elegans behavior can only be meaningfully understood in the context of its ecology and evolution ensures that the coming years will see similarly exciting progress.

关键词： c elegans social behavior sexual behavior pheromones

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Response of Dendrobium officinale Kimura et Migo, a Prized Medicinal Plant, to continuous UV-B Irradiation at Different c/N Ratios

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JOURNAL OF PLANT GROWTH REGULATION 2020年第1期39卷 358-369页

作者： cui, Dandan Mo, Yuncai Zeng, Lingjie Feng, Kai Feng, Xiaoyun Huang, Jialing He, Mengling Zhang, Xiaoyuan Teng, Xifeng Guangdong Pharmaceut Univ Sch Chinese Med Guangzhou 510006 Peoples R China Key Lab State Adm Tradit Chinese Med Prod & Dev C Guangzhou 510006 Peoples R China South China Univ Technol Shaoguan Inst High Tech Ind Shaoguan 512028 Peoples R China

The response of Dendrobium officinale Kimura et Migo (D. officinale) to continuous UV-B irradiation at different carbon to nitrogen ratios (c/N ratios) was investigated. Seedlings grown for 60 days were incubated under aseptic conditions with UV-B irradiation (15.6 mu W cm(-2)) at different c/N ratios: control group (cK;c/N 30 without UV-B), UV-B + cK (c/N 30 with UV-B irradiation, similarly hereafter), UV-B + c/N 120, UV-B + c/N 60, UV-B + c/N 15, UV-B + c/N 10, UV-B + c/N 7.5. Growth parameters (the defoliation rate and the sprout number), photosynthetic pigments (carotenoids, chlorophyll a and chlorophyll b), total polysaccharides, total alkaloids, and activities of antioxidant enzymes were determined following 4, 8, 12, and 16 days of continuous UV-B exposure. Results indicated that UV-B irradiation increased the defoliation rate and the content of carotenoids, total polysaccharides and total alkaloids, as well as the activities of antioxidant enzymes. conversely, UV-B irradiation reduced the sprout number and chlorophyll content in D. officinale. compared with UV-B + cK, lower c/N ratio treatments (UV-B + c/N 15, UV-B + c/N 10 and UV-B + c/N 7.5) enhanced the defoliation rate and sprout number, but decreased antioxidant enzyme activities and total polysaccharide content during the whole period, and reduced total alkaloid content after 4 days of UV-B exposure. Following initial UV-B irradiation, lower c/N ratios increased the contents of carotenoid and chlorophyll b, while after 8 days, a reversal in carotenoid content was observed, and after 12 days, a reversal in chlorophyll b content was observed. Optimizing the c/N ratio (c/N 60) resulted in lower defoliation rate, higher photosynthetic pigments and total polysaccharides, and increased activities of antioxidant enzymes, whereas no significant change in sprout number and total alkaloid content was recorded under long-term UV-B irradiation. Furthermore, the UV-B + c/N 120 treatment negatively affected D. offic

关键词： Dendrobium officinale Kimura et Migo UV-B irradiation c N ratio Photosynthetic pigments Antioxidant enzymes Main active compounds

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Hypomethylation of nerve growth factor (NGF) promotes binding of c/EBPα and contributes to inflammatory hyperalgesia in rats

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JOURNAL OF NEUROINFLAMMATION 2020年第1期17卷 1-11页

作者： Yuan, Hongjie Du, Shibin chen, Liping Xu, Xiaoqing Wang, Yufeng Ji, Fuhai Soochow Univ Affiliated Hosp 1 Suzhou 215006 Jiangsu Peoples R China Nantong Hosp Tradit Chinese Med Dept Pain Med Nantong 226001 Jiangsu Peoples R China Shenzhen Univ Gen Hosp Clin Med Acad Dept Anesthesiol Shenzhen 518055 Guangdong Peoples R China Nantong Hosp Tradit Chinese Med Dept Radiol Nantong 226001 Jiangsu Peoples R China

Background chronic pain usually accompanied by tissue damage and inflammation. However, the pathogenesis of chronic pain remains unclear. Methods We investigated the role of nerve growth factor (NGF) in chronic inflammatory pain induced by complete Freund's adjuvant (cFA), explored the methylation status of cpG islands in the promoter region of the NGF gene, and clarified the function and mechanism of c/EBP alpha-NGF signaling pathway from epigenetic perspective in the chronic inflammatory pain model. Results cFA induced significant hyperalgesia and continuous upregulation of NGF mRNA and protein levels in the L4-6 dorsal root ganglions (DRGs) in rats. Hypomethylation of cpG islands occurred in the NGF gene promoter region after cFA treatment. At the same time, the miR-29b expression level was significantly increased, while the DNA methyltransferase 3b (DNMT3b) level reduced significantly. Moreover, cFA treatment promoted binding of c/EBP alpha to the NGF gene promoter region and c/EBP alpha siRNA treatment obviously decreased expression of NGF levels and also alleviate inflammatory hyperalgesia significantly in rats. conclusion collectively, the results indicated that cFA leads to the upregulation of miR-29b level, which represses the expression of DNMT3b, enhances the demethylation of the NGF gene promoter region, and promotes the binding of c/EBP alpha with the NGF gene promoter, thus results in the upregulation of NGF gene expression and maintenance of chronic inflammatory pain.

关键词： NGF c EBP alpha Inflammatory pain DNA methylation Epigenetics

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Magnetic-Field-Regulated TiO2 {100} Facets: A Strategy for c-c coupling in cO2 Photocatalytic conversion

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cHEM 2020年第9期6卷 2335-2346页

作者： Jiang, Meng-Pei Huang, Ke-Ke Liu, Jing-Hai Wang, Dan Wang, Ying Wang, Xia Li, Zhi-Da Wang, Xi-Yang Geng, Zhi-Bin Hou, Xiang-Yan Feng, Shou-Hua Jilin Univ Coll Chem Int Joint Res Lab Nano Micro Architecture Chem State Key Lab Inorgan Synth & Preparat ChemNMAC Changchun Peoples R China Inner Mongolia Univ Nationalities Coll Chem & Chem Engn Nano Innovat Inst NII Inner Mongolia Key Lab Carbon Nanomat Tong Liao Peoples R China Chinese Acad Sci Inst Proc Engn State Key Lab Biochem Engn Beijing Peoples R China Chinese Acad Sci Changchun Inst Appl Chem Changchun Peoples R China Northeast Petr Univ Coll Chem & Chem Engn Prov Key Lab Oil & Gas Chem Technol Daqing Peoples R China

Solar-driven cO2 conversion is an attractive option for producing usable fuels and chemicals. However, traditionally synthesized TiO2 materials suffer from the low activity of cO2 conversion into multi-carbon products. In this study, for the first time, strong magnetic fields were introduced into the synthesis of TiO2. By regulating the splitting ratio of high-angle and low-angle quantum orbitals, we developed a new type of TiO2{100} facets containing more active low-coordinate Ti atoms. In-situ Fourier transform infrared spectroscopy (FTIR) and DFT calculations both revealed that the interfacial charge redistribution and lattice structure of such TiO2{100} are beneficial to the coupling of adsorbed cO*. This enables highly efficient conversion of cO2 into c2H5OH with a yield rate of 6.16 mmol g(-1) h(-1), which is 22-fold higher than that of pristine TiO2. This strategy provides a new platform for desirable photocatalyst synthesis and furthers our understanding of the relationship between atomic orbital control and cO2 conversion.

关键词： cO 2 conversion TiO 2 facets orbital splitting active low-coordinate Ti atoms c-c coupling c 2 H 5 OH SDG7: Affordable and clean energy

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维生素c防治2型糖尿病研究进展

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食品工业科技 2021年第15期42卷 372-376页

作者：丁丽娜王志斌王瑶宁杰张宪党丁文宇山东第一医科大学附属内分泌与代谢病医院(山东省内分泌与代谢病研究所) 山东济南250062 山东第一医科大学(山东省医学科学院) 山东济南250062

2型糖尿病(T2DM)是由胰岛素缺乏和胰岛素抵抗引起的复杂代谢紊乱性疾病。维生素c(Vc)是人体必需的营养素,是众所周知的抗氧化剂,可保护细胞免受氧化应激的伤害。T2DM患者的氧化应激状态对并发症的发生发展起重要作用,适量补充Vc可降低T... 详细信息

2型糖尿病(T2DM)是由胰岛素缺乏和胰岛素抵抗引起的复杂代谢紊乱性疾病。维生素c(Vc)是人体必需的营养素,是众所周知的抗氧化剂,可保护细胞免受氧化应激的伤害。T2DM患者的氧化应激状态对并发症的发生发展起重要作用,适量补充Vc可降低T2DM的发病风险。Vc与T2DM及其并发症密切相关,T2DM患者血浆Vc水平普遍偏低,且血浆Vc水平与T2DM的患病风险呈负相关;补充Vc可以改善胰岛素抵抗、改善炎症状态,同时可延缓糖尿病肾病的发生发展和心血管的发生风险,但在糖尿病牙周疾病方面并没有明显的改善作用。本文对Vc与T2DM发生发展中的作用予以综述,旨在为T2DM的防治提供一定的参考。

关键词：维生素 c 2 型糖尿病氧化应激自由基抗氧化剂

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LINc00160 mediated paclitaxel-And doxorubicin-resistance in breast cancer cells by regulating TFF3viatranscription factor c/EBPβ

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JOURNAL OF cELLULAR AND MOLEcULAR MEDIcINE 2020年第15期24卷 8589-8602页

作者： Wu, Huaiguo Gu, Juan Zhou, Daoping cheng, Wei Wang, Yueping Wang, Qingping Wang, Xuedong Anhui 2 Prov Peoples Hosp Ctr Precis Med Hefei Peoples R China Nanjing Med Univ Peoples Hosp Wuxi 5 Dept Med Lab Sci 1215 Guangrui Rd Wuxi 214000 Jiangsu Peoples R China Jiangnan Univ Peoples Hosp Wuxi 5 Med Sch Dept Pathol Wuxi Jiangsu Peoples R China Massachusetts Univ Coll Arts & Sci Dept Biol Boston MA USA

chemoresistance represents a major challenge in breast cancer (Bc) treatment. This study aimed to probe the roles of LINc00160 in paclitaxel- and doxorubicin-resistant Bc cells. Three pairs of Bc and adjacent normal tissue were used for lncRNA microarray analysis. Paclitaxel-resistant McF-7 (McF-7/Tax) and doxorubicin-resistant BT474 (BT474/Dox) cells were generated by exposure of parental drug-sensitive McF-7 or BT474 cells to gradient concentrations of drugs. correlation between LINc00160 expression and clinical response to paclitaxel in Bc patients was examined. Short interfering RNAs specifically targeting LINc00160 or TFF3 were designed to construct LINc00160- and TFF3-depleted Bc cells to discuss their effects on biological episodes of McF-7/Tax and BT474/Dox cells. Interactions among LINc00160, transcription factor c/EBP beta and TFF3 were identified. McF-7/Tax and BT474/Dox cells stable silencing of LINc00160 were transplanted into nude mice. consequently, up-regulated LINc00160 led to poor clinical response to paclitaxel in Bc patients. LINc00160 knockdown reduced drug resistance in McF-7/Tax and BT474/Dox cells and reduced cell migration and invasion. LINc00160 recruited c/EBP beta into the promoter region of TFF3 and increased TFF3 expression. LINc00160-depleted McF-7/Tax and BT474/Dox cells showed decreased tumour growth rates in nude mice. Overall, we identified a novel mechanism of LINc00160-mediated chemoresistance via the c/EBP beta/TFF3 axis, highlighting the potential of LINc00160 for treating Bc with chemoresistance.

关键词： breast cancer c EBP beta drug resistance long non-coding RNA-00160 TFF3

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New c,O-Glycosylflavones from the Genus Silene

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cHEMISTRY OF NATURAL cOMPOUNDS 2020年第6期56卷 1026-1034页

作者： Olennikov, D. N. Kashchenko, N. I. Russian Acad Sci Siberian Branch Inst Gen & Expt Biol 6 Sakhyanovoi St Ulan Ude 670047 Russia

chromatographic separation of extracts from the aerial parts of three Silene species (caryophyllaceae) isolated 26 flavonoids including the four new c,O-glycosylflavones acacetin-6-c-(2 ''-O-beta-D-glucopyranosyl)-beta-D-glucopyranoside-7-O-beta-D-glucopyranoside (sileneside D, 1) from S. jeniseensis Willd., apigenin-6-c-(2 ''-O-beta-D-glucopyranosyl)-beta-D-glucopyranoside-8-c-alpha-L-arabinopyranoside (sileneside E, 2) and genkwanin-6-c-(2 ''-O-beta-D-glucopyranosyl)-beta-D-glucopyranoside-8-c-alpha-L-arabinopyranoside (sileneside F, 3) from S. italica (L.) Pers., and apigenin-6-c-(2 ''-O-beta-D-xylopyranosyl)-beta-D-glucopyranoside-7-O-(6 ''''-O-feruloyl)-beta-D-glucopyranoside (sileneside G, 4) from S. dioica (L.) clairv. The structures of 1-4 were studied using UV, IR, and NMR spectroscopy and mass spectrometry.

关键词： Silene jeniseensis Silene italica Silene dioica caryophyllaceae c O-glycosylflavones sileneside

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介孔Ti3c2负载酞菁铁电催化剂设计及其碱性条件下氧还原性能研究（英文）

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Journal of Donghua University(English Edition) 2024年

作者：王鑫惠明明杨升元卜凡兴罗维东华大学材料科学与工程学院上海大学硅酸盐质文物保护教育部重点实验室

MXene因其高导电性、大比表面积和可调表面官能团而受到广泛关注。然而，MXene纳米片极易堆叠，其负载位点主要为面内位点，对酞菁铁（FePc）的氧还原性能提升有限。该文通过采用简单的超声液相复合策略制备了介孔MXene(Ti3c2)负载的FeP... 详细信息

MXene因其高导电性、大比表面积和可调表面官能团而受到广泛关注。然而，MXene纳米片极易堆叠，其负载位点主要为面内位点，对酞菁铁（FePc）的氧还原性能提升有限。该文通过采用简单的超声液相复合策略制备了介孔MXene(Ti3c2)负载的FePc催化剂(FePc/Meso-Ti3c2)。Meso-Ti3c2具有大量介孔和丰富的边缘位点，可优化FePc分子的四配位FeN4中心的配位环境和电子结构，并改善传质和提高活性位点的可及性，从而显著提升氧还原性能。FePc/Meso-Ti3c2展现出优异的活性和稳定性，半波电位为0.914 V vs. RHE，Tafel 斜率为57.2 mV/dec。由FePc/Meso-Ti3c2催化剂组装的锌空气电池峰值功率密度为183.1 mW/cm2，且具有高循环稳定性，性能超过商业Pt/c和FePc/Ti3c2催化剂。

关键词：介孔Ti c 酞菁铁氧还原反应边缘位点

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Microbial Shifts and Shorter Time to Bowel Resection Surgery Associated with c. difficile in Pediatric crohn's Disease

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INFLAMMATORY BOWEL DISEASES 2020年第8期26卷 1212-1221页

作者： Hellmann, Jennifer Andersen, Heidi Fei, Lin Linn, Aaron Bezold, Ramona Lake, Kathleen Jackson, Kimberly Meyer, Danielle Dirksing, Kelsie Bonkowski, Erin Ollberding, Nicholas J. Haslam, David B. Denson, Lee Cincinnati Childrens Hosp Med Ctr Div Gastroenterol Hepatol & Nutr Cincinnati OH 45229 USA Cincinnati Childrens Hosp Med Ctr Div Infect Dis Cincinnati OH 45229 USA Cincinnati Childrens Hosp Med Ctr Div Biostat & Epidemiol Dept Pediat Cincinnati OH 45229 USA Univ Cincinnati Coll Med Cincinnati OH USA

Background clostridioides difficile infection and colonization are common in pediatric crohn's disease (cD). Our aims were to test the relationship between c. difficile positivity and bowel resection surgery and to characterize microbial shifts associated with c. difficile carriage and surgery. Methods A retrospective single-center study of 75 pediatric cD patients tested for association between c. difficile carriage and bowel resection surgery. A prospective single-center study of 70 cD patients utilized c. difficile testing and shotgun metagenomic sequencing of fecal samples to define microbiota variation stratified by c. difficile carriage or history of surgery. Results The rate of bowel resection surgery increased from 21% in those without c. difficile to 67% in those with (P = 0.003). From a Kaplan-Meier survival model, the hazard ratio for time to first surgery was 4.4 (95% cI, 1.2-16.2;P = 0.00) in patients with positive c. difficile testing in the first year after diagnosis. Multivariable logistic regression analysis confirmed this association (odds ratio 16.2;95% cI, 2.2-120;P = 0.006). Larger differences in microbial abundance and metabolic pathways were observed in patients with prior surgery than in those with c. difficile carriage. Depletion of Alistipes and Ruminococcus species and reduction in methionine biosynthesis were noted in patients with both c. difficile carriage and past surgery. conclusions A positive c. difficile test during the first year after diagnosis is associated with decreased time to first bowel resection surgery in pediatric crohn's disease. Depletion of beneficial commensals and methionine biosynthesis in patients with c. difficile carriage may contribute to increased risk for surgery. In the first year after diagnosis, c. difficile is associated with shorter time to first surgery in pediatric crohn's disease. Reduction in beneficial commensals and methionine biosynthesis in those with c. difficile may contribute to this increased

关键词： c difficile infection pediatric inflammatory bowel disease bowel resection surgery shotgun metagenomic sequencing fecal microbiome

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急性脑梗死患者血清胱抑素c及凝血功能的临床检验价值分析

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中文科技期刊数据库（引文版）医药卫生 2024年第5期 0009-0012页

作者：孙承雨乌鲁木齐市中医医院新疆乌鲁木齐830000

文章的研究对象为急性脑梗死病例,采取对照分析的方式,探讨血清胱抑素c(cys c)及凝血功能临床检验的价值。方法文章所对应的研究时间是2021年1月~2023年12月,在按照时间标准先后选择了80例病例,其中有40例病例是急性脑梗死患者,另外的4... 详细信息

文章的研究对象为急性脑梗死病例,采取对照分析的方式,探讨血清胱抑素c(cys c)及凝血功能临床检验的价值。方法文章所对应的研究时间是2021年1月~2023年12月,在按照时间标准先后选择了80例病例,其中有40例病例是急性脑梗死患者,另外的40例是普通的受检者。首先,科室在第一个研究阶段精心选择了40例病例,本阶段的研究时间对应为2021年1月~2022年6月,科室设置研究组A,在A组纳入40例急性脑梗死患者,根据患者的病情,将A组患者划分为完全型(18例),进展型(22例);研究第二阶段(2022年7月~2023年12月),科室设置研究组B,在B组纳入40例健康受检者,对比两组患者在临床检验中的cys c与凝血功能指标。结果在cys c与Fg这两项指标值的对比上,明显是A组的比B组的更高(P<0.05),在APPT、PT、TT三项凝血功能相关指标的对比时,明显上B组比A组更短(P<0.05),A组Fg值显著高于B组(P<0.05)。在A组当中,cys c与Fg两项指标的对比是完全型比进展型的更短(P<0.05)。结论急性脑梗死发生以后,可以通过掌握cys c和凝血功能指标,相对准确地将患者的病情反映,大体了解患者的病后的情况,这样可以给临床提供治疗及护理干预提供可靠的依据,这也直接证明了在收治急性脑梗死患者以后,做好cys c与凝血功能检验工作很有必要。

关键词：急性脑梗死 cys c 凝血功能

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