检索结果-内蒙古大学图书馆

Management of c-shaped root canal configuration with three different obturation systems

European Journal of General Dentistry 2021年第1期4卷 25-28页

作者： Deenadayalan Elumalai Ashok Kumar Rajendra Kumar Tewari Surendra Kumar Mishra Syed Mukhtar-Un-Nisar Andrabi Huma Iftekhar Sharique Alam Department of Conservative Dentistry and Endodontics Aligarh Muslim University Aligarh Uttar Pradesh India

Unusual root canal anatomy always poses a diagnostic and treatment challenge. Identification of such variation is important for the success of the root canal treatment outcome. The c-shaped root canal configuration is one of the aberrant morphology of molar teeth, commonly the mandibular second molar. In this configuration, the canals are connected by slit or web. The presence of fin, slit and web makes through debridement obstacle for the clinician. This case reports present successful management of c-shaped mandibular molars with three different obturation systems.

关键词： c shaped canals Obtura III RealSeal resilon epiphany

来源：评论

学校读者我要写书评

暂无评论

chemical composition of crepis foetida L. and c. rubra L. volatile constituents and evaluation of the in vitro anti-inflammatory activity of salicylaldehyde rich volatile fraction

引用

BIOcHEMIcAL SYSTEMATIcS AND EcOLOGY 2021年 96卷

作者： Barda, c. Grafakou, M-E Kalpoutzakis, E. Heilmann, J. Skaltsa, H. Natl & Kapodistrian Univ Athens Sch Pharm Dept Pharmacognosy & Chem Nat Prod Athens 15771 Greece Univ Regensburg Fac Pharm & Chem Chair Pharmaceut Biol Regensburg Germany

The genus crepis L. (Asteraceae) comprises more than 200 currently recognized species. Several studies have been conducted on non-volatile phytochemicals of crepis spp., featuring mainly sesquiterpene lactones and phenolic derivatives. Nevertheless, no report has been made on assessing the volatile constituents of the genus. Therefore, the present study is the first report to the chemical composition of the volatile constituents of two odoriferous crepis spp., namely c. foetida L. and c. rubra L. Flowers and stems with leaves volatiles were analysed separately by gas chromatography coupled with mass spectrometry. In total, 37 volatile compounds were detected. Salicylaldehyde, carvacrol and aliphatic hydrocarbons are the main components of both c. foetida fractions, however c. rubra flowers are characterized by the abundance of beta-sitosterol and eicosanoic acid, while the stems-leaves volatiles revealed to be more complex with hydrocarbons as main constituents. In addition, we investigated the salicylaldehyde rich volatile fraction for its in vitro activity on TNF-alpha induced IcAM-1 expression.

关键词： crepis c foetida c rubra Gc-MS Volatile constituents

来源：评论

学校读者我要写书评

暂无评论

Remarkable enhancement of visible light driven photocatalytic performance of TiO2 by simultaneously doping with c, N, and S

引用

cHEMIcAL PHYSIcS 2021年 545卷

作者： Thi Thanh Thuy Le Dinh Trinh Tran Thi Huong Danh Qui Nhon Univ Fac Sci Dept Chem 170 Duong Vuong Str Qui Nhon Vietnam Vietnam Natl Univ Univ Sci VNU Key Lab Adv Mat Green Growth 19 Le Thanh Tong Str Hanoi Vietnam

TiO2 modified with c, N and S were produced by hydrothermal treatment and sol-gel method using thiourea as the precursor. The characteristic of the materials were examined by means of XPS, XRD, UV-VIS, SEM, EDX, and FT-IR. The results showed that c, N and S were successfully doped into TiO2 lattice, leading to a decline in recombination rate of electrons/holes, and a shift of absorption edge of TiO2 to visible light region. The photocatalytic performance of as synthesized catalysts were evaluated via the degradation of rhodamine B under visible light irradiation. N,c,S-TiO2 demonstrated the highest photocatalytic efficiency and a perspective recyclable potential. The optimal photocatalyst dose was 1.8 g/L, and the best RhB initial concentration was 20 mg/ L. At the optimal conditions, almost 100% of RhB were removed after 1.5 h. The photodegradation of RhB followed the seudo first-order kinetics, with the maximum rate constant of 0.0410 min(-1).

关键词： Titanium dioxide c N S tri-doping Visible light Photocatalytic enhancement Rhodamine B Kinetics

来源：评论

学校读者我要写书评

暂无评论

Interleukin-6 versus c-reactive Protein as Markers for Early Detection of Bacteremia in Febrile Neutropenia in Pediatric Population

引用

Indian Journal of Medical and Paediatric Oncology 2021年第5期41卷 702-706页

作者： Manasi Gupta Pushpa G Kini Y Ramesh Bhat Shrikiran Aroor Department of Paediatrics Kasturba Medical College and Hospital Manipal Academy of Higher Education Manipal Karnataka India

来源：评论

学校读者我要写书评

暂无评论

Use of c. elegans as a 3R-compliant in vivo model for the chemoprevention of cisplatin-induced neurotoxicity

引用

EXPERIMENTAL NEUROLOGY 2021年 341卷 113705页

作者： Wellenberg, Anna Weides, Lea Kurzke, Jennifer Hennecke, Till Bornhorst, Julia crone, Barbara Karst, Uwe Brinkmann, Vanessa Fritz, Gerhard Honnen, Sebastian Heinrich Heine Univ Fac Med Inst Toxicol Univ Str 1 D-40225 Dusseldorf Germany Univ Munster Inst Inorgan & Analyt Chem Corrensstr 30 D-48149 Munster Germany Univ Potsdam Inst Nutr Sci Arthur Scheunert Allee 114-116 D-14558 Nuthetal Germany Univ Wuppertal Fac Math & Nat Sci Food Chem Gaussstr 20 D-42119 Wuppertal Germany

Anticancer therapeutics can provoke severe side effects that impair the patient's quality of life. A frequent doselimiting side effect of platinum-based anticancer therapy is neurotoxicity. Its pathophysiology is poorly understood, and effective preventive or therapeutic measures are missing. Therefore, elucidation of the molecular mechanism of platinating drug-induced neurotoxicity and the development of preventive strategies is urgently needed. To this end, we aim to use c. elegans as a 3R-compliant in vivo model. The 3R principles were conceived for animal welfare in science concerning animal experiments, which should be replaced, reduced or refined. We can analytically demonstrate dose-dependent uptake of cisplatin (cisPt) in c. elegans, as well as genotoxic and cytotoxic effects based on DNA adduct formation (i.e., 1,2-GpG intrastrand crosslinks), induction of apoptosis, and developmental toxicity. Measuring the impairment of pharyngeal pumping as a marker of neurotoxicity, we found that especially cisPt reduces the pumping frequency at concentrations where basal and touch-provoked movement were not yet affected. cisPt causes glutathione (GSH) depletion and RNAi-mediated knockdown of the glutamatecysteine ligase GcS-1 aggravates the cisPt-induced inhibition of pharyngeal pumping. Moreover, N-acetylcysteine (NAc) mitigated cisPt-triggered toxicity, indicating that GSH depletion contributes to the cisPt-induced pharyngeal damage. In addition to NAc, amifostine (WR1065) also protected the pharynx of c. elegans from the toxic effects of cisPt. Measuring pharyngeal activity by the electrophysiological recording of neurotransmission in the pharynx, we confirmed that cisPt is neurotoxic in c. elegans and that NAc is neuroprotective in the nematode. The data support the hypothesis that monitoring the pharyngeal activity of c. elegans is a useful surrogate marker of cisPt-induced neurotoxicity. In addition, a low GSH pool reduces the resistance of neurons to cisPt treat

关键词： c elegans chemotherapy Neurotoxicity Platinating agents Neuroprotection 3-R principles Electrophysiological measurement

来源：评论

学校读者我要写书评

暂无评论

Explaining inter-lab variance in c. elegans N2 lifespan: Making a case for standardized reporting to enhance reproducibility

引用

EXPERIMENTAL GERONTOLOGY 2021年 156卷 111622页

作者： Urban, Nicholas D. cavataio, Joseph P. Berry, Yasmeen Vang, Brandon Maddali, Anirudh Sukpraphrute, Richard J. Schnell, Santiago Truttmann, Matthias c. Univ Michigan Dept Mol & Integrat Physiol Ann Arbor MI 48109 USA Univ Michigan Undergrad Res Opportun Program Ann Arbor MI 48109 USA Univ Michigan Geriatr Ctr Ann Arbor MI 48109 USA Univ Notre Dame Dept Biol Sci Notre Dame IN 46556 USA Univ Notre Dame Dept Appl & Computat Math & Stat Notre Dame IN 46556 USA

The nematode caenorhabditis elegans is a powerful model organism for studying cell development, apoptosis, neuronal circuits, and aging. The isolate N2 is recognized by the c. elegans community as the reference wild-type strain. Interestingly, the lifespan of presumably isogenic c. elegans N2 worms-even when grown under comparable conditions-varies significantly amongst distinct laboratories. This hinders the inter-laboratory comparability of c. elegans lifespan data and raises questions regarding data interpretation and reproducibility. Here, we hypothesized slight alterations in experimental design and worm handling could explain the observed discrepancies. To test this hypothesis, we collected and assessed data from over 1000 published c. elegans N2 lifespan assays as well as corresponding methodological meta-data. We find that mean N2 lifespans range from approximately 7 days to upwards of 35 days, despite laboratories disclosing seemingly comparable experimental conditions. We further demonstrate that, in addition to temperature, the use of the chemical sterilizer 5-fluoro-2 '-deoxyuridine (FUDR) may change N2 lifespan. Additionally, we observed differences in average N2 lifespan from experiments originating from distinct geographic locations, indicating a potential effect of location-specific factors on experimental outcomes. Taken as a whole, our work indicates the sum of many small, rather than a few critical, differences in experimental conditions may account for the observed variance in N2 lifespan. We also find that the absence of standardized experimental methods and the insufficient disclosure of experiment details in the peer-reviewed literature limits the inter-lab comparability of published results. We thus propose the establishment of a succinct reporting standard for c. elegans lifespan experiments to increase the reliability and reproducibility, and thus scientific value, of these studies.

关键词： N2 c elegans Lifespan Aging Variation Reproducibility

来源：评论

学校读者我要写书评

暂无评论

Phenolic acid metabolites of polyphenols act as inductors for hormesis in c. elegans

引用

MEcHANISMS OF AGEING AND DEVELOPMENT 2021年 198卷 111518页

作者： Dilberger, Benjamin Weppler, Selina Eckert, Gunter P. Justus Liebig Univ Giessen Biomed Res Ctr Seltersberg BFS Inst Nutr Sci Lab Nutr Prevent & Therapy Schubertstr 81 D-35392 Giessen Germany

Introduction: Aging represents a major risk factors for metabolic diseases, such as diabetes, obesity, or neurodegeneration. Polyphenols and their metabolites, especially simple phenolic acids, gained growing attention as a preventive strategy against age-related, non-communicable diseases, due to their hormetic potential. Using caenorhabditis elegans (c. elegans) we investigate the effect of protocatechuic, gallic, and vanillic acid on mitochondrial function, health parameters, and the induction of potential hormetic pathways. Methods: Lifespan, heat-stress resistance and chemotaxis of c. elegans strain P X 627, a specific model for aging, were assessed in 2-day and 10-day old nematodes. Mitochondrial membrane potential (Delta Psi m) and ATP generation were measured. mRNA expression levels of longevity and energy metabolism-related genes were determined using qRT-PcR. Results: All phenolic acids were able to significantly increase the nematodes lifespan, heat-stress resistance and chemotaxis at micromolar concentrations. While Delta Psi m was only affected by age, vanillic acid (VA) significantly decreased ATP concentrations in aged nematodes. Longevity pathways, were activated by all phenolic acids, while VA also induced glycolytic activity and response to cold. conclusion: While life- and health span parameters are positively affected by the investigated phenolic acids, the concentrations applied were unable to affect mitochondrial performance. Therefore we suggest a hormetic mode of action, especially by activation of the sirtuin-pathway.

关键词： c elegans PX627 Polyphenols Metabolites Hormesis Mitochondria

来源：评论

学校读者我要写书评

暂无评论

Nutritive Manganese and Zinc Overdosing in Aging c. elegans Result in a Metallothionein-Mediated Alteration in Metal Homeostasis

引用

MOLEcULAR NUTRITION & FOOD RESEARcH 2021年第8期65卷 e2001176页

作者： Baesler, Jessica Michaelis, Vivien Stiboller, Michael Haase, Hajo Aschner, Michael Schwerdtle, Tanja Sturzenbaum, Stephen R. Bornhorst, Julia Univ Wuppertal Food Chem Fac Math & Nat Sci Wuppertal Germany Univ Potsdam Dept Food Chem Inst Nutr Sci Nuthetal Germany TraceAge DFG Res Unit 2558 Berlin Germany TU Berlin Dept Food Chem & Toxicol Berlin Germany Albert Einstein Coll Med Dept Mol Pharmacol Neurosci & Pediat Bronx NY 10467 USA IM Sechenov First Moscow State Med Univ Moscow Russia Kings Coll London Fac Life Sci & Med Sch Populat Hlth & Environm Sci Dept Analyt Environm & Forens Sci London England

Scope Manganese (Mn) and zinc (Zn) are not only essential trace elements, but also potential exogenous risk factors for various diseases. Since the disturbed homeostasis of single metals can result in detrimental health effects, concerns have emerged regarding the consequences of excessive exposures to multiple metals, either via nutritional supplementation or parenteral nutrition. This study focuses on Mn-Zn-interactions in the nematode caenorhabditis elegans (c. elegans) model, taking into account aspects related to aging and age-dependent neurodegeneration. Methods and Results chronic co-exposure of c. elegans to Mn and Zn increases metal uptake, exceeding levels of single metal exposures. Supplementation with Mn and/or Zn also leads to an age-dependent increase in metal content, a decline in overall mRNA expression, and metal co-supplementation induced expression of target genes involved in Mn and Zn homeostasis, in particular metallothionein 1 (mtl-1). Studies in transgenic worms reveal that mtl-1 played a prominent role in mediating age- and diet-dependent alterations in metal homeostasis. Metal dyshomeostasis is further induced in parkin-deficient nematodes (Parkinson's disease (PD) model), but this did not accelerate the age-dependent dopaminergic neurodegeneration. conclusions A nutritive overdose of Mn and Zn can alter interactions between essential metals in an aging organism, and metallothionein 1 acts as a potential protective modulator in regulating homeostasis.

关键词： aging c elegans homeostasis manganese zinc

来源：评论

学校读者我要写书评

暂无评论

Distributions of Ion Density Irregularities and Their Gradients Inside Low-Latitude Ionospheric Plasma Bubbles Based on c/NOFS Planar Langmuir Probe Data

引用

SPAcE WEATHER-THE INTERNATIONAL JOURNAL OF RESEARcH AND APPLIcATIONS 2021年第3期19卷 e2020SW002644-e2020SW002644页

作者： costa, Emanoel Roddy, Patrick A. Ballenthin, John O. Pontificia Univ Catolica Rio de Janeiro PUC Rio Ctr Estudos Telecomunicacoes CETUC Rio De Janeiro Brazil Air Force Res Lab Space Vehicles Directorate Kirtland Air Rorce Base NM USA

Data from the planar Langmuir probe onboard the communication/Navigation Outage Forecasting System has been processed, with focus on the: (1) identification of Equatorial Plasma Bubbles located within the eclipse sections of the satellite orbits;(2) subdivision of each Equatorial Plasma Bubble into three sections (West Wall, center, and East Wall);and (3) statistical analyses of the standard deviations and gradients of ion density data for each section. The statistical distributions resulted from the application of the above processing to structures identified during the years October 1, 2008 to September 30, 2009 (solar minimum conditions) and June 5, 2012 to June 4, 2013 (close to maximum conditions of solar cycle 24). The statistical distributions have also been classified considering all longitudes or three 60 degrees longitude sectors in South America, Africa, India-Asia, as well as all altitudes of the c/NOFS satellite or the limited range from 650 to 800 km. It will be shown that all the parameters (Equatorial Plasma Bubble sections, solar activity, longitude sector, and altitude range) affect the resulting statistical distributions. Additionally, the probability density functions (pdfs) of ion density gradients for the EPB West Walls, centers, and East Walls and the South American longitude sector, detected during 2012 and estimated with different resolutions will be compared. While the pdfs based on 1-Hz low-resolution data (sampling large-scale structures) display east-west asymmetries, those based on the original 512-Hz high-resolution data (sampling small-scale structures), created by secondary plasma instabilities, are essentially symmetric around the reference 0 mm/km gradient.

关键词： c NOFS PLP Equatorial Plasma Bubbles standard deviations and gradients of ion density data

来源：评论

学校读者我要写书评

暂无评论

Toxocara DNA amplification in serum and tissue samples in BALB/c mice

引用

MOLEcULAR AND BIOcHEMIcAL PARASITOLOGY 2021年 246卷 111429页

作者： Rodrigues e Fonseca, Gabriela de Melo, Gessica Baptista de Paula, Fabiana Martins Malta, Fernanda Mello Borges Gryschek, Ronaldo cesar Zevallos Lescano, Susana Angelica Univ Sao Paulo Lab Invest Med Imunopatol Esquistossomose LIM 06 Hosp Clin Fac Med Av Dr Eneas Carvalho Aguiar 470 BR-05403000 Sao Paulo SP Brazil Univ Sao Paulo Inst Med Trop Fac Med Ave Dr Eneas Carvalho Aguiar 470 BR-05403000 Sao Paulo SP Brazil Univ Sao Paulo Lab Gastroenterol Clin Expt LIM 07 Hosp Clin Fac Med Av Dr Eneas Carvalho Aguiar 470 BR-05403000 Sao Paulo SP Brazil Hosp Israelita Albert Einstein Av Albert Einstein 627-701 BR-05652900 Sao Paulo SP Brazil

Toxocariasis is still a neglected parasitic disease worldwide and much about its biology and diagnosis has yet to be understood. The migration of third stage larvae via bloodstream suggests a potential use of molecular tools in diagnosis as well to deepen the knowledge about its migration behaviors. conventional PcR was applied in serum and tissue samples from BALB/c mice infected with 5 and 500 embryonated eggs. Blood samples were collected at 15, 30, 60, 90 and 120 days post-infection. Organs were excised at 170 days post infection. There was no DNA amplification in serum samples in any group or day post-infection;contrarily, tissue samples showed DNA amplification. These results also support a continuous larval migration after and/or simultaneously with the neurotropic-myotropic phase. Thus, molecular tools might be useful as a differential diagnosis method, but do not replace immunodiagnostics techniques.

关键词： PcR Toxocara Migration BALB c

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：