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cardiovascular disease and radiopharmaceutical therapies- an underestimated risk?

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 2025年第4期52卷 1246-1248页

作者： Lassmann, Michael Eberlein, Uta Verburg, Frederik A. Univ Hosp Wurzburg Dept Nucl Med D-97080 Wurzburg Germany Erasmus MC Dept Radiol & Nucl Med NL-3015 GD Rotterdam Netherlands

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cardiovascular disease in women with early-onset preeclampsia: a matched case-control study

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JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE 2025年第1期38卷 2459302页

作者： Dominguez del Olmo, P. Dominguez Herraiz, I. Villalain, C. de la Parte, B. Rodriguez-Sanchez, E. Ruiz-Hurtado, G. Fernandez-Friera, L. Morales, E. Ayala, J. L. Solis, J. Galindo, A. Univ Complutense Madrid Fac Informat Dept Comp Architecture & Automat Madrid Spain RICORS SAMID Network Maternal & Child Hlth & Dev Res Network Madrid Spain Univ Complutense Madrid 12 Octubre Univ Hosp Dept Publ & Maternal Child Hlth Madrid Spain Res Inst Hosp 12 Octubre i 12 Madrid Spain HM Hosp Ctr Integral Enfermedades Cardiovasc CIEC Madrid Spain AtriaClinic Madrid Spain CIBERCV ISCiii Madrid Spain Univ Complutense Madrid 12 Octubre Univ Hosp Dept Nephrol Madrid Spain 12 Octubre Univ Hosp Dept Cardiol Madrid Spain

Objective: To compare the risk of cardiovascular disease and the occurrence of cardiovascular events in the mid-long term after delivery, between women with and without a history of early-onset preeclampsia. Methods: A prospective case-control study has been conducted in Hospital Universitario 12 de Octubre, Madrid. 50 women with early-onset preeclampsia (diagnosed < 34 + 0 weeks) who delivered between 2008 and 2017 and a matched group (by age, parity, pregestational body mass index and date of delivery) of 50 women with uncomplicated pregnancies were recruited. In them, a 1-day visit for cardiovascular assessment was performed 3-12 years after delivery, consisting of the completion of blood and urine tests including oxidative stress analysis, vascular ultrasound to assess subclinical atherosclerosis and 24-hour blood pressure monitoring. Furthermore, Framingham10 and Framingham30 scales of cardiovascular disease risk were applied. Univariate analysis was used for comparisons, and the Kaplan-Meier method was performed to estimate their survival time until the development of a cardiovascular disease event (chronic hypertension, renal disease, myocardial infarction, thromboembolism and cerebrovascular disease). Results: Patients were evaluated at a median of 7.5 years (interquartile range, 6.5-9) after delivery. Women with a history of early-onset preeclampsia vs controls showed significantly lower levels of hemoglobin (12.9 vs 13.7 g/dL), hematocrit (38.9 vs 40.8%), prothrombin activity (93.1 vs 99.8%), IgA (223.5 vs 279.9 mg/dL) and C3 factor (101.0 vs 110.5 mg/dL) and prolongated prothrombin time (12.4 vs 11.6 s). Early-onset preeclampsia cases showed worse blood pressure control, with higher percentages of over-limit systolic blood pressure (17.9 vs. 11.2%, p < 0.01) and diastolic blood pressure (28.1 vs. 18.7%, p < 0.01) readings in 24 h. There were no significant differences in the vascular ultrasound studies as well as in the estimated cardiovascular risk obtai

关键词： cardiovascular disease chronic hypertension preeclampsia pregnancy women

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cardiovascular disease, bone fracture, and all-cause mortality risks among postmenopausal women by arthritis and veteran status: A multistate Markov transition analysis

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GEROSCIENCE 2025年 1-18页

作者： Beydoun, Hind A. Beydoun, May A. Weiss, Jordan Brunner, Robert Mishra, Nishant K. Ding, Ming Wactawski-Wende, Jean Gradidge, Philippe Jean-Luc Liu, Simin Tsai, Jack VA Natl Ctr Homelessness Vet US Dept Vet Affairs Washington DC USA Univ Texas Hlth Sci Ctr Houston Sch Publ Hlth Dept Management Policy & Community Hlth Houston TX USA Natl Inst Aging Intramural Res Program Lab Epidemiol & Populat Sci Baltimore MD USA NYU Optimal Aging Inst Grossman Sch Med New York NY USA NYU Dept Med Div Precis Med Grossman Sch Med New York NY USA Univ Nevada Reno Sch Med Dept Family & Community Med Emeritus Reno NV USA Yale Univ Sch Med Dept Neurol New Haven CT USA West Haven VA Med Ctr Dept Neurol West Haven CT USA Univ North Carolina Chapel Hill Sch Med Dept Emergency Med Chapel Hill NC USA Univ Buffalo Dept Epidemiol & Environm Hlth Buffalo NY USA Univ Witwatersrand Fac Hlth Sci Sch Therapeut Sci Dept Exercise Sci & Sports Med Johannesburg South Africa Univ Calif Irvine Joe Wen Sch Populat & Publ Hlth Dept Epidemiol & Biostat Irvine CA USA Yale Sch Med Dept Psychiat New Haven CT USA

Arthritis, a chronic inflammatory condition linked to cardiovascular disease (CVD) and bone fracture, is more frequent among military veterans and postmenopausal women. This study examined correlates of arthritis and relationships of arthritis with risks of developing CVD, bone fractures, and mortality among postmenopausal veteran and non-veteran women. We analyzed longitudinal data on 135,790 (3,436 veteran and 132,354 non-veteran) postmenopausal women from the Women's Health Initiative who were followed-up for an average of 16 years between enrollment (1993-1998) and February 17, 2024. Regression and multistate Markov modeling were applied to meet study objectives. The prevalence of arthritis at enrollment (1993-1998) did not differ by veteran status in a fully adjusted logistic model. Variable selection yielded 5 key predictors of prevalent arthritis among veterans and 15 key predictors among non-veterans. In fully-adjusted Cox models, prevalent arthritis was associated with CVD (hazard ratio [HR] = 1.08, 95% confidence interval [CI]: 1.05, 1.10) and all-cause mortality (HR = 1.03, 95% CI: 1.01, 1.05) risks among non-veterans only, but was not associated with bone fracture risk irrespective of veteran status. Transition probabilities between health and CVD and between bone fracture and death were higher among women with vs. without arthritis. The latter transition was more strongly related to arthritis among non-veteran vs. veteran women. In conclusion, among postmenopausal women, prevalent arthritis was associated with greater probabilities of transitioning from a healthy state to CVD and from bone fracture to death, with worse prognosis after bone fracture among those who did not serve in the military.

关键词： Arthritis Bone fracture cardiovascular disease Menopause Multistate Veteran

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cardiovascular disease morbidity is associated with social deprivation in subjects with familial hypercholesterolaemia (FH): A retrospective cohort study of individuals with FH in UK primary care and the UK Simon Broome register, linked with national hospital records

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ATHEROSCLEROSIS 2025年 403卷 119142-119142页

作者： Iyen, B. Qureshi, N. Kai, J. Capps, N. Durrington, P. N. Cegla, J. Soran, H. Schofield, J. Neil, H. A. W. Humphries, S. E. Univ Nottingham Ctr Acad Primary Care Sch Med Nottingham England Princess Royal Hosp Shrewsbury & Telford Hosp NHS Trust Clin Biochem Telford England Univ Manchester Cardiovasc Res Grp Manchester England Imperial Coll London Div Diabet Endocrinol & Metab London England Manchester Univ NHS Fdn Trust Manchester England Univ Oxford Wolfson Coll Oxford England UCL Inst Cardiovasc Sci Ctr Cardiovasc Genet London England

Background: Social deprivation is associated with higher cardiovascular disease (CVD) morbidity and mortality. We examined whether this is also observed in people with Familial Hypercholesterolaemia (FH). Methods: Subjects with FH and linked secondary care records in Hospital Episode Statistics (HES) were identified from UK Clinical Practice Research Datalink (CPRD) and the Simon Broome (SB) adult FH register. Cox proportional hazards regression estimated hazard ratios (HR) for composite CVD outcomes (first HES outcome of coronary heart disease, myocardial infarction, angina, stroke, transient ischaemic attack, peripheral vascular disease, heart failure, coronary revascularisation interventions (PCI and CABG)) in Index of Multiple Deprivation (IMD) quintiles. Results: We identified 4309 patients with FH in CPRD (1988-2020) and 2956 in the SB register. Both cohorts had considerably fewer subjects in the most deprived compared to the least deprived quintile (60 % lower in CPRD and 52 % lower in SB). In CPRD, the most deprived individuals had higher unadjusted HRs for composite CVD (HR 1.71 [CI 1.22-2.40]), coronary heart disease (HR 1.63 [1.11-2.40]) and mortality (HR 1.58 [1.02-2.47]) compared to the least deprived but these became insignificant after adjusting for age, sex, smoking and alcohol consumption. In the SB register, hazard ratios for composite CVD increased with increasing deprivation quintiles and remained significant after adjustment for age, sex, smoking and alcohol consumption (adjusted HR in quintile 5 vs quintile 1 = 1.83 [1.54-2.17]). Conclusions: Strikingly fewer individuals with FH are identified from lower socioeconomic groups, though the most deprived FH patients have the highest risk of CVD and mortality. In CPRD, this risk was largely explained by smoking and alcohol consumption, but not in the SB register. More effective strategies to detect FH and optimise risk factor management, are needed in lower socioeconomic groups.

关键词： Familial hypercholesterolaemia Deprivation cardiovascular disease Lifestyle Smoking Alcohol

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cardiovascular disease essential medicines listing by countries: changes over time and association with health outcomes

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BMC cardiovascular DISORDERS 2025年第1期25卷 1-11页

作者： Heredia, Camila Ul Haq, Moizza Zia Buadu, Adelaide Rizvi, Amal Workentin, Aine Persaud, Navindra Unity Hlth Toronto St Michaels Hosp Li Ka Shing Knowledge Inst MAP Ctr Urban Hlth Solut 80 Bond St Toronto ON M5B 1X2 Canada Univ Toronto Fac Med Dept Family & Community Med Toronto ON Canada

BackgroundSince national essential medicine lists guide the procurement of medicines for populations in many countries, and cardiovascular diseases are the leading cause of death globally, including cardiovascular medicines on these lists can significantly impact healthcare *** this cross-sectional study, national essential medicines' lists from 158 countries were analysed on whether or not they included medicines to treat ischemic heart disease, cerebrovascular disease, and hypertensive heart disease. A linear regression model was used to evaluate the association between countries' coverage scores and amenable *** of cardiovascular disease treatment was associated with amenable mortality from hypertensive heart disease. Health expenditure per capita was also associated with amendable mortality due to ischemic heart disease, and hypertensive heart *** essential medicines for cardiovascular disease is an important aspect of healthcare quality that is associated with cardiovascular mortality.

关键词： Essential medicines cardiovascular disease Ischemic heart disease Cerebrovascular disease Hypertensive heart disease Amenable mortality

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cardiovascular disease risk in Korean patients with systemic lupus erythematosus compared to diabetes mellitus and the general population

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SCIENTIFIC REPORTS 2025年第1期15卷 1-10页

作者： Han, Jung-Yong Cho, Soo-Kyung Jeon, Yena Kang, Gaeun Jung, Sun-Young Jang, Eun Jin Sung, Yoon-Kyoung Hanyang Univ Hosp Rheumat Dis Dept Rheumatol Seoul 04763 South Korea Hanyang Univ Inst Rheumatol Res Seoul South Korea Kyungpook Natl Univ Dept Stat Daegu South Korea Chung Ang Univ Coll Pharm Seoul South Korea Andong Natl Univ Dept Informat Stat Andong South Korea

To evaluate the incidence and risk of cardiovascular disease (CVD) among Korean patients with systemic lupus erythematosus (SLE) comparing them to diabetes patients and the general population. This nationwide cohort study focused on incident SLE patients aged over 40 years, matched with diabetes patients and the general population (1:4:4 ratio). CVD was defined as ischaemic heart disease, ischaemic stroke, and cardiac arrest. Incidence rate and incidence rate ratio (IRR) of CVD were calculated using generalised estimating equation models. The Fine-Gray model assessed risk factors for CVD in both SLE and diabetes patients. The study included 4272 incident SLE patients, 17,003 diabetes patients, and 17,088 from the general population. SLE patients had higher CVD risk compared to the general population, with adjusted IRRs of 1.99 for overall CVD. Diabetes patients showed increased CVD risk, but to a lesser extent, with an IRR of 1.39. SLE patients aged 40-59 years displayed a significantly elevated CVD risk. Advanced age, male gender, and current use of glucocorticoids, immunosuppressive, and anti-platelet agents were associated with increased CVD risk in SLE patients. SLE patients have a higher risk of CVD compared to the general population, more so than diabetes patients.

关键词： Systemic lupus erythematosus cardiovascular disease Diabetes mellitus

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cardiovascular disease attenuates the protective effect of folate on global cognitive function in an elderly population: a cross-sectional study

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SCIENTIFIC REPORTS 2025年第1期15卷 1-14页

作者： Zhang, Jianqiang Yue, Di Zhang, Huifeng Henan Univ Sci & Technol Affiliated Hosp 1 Dept Neurol Luoyang Peoples R China Henan Univ Sci & Technol Coll Clin Med 24 Jinghua Rd Luoyang Henan Peoples R China Henan Univ Sci & Technol Affiliated Hosp 1 Dept Med Intens Care Unit Luoyang Peoples R China Shanghai Univ Finance & Econ Sch Math Shanghai Peoples R China Henan Univ Sci & Technol Affiliated Hosp 1 Dept Cardiovasc 24 Jinghua Rd Luoyang Henan Peoples R China

Research suggests that folic acid contributes to improving cognitive function. However, there is a lack of systematic research on the association of dietary intake of folate and serum, and red blood cell (RBC) folate levels with global cognitive impairment (CoI) in the elderly population. Importantly, excessive supplementation with folate among American adults at high risk of cardiovascular disease (CVD) may have harmful effects. CVD often leads to worse cognitive function;therefore, it is necessary to explore the characteristics of the association of folate with CoI in both CVD and non-CVD populations. Participants aged >= 60 years from the national health and nutrition examination survey (NHANES) 2011-2014 were included. Dietary intake of folate and serum and RBC folate levels were determined through questionnaires or laboratory measurements. Global cognitive function was assessed via the results of three cognitive assessments. Multivariable logistic regression and restricted cubic splines (RCS) were employed to assess the odds ratios (ORs), 95% confidence intervals (CIs), and potential non-linearities of folate with cognition. Additionally, the interaction term of CVD with RBC folate was included in the model, and effect modification was detected through likelihood ratio tests. Finally, several sensitivity analyses were conducted to validate our findings. This study included 2104 participants with complete data and a median age of 68 years, with females comprising 51% of the participants. Of the participants, 444 individuals were defined as having CoI. In the NHANES, Pearson correlation analysis revealed moderate to weak correlations between dietary, serum, and RBC folate levels and CoI (all < 0.6). In addition, when different sources of folate were included separately in the models, fully adjusted logistic regression with continuous variables included in the model revealed that only RBC folate was significantly associated with CoI [odds ratio (OR) 0.86, 95% conf

关键词： Folate Folic acid Cognitive impairment cardiovascular disease Cross-sectional study NHANES

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cardiovascular disease in the Americas: optimizing primary and secondary prevention of cardiovascular disease series: cardiovascular disease in the Americas

LANCET REGIONAL HEALTH-AMERICAS

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LANCET REGIONAL HEALTH-AMERICAS 2025年 42卷 100964-100964页

作者： Schwalm, J. D. Joseph, Philip Leong, Darryl Lopez-Lopez, Jose Patricio Onuma, Oyere Bhatt, Palki Avezum, Alvaro Walli-Attaei, Marjan Mckee, Martin Salim, Yusuf McMaster Univ Populat Hlth Res Inst Hamilton ON Canada Hamilton Hlth Sci Hamilton ON Canada Hamilton Hlth Sci Ctr Evidence Based Implementat Hamilton ON Canada Univ Santander UDES Masira Res Inst Bucaramanga Colombia McMaster Univ Dept Med Hamilton ON Canada Massachusetts Gen Hosp Boston MA USA Hosp Alemao Oswaldo Cruz Int Res Ctr Sao Paulo SP Brazil Univ Oxford Hlth Econ Res Ctr Nuffield Dept Populat Hlth Old Rd Campus Oxford England London Sch Hyg & Trop Med Dept Publ Hlth & Policy London England

While, many interventions can prevent cardiovascular disease (CVD), and its resulting morbidity or mortality, these are used sub-optimally in most countries. Therefore, health systems need to develop new approaches to ensure that proven CVD therapies are delivered widely. In this review, we describe five impactful implementation strategies which include: (1) Task shifting, (2) Use of mobile-Health (mHealth) support and virtual access to care, (3) simplified diagnostic and management algorithms for the prevention of CVD, (4) improving the use of combinations of medicines (i.e., polypill), and (5) patient engagement and role of patient-nominated peer support (i.e., treatment supporters). Adapting and tailoring these strategies to the local context in different settings in various countries in the Americas and the Caribbean can reduce the morbidity and mortality of CVD substantially. Copyright (c) 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).

关键词： cardiovascular disease Primary prevention Secondary prevention Implementation

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cardiovascular disease Prediction Using Particle Swarm Optimization and Neural Network Based an Integrated Framework

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SN Computer Science 2025年第2期6卷 1-15页

作者： Reddy, S. Ramchandra Murthy, G. Vishnu Department of Computer Science and Engineering Anurag University Telangana Hyderabad 500088 India

cardiovascular diseases (CVD) are among the leading causes of mortality globally, posing significant challenges to healthcare systems. Therefore, this paper introduces a novel framework, cardiovascular disease Prediction using Particle Swarm Optimization and Neural Network based an Integrated Framework (PSO-NN) for CVD prediction, combining Particle Swarm Optimization and Neural Networks (PSO-NN). The PSO-NN framework enhances prediction accuracy by addressing missing data through mean replacement techniques and managing data imbalances via a tailored cost function. Additionally, it utilizes Feature Importance methods for optimal feature selection. Comparative analyses reveal that PSO-NN consistently outperforms traditional models, such as k-Nearest Neighbors, Gradient Boosting Classifier, Random Forest, Hybrid Bagging and Boosting Classifier, Decision Tree Classifier, Support Vector Machines, Firefly Algorithm, Sine Cosine Algorithm, Bat Algorithm, Harris Hawks Optimization, Crow Search Algorithm, Artificial Bee Colony, and Flower Pollination Algorithm by achieving superior cost and model score computation results of 30%, 20%, 25%, 15%, 21%, 12%, 20%, 15%, 15%, 12%, 13%, 10%, 10%, and 14.64, 26.17, 28.41, 28.9, 35.97, 41.45, 20%, 25%, 22%, 28%, 25%, 20%, and 20%, respectively. These results establish PSO-NN as a reliable tool for early CVD diagnosis in real-world applications. © The Author(s), under exclusive licence to Springer Nature Singapore Pte Ltd. 2025.

关键词： Boost cardiovascular disease cardiovascular prediction Cost Deep learning Integration Machine learning

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cardiovascular disease in Tactical Athletes: A Focused Review on First Responders

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CURRENT TREATMENT OPTIONS IN cardiovascular MEDICINE 2025年第1期27卷 1-11页

作者： Phillips, Tarin C. Husaini, Mustafa Tayon, Kevin G. Kales, Stefanos N. Smith, Denise L. Elfessi, Nadia M. Petek, Bradley J. Dineen, Elizabeth H. Naval Undersea Med Inst Groton CT USA Washington Univ St Louis St Louis MO USA Mayo Clin Florida Jacksonville FL 32224 USA Harvard Med Sch Harvard TH Chan Sch Publ Hlth Cambridge Hlth Alliance Boston MA USA Skidmore Coll Saratoga Springs NY 12866 USA Mayo Clin Rochester Rochester NY USA Oregon Hlth & Sci Univ Knight Cardiovasc Inst Sports Cardiol Program Portland OR 97239 USA

Purpose of ReviewTo provide the reader with an understanding of sudden cardiac death (SCD), cardiovascular risk factors, and unique occupational stressors among tactical athletes, herein referring specifically to first responders, including firefighters, law enforcement officers, and emergency medical services (EMS) *** FindingsTactical athletes experience SCD at increasing rates with age with the highest risks observed during strenuous emergency responses. cardiovascular risk factors are often underdiagnosed and inadequately managed, compounded by unique occupational exposures that may contribute to SCD risk. Pre-employment and periodic medical and fitness screening requirements vary widely across tactical athlete communities and employers/*** research is required to better elucidate SCD rates and risk mitigation strategies among this population to optimize first responder health and ensure public safety. Collaboration and advocacy are essential to establish minimum medical and fitness screening requirements and to implement these standards broadly across all tactical athlete communities.

关键词： cardiovascular disease Tactical athlete Firefighter Police EMS Risk mitigation

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