The model describing the binding of three ligands to the sites of a receptor is theoretically studied in order to characterize the binding interaction between two unlabelled ligands. For this, the binding of a third l...
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The model describing the binding of three ligands to the sites of a receptor is theoretically studied in order to characterize the binding interaction between two unlabelled ligands. For this, the binding of a third labelled ligand, the affinity of which is dependent on the presence of the unlabelled ligands, must be measured in different conditions. This paper describes an experimental strategy leading to an accurate determination of the equilibrium parameters of the model. This strategy, which assumes that the model is compatible with the data, rests on the determination of the optimal experimental conditions, i.e. the choice of the ligand concentrations which minimize the error of the parameter estimates. For this purpose, a computer program which runs on a microcomputer under the MS-DOS operating system has been elaborated on the basis of the D-optimization criterion. This work shows that such a computer analysis is essential to the determination of the optimal experimental design, even when very simple biochemical systems are considered.
A computer algorithm is explained in order to determine the performance of capacitor self-excited induction generators (SEIG) taking the machine design details as the input data. The magnetisation characteristic which...
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A computer algorithm is explained in order to determine the performance of capacitor self-excited induction generators (SEIG) taking the machine design details as the input data. The magnetisation characteristic which forms the basis of analysis is obtained using theB/Hcurve of the core material and by employing a curve-fitting technique. The predicted parameter and performance characteristics of a normal induction motor operating as SEIG are compared with corresponding experimental results. Effects of variation of realistic design parameters are studied to obtain guidelines on optimum design. Typical results on a range of normal induction machines are presented to assess their suitability as SEIG.
Many power system circuits contain iron cored coils, which are common nonlinear circuit elements. Systems engineers have to model these elements while studying such phenomena as inrush current, ferroresonance, subharm...
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Many power system circuits contain iron cored coils, which are common nonlinear circuit elements. Systems engineers have to model these elements while studying such phenomena as inrush current, ferroresonance, subharmonics etc. The nonlinearity involved in these elements cannot be appropriately taken into account unless due regard is given to the damping effects on account of hysteresis. This paper attempts to simulate digitally the appropriate paths ofB/Hexcursions in a piecewise linear manner when the magnetic core is subjected to random variations of magnetic field intensity and sets up a computer algorithm. The algorithm may be used in digital analysis of systems containing iron cored coils.
Deals with the analysis of arbitrarily shaped microstrip antennas. A powerful and flexible technique is obtained by combining a mixed potential integral equation, successfully used for rectangular patches, with a meth...
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Deals with the analysis of arbitrarily shaped microstrip antennas. A powerful and flexible technique is obtained by combining a mixed potential integral equation, successfully used for rectangular patches, with a method of moments, using a division of the patch into triangular cells and overlapping basis functions, defined over cell couples. The resulting computer algorithm is validated by comparing its predictions with the measurements obtained from an equilateral triangular patch
作者：
ZERGAW, GUNIV KENT
SCH MATH STUDIES DEPT STAT CANTERBURY CT2 7NF KENT ENGLAND
Based on simple updating formulae, a computer algorithm for searching optimal designs when the errors are believed to be serially correlated in the one-dimensional situation is described. The performance of the design...
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Based on simple updating formulae, a computer algorithm for searching optimal designs when the errors are believed to be serially correlated in the one-dimensional situation is described. The performance of the designs found by the algorithm is compared with the optimal designs avaiable in the literature.
Since its development as a practical procedure, autoradiography has proved to be one of the most powerful analytic techniques in cell biology. One of its principal advantages is that it can be used to obtain quantitat...
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Since its development as a practical procedure, autoradiography has proved to be one of the most powerful analytic techniques in cell biology. One of its principal advantages is that it can be used to obtain quantitative as well as qualitative data, since under standardized conditions the amount of radioactivity in the tissue is directly related to the number of silver grains in the overlying emulsion. In order to do this, it is necessary to directly count or otherwise estimate the relative density of grains in different regions of the autoradiograms. As visual counting of silver grains is usually slow and always tedious, one does need semi-automated or even fully automated systems for estimating the silver grain *** this thesis, we have addressed the problem of developing an automated system for estimating the grain count over specific areas outlined by the user on the image. We have developed two methodsMethod 1:1) We have developed a computer algorithm for evaluating the area fraction of the grains and the mean and rms of the grey value over measuring windows placed by the user on the image and have used these parameters as estimates of the grain count.2) We have made a comparitive study of the performance of this algorithm for different combinations of optics and magnification to determine the combination of optics and magnification that gives the best estimate of the grain *** 2:1) We have developed a statistical model for the grey level distribution, due to the grains over an area on the image.2) We have used a nonlinear optimization technique to estimate the parameters of the distribution and have used these parameters to estimate the grain count.
ABSTRACT: A mechanical drum‐type data logger registers data on a recording chart in graphic form. Subsequent computer analysis requires that the data be transformed into digital form. Besides the traditional manual c...
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A real-time computer algorithm to control and optimize aircraft flight profiles is described and applied to a three-dimensional minimum-time intercept mission. The proposed scheme has roots in two well-known technique...
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This paper describes a method for designing a controller with improved robustness with respect to truncated flexible modes. The approach involves minimization of a quadratic performance index subject to constraints in...
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This paper describes a method for designing a controller with improved robustness with respect to truncated flexible modes. The approach involves minimization of a quadratic performance index subject to constraints in the frequency domain. The frequency domain criteria are chosen so as to sufficiently attenuate the high frequency response of the full dynamic system while attempting to maintain the overall performance of the closed-loop system. The resulting constraint relationships are cast into a functional minimization framework and parameter optimization techniques are used to determine the solution. (Author)
Clinical measurement of periodontitis has historically focused on the concept of periodontitis as a slow, continuous process which has emphasized measurements of the static condition of periodontal pockets. Observatio...
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Clinical measurement of periodontitis has historically focused on the concept of periodontitis as a slow, continuous process which has emphasized measurements of the static condition of periodontal pockets. Observations based on longitudinal measurement of attachment loss in untreated subjects have indicated that periodontal destruction occurs in discrete episodes of short duration. Based on these studies, it has been suggested that chronic periodontal disease proceeds through a series of random episodic attacks. Periodontal sites are considered as existing in 2 states, either disease active or inactive. During periods of disease activity, sites increase in their probeable depth, whereas during the inactive state, no significant change in probing depth can be detected. The detection of changes at periodontal sites from time series data has been addressed by 3 analytical procedures: regression, running medians, and tolerance. The standard deviation of differences between replicate measurements of 48, 064 sites for 56 subjects was 0.7727 mm. From this estimate, the computed standard deviation for a single measurement was 0.5464 mm and for the mean of 2 measurements was 0.386 mm. The expected error rates of each method have been estimated by computer simulation. The type‐I error for the regression (p=0.028), running median (p=0.000025), and tolerance (p=0.00012) methods were all sufficiently low to consider it unlikely that reported observations could be accounted for by methodologic error. The estimated type‐II error for the regression (p=0.446), running median p=0.152), and tolerance p=0.068) methods suggests that a substantial fraction of disease active sites was not detected by these methods. Several data set properties have been investigated. Intraclass correlation coefficients were computed from attachment level changes on 8,130 sites in 105 patients. By this analysis, 7% of the variation was associated with the subject and 93.3% with the individual sites, indica
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