A generalized interactive computer program (CNVSPI) is presented that enables the analyst to apply several methods for multicomponent analysis using conventional absorbance as well as orthogonal polynomials coefficien...
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A generalized interactive computer program (CNVSPI) is presented that enables the analyst to apply several methods for multicomponent analysis using conventional absorbance as well as orthogonal polynomials coefficients. The program performs the following : (i) stores data collected from spectrophotometer ,(II) processes data already stored in a file which include convolution with orthogonal polynomials, solving simultaneous linear equations and applying the least squares principle and (iii) displays data on screen, printer and plotter. Using that program multicomponent spectrophotometric methods have been applied to assay four component mixture in different matrices.
An interactive computer program is described which permits computation of platelet survivals based on the gamma function model of Murphy. An additional feature permits the treatment of other labeled proteins, e.g., fi...
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An interactive computer program is described which permits computation of platelet survivals based on the gamma function model of Murphy. An additional feature permits the treatment of other labeled proteins, e.g., fibrinogen, disappearing via an exponential process. The program requires no prior computer background, and typical determinations of survivals can be effected in about 5 min, representing a substantial enhancement to the gamma function program as currently provided by the International Committee for the Standardization of Hematology. Provision was also made for modifications to meet individual needs. The program is described in sufficient detail, including sample calculations, to permit evaluation for possible applications.
Designing parameters of blasting is the procedure using mathematical equations, intuition and experience of the blaster. To simplify design parameters of blasting the author has worked out a computer program which sim...
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Designing parameters of blasting is the procedure using mathematical equations, intuition and experience of the blaster. To simplify design parameters of blasting the author has worked out a computer program which simulates propagating of explosion energy in the rock massif, The result of the model is a state of basic construction elements of the rock model after modelled blasting.
A BASIC computer program for calculating ED50 and LD50 values and their confidence limits by probit analysis and weighted linear regression is presented. It also includes the Chi square procedure for testing the mathe...
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A BASIC computer program for calculating ED50 and LD50 values and their confidence limits by probit analysis and weighted linear regression is presented. It also includes the Chi square procedure for testing the mathematical model and allows on-screen high resolution graphic display. The portable program can easily be modified for use in different models of microcomputers.
Standardisation is an essential procedure to eliminate the effect of confounding when comparisons between populations are carried out, where a standard population is used as a reference. There are two methods of stand...
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Standardisation is an essential procedure to eliminate the effect of confounding when comparisons between populations are carried out, where a standard population is used as a reference. There are two methods of standardisation, i.e., direct and indirect standardisation. Standardisation is commonly used in epidemiology studies especially when the morbidity or/and mortality rates of a disease are studied. A computer program (StdAn) which aims to simplify the process of standardisation of population morbidity data was developed with Microsoft Visual Studio 2010 Express software, using C++/CLI (C++ on common language infrastructure) as the programming language. StdAn program provides a graphically easy-to-use interface for the implementation of standardisation analysis. It is simple, practical and easy to interpret.
A computer program for use in the conversion of electron probe X-ray intensity ratios into chemical compositions has been written. The inclusion of several of the more successful correction procedures facilitates the ...
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A computer program for use in the conversion of electron probe X-ray intensity ratios into chemical compositions has been written. The inclusion of several of the more successful correction procedures facilitates the comparison of these procedures and allows an investigator to select the correction procedure which will give the best results for the system being studied. Theoretical calibration calculations of the intensity ratio versus composition can be performed and these results can be plotted by machine. The program has been designed to be as versatile as possible and still retain simple experimental input requirements. Some results obtained using recently published correction procedure are discussed.
Objective: To assess the impact of the setting-up of a computer program designed by the Hospital Pharmacy Department as a tool that provides information for the antimicrobial therapy monitoring. To assess its influenc...
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Objective: To assess the impact of the setting-up of a computer program designed by the Hospital Pharmacy Department as a tool that provides information for the antimicrobial therapy monitoring. To assess its influence on pharmaceutical costs. Material and method: The computer application for the follow-up of antimicrobial treatments integrates information from the Pharmacy Department and the Microbiology Laboratory and selects all patients to whom some controlled antibiotic has been prescribed. The pharmacist reviews all the controlled antibiotic treatments, suggests any change to the physician if needed and quantifies the economic impact of the accepted interventions. Results: On average, 12.5% of controlled antibiotic treatments warranted a pharmaceutical intervention, and 92% of them were accepted. The most frequent interventions related to prescriptions were change of dosage and administration route and related to the disease were in respiratory and urinary tract infections. From the economic point of view, the accepted interventions represented a saving of 12,087,029 pesetas (83,359 $)/year, on average. Conclusion: The applied computer program resulted a useful tool for a clinical pharmacist to reach more correct antibiotical therapeutics and better cost-effectiveness relation. It also helped to achieve favorable clinical outcomes.
The Basso, Beattie and Bresnahan (BBB) Locomotor Rating Scale is a standardized assessment scale for use in experimental spinal cord injury (SCI) research. This paper describes a computer program, ScoreCentre, which a...
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The Basso, Beattie and Bresnahan (BBB) Locomotor Rating Scale is a standardized assessment scale for use in experimental spinal cord injury (SCI) research. This paper describes a computer program, ScoreCentre, which aims to simplify the recording and handling of BBB locomotor scale data. The program assists with the recording of observational data from open-field testing and then automatically calculates BBB scores. Possible errors associated with data entry and manual calculation of scores are thus essentially eliminated. In addition, significant time is saved by the automated derivation of scores and subscores and elimination of the need to manually transfer data from paper records to a computer. ScoreCentre can also be used as a training aid, to help familiarize users with the BBB scale and to explore how changes in the observations impact on overall BBB score. ScoreCentre includes simple experiment management functions such as control of trial blinding, administration of drugs in a blinded fashion and longitudinal data analysis. ScoreCentre provides all the advantages of electronic records, such as ease of use, analysis and archiving, and allows the elimination of paper records if appropriate. When paper records are required, for example for archiving and auditing, they can be automatically produced by ScoreCentre. ScoreCentre will assist with both the learning and use of the BBB locomotor scale, thus facilitating the use of this standardized outcome measure in SCI research. ScoreCentre is available to download from ***/scorecentre. (C) 2010 Elsevier B.V. All rights reserved.
Modularly assembled combinatorial libraries are often used to identify ligands that bind to and modulate the function of a protein or a nucleic acid. Much of the data from screening these compounds, however, is not ef...
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Modularly assembled combinatorial libraries are often used to identify ligands that bind to and modulate the function of a protein or a nucleic acid. Much of the data from screening these compounds, however, is not efficiently utilized to de. ne structure-activity relationships (SAR). If SAR data are accurately constructed, it can enable the design of more potent binders. Herein, we describe a computer program called Privileged Chemical Space Predictor (PCSP) that statistically determines SAR from high-throughput screening (HTS) data and then identifies features in small molecules that predispose them for binding a target. Features are scored for statistical significance and can be utilized to design improved second generation compounds or more target-focused libraries. The program's utility is demonstrated through analysis of a modularly assembled peptoid library that previously was screened for binding to and inhibiting a group I intron RNA from the fungal pathogen Candida albicans. (C) 2010 Elsevier Ltd. All rights reserved.
Chronic suppurative otitis media is characterized by the presence of a persistent perforation of the tympanic membrane. Accurate estimation of the perforation size is helpful in clinical management and research. In th...
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Chronic suppurative otitis media is characterized by the presence of a persistent perforation of the tympanic membrane. Accurate estimation of the perforation size is helpful in clinical management and research. In this study, a computer program was developed to calculate the percentage of a perforation relative to the whole tympanic membrane including the pars tensa and pars flaccida. In order to demonstrate the variability of estimations of perforation size by different surgeons, we calculated the percentage of perforation for four tympanic membranes, and compared the results with those estimated by five experienced otologists and 10 senior residents. The results show that the estimations from both otologists and residents departed from the values calculated by the computer program quite substantially. Beside, the variance of the estimation is large. However, the variances of computer calculation are quite small, which means that the results obtain from different users are quite consistent. Therefore, we concluded that this program is necessary and useful to evaluate the size of the perforation as the differences in visual estimations can be very big and the variances can be large for different individuals, even by experienced otologists.
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