The effect of endotoxin induced fever on the “steady state” concentration of sulphadimethoxine in pigs has been *** 20 mg/kg ***. was injected at 9 a.m. in an ear vein each day for eleven days. From day 6 until the ...
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The effect of endotoxin induced fever on the “steady state” concentration of sulphadimethoxine in pigs has been *** 20 mg/kg ***. was injected at 9 a.m. in an ear vein each day for eleven days. From day 6 until the end of the experiment, endotoxin fromEscherichia coli 1.5 μg/kg ***. was injected at 9 a.m. and at 3 p.m. The plasma concentration versus time curves were calculated by means of a computer program, assuming a two-compartment model. During the endotoxin injections the plasma concentrations were simulated and compared with those *** was not possible to show any clinically significant changes in pharmacokinetics of sulphadimethoxine after the start of endotoxin injections.
A new computational method using a Monte Carlo technique is described for the calculation of plausibility of paternity in blood group systems. Gene frequencies of a blood group system are simulated by the range of 7 d...
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A new computational method using a Monte Carlo technique is described for the calculation of plausibility of paternity in blood group systems. Gene frequencies of a blood group system are simulated by the range of 7 digit random numbers. By using a Monte Carlo method, 4 random numbers are generated and converted into paternal and maternal genotypes. The genotype of the child is determined according to the law of inheritance and genotypes of the father, mother and child are converted into phenotypes. Repeating this process more than 100,000 times, the phenotypic frequencies of child-mother-father combinations (trio) and the likelihood ratio of paternity in any blood group system are calculated for all phenotypic combinations of the trios. This method is easier than methods reported previously, and is sufficiently accurate.
The program which is written in FORTRAN estimates haplotype frequencies in two-locus and three-locus genetic systems from population diploid data. It is based on the gene counting method which leads to maximum likelih...
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Phenotypes in an ABO-like system of a number of genetically-independent persons from a number of populations are supposed to be observed. The program which is written in FORTRAN calculates maximum likelihood estimates...
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The analysis of differences in occurrence of antibiotic-resistant strains belonging to ten species of “problem” bacteria was performed by means of a computer program in more than 150,000 bacterial strains isolated i...
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The analysis of differences in occurrence of antibiotic-resistant strains belonging to ten species of “problem” bacteria was performed by means of a computer program in more than 150,000 bacterial strains isolated in Slovakia in 1977. In all respects, strains isolated in general medical practice were considerably more sensitive to classical as well as to newer antibiotics. Marked differences in resistance within individual medical services could be a reflection of both quantitative and qualitative aspects of the use of a given antibiotic. Urological and surgical wards, and in some respects pediatric and infectious diseases services, rendered the highest percentage of strains resistant to various drugs. There are still several antibiotics which are effective in vitro against staphylococci, while gentamicin, colistin and cotrimoxazole are the only antibiotics displaying more general activity against gram-negative “problem” bacteria. Nevertheless, strains from general practice show a good response in vitro, even to older antibiotics, despite the fact that these have been widely used for decades in general practice.
This paper presents the results of computations of wave loads on fixed antifloating structures using three-dimensional, sink-source techniques (diffraction theory). Theoretical calculations are compared with model exp...
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This paper presents the results of computations of wave loads on fixed antifloating structures using three-dimensional, sink-source techniques (diffraction theory). Theoretical calculations are compared with model experiments. Statistical methods are discussed also. Introduction Basic contributions to the use of three-dimensional diffraction theory are the studies of Lebreton and Cormault and Garrison and Seetharama Rao. Since their presentations, this method increasingly has become the predominant technique for handling wave-induced loads on large offshore structures of arbitrary form. However, strip theories based on two-dimensional (diffraction) solutions have been applied in ship design to determine responses in regular waves for some time. The linear superposition technique proposed by St. Denis and Pierson normally is used to determine the responses in irregular seas. Different computer programs have been developed on the basis of the method proposed by Lebreton and Cormault. This paper presents the applications of a computer program and information gained from experimental program and information gained from experimental results. Computations of short-term responses in irregular seas using different wave-spectrum formulations are included also. This procedure has not been prominent in the design of large offshore structures yet, although it long has been used widely in ship design. Theoretical Formulation A review of the basic equations used in the diffraction theory program is presented in the following section. The Equations of Motions The motions of a floating structure are derived from the condition of dynamic equilibrium between excitation and restoring and the damping and inertial reactions of the system. Assuming that the system is harmonic, the six coupled linear differential equations of motions may be written as 6 -iwt (mjl + mjl ) nl + Wjl nl + Cjl Nl = Fje. l=1 .................................(1) Here, mj is the component of the generalized mass
This paper describes a general-purpose computer program developed to determine ultimate load capacities in tubular steel beam-columns. An analytical model and a computer method are presented also. Analytical results a...
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This paper describes a general-purpose computer program developed to determine ultimate load capacities in tubular steel beam-columns. An analytical model and a computer method are presented also. Analytical results are compared with published test data and the experimental data obtained in this investigation. Introduction Previous investigators have shown that tubular members Previous investigators have shown that tubular members of annular shapes exhibit structural characteristics markedly different from wide-flange shapes when subjected to loads that cause stresses above first yield. Methods for calculating failure loads and developing interaction diagrams for wide-flange members used as beam-columns have been developed and are used in design practice currently. Because the same type of technique practice currently. Because the same type of technique for tubular members is not available now, an investigation as launched to develop an analytical tool. This took the form of a computer program that could be used to generate load displacement histories and to calculate failure loads of circular steel tubes subjected to the combined effects of axial force and flexure. This study briefly documents the development of the mathematical model and presents experimental data verifying the results of this computer program. The computer program can account for the effects of residual stresses during the generation of moment-thrust-curvature (MP) data, the first phase in calculating beam-column failure loads. Any configuration of stress-strain relationships may be included by providing appropriate data in tabular form. However, while this investigation includes the determination of MP data, those provided by other investigators also may be put directly into the computer program. Failure loads are calculated by a numerical technique that increases the load in increments until no further load can be supported, when the beam-column is considered to have failed. A testing program w
A least-squares procedure was developed to aid in deriving restriction-fragment [DNA digested by restriction endonuclease] maps once the order of cut sites is determined. A computer program which carries out this meth...
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A least-squares procedure was developed to aid in deriving restriction-fragment [DNA digested by restriction endonuclease] maps once the order of cut sites is determined. A computer program which carries out this method can be used to map either linear or circular molecules.
The paper describes a computer program for the systematic numerical predetermination of a performance indexJ=∫∞0(xtQx+u2)dtsuch that the synthesised feedback controller that minimisesJresults in ...
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The paper describes a computer program for the systematic numerical predetermination of a performance indexJ=∫∞0(xtQx+u2)dtsuch that the synthesised feedback controller that minimisesJresults in a controlled system with satisfactory eigenvalues that all lie to the left of the set {s|s=α, α≤0} in the complex plane. The computer algorithm, which is based on the derivatives of the eigenvalues with respect to the coefficients ofQ, may be used in isolation or can be included in an overall synthesis procedure. Examples illustrating the method are included.
The theory of multivariate statistical processing of the anisotropy of magnetic susceptibility, measured on a group of specimens, originating from a single geological body (outcrop, locality, etc.), is described. The ...
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The theory of multivariate statistical processing of the anisotropy of magnetic susceptibility, measured on a group of specimens, originating from a single geological body (outcrop, locality, etc.), is described. The result of the processing is an estimate of the mean normalized tensor and the estimates of the principal susceptibilities, derived from it, together with the respective intervals of confidence, and the estimates of the principal directions with the respective regions of confidence. An anisotropy test for a group of specimens is proposed. The function of the ANS21 computer program employed is briefly described and an example of its output plot is presented.
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