The problems of curve fitting and modeling in pharmacokinetics are discussed. A new nonlinear regression program FUNFIT, written for interactive time sharing, is presented which should be more reliable than programs b...
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The problems of curve fitting and modeling in pharmacokinetics are discussed. A new nonlinear regression program FUNFIT, written for interactive time sharing, is presented which should be more reliable than programs based on the Gauss-Newton or other related gradient methods. The new program and the well-established program NONLIN were tested on 2 linear models using human plasma drug [pancuronium] level data. FUNFIT found a substantially better solution than NONLIN in the majority of the cases.
3- and 4-element spring and dashpot models have frequently been applied to the behaviour of some visco-elastic materials, although somewhat less frequently to wood and wood-based sheet materials which are themselves v...
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3- and 4-element spring and dashpot models have frequently been applied to the behaviour of some visco-elastic materials, although somewhat less frequently to wood and wood-based sheet materials which are themselves visco-elastic. However there exists a need to develop a good analytical procedure for fitting the non-linear response curves corresponding to these models to experimental data. This paper describes such a method and applies it to the data from a creep experiment on UF chipboard bending specimens under sustained three-point loading. The computer program written for the solution process illustrates the response curves on a graph plot.
An algorithm for zero-one integer programming problems with more than one objective functions is developed, implemented and tested. For a multiob jective problem the notion of opti- mality must be replaced with that o...
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An algorithm for zero-one integer programming problems with more than one objective functions is developed, implemented and tested. For a multiob jective problem the notion of opti- mality must be replaced with that of efficiency. A solution is said to be efficient if (1) it satisfies the constraints and (2) no other solution satisfying them scores as well with respect to all objective functions and better with respect to at least one of them. In the presented algorithm, the problem variables are partitioned into two sets; those whose coeffi- cients in the objective functions are all of the same sign, and the remainder. A tree search implicit enumeration algorithm based on this partition is developed and computa- tional results are presented.
Model calculations of the time course of the intraocular pressure are performed in cases where the four determinants mentioned in the title vary, singly or simultaneously, according to specified time functions. Assump...
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Model calculations of the time course of the intraocular pressure are performed in cases where the four determinants mentioned in the title vary, singly or simultaneously, according to specified time functions. Assumptions are 1) that the outflow of the aqueous humour is proportional to the driving pressure, and 2) that the intraocular pressure and volume are related to each other as described by Friedenwald. The mathematical solution is numerical and involves the repetition of the same calculatory step process. It is rendered probable that the maximal inhibitory effect of acetazolamide on the secretion of aqueous humour is reached in less than one minute after the drug has reached the receptors. A programmable calculator with 224 storage locations is used, the programs are given.— 1977 Institution Acta Ophthalmologica Scandinavica
A computer program is available for fitting any linear or nonlinear ordinary differential equations to data, and for estimating transfer rates and/or compartment sizes from time—series tracer data in a compartmental ...
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A computer program is available for fitting any linear or nonlinear ordinary differential equations to data, and for estimating transfer rates and/or compartment sizes from time—series tracer data in a compartmental system. The program is easy to use because compartment problems are specified simply in terms of the geometry of the components and transfers between them. The program generates confidence limits for the estimates, a feature that can be used to examine in advance the effectiveness of proposed tracer experiments.
A computer program for the design of a dual-speed single-winding 3-phase induction motor is presented. A novel feature of the program is the treatment of different classes of pole ratios by a unified logic, enabling a...
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A computer program for the design of a dual-speed single-winding 3-phase induction motor is presented. A novel feature of the program is the treatment of different classes of pole ratios by a unified logic, enabling an exhaustive study of the effects of initial pole distribution, coil pitch and switching arrangement on performance at both speeds.
Existing programs for evaluating the static parameters of the Ebers--Moll transistor model provide either high accuracy or economical operation. The method presented here as a computer program combines both high accur...
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Existing programs for evaluating the static parameters of the Ebers--Moll transistor model provide either high accuracy or economical operation. The method presented here as a computer program combines both high accuracy and economy. Examples of the improved agreement between experimental data and theoretical estimates are given.
This paper highlights some of the difficulties involved in the implementation of complex cost structures in the tree-building section of a transport demand model. The conventional tree-building algorithm is briefly de...
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This paper highlights some of the difficulties involved in the implementation of complex cost structures in the tree-building section of a transport demand model. The conventional tree-building algorithm is briefly described and is seen to be inadequate for the present purpose. A new algorithm is then presented which is able to implement complex cost structures properly. An example is given of the application of this algorithm to the building of tree in a public transport network. The performance of a computer program incorporating the new alrogrithm is evaluated against alternative methods of implementing complex cost structures. Some mention is then made of the vast range of potential uses for the new algorithm in the field of transport modelling and simulation.
A study was continued of the design characteristics and optimization procedures leading to an improvement of the maximum cell capacity obtainable with the high power type lithium inorganic batteries. The general relat...
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A study was continued of the design characteristics and optimization procedures leading to an improvement of the maximum cell capacity obtainable with the high power type lithium inorganic batteries. The general relations derived for the low power type cells have been modified for use in the design of the high power type cells. A materials balance was established for the interior components of cylindrical cells made for high discharge *** parameters were calculated using a computer program for several sizes of cylindrical cells. A satisfactory agreement was reached between the predicted and the realized performance of the cells built with the calculated design parameters.
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