Bioinformatics is playing an increasingly important role in nearly all aspects of drug discovery, drug assessment, and drug development. This growing importance lies not only in the role that bioinformatics plays in h...
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Bioinformatics is playing an increasingly important role in nearly all aspects of drug discovery, drug assessment, and drug development. This growing importance lies not only in the role that bioinformatics plays in handling large volumes of data, but also in the utility of bioinformatics tools to predict, analyze, or help interpret clinical and preclinical findings. This review focuses on describing and evaluating some of the newer or more important bioinformatics resources ( i. e., databases and software) that are of growing importance to understanding or predicting drug metabolism, especially with respect to the absorption, distribution, metabolism, excretion, ( ADME), and toxicity ( T) of both existing drugs and potential drug leads. Detailed descriptions and critical assessments of a number of potentially useful bioinformatics/ cheminformatics databases and predictive ADMET software tools are provided. Additionally, several pharmaceutically important applications of both the databases and software are highlighted. Given the rapid growth in this area and the rapid changes that are taking place, a special emphasis is placed on freely available or Web- accessible resources.
The bit-rate control algorithm for video sequence encoding with Region Of Interest (ROI) is presented in this paper The algorithm distributes available bit budget among image layers taking into consideration both the ...
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ISBN:
(纸本)0780393856
The bit-rate control algorithm for video sequence encoding with Region Of Interest (ROI) is presented in this paper The algorithm distributes available bit budget among image layers taking into consideration both the distance from ROI and the local complexity. It improves the image quality, in ROI by lowering the image quality, outside ROI with the preservation of the global constraint of the encoded stream bit-rate. The algorithm also ensures the gradual image quality degradation outside ROI.
This paper investigates the possibilities for the design of current control for VSI from the discrete event point if view. Event-driving determines the transistor switching pattern directly from the current error logi...
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ISBN:
(纸本)0780387384
This paper investigates the possibilities for the design of current control for VSI from the discrete event point if view. Event-driving determines the transistor switching pattern directly from the current error logic signals change and is designed using a novel matrix based approach for the description of the discrete event systems. A new approach for description of event-driven systems is introduced. It is based on matrix description of Petri Nets, supplemented with a combination of logic and algebraic equations. The control algorithms designed by proposed approach can be easily implemented on modern DSP an FPGA devices. Instead of traditional coding, the control algorithms are loaded in the form of logical matrices. Such implementation does not include time consumptive AID converters and transistor duty cycle algebraic calculations which significantly reduces the modulator calculation efforts. The approach is illustrated by the design of direct current controller for a three phase inverter fed Permanent Magnet Synchronous Machine and is examined by simulations.
The paper describes operation of three-level inverters with synchronized pulsewidth modulation (PWM) at control regimes different from standard Volts/Hertz control. Control algorithms provide common-mode voltage cance...
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ISBN:
(纸本)0780387384
The paper describes operation of three-level inverters with synchronized pulsewidth modulation (PWM) at control regimes different from standard Volts/Hertz control. Control algorithms provide common-mode voltage cancellation in three-phase load in this case. The output voltage of converters has quarter-wave symmetry ring the whole control range including the zone of overmodulation. Simulations give the behaviour of different versions of synchronous PWM.
In this paper we propose an admission control algorithm which is suitable for real time traffic in a sink-tree network in which per-aggregate resource management is in place. Every flow specifies its leaky-bucket para...
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ISBN:
(纸本)0769524478
In this paper we propose an admission control algorithm which is suitable for real time traffic in a sink-tree network in which per-aggregate resource management is in place. Every flow specifies its leaky-bucket parameters and a required delay bound, and the algorithm admits a new flow if a guarantee can be given that the delay bound for every established flow is not exceeded. The algorithm is based on a formula, derived through Network Calculus, that relates the worst-case delay of a single flow to the transmission rate provisioned for the aggregate and to the leaky-bucket parameters of flows at the ingress of the network. We describe the algorithm and the employed data structures, and we evaluate its complexity.
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