Motivation: Next-generation sequencing technologies have enabled the large-scale assessment of the impact of rare and low-frequency genetic variants for complex human diseases. Gene-level association tests are often p...
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Motivation: Next-generation sequencing technologies have enabled the large-scale assessment of the impact of rare and low-frequency genetic variants for complex human diseases. Gene-level association tests are often performed to analyze rare variants, where multiple rare variants in a gene region are analyzed jointly. Applying gene-level association tests to analyze sequence data often requires integrating multiple heterogeneous sources of information (e.g. annotations, functional prediction scores, allele frequencies, genotypes and phenotypes) to determine the optimal analysis unit and prioritize causal variants. Given the complexity and scale of current sequence datasets and bioinformatics databases, there is a compelling need for more efficient software tools to facilitate these analyses. To answer this challenge, we developed RVTESTS, which implements a broad set of rare variant association statistics and supports the analysis of autosomal and X-linked variants for both unrelated and related individuals. RVTESTS also provides useful companion features for annotating sequence variants, integrating bioinformatics databases, performing data quality control and sample selection. We illustrate the advantages of RVTESTS in functionality and efficiency using the 1000 Genomes Project data.
A recent article identified an artifact in multiple single-cell RNA-seq (scRNA-seq) datasets generated by the Fluidigm C1 platform. Specifically, Leng et al. showed significantly increased gene expression in cells cap...
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A recent article identified an artifact in multiple single-cell RNA-seq (scRNA-seq) datasets generated by the Fluidigm C1 platform. Specifically, Leng et al. showed significantly increased gene expression in cells captured from sites with small or large plate output IDs. We refer to this artifact as an ordering effect (OE). Including OE genes in downstream analyses could lead to biased results. To address this problem, we developed a statistical method and software called OEFinder to identify a sorted list of OE genes. OEFinder is available as an R package along with user-friendly graphical interface implementations which allows users to check for potential artifacts in scRNA-seq data generated by the Fluidigm C1 platform.
This study investigates how individual creativity is related to the quality of team decision processes and team climate, and the mediating role of team decision processes between individual creativity and team climate...
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This study investigates how individual creativity is related to the quality of team decision processes and team climate, and the mediating role of team decision processes between individual creativity and team climate. A multi-level theoretical model was proposed and partial least squares structural equation modelling (PLS-SEM) was conducted on a sample of 139 softwaredevelopment projects. The results suggest that: (i) individual creativity improves the quality of team decision processes, (ii) team decision processes are positively associated with four dimensions of team climate (organizational support, innovation orientation, goal orientation and informal structure), and (iii) team decision processes partially mediate between individual creativity and team climate. In particular, the obtained results stress the role of individual creativity in the formation and evolution of a positive climate by means of team decision processes. The study implies that managers should recognize the value of creative individuals as the basic source of competitive advantage and success. It further discusses the managerial implications of the findings as well as limitations and constructive new directions for future studies to improve softwaredevelopment team performance.
Background: Cardiotocograph (CTG) interpretation is a core skill for health care professionals working on the labour ward;however, training appears to be deficient in respect of the development of decision-making skil...
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Background: Cardiotocograph (CTG) interpretation is a core skill for health care professionals working on the labour ward;however, training appears to be deficient in respect of the development of decision-making skills relating to CTG findings. Simulation offers a potential solution to address such 'human factors'. Current access to simulators is limited by cost and operational complexity. We therefore decided to develop an accessible CTG simulator application ('app') that could be operated on a smartphone, a technology already possessed by the majority of health care professionals in the UK and elsewhere. Context: A multidisciplinary team with backgrounds in obstetrics, anaesthesia and information technology was assembled to undertake the softwaredevelopment process. An evaluation of the pilot software was undertaken by trainee obstetric doctors. Innovation: A softwaredevelopment project was undertaken in order to produce a mobile app that simulates CTG accurately and dynamically. This process was based on Davis' Technology Acceptance Model, in which usefulness and ease of use are the central principles. Implications: Mobile technology can be used to run simulation software that is both useful and easy to use;however, our evaluation indicated that in order to use the app effectively the operator requires some expertise in the behaviour of the CTG in response to interventions, in common with all current patient simulators. We envisage using this app in hybrid simulation scenarios, in which a live actor and a simulated monitor are used together.
[Auto Generated] EXECUTIVE SUMMARY 1 I. BACKGROUND 3 A. Introduction B. The Environment II. MAJOR CONCEPTS 5 A. Open Systei lvironments B. Multimedia Technology C. The Standards Process D. Migration E. Infrastructure ...
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[Auto Generated] EXECUTIVE SUMMARY 1 I. BACKGROUND 3 A. Introduction B. The Environment II. MAJOR CONCEPTS 5 A. Open Systei lvironments B. Multimedia Technology C. The Standards Process D. Migration E. Infrastructure Issues III. THE FEDERAL STRATEGY A. Introduction B. Systems Architecture C. Standards development D. Migration E. Infrastructure IV. NIST'S ROLE 19 A. Overview B. The Multimedia Courseware Project APPENDICES A. Open System Environments 23 B. The Applications Portability Profile 29 C
Eric Ed324841: Investigation of Interactive Technologies for Early Math and Science Concepts for Preschool Children. Report--Phase I. by Eric; published by
Eric Ed324841: Investigation of Interactive Technologies for Early Math and Science Concepts for Preschool Children. Report--Phase I. by Eric; published by
Eric Ed388309: Ed-Media 94--World Conference on Educational Multimedia and Hypermedia (Vancouver, British Columbia, Canada, June 25-30, 1994). Short Papers. by Eric; published by
Eric Ed388309: Ed-Media 94--World Conference on Educational Multimedia and Hypermedia (Vancouver, British Columbia, Canada, June 25-30, 1994). Short Papers. by Eric; published by
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