The Coronavirus Disease 2019 (COVID-19) has become an international public health emergency, posing a serious threat to human health and safety around the world. The 2019-nCoV coronavirus spike protein was confirmed t...
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The Coronavirus Disease 2019 (COVID-19) has become an international public health emergency, posing a serious threat to human health and safety around the world. The 2019-nCoV coronavirus spike protein was confirmed to be highly susceptible to various mutations, which can trigger apparent changes of virus transmission capacity and the pathogenic mechanism. In this article, the binding interface was obtained by analyzing the interaction modes between 2019-nCoV coronavirus and the human ACE2. Based on the "SIFT server" and the "bubble" identification mechanism, 9 amino acid sites were selected as potential mutation-sites from the 2019-nCoV-S1-ACE2 binding interface. Subsequently, a total number of 171 mutant systems for 9 mutation-sites were optimized for binding-pattern comparsion analysis, and 14 mutations that may improve the binding capacity of 2019-nCoV-S1 to ACE2 were selected. The Molecular Dynamic Simulations were conducted to calculate the binding free energies of all the 14 mutant systems. Finally, we found that most of the 14 mutations on the 2019-nCoV-S1 protein could enhance the binding ability between 2019-nCoV coronavirus and human ACE2. Among which, the binding capacities for G446R, Y449R and F486Y mutations could be increased by 20 percent, and that for S494R mutant increased even by 38.98 percent. We hope this research could provide significant help for the future epidemic detection, drug and vaccine development.
This paper proposes a new method based on the comprehensive transition criteria of speed, flux position, and voltage vector to solve the transition problem in hybrid direct torque control. In addition, the control ang...
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This paper proposes a new method based on the comprehensive transition criteria of speed, flux position, and voltage vector to solve the transition problem in hybrid direct torque control. In addition, the control angle is introduced that is adjusted by the smoothness and rapidity. Peak current, flux distortion, and torque ripple can be significantly reduced by the proposed method.
This book investigates the susceptibility of intrinsic physically unclonable function (PUF) implementations on reconfigurable hardware to optical semi-invasive attacks from the chip backside. It explores different cla...
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ISBN:
(数字)9783319758206
ISBN:
(纸本)9783319758190
This book investigates the susceptibility of intrinsic physically unclonable function (PUF) implementations on reconfigurable hardware to optical semi-invasive attacks from the chip backside. It explores different classes of optical attacks, particularly photonic emission analysis, laser fault injection, and optical contactless probing. By applying these techniques, the book demonstrates that the secrets generated by a PUF can be predicted, manipulated or directly probed without affecting the behavior of the PUF. It subsequently discusses the cost and feasibility of launching such attacks against the very latest hardware technologies in a real scenario. The author discusses why PUFs are not tamper-evident in their current configuration, and therefore, PUFs alone cannot raise the security level of key storage. The author then reviews the potential and already implemented countermeasures, which can remedy PUFs’ security-related shortcomings and make them resistant to optical side-channel and optical fault attacks. Lastly, by making selected modifications to the functionality of an existing PUF architecture, the book presents a prototype tamper-evident sensor for detecting optical contactless probing attempts.
This book should not be the first book you read on programming, if you have never programmed before, put this book aside for a while and learn some basics of programming with a higher-level language such as C.
ISBN:
(数字)9781484250761
ISBN:
(纸本)9781484250754
This book should not be the first book you read on programming, if you have never programmed before, put this book aside for a while and learn some basics of programming with a higher-level language such as C.
Topics covered range from parallel algorithms, programming tools, OpenMP, MPI and OpenCL, followed by experimental measurements of parallel programs’ run-times, and by engineering analysis of obtained results fo...
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ISBN:
(数字)9783319988337
ISBN:
(纸本)9783319988320
Topics covered range from parallel algorithms, programming tools, OpenMP, MPI and OpenCL, followed by experimental measurements of parallel programs’ run-times, and by engineering analysis of obtained results for improved parallel execution performances.
One of the old techniques for performance improvements is branch prediction. As the branch misprediction rate has reached less than 0.01 for certain techniques, it is safe to say that current branch prediction techniq...
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ISBN:
(纸本)9781509043071
One of the old techniques for performance improvements is branch prediction. As the branch misprediction rate has reached less than 0.01 for certain techniques, it is safe to say that current branch prediction techniques are very efficient. But for certain critical applications a small misprediction also poses a problem. In this paper, a new prediction technique is discussed which always predicts the branch correctly. This technique works well for else if loop at the cost of increased hardware resources.
Advances in GPU Research and Practice focuses on research and practices in GPU based systems. The topics treated cover a range of issues, ranging from hardware and architectural issues, to high level issues, such as a...
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ISBN:
(数字)9780128037881
ISBN:
(纸本)9780128037386
Advances in GPU Research and Practice focuses on research and practices in GPU based systems. The topics treated cover a range of issues, ranging from hardware and architectural issues, to high level issues, such as application systems, parallel programming, middleware, and power and energy issues. Divided into six parts, this edited volume provides the latest research on GPU computing. Part I: Architectural Solutions focuses on the architectural topics that improve on performance of GPUs, Part II: System Software discusses OS, compilers, libraries, programming environment, languages, and paradigms that are proposed and analyzed to help and support GPU programmers. Part III: Power and Reliability Issues covers different aspects of energy, power, and reliability concerns in GPUs. Part IV: Performance Analysis illustrates mathematical and analytical techniques to predict different performance metrics in GPUs. Part V: Algorithms presents how to design efficient algorithms and analyze their complexity for GPUs. Part VI: Applications and Related Topics provides use cases and examples of how GPUs are used across many sectors. Discusses how to maximize power and obtain peak reliability when designing, building, and using GPUsCovers system software (OS, compilers), programming environments, languages, and paradigms proposed to help and support GPU programmersExplains how to use mathematical and analytical techniques to predict different performance metrics in GPUsIllustrates the design of efficient GPU algorithms in areas such as bioinformatics, complex systems, social networks, and cryptographyProvides applications and use case scenarios in several different verticals, including medicine, social sciences, image processing, and telecommunications
Discover the difference between making a robot move and making a robot think. Using Mindstorms EV3 and LeJOSan open source project for Java Mindstorms projectsyoull learn how to create Artificial Intelligence for your...
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ISBN:
(数字)9781484220054
ISBN:
(纸本)9781484220047;9781484220054
Discover the difference between making a robot move and making a robot think. Using Mindstorms EV3 and LeJOSan open source project for Java Mindstorms projectsyoull learn how to create Artificial Intelligence for your bot. Your robot will learn how to problem solve, how to plan, how to learn, and how to communicate. Along the way, youll learn about classical AI algorithms for teaching hardware how to think, algorithms that you can then apply to your own robotic inspirations. If youve ever wanted to learn about robotic intelligence in a practical, playful way, Beginning Robotics Programming in Java with LEGO Mindstormsis for you. What youll learn: Build your first LEGO EV3 robot step-by-step Install LeJOS and its firmware on Lego EV3 Create and upload your first Java Program into Lego EV3 LeJOS API FunctionsJava Programming for MotorsRobotics Behavior Programming with SensorsCommon AI Algorithms like DFS, BFS, and Dijkstras AlgorithmJava Multithreading Programming with Lego EV3 Who this book is for: Students, teachers, and makers with basic Java programming experience who want to learn how to apply Artificial Intelligence to a practical robotic system.
This is the perfect book for musicians who want to dive into the world of computer music and physical computing. This book is aimed at adventurous musicians who want to learn about music programming with Arduino, sens...
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ISBN:
(数字)9781484215838
ISBN:
(纸本)9781484215845
This is the perfect book for musicians who want to dive into the world of computer music and physical computing. This book is aimed at adventurous musicians who want to learn about music programming with Arduino, sensors, and Pure Data, and how to make new interfaces and even new instruments with that ***’ll learn the basics of the Pure Data and Arduino languages, how to incorporate sensors into your musical projects, and how to use embedded computers, like the Raspberry Pi, to create stand-alone projects. Along the way, you’ll learn how to create a variety of innovative (Mark, Michelle, I guess they are innovative, but not 100% sure) musical projects, including an interactive bow for stringed instruments, a MIDI clavier synthesizer, an interactive drum set, a patch-bay matrix synthesizer, a guitar looper, and even a DIY *** you are a musician or tinkerer who wants to explore the world of electronic and electroacoustic music and musical interfaces with Arduino, sensors, and Pure Data, Digital Electronics for Musicians is the book for *** You Will Learn•Learn the basics of the Pure Data and the Arduino languages•Learn more about the available sensors on the market, and how you can incorporate them into your musical projects•Focus on physical computing by combining Arduino and Pure Data, bringing the physical world to the world of the computers•Make use of additional libraries that extend the capabilities of the Arduino•Make use of external objects in Pure Data that help achieve certain goals, depending on the project•Learn how a Pure Data patch functions and be able to modify other people's work that fits your needs•Learn how the Arduino language works, enabling the modification of already existing code, according to your needs•Get insight on the serial communication between the Arduino and Pure Data•Learn how to approach various programming challenges in different waysWho This is ForMusicians who want to explore the world of electronic and
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