The widespread deployment of large language models (LLMs) has led to impressive advancements, yet information about their training data, a critical factor in their performance, remains undisclosed. Membership inferenc...
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We present a novel method for identifying transients suitable for both strong signal-dominated and background-dominated objects. By employing the unsupervised machine learning algorithm known as expectation Maximizati...
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Patient body-motion and respiratory-motion impacts the image quality of cardiac SPECT and PET perfusion images. Several algorithms exist in the literature to correct for motion within the iterative maximum-likelihood ...
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Patient body-motion and respiratory-motion impacts the image quality of cardiac SPECT and PET perfusion images. Several algorithms exist in the literature to correct for motion within the iterative maximum-likelihood reconstruction framework. In this work. three algorithms are derived starting with Poisson statistics to correct for patient motion. The first one is a motion compensated MLEM algorithm (MC-MLEM). The next two algorithms called MGEM-1 and MGEM-2 (short for Motion Gated OSEM, 1 and 2) use the motion states as subsets, in two different ways. Experiments were performed with NCAT phantoms (with exactly known motion) as the source and attenuation distributions. Experiments were also performed on in anthropomorphic phantom and a patient study. The SIMIND Monte Carlo simulation software was used to create SPECT projection images of the NCAT phantoms. The projection images were then modified to have Poisson noise levels equivalent to that of clinical acquisition. We investigated application of these algorithms to correction of (1) 1 large body-motion of 2 cm in Superior-Inferior (SI) and Anterior-Posterior (AP) directions each and (2) respiratory motion of 2 cm in SI and 0.6 cm in AP. We determined the bias with respect to the NCAT phantom activity for noiseless reconstructions as well as the bias-variance for noisy reconstructions. The MGEM-1 advanced along the bias-variance curve faster than the MC-MLEIM with iterations. The MCEM-1 also lowered the noiseless bias (with respect to NCAT truth) faster with iterations, compared to file MC-MLEM algorithms, as expected with subset algorithms. For the body motion correction with two motion states, after the 9th iteration the Was was close to that of MC-MLEM at iteration 17, reducing the number of iterations by a factor of 1.89. For the respiratory motion correction with 9 motion states, based on the noiseless bias, the iteration reduction factor was approximately 7. For the MGEM-2, however. bias-plot or the bias-var
Protein-protein interactions (PPIs) play important roles in most fundamental cellular processes including cell cycle, metabolism, and cell proliferation. Therefore, the development of effective statistical approaches ...
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Protein-protein interactions (PPIs) play important roles in most fundamental cellular processes including cell cycle, metabolism, and cell proliferation. Therefore, the development of effective statistical approaches to predicting protein interactions based on recently available large-scale experimental data is very important. Because protein domains are the functional units of proteins and PPIs are mostly achieved through domain-domain interactions (DDIs), the modeling and analysis of protein interactions at the domain level may be more informative and insightful. However, due to the large number of domains, the number of parameters to be estimated is very large, yet the amount of information for statistical inference is quite limited. In this article we propose a full Bayesian method and a semi-Bayesian method for simultaneously estimating DDI probabilities, the false positive rate, and the false negative rate of high-throughput data through integrating data from several organisms. We also propose a model to associate protein interaction probabilities with domain interaction probabilities that reflects the number of domains in each protein, Our Bayesian methods are compared with the likelihood-based approach (Deng et al., 2002, Genome Research 12, 1504-1508;Liu, Liu, and Zhao, 2005, Bioinformatics 21, 3279-3285) developed using the expectation maximization algorithm. We show that the full Bayesian method has the smallest mean square error through both simulations and theoretical justification under a special scenario. The large-scale PPI data obtained from high-throughput yeast two-hybrid experiments are used to demonstrate the advantages of the Bayesian approaches.
Enormous data are continuously collected by the structural health monitoring system of civil infrastructures. The structural health monitoring data inevitably involve anomalies caused by sensors, transmission errors, ...
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Enormous data are continuously collected by the structural health monitoring system of civil infrastructures. The structural health monitoring data inevitably involve anomalies caused by sensors, transmission errors, or abnormal structural behaviors. It is important to identify the anomalies and find their origin (e.g. sensor fault or structural damage) to make correct interventions. Moreover, online anomaly identification of the structural health monitoring data is critical for timely structural condition assessment and decision-making. This study proposes an online approach for detecting anomalies of the structural health monitoring data based on the Bayesian dynamic linear model. In particular, Bayesian dynamic linear model, consisting of various components, is implemented to characterize the feature of real-time measurements. expectation maximization algorithm and Kalman smoother are combined to estimate the Bayesian dynamic linear model parameters and generate log-likelihood functions. The subspace identification method is introduced to overcome the initialization issue of the expectation maximization algorithm. The log-likelihood difference of consecutive time steps is then used to determine thresholds without introducing extra anomaly detectors. The proposed Bayesian dynamic linear model-based approach is first illustrated by the simulation data and then applied to the structural health monitoring data collected from two long-span bridges. The results indicate that the proposed method exhibits good accuracy and high computational efficiency and also allows for reconstructing the strain measurements to replace anomalies.
Computing the modal parameters of structural systems often requires processing data from multiple non-simultaneously recorded setups of sensors. These setups share some sensors in common, the so-called reference senso...
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Computing the modal parameters of structural systems often requires processing data from multiple non-simultaneously recorded setups of sensors. These setups share some sensors in common, the so-called reference sensors, which are fixed for all measurements, while the other sensors change their position from one setup to the next. One possibility is to process the setups separately resulting in different modal parameter estimates for each setup. Then, the reference sensors are used to merge or glue the different parts of the mode shapes to obtain global mode shapes, while the natural frequencies and damping ratios are usually averaged. In this paper we present a new state space model that processes all setups at once. The result is that the global mode shapes are obtained automatically, and only a value for the natural frequency and damping ratio of each mode is estimated. We also investigate the estimation of this model using maximum likelihood and the expectation maximization algorithm, and apply this technique to simulated and measured data corresponding to different structures. (C) 2013 Elsevier Ltd. All rights reserved.
The problem of robust attack detection and prediction for networked control systems in the presence of outliers is discussed in this article. The conventional hidden Markov model (HMM) is trained to learn the system b...
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The problem of robust attack detection and prediction for networked control systems in the presence of outliers is discussed in this article. The conventional hidden Markov model (HMM) is trained to learn the system behavior (ie, transitions between different operating modes) in the nominal process. The HMM with time-varying transition probabilities is used to track the attack behavior in which the adversary triggers more hazard modes to hasten fatigue of control devices by injecting attack signals with random magnitude and frequency. For different operating modes, the observations are assumed to follow different multivariate Student'stdistributions instead of Gaussian distributions and thus address the robust estimation problem. The expectation maximization algorithm is used to estimate parameters. Finally, simulations are conducted to verify the effectiveness of the proposed method.
This paper introduces a uniform statistical framework for both 3-D and 2-D object recognition using intensity images as input data. The theoretical part provides a mathematical tool for stochastic modeling. The algori...
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This paper introduces a uniform statistical framework for both 3-D and 2-D object recognition using intensity images as input data. The theoretical part provides a mathematical tool for stochastic modeling. The algorithmic part introduces methods for automatic model generation, localization, and recognition of objects. 2-D images are used for learning the statistical appearance of 3-D objects;both the depth information and the matching between image and model features are missing for model generation. The implied incomplete data estimation problem is solved by the expectation maximization algorithm. This leads to a novel class of algorithms for automatic model generation from projections. The estimation of pose parameters corresponds to a non-linear maximum likelihood estimation problem which is solved by a global optimization procedure. Classification is done by the Bayesian decision rule. This work includes the experimental evaluation of the various facets of the presented approach. An empirical evaluation of learning algorithms and the comparison of different pose estimation algorithms show the feasibility of the proposed probabilistic framework.
Film cooling is an advanced external cooling technology for protecting gas turbine blades from excessive temperatures. To counteract non-uniform heat loads caused by hot streak and swirl effects at the combustion cham...
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Film cooling is an advanced external cooling technology for protecting gas turbine blades from excessive temperatures. To counteract non-uniform heat loads caused by hot streak and swirl effects at the combustion chamber outlet, fine design of film hole positions is necessary. However, the complexity due to the numerous film holes and their positional parameters presents challenges in the independent optimization of film hole positions in a continuous parameter space. This study proposed an optimization method grounded in the divide and conquer approach to address optimization for film hole layout. The film hole layout was decomposed into multiple single rows and optimized systematically by iteratively refining the single-row film hole layout along the streamwise direction using the expectation maximization algorithm. Optimized layouts for five different inlet temperature distributions were obtained using the proposed method and adiabatic wall temperature distributions were compared and analyzed for optimized and staggered layouts. Additionally, the cooling performance of the optimized layout was evaluated against the staggered layout under conjugate heat transfer conditions and the robustness of the optimized layout under various blowing ratios and peak temperature positions was tested. The results demonstrated that the proposed method can optimize the positions of 52 film holes within 0.3 h, and it was generalized to various inlet temperature distributions. By enhancing lateral interactions among downstream film jets, the lifting effect of kidney vortex in the optimized layout was weakened, bringing the film jets closer to the wall and significantly increasing coolant coverage during streamwise development. Comparative analysis reveals the superior cooling performance of the optimized layout at the blowing ratio of 1.0, evidenced by a 15.1% reduction in total input heat transfer rate and a 12.3% enhancement in overall cooling efficiency relative to the staggered l
The paper provides both classical and Bayesian estimation of the parameters of a competing risk model defined on the basis of minimum of exponential and gamma failure modes. Usually such situations are the examples of...
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The paper provides both classical and Bayesian estimation of the parameters of a competing risk model defined on the basis of minimum of exponential and gamma failure modes. Usually such situations are the examples of incomplete specification of data that naturally opens the way to expectation maximization algorithm for obtaining maximum likelihood estimates of model parameters. This incomplete specification of the data simultaneously explores the possibility of sampling importance resampling strategy with intermediate Markov chain Monte Carlo steps for the Bayesian estimation of parameters. Although this paper focuses primarily on estimation of model parameters, other inferential developments can be routinely done. Numerical illustration is provided based on both simulated and real-data examples.
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