In order to effectively improve the recommendation accuracy of collaborative screening of e-commerce products, ensure the results of collaborative screening of e-commerce products, and reduce the time consumption of c...
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Public security heroic model culture is a political-cultural phenomenon with Chinese characteristics formed by public security organs in the process of selecting, recognizing, publicizing, and appeasing heroic models....
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BackgroundThe Naive Bayes (NB) classifier is a powerful supervised algorithm widely used in Machine Learning (ML). However, its effectiveness relies on a strict assumption of conditional independence, which is often v...
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BackgroundThe Naive Bayes (NB) classifier is a powerful supervised algorithm widely used in Machine Learning (ML). However, its effectiveness relies on a strict assumption of conditional independence, which is often violated in real-world scenarios. To address this limitation, various studies have explored extensions of NB that tackle the issue of non-conditional independence in the data. These approaches can be broadly categorized into two main categories: feature selection and structure *** this particular study, we propose a novel approach to enhancing NB by introducing a latent variable as the parent of the attributes. We define this latent variable using a flexible technique called Bayesian Latent Class Analysis (BLCA). As a result, our final model combines the strengths of NB and BLCA, giving rise to what we refer to as NB-BLCA. By incorporating the latent variable, we aim to capture complex dependencies among the attributes and improve the overall performance of the *** expectation-maximization (EM) algorithm and the Gibbs sampling approach were offered for parameter learning. A simulation study was conducted to evaluate the classification of the model in comparison with the ordinary NB model. In addition, real-world data related to 976 Gastric Cancer (GC) and 1189 Non-ulcer dyspepsia (NUD) patients was used to show the model's performance in an actual application. The validity of models was evaluated using the 10-fold *** presented model was superior to ordinary NB in all the simulation scenarios according to higher classification sensitivity and specificity in test data. The NB-BLCA model using Gibbs sampling accuracy was 87.77 (95% CI: 84.87-90.29). This index was estimated at 77.22 (95% CI: 73.64-80.53) and 74.71 (95% CI: 71.02-78.15) for the NB-BLCA model using the EM algorithm and ordinary NB classifier, *** considering the modification of the NB classifier, incorporating a lat
The widespread adoption of nonlinear power electronic devices in residential settings has significantly increased the stochasticity and uncertainty of power systems. The original load power data, characterized by nume...
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The Dynamic State Estimation (DSE) for Inverter-Based Resources (IBRs) is an emerging topic as IBRs gradually replace synchronous generators (SGs) in power systems. Unlike SGs, the dynamic models of IBRs heavily depen...
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The Genetic Analysis Workshop 16 rheumatoid arthritis data include a set of 868 cases and 1194 controls genotyped at 545,080 single-nucleotide polymorphisms (SNPs) from the Illumina 550 k chip. We focus on investigati...
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The Genetic Analysis Workshop 16 rheumatoid arthritis data include a set of 868 cases and 1194 controls genotyped at 545,080 single-nucleotide polymorphisms (SNPs) from the Illumina 550 k chip. We focus on investigating chromosomes 6 and 18, which have 35,574 and 16,450 SNPs, respectively. Association studies, including single SNP and haplotype-based analyses, were applied to the data on those two chromosomes. Specifically, we conducted a generalized linear model with regularization (rGLM) approach for detecting disease-haplotype association using unphased SNP data. A total of 444 and 43 four-SNP tests were found to be significant at the Bonferroni corrected 5% significance level on chromosome 6 and 18, respectively.
Objective: Zimbabwe is one of the poorest countries in the world, just emerging from a broken health care system. The objective is to figure out variables affecting hospital charge for *** and methods: The variables u...
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Objective: Zimbabwe is one of the poorest countries in the world, just emerging from a broken health care system. The objective is to figure out variables affecting hospital charge for *** and methods: The variables used are sex, smoking status, number of children, region, age and body mass index. The first six of these are factors and the remaining are covariates. A mixture model was fitted to describe the dependence of hospital charge on these variables. Results: A mixture model with five components each having a reversed Gumbel distribution was found to give an adequate fit. Both the covariates and all but one of the factors were found to be significant. Estimates of value at risk of hospital charge are given for all combinations of the ***: The results suggest that the hospital charge could be higher for females, higher for smokers, higher if the patient had more children and higher if the patient is older. Further, estimates of value at risk given suggest, for example, that a 90 year old female not smoking and having no children and an average body mass index will have a hospital charge less than Z$49851 with probability 0.999.
作者:
Teraguchi, ShunsukeKumagai, YutaroTohoku Univ
Tohoku Med Megabank Org Aoba Ku 2-1 Seiryo Machi Sendai Miyagi 9808573 Japan Osaka Univ
Immunol Frontier Res Ctr Quantitat Immunol Res Unit 3-1 Yamada Oka Suita Osaka 5650871 Japan
Background: Time course measurement of single molecules on a cell surface provides detailed information about the dynamics of the molecules that would otherwise be inaccessible. To extract the quantitative information...
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Background: Time course measurement of single molecules on a cell surface provides detailed information about the dynamics of the molecules that would otherwise be inaccessible. To extract the quantitative information, single particle tracking (SPT) is typically performed. However, trajectories extracted by SPT inevitably have linking errors when the diffusion speed of single molecules is high compared to the scale of the particle density. Methods: To circumvent this problem, we develop an algorithm to estimate diffusion constants without relying on SPT. The proposed algorithm is based on a probabilistic model of the distance to the nearest point in subsequent frames. This probabilistic model generalizes the model of single particle Brownian motion under an isolated environment into the one surrounded by indistinguishable multiple particles, with a mean field approximation. Results: We demonstrate that the proposed algorithm provides reasonable estimation of diffusion constants, even when other methods suffer due to high particle density or inhomogeneous particle distribution. In addition, our algorithm can be used for visualization of time course data from single molecular measurements. Conclusions: The proposed algorithm based on the probabilistic model of indistinguishable Brownian particles provide accurate estimation of diffusion constants even in the regime where the traditional SPT methods underestimate them due to linking errors.
Single particle cryo-EM excels in determining static structures of protein molecules, but existing 3D reconstruction methods have been ineffective in modelling flexible proteins. We introduce 3D variability analysis (...
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Single particle cryo-EM excels in determining static structures of protein molecules, but existing 3D reconstruction methods have been ineffective in modelling flexible proteins. We introduce 3D variability analysis (3DVA), an algorithm that fits a linear subspace model of conformational change to cryo-EM data at high resolution. 3DVA enables the resolution and visualization of detailed molecular motions of both large and small proteins, revealing new biological insight from single particle cryo-EM data. Experimental results demonstrate the ability of 3DVA to resolve multiple flexible motions of a-helices in the sub-50 kDa transmembrane domain of a GPCR complex, bending modes of a sodium ion channel, five types of symmetric and symmetry-breaking flexibility in a proteasome, large motions in a spliceosome complex, and discrete conformational states of a ribosome assembly. 3DVA is implemented in the cryoSPARC software package.
Deep Neural network learning for image processing faces major challenges related to changes in distribution across layers, which disrupt model convergence and performance. Activation normalization methods, such as Bat...
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