Glucocorticoids possess extensive and potent pharmacological effects, but their misuse and overuse are widespread concerns. Consequently, the environmental pollution and health hazards associated with their excessive ...
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Glucocorticoids possess extensive and potent pharmacological effects, but their misuse and overuse are widespread concerns. Consequently, the environmental pollution and health hazards associated with their excessive usage cannot be overlooked. There is an urgent need for enhanced removal and a thorough understanding of the environmental and safety risks arising from the overconsumption of these drugs. In this study, a novel f, Nenriched covalent organic framework (designated as TAPT-COf) with high crystallinity was synthesized. TAPTCOffeatures numerous active sites, including f-f interaction and hydrogen bond interaction sites, along with a high specific surface area and good thermal stability. These characteristics enable TAPT-COf to serve as an advanced adsorbent for dispersed solid-phase extraction (D-SPE) of glucocorticoids such as fluocinonide acetate, budesonide, and dexamethasone, with adsorption capacities ranging from 146.77 to 228.90 mg & sdot;g-1 . Notably, TAPT-COf exhibits exceptional protein exclusion efficiency, achieving exclusion rates exceeding 95 %. Due to these advantages, TAPT-COf based D-SPE demonstrates strong applicability in the analysis of complex practical samples, including water and plasma, with satisfactory recoveries ranging from 76.48 % to 112.76 %. Compared to a COf (TPB-COf) that lacks a triazine group, TAPT-COf exhibits superior adsorption performance for target glucocorticoids. This is attributed to its ability to provide enhanced electrostatic interactions, as well as the synergistic effects of hydrogen bonding and f-f interactions. Additionally, TAPT-COf displays a low hemolytic activity, indicating its potential for in vivo analysis.
The Lindel & ouml;f property of lexicographic products of GO-spaces is characterized. (c) 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
The Lindel & ouml;f property of lexicographic products of GO-spaces is characterized. (c) 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
fibre and fabric production technologies-especially in the area of com-posite reinforcements-have played an as-yet largely unheralded role in thedevelopment of the UKs formula One industry,but the British Textile Mach...
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fibre and fabric production technologies-especially in the area of com-posite reinforcements-have played an as-yet largely unheralded role in thedevelopment of the UKs formula One industry,but the British Textile MachineryAssociation(BTMA)aims to change that.
In this work, we aim to device a f ( R ) gravity model of new type using Barrow holographic dark energy (BHDE) in presence offLRW metric. The model is subsequently examined for its ability to address the problem of l...
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In this work, we aim to device a f ( R ) gravity model of new type using Barrow holographic dark energy (BHDE) in presence offLRW metric. The model is subsequently examined for its ability to address the problem of late-time dark energy. To be considered viable, the reconstructed f ( R ) model must meet with certain conditions, including (1) an effective gravitational coupling that is positive in nature, giving f ′ R > 0 , which also avoids the introduction of ghost like behavior of graviton from a quantum mechanical point of view; (2) a cosmological perturbation must be exhibited which is stable in nature and the gravitational wave must ensure positivity in the scalar mode that necessitates f ′ ′ R > 0 , which from quantum mechanical point of view says the model is free from tachyonic instabilities; (3) In the areas of high curvature, the model has to show an asymptotic behavior similar to that of Λ CDM model, thus, f ( R ) tends to f ( R ) → ( R − 2 Λ ) when R → ∞ ; (4) the model at late-time must have a de-Sitter solution which is stable; and finally, (5) the model is made to satisfy the constraints of local system under the consideration of a proper chameleon mechanism. These are the five criteria employed to the verify f ( R ) gravity model feasibility. In this work, we are investigating these tests and hence the newly formed model viability.
Background In patients with ARDS, positive end-expiratory pressure (PEEP) titration remains a challenge and recommendations are not in agreement. In mechanically ventilated patients with COVID-19, subphenotypes based ...
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Background In patients with ARDS, positive end-expiratory pressure (PEEP) titration remains a challenge and recommendations are not in agreement. In mechanically ventilated patients with COVID-19, subphenotypes based on different respiratory trajectories have been identified, but their heterogeneity in response to PEEP/f io 2 strategy remains understudied. Research Question Can these previously determined subphenotypes be detected early in the course of mechanical ventilation, and do these subphenotypes moderate the association between PEEP and f io 2 ventilation strategy and mortality? Study Design and Methods Retrospective analysis of invasively ventilated patients with COVID-19. Patients were categorized into 2 treatment groups: high PEEP/low f io 2 strategy and low PEEP/high f io 2 strategy. To replicate previously described longitudinal respiratory subphenotypes, hereafter named the low-power or high-power subphenotype, a prediction model was created. The primary outcome was the interaction between PEEP/f io 2 strategy and subphenotype, with mortality as the dependent variable. Results Of the 1,464 patients included in this analysis, 361 patients (25%) were allocated into the high PEEP/low f io 2 strategy and 1,103 patients (75%) were allocated into the low PEEP/high f io 2 strategy. A prediction model consisting of respiratory data of the first 2 days of invasive ventilation (area under the receiver operating characteristics curve, 0.88) assigned 908 patients (62%) to the low-power subphenotype and 556 patients (38%) to the high-power subphenotype. The high-power subphenotype was characterized by higher minute volume, mechanical power, ventilatory ratio, and driving pressure. The association between PEEP/f io 2 ventilation strategy and ICU mortality was moderated by the subphenotype ( P = . 03), with high PEEP/low f io 2 ventilation being associated with lower mortality in the low-power subphenotype (OR, 0.46; 95% CI, 0.31-0.67; P < . 001) and not in the high-
A new integrated filler metal/base metal manufacturing method by cold spray additive manufacturing is proposed. The integrated CuTi filler metal/GH3536 and CuTi + W composite filler metal/GH3536 are prepar...
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A new integrated filler metal/base metal manufacturing method by cold spray additive manufacturing is proposed. The integrated CuTi filler metal/GH3536 and CuTi + W composite filler metal/GH3536 are prepared by cold spray additive manufacturing techniques. The large plastic deformation of Cu and Ti particles and the tamping effect of W particles promote the interfacial bonding of particles, which improves the weldability of cold sprayed CuTi + W composite filler metals. Based on the cold sprayed CuTi + W composite filler metal, the C f /SiC composites and GH3536 are successfully brazed, and the typical microstructure and brazing mechanism are investigated. As a result, the shear strength of C f /SiC-GH3536 joint brazed by cold sprayed CuTi + W composite filler metal reaches 77 MPa. This study highlightes the great potential of cold spray additive manufacturing for integrated filler metal/base metal manufacturing in brazing.
We investigate the interplay between ferromagnetism and unconventional superconductivity in a two-dimensional anisotropic triangular-lattice Hubbard model using the density-matrix renormalization group (DMRG) method. ...
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We investigate the interplay between ferromagnetism and unconventional superconductivity in a two-dimensional anisotropic triangular-lattice Hubbard model using the density-matrix renormalization group (DMRG) method. A novel mechanism for spin-triplet f -wave superconductivity is identified, driven by three-site cyclic-exchange interactions. This mechanism highlights the crucial role of lattice anisotropy and triangular hopping networks in stabilizing ferromagnetic correlations necessary for spin-triplet pairing. The slow decay of pair-correlation functions and their sign change under a π / 3 rotation confirm the dominant f -wave symmetry of the superconducting state. These findings offer a unified theoretical framework for understanding unconventional superconductivity in strongly correlated electron systems, with potential relevance to materials such as Bechgaard salts ( TMTSf ) 2 X , cobalt oxide Na 0 . 35 CoO 2 ⋅ 1 . 3 H 2 O , and layered perovskite Sr 2 RuO 4 .
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