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Characterization of Irradiation Sites of Apsara Reactor for k₀-Based IM-NAA and Its Validation and Application

IEEE TRANSACTIONS ON NUCLEAR SCIENCE 2013年第4期60卷 3051-3056页

作者： Acharya, R. Dasari, K. B. Rao, J. S. Brahmaji Subramani, C. R. Venkata Reddy, A. V. R. Bhabha Atom Res Ctr Div Radiochem Bombay 400085 Maharashtra India IGCAR Div Fuel Chem Chem Grp Kalpakkam 603102 Tamil Nadu India Bhabha Atom Res Ctr Div Analyt Chem Bombay 400085 Maharashtra India

Three irradiation positions of Apsara reactor were characterized by determining epithermal neutron spectrum shape factor (alpha) and sub-cadmium to epithermal neutron flux ratio (f) for k(0)-based Internal Monostandard Neutron Activation Analysis (IM-NAA). The alpha values were determined by cadmium ratio method using six neutron flux monitors (In, Au, Co, Mo, Zn and Zr). The f-value was also determined by cadmium ratio method using an Au monitor. The alpha values of two irradiation positions are found to be positive, which indicated softened epithermal neutron spectra whereas alpha value of the third one is negative indicating hardened neutron spectrum. IAEA reference material, RM SL-1 (Lake Sediment) was analyzed by IM-NAA using experimentally determined f and alpha values of all three irradiation positions. A total of 16 elemental concentrations were determined using Sc as the internal monostandard and the values are found to be in good agreement with respect to the certified or information values. As an application of IM-NAA, two ceramic archaeological samples along with one soil sample were analyzed using Sc as the monostandard.

关键词： alpha Apsara reactor archaeological ceramic sample cadmium ratio method In situ detection efficiency f k(0)-based internal monostandard method method validation multi-monitors NAA neutron spectrum characterization

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Model tests on horizontal pile-to-pile interaction incorporating local non-linearity and resonance effects

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SOIL DYNAMICS AND EARTHQUAKE ENGINEERING 2013年 48卷 175-192页

作者： Goit, Chandra Shekhar Saitoh, Masato Mylonakis, George Kawakami, Hideji Oikawa, Hiroki Saitama Univ Grad Sch Sci & Engn Saitama 3388570 Japan Univ Patras Dept Civil Engn Patras 26500 Greece

Dynamic experimental studies on horizontal interaction factors for laterally loaded model soil-pile systems subjected to low-to-high amplitude pile head loading are reported, focusing on the effect of dynamics and local non-linearity. Results obtained from dynamic experiments with different amplitudes of harmonic lateral loading on instrumented model soil-pile systems conducted on a shaking table indicate that the resonance of soil-pile system shows a profound impact on the horizontal interaction factors. furthermore, behavior of the soil-pile system becomes highly non-linear with increasing amplitude of loading, as the extent of local non-linearity around the pile increases. Consequently, group effects cannot be predicted by using established approximate equations based on the assumption of linear viscoelastic behavior. To this end, new semi-empirical equations are proposed for obtaining the horizontal interaction factors, as an extension of available approximate equations to incorporate the local non-linear behavior of soil-pile system for both small and large pile spacings. (C) 2013 Elsevier Ltd. All rights reserved.

关键词： d pile diameter s pile spacing s / d spacing to diameter ratio V s shear wave velocity ω cyclic frequency f n natural frequency of soil ω n cyclic natural frequency of soil f ′ n natural frequency of soil-pile system ω ′ n cyclic natural frequency of soil–pile system q applied loading amplitude (m/s 2 ) β hysteretic soil damping ζ amplification parameter a 0 dimensionless frequency= ωd / V s θ aperture angle I hh horizontal interaction factor λ geometric ratio of prototype to model η density ratio of prototype to model i = − 1 imaginary unit

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Low-power pipelined phase accumulator with sequential clock gating for DDfSs

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ELECTRONICS LETTERS 2013年第23期49卷 1445-1446页

作者： Kim, Y. S. Lee, J. Hong, Y. Kim, J. E. Baek, K. -H. Chung Ang Univ Sch Elect & Elect Engn Seoul 156756 South Korea

A pipelined phase accumulator (PACC) for direct digital frequency synthesisers (DDfSs) is presented. A highly pipelined structure is inevitable in a PACC design to achieve high-speed performance, which causes a large number of pre-skewing flip-flops (f/fs) and leads clock signals to be a large source of power dissipation. Since the input data do not change every single cycle, clock gating can save power by decreasing the number of unnecessary clock switching in the pre-skewing f/fs. Sequential clock gating for pipelined PACCs is proposed. Compared with the conventional pipelined PACCs with and without clock gating, the proposed scheme reduces power dissipation by up to 55.4 and 77.2%, respectively, for the 32-bit 8-pipeline-stage PACCs.

关键词： clocks flip-flops frequency synthesizers secondary cells low-power pipelined phase accumulator sequential clock gating DDfS PACC direct digital frequency synthesisers flip-flops clock signals power dissipation clock switchings preskewing f f

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Meeting Report VLPNPV: Session 3: Immune Responses

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HUMAN VACCINES & IMMUNOTHERAPEUTICS 2014年第10期10卷 3064-3067页

作者： Morrison, Trudy G. Univ Massachusetts Sch Med Dept Microbiol & Physiol Syst Worcester MA 01610 USA

Virus-like particles (VLPs) and nano-particles (NP) are increasingly considered for both prophylactic and therapeutic vaccines for a wide variety of human and animal diseases. Indeed, 2 VLPs have already been licensed for use in humans, the human papilloma virus vaccine and the hepatitis B virus vaccine.(1) Reflecting this increased interest, a second international conference with a specific focus on VLPs and NP was held at the Salk Institute for Biological Studies in La Jolla, California, in June 2014. Approximately 100 attendees, hailing from many nations, came from academic institutions, research institutes, and biotech companies. A wide variety of topics were discussed, ranging from development and characterization of specific VLP and NP vaccine candidates to methods of production of these particles. Session three was focused on the general question of immune responses to VLPs.

关键词： adjuvants anti-glycan immunity human humoral immune responses mucosal immunity memory responses T cell responses Virus-like particles VLPs virus-like particles NP nanoparticles or nucleocapsid protein MHC major histocompatibility complex HIV human immunodeficiency virus RSV respiratory syncytial virus NDV Newcastle disease virus M membrane f fusion G glycoprotein HN hemagglutinin-neuraminidase LLPC long-lived plasma cells TrV triatoma virus TMV tobacco mosaic virus TLR toll-like receptor NOD nucleotide-binding oligomerization domains RHDV rabbit hemorrhagic disease virus PBL peripheral blood lymphocytes BLys B lymphocyte stimulator ELISpot enzyme-linked immunoSpot

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Topographic effects on current variability in the Caspian Sea

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JOURNAL Of GEOPHYSICAL RESEARCH-OCEANS 2013年第12期118卷 7107-7116页

作者： Ghaffari, P. Isachsen, P. E. LaCasce, J. H. Univ Oslo Dept Geosci N-0315 Oslo Norway Norwegian Meteorol Inst Dept Res & Dev Oslo Norway

Satellite-derived surface height fields reveal that variability in the central and southern basins of the Caspian Sea is correlated with topography. Consistently, empirical orthogonal functions from current meter data from the southern basin are aligned with the isobaths. In addition, the gravest mode, which accounts for over 80% of the variance, has an equivalent barotropic structure in the vertical. To what extent this variability can be modeled using a linear analytical model is examined. The latter assumes equivalent barotropic flow aligned with the geostrophic contours, which in turn are dominated by the topography. With ECMWf winds and ETOPO2 topography, the model yields surface height deviations which are significantly correlated with satellite-derived estimates on seasonal and longer time scales in the central basin. The model is somewhat less successful in the southern basin, where the stratification is stronger. Nevertheless, the results are encouraging, given the extreme simplicity of the model.

关键词： Caspian Sea variability f f contours EB model

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fusarium populations in soil under long-term organic and chemical fertilizer treatments

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ACTA AGRICULTURAE SCANDINAVICA SECTION B-SOIL AND PLANT SCIENCE 2013年第3期63卷 253-260页

作者： Han, Xuemei Zhang, Dianpeng Cao, Zhiping Dehne, Heinz-W. Nanyang Normal Univ Sch Life Sci & Technol Nanyang City 473061 Henan Peoples R China China Agr Univ Dept Ecol & Ecol Engn Coll Resources & Environm Sci Beijing 100094 Peoples R China Beijing Acad Agr & Forestry Sci Inst Plant & Environm Protect Biocontrol Microbe Lab Beijing Peoples R China Univ Bonn Inst Crop Sci & Resource Conservat INRES Bonn Germany

fusarium spp. in soil are potential threats to crops, so the purpose of this study was to explore the response of their population levels and species composition to long-term fertilizer applications. Two experiments were established in 1993 (consecutive 13 years) and 1997 (consecutive 9 years), where organic fertilizer (Of) and chemical fertilizer (Cf) treatments were conducted in the winter wheatsummer maize rotation system in the North China Plain. Unfertilized soil served as controls. Eight fusarium species were isolated and identified based on their morphological characteristics and nucleic acid analysis. four dominant species including f. proliferatum, f. solani, f. equiseti, and f. semitectum accounted for 95% of isolates. No differences in total fusarium population levels and diversity indices with organic and Cf were found. Both fertilizer applications increased population levels of f. equiseti in soil, due to its better competition for nutrients. High nutrients also impacted f. solani population. These two species should be monitored when applying Of and Cf. The decrease of f. proliferatum population across the growing seasons was attributed to decomposition of maize debris from preceding crop in soil.

关键词： Chemical fertilizer f equiseti f solani fusarium population organic fertilizer

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尘螨变应原Der f 2编码基因重组pCold Tf体系构建及可溶性表达

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中国病原生物学杂志 2012年第2期7卷 118-120,123页

作者：王运刚周鹰杨李马桂芳孙金霞卞永华崔玉宝盐城卫生职业技术学院江苏盐城224006

目的建立尘螨变应原Der f 2编码基因重组pCold Tf体系并诱导表达。方法以质粒pMD19-T-Der f 2为模板扩增目的基因Der f 2,克隆至pCold Tf DNA载体,转化BL21细菌,用IPTG诱导表达,用SDS-PAGE和West-ern blot鉴定表达产物。结果 PCR扩增获... 详细信息

目的建立尘螨变应原Der f 2编码基因重组pCold Tf体系并诱导表达。方法以质粒pMD19-T-Der f 2为模板扩增目的基因Der f 2,克隆至pCold Tf DNA载体,转化BL21细菌,用IPTG诱导表达,用SDS-PAGE和West-ern blot鉴定表达产物。结果 PCR扩增获得Der f 2编码基因,成功构建表达质粒pCold Tf-Der f 2。SDS-PAGE检测表明该质粒在大肠埃希菌中正常表达,且基本为可溶性表达,表达产物分子质量单位为69ku,Western blot检测该蛋白能被鼠抗Penta-His抗体识别。结论成功建立尘螨变应原Der f 2编码基因重组pCold Tf体系,并实现其可溶性原核表达。

关键词：粉尘螨变应原(Der f 2) 基因重组原核表达

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Spinal Cord Stimulation as Treatment for Complex Regional Pain Syndrome Should Be Considered Earlier Than Last Resort Therapy

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NEUROMODULATION 2013年第2期16卷 125-141页

作者： Poree, Lawrence Krames, Elliot Pope, Jason Deer, Timothy R. Levy, Robert Schultz, Louise Univ Calif San Francisco Dept Anesthesiol San Francisco CA 94143 USA Pacific Pain Treatment Ctr San Francisco CA 94109 USA Napa Pain Inst Napa CA USA Vanderbilt Univ Sch Med Nashville TN 37212 USA W Virginia Univ Sch Med Charleston WV 25304 USA Univ Florida Coll Med Jacksonville Dept Neurosurg Jacksonville FL USA Univ Florida Coll Med Jacksonville Shands Jacksonville Neurosci Inst Jacksonville FL USA Touro Med Sch Vallejo CA USA

Background Spinal cord stimulation (SCS), by virtue of its historically described up-front costs and level of invasiveness, has been relegated by several complex regional pain syndrome (CRPS) treatment algorithms to a therapy of last resort. Newer information regarding safety, cost, and efficacy leads us to believe that SCS for the treatment of CRPS should be implemented earlier in a treatment algorithm using a more comprehensive approach. Methods We reviewed the literature on pain care algorithmic thinking and applied the safety, appropriateness, fiscal or cost neutrality, and efficacy (S.A.f.E.) principles to establish an appropriate position for SCS in an algorithm of pain care. Results and Conclusion Based on literature-contingent considerations of safety, efficacy, cost efficacy, and cost neutrality, we conclude that SCS should not be considered a therapy of last resort for CRPS but rather should be applied earlier (e.g., three months) as soon as more conservative therapies have failed.

关键词： Cost neutrality efficacy fiscal neutrality pain treatment continuum S A f E principles safety spinal cord stimulation

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鲍小红:东方破晓

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浙江画报 2015年第8期 32-33页

作品创作于浙江省平阳县鳌江镇西湾滩涂,拍摄时间为2014年7月19日早晨5点半。因为潮起潮落,所以必须要等潮落时的最佳时刻才能拍到滩涂上的倒影。我在几天前查询好当地退潮的时间,提前30分钟到达之前踩点后确定的拍摄位置。拍摄点既要... 详细信息

作品创作于浙江省平阳县鳌江镇西湾滩涂,拍摄时间为2014年7月19日早晨5点半。因为潮起潮落,所以必须要等潮落时的最佳时刻才能拍到滩涂上的倒影。我在几天前查询好当地退潮的时间,提前30分钟到达之前踩点后确定的拍摄位置。拍摄点既要考虑日出位置,还要有一个漂亮的前景。之后按想法设置白平衡,如突出黄红色调,白平衡可设"阴天"模式。

关键词：最佳时刻鳌江镇白平衡拍摄位置西湾拍摄时间作品创作浙江省平阳县 photograph f

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Hypothalamic-Pituitary-Adrenal Axis Effects of Mometasone furoate/formoterol fumarate vs fluticasone Propionate/Salmeterol Administered Through Metered-Dose Inhaler

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CHEST 2013年第6期144卷 1795-1802页

作者： Kosoglou, Teddy Hubbell, James Cutler, David L. Johnson-Levonas, Amy O. Xu, Danlin Kantesaria, Bhavna S. Kim, Kenneth Miller, S. David Merck & Co Inc Whitehouse Stn NJ USA WCCT Global Cypress CA USA Northeast Med Res Associates N Dartmouth MA USA

Background: The effects of mometasone furoate and fluticasone propionate on the hypothalamic-pituitary-adrenal axis were compared when administered from combination metered-dose inhaler (MDI) products. Methods: In a randomized, open-label, placebo-controlled, parallel group study, 66 patients with mild to moderate asthma received one of the following four treatments bid through an MDI for 42 days: mometasone furoate/formoterol (Mf/f) 200 mu g/10 mu g, Mf/f 400 mu g/10 mu g, fluticasone propionate/salmeterol (fP/S) 460 mu g/42 mu g, or placebo. Plasma cortisol concentrations were measured over 24 h on days -1 (baseline) and 42. Geometric mean ratio (GMR) and 90% CI for mean change from baseline to day 42 in 24-h plasma cortisol area under the curve (AUC) were calculated for each treatment. If the 90% CI for the GMRs fell within 70% to 143%, treatments were deemed comparable. Results: Mean baseline cortisol AUCs were similar across groups. Mean cortisol effects (change from baseline) were similar for Mf/f 400 mu g/10 mu g and fP/S 460 mu g/42 mu g (GMR, 119%;90% CI, 101%-140%). Effects of Mf/f 200 mu g/10 mu g on cortisol AUC were similar to placebo (GMR, 92%;90% CI, 78%-110%), whereas Mf/f 400 mu g/10 mu g and fP/S 460 mu g/42 mu g lowered cortisol AUC vs placebo (GMR, 78% [90% CI, 66%-92%] and 66% [90% CI 56%-78%], respectively). All treatments were generally well tolerated. Conclusions: Mf/f 400 mu g/10 mu g or fP/S 460 mu g/42 mu g bid through an MDI led to similar reductions from baseline in mean cortisol AUC (22% and 34% lower than placebo, respectively), whereas the effect of Mf/f 200 mu g/10 mu g was similar to placebo.

关键词： ANOVA analysis of variance AUC area under the plasma concentration-time curve AUCτ area under the plasma concentration-time curve 0 to 12 h postdose Cmax peak plasma concentration Ctrough plasma cortisol trough level DPI dry powder inhaler f formoterol fumarate feno fractional exhaled nitric oxide fP fluticasone propionate GMR geometric mean ratio HPA hypothalamic-pituitary-adrenal ICS inhaled corticosteroid LABA long-acting β2-agonist LC-MS/MS liquid chromatography-tandem mass spectrometry LLOQ lower limit of quantitation MDI metered-dose inhaler Mf mometasone furoate ppb parts per billion S salmeterol Tmax time to reach peak plasma concentration

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