Introduction: The use of methotrexate (MTX) for rheumatoid arthritis (RA) is increasing. However, the immune suppression state leads to the occurrence of lymphoproliferative disorder (MTX-LPD). The purpose of this stu...
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Introduction: The use of methotrexate (MTX) for rheumatoid arthritis (RA) is increasing. However, the immune suppression state leads to the occurrence of lymphoproliferative disorder (MTX-LPD). The purpose of this study was to describe the findings of 18f-fluorodeoxyglucose (fDG) positron emission tomography (PET) in MTX-LPD patients, and compare it with non-MTX-related malignant lymphoma (ML). Materials and Methods: We retrospectively reviewed 11 MTX-LPD patients (9 female, mean age 68.3 years) and 21 ML patients (7 female, mean age 60.6 years) with a histopathological diagnosis. fDG-PET imaging was performed using a standard oncology procedure. We assessed the disease distribution based on fDG-PET images and measured the maximum standardized up take values (SUVmax) for each region. Results: Mean values of SUVmax in MTX-LPD and ML were 14.6 and 17.2, respectively (p = 0.49). In MTX-LPD, 55 lesions met the Cotswold classification, consisting of 37 nodal and 18 extranodal lesions. In ML, 82 lesions were found, consisting of 68 nodal and 14 extranodal lesions. MTX-LPD showed a higher incident of the involvement in extranodal lesions throughout the whole body (p < 0.001). Conclusion: Because this disease occurs widely throughout the whole body, we need to pay attention to the less frequent sites as well when performing PET imaging in patients with MTX-LPD.
fluorine-doped tin oxide (fTO) thin films were deposited on glass substrates using ultrasonic spray pyrolysis (USP) at a fixed substrate temperature of 400 degrees C and various fluorine/Tin (f/Sn) atomic ratios of 0,...
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fluorine-doped tin oxide (fTO) thin films were deposited on glass substrates using ultrasonic spray pyrolysis (USP) at a fixed substrate temperature of 400 degrees C and various fluorine/Tin (f/Sn) atomic ratios of 0, 0.1, 0.5, and 1.0. Effects off/Sn atomic ratios on structural-morphological, compositional, electrical, optical, and nanomechanical properties of the fTO thin films were systematically studied. The fTO films exhibited a tetragonal structure with preferred orientations of (110), (200), and (211), and polycrystalline morphology with spear-like or coconut shell-like particles on the surfaces. The presence off-doping was confirmed by XPS results with clear f1s peaks, and f-concentration was determined to be 0.7% for f/Sn = 0.1 and 5.1% for f/Sn = 0.5. Moreover, the resistivity offTO films reduced remarkably from 4.1 mcm at f/Sn = 0 to 0.7 mcm at f/Sn = 1, primarily due to the corresponding increase of carrier concentration from 2 x 10(20) cm(-3) to 1.2 x 10(21) cm(-3). The average optical transmittance of the films prepared at f/Sn of 0-0.5 was over 90%, and it decreased to 84.4% for the film prepared at f/Sn = 1. The hardness (H) and Young's modulus (E) of the fTO films increased when the f/Sn ratios increased from 0 to 0.5, reaching maximum values of H = 12.3 +/- 0.4 GPa, E = 131.7 +/- 8.0 GPa at f/Sn = 0.5. Meanwhile, the H and E reduced considerably when the f/Sn ratio further increased to 1.0, following the inverse Hall-Petch effect approximately, suggesting that the grain boundary effect played a primary role in manipulating the nanomechanical properties of the fTO films. furthermore, favorable mechanical properties with large H/E-f and ratios were found for the fTO film prepared at f/Sn = 0.5, which possessed high crystallinity, large grain size, and compact morphology.
Reciprocal cross effects with respect to larval salivary secretory protein levels were studied in the interspecific fertile reciprocal hybrids by crossing Drosophila nasuta nasuta, and Drosophila nasuta albomicans. Th...
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Reciprocal cross effects with respect to larval salivary secretory protein levels were studied in the interspecific fertile reciprocal hybrids by crossing Drosophila nasuta nasuta, and Drosophila nasuta albomicans. These proteins are produced copiously during the third larval instar stage and are believed to play a role in the attachment of pupa to the substratum prior to pupariation as well as in insect immunity. Quantitative variations were encountered among the reciprocal hybrids. Significant heterosis was observed between D. n. nasuta and the f 1 hybrid female of a cross between D. n. albomicans female and D. n. nasuta male (21.39%) while the f 1 hybrids of a cross between D. n. nasuta female and D. n. albomicans male showed a marginal increase (4.24%) from the mid parent level. The glue secretions were correlated to total cell number but independent of gland size. SDS PAGE revealed a considerable heterosis with respect to X-linked protein fractions. Here we report sex specific biochemical heterosis. However the X-linked fractions undergo dosage compensation in both parents and hybrids indicating strict regulatory control.
A continuous inverse class-f (CCf-1) and class-J hybrid mode for the carrier power amplifier (PA) of the Doherty power amplifier (DPA) is proposed in this paper. In this hybrid mode, the carrier PA works in the CCf-1 ...
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A continuous inverse class-f (CCf-1) and class-J hybrid mode for the carrier power amplifier (PA) of the Doherty power amplifier (DPA) is proposed in this paper. In this hybrid mode, the carrier PA works in the CCf-1 mode at the saturated output power and the class-J mode at the low output power, which extends the design space of the conventional single continuous mode. A highly efficient Doherty power amplifier based on this hybrid mode is designed and fabricated using a CGH40010f 10 W GaN HEMT packaged device. The measurement results illustrate that drain efficiency (DE) of 67.2% to 81.7% at the saturated output power (Pout) and 50.4% to 60.1% at 6 dB output back-off (OBO) is achieved across the band 1.5 to 2.1 GHz with the saturated output power is about 43.3 to 44.6 dBm.
The microstructure and mechanical behavior of the Gas Tungsten Arc (GTA) welded joint offerritic/martensitic (f/M) P91 and austenitic SS304L steel was investigated in as-welded and post-weld heat treatment (PWHT) con...
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The microstructure and mechanical behavior of the Gas Tungsten Arc (GTA) welded joint offerritic/martensitic (f/M) P91 and austenitic SS304L steel was investigated in as-welded and post-weld heat treatment (PWHT) conditions. The microstructural studies included the particle size and its distribution, grain size, and percentage area fraction of the precipitates (%AfP) in different zones of the weldments. In as-welded condition, weld metal showed untempered martensitic microstructure devoid of carbide precipitates. After the PWHT, weld metal was characterized by tempered martensitic microstructure along with the decoration of the coarse carbide particles at PAGBs and fine carbonitride particles inside the matrix region. The mechanical behavior of the dissimilar weld was analyzed in as-welded and PWHT conditions by performing tensile testing, Charpy impact testing, and microhardness testing. A significant variation in microstructure and mechanical properties was obtained across the dissimilar welded joint (DWJ) for as-welded, which was minimized after the PWHT. The minimum%AfP in the coarse grain heat-affected zone was measured due to the formation of the precipitate-free soft delta ferrite patches, which also showed a negligible response to PWHT. The poor Charpy impact toughness (CIT) of 0.8 +/- 1.5 J and high tensile strength of 864 +/- 12.5 MPa were measured for the as-welded joint. The combination of high strength and low CIT was obtained mainly due to the untempered martensitic microstructure in the weld fusion zone. The DWJ after the PWHT showed a significant increase in Charpy impact toughness (CIT), and it was measured 70 +/- 4 J. Improved mechanical behavior with a good combination of ultimate tensile strength and CIT were obtained after the PWHT.
In this research, a novel Ag3PO4 NPs@MoS2 nanosheet-based electrochemiluminescence (ECL) sensing system was developed to provide an effective method for tumor gene detection. At first, fluorine, sulfur-doped BN quantu...
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In this research, a novel Ag3PO4 NPs@MoS2 nanosheet-based electrochemiluminescence (ECL) sensing system was developed to provide an effective method for tumor gene detection. At first, fluorine, sulfur-doped BN quantum dot (f, S-BN QD) were prepared as ECL emitter. Sulfur dopant can provide more reactive sites in the ECL reaction. fluorine atoms in the QD structure further improved the stability of the crystal. furthermore, Ag3PO4 NP@MoS2 nanosheets were fabricated via a hydrothermal route as ECL reaction catalyst. On the one hand, Ag3PO4 NP@MoS2 nanosheets promoted the generation of more oxidant of coreactant in the f, S-BN QD/H2O2 coreactant ECL pathway. On the other hand, the excellent conductivity of Ag3PO4 NP@MoS2 nanosheets facilitated the electron transfer and effectively reduce the damage off, S-BN QD by excessive hot electrons. finally, the proposed biosensor was designed to accurately quantify K-ras tumor gene from 10 fM to 100 pM with a limit of detection (LOD) of 0.2 fM. The sensing system was used to detect K-ras gene in human colorectal cancer tumor and tumor-adjacent tissues samples with satisfactory results. The amplified ECL sensing strategy with Ag3PO4 NPs@MoS2 nanosheet has significant potential value in the clinical detection.
PET-radiopharmaceuticals are an important part of modern nuclear medicine, even though the availability of these compounds to registered nuclear doctors is limited in many ways.New regulations dealing with availabilit...
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PET-radiopharmaceuticals are an important part of modern nuclear medicine, even though the availability of these compounds to registered nuclear doctors is limited in many ways.
New regulations dealing with availability will enter into force along with the 15
§ 4a Clause 1 No. 3 will no longer apply, meaning that production and application will be encompassed within the AMG and the performance of all related practices will require registration with the approving authority in accordance with § 67 paragraph 2.
In this situation, it is necessary to develop radiopharmaceutical production within normal working conditions. MVZ-DTZ Berlin has done this in cooperation with the Institute for Nuclear Chemistry at Mainz University. After operating for 2 years MVZ-DTZ Berlin guarantees successful and reliable medical care of its patients. Due to the reliability of its production, MVZ-DTZ Berlin has also begun radiotherapy. Additional
The development and application of V2O3-based anodes are hindered by their poor reversible capacity and rate performance. Doping f and combined with N-doped carbon at the same time would achieve excellent electrochemi...
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The development and application of V2O3-based anodes are hindered by their poor reversible capacity and rate performance. Doping f and combined with N-doped carbon at the same time would achieve excellent electrochemical performance, but the related materials are not prepared and employed to lithium-ion batteries due to the absent synthetic method. In this investigation, a simple strategy was firstly invented to achieve f-doped V2O3/N-doped carbon composite. The f-doped V2O3 nanoparticles are adhered to N-doped carbon, which would enhance electrochemical reaction kinetics. As a result, a high capacity of 481 mAh/g can be obtained at 2 A/g.
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