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PARLIAMENTARY HISTORY 2021年第1期40卷 45-58页

作者： Cavill, Paul Univ Cambridge Early Modern British Hist Cambridge England Pembroke Coll Cambridge England

A.f. Pollard is now better remembered for founding the Institute of Historical Research than he is for his scholarship. In his heyday, however, Pollard was a formidable and prolific historian, primarily of parliament and the Tudor period. Pollard has been characterised both as a modernist and as a whig historian. Rejecting romantic invocations of liberty, he extolled instead the sovereign nation state, pinpointing the 16th century as the moment when it was achieved. Pollard rejected anachronistic accounts of parliament's development: for him, the assembly had grown by accident (out of the medieval king's council), rather than by design. This adaptability had ensured parliament's longevity and would preserve it into the future. Pollard revered the English parliament all the more for its embodiment of this national good fortune. Pollard helped to professionalise the discipline of history, but his own writings could be found wanting when measured against the standards that he had advocated. Criticism of his approach and assumptions comes easily now. Yet, upon reacquaintance, historians of parliament may find enduring interest in Pollard's shrewd and extensive work.

关键词： Dictionary of National Biography evolution f W Maitland G R Elton History of Parliament Institute of Historical Research J E Neale Josiah Wedgwood modernism whig history

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Neuropyrones A-E, five undescribed α-pyrone derivatives with tyrosinase inhibitory activity from the endophytic fungus Neurospora dictyophora WZ-497

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PHYTOCHEMISTRY 2023年第1期207卷 113579页

作者： Li, Xin Gong, Yuan-Xiang feng, Li Wang, Xin-Jia Wang, Jing-Wen Zhang, An-Xin Tan, Ning-Hua Wang, Zhe China Pharmaceut Univ Sch Tradit Chinese Pharm Nanjing 211198 Peoples R China

five undescribed alpha-pyrone derivatives, named neuropyrones A-E, were isolated from the endophytic fungus Neurospora dictyophora WZ-497 derived from the stems of Aster tataricus L. f. The structures of these alpha-pyrones with absolute configurations were determined by comprehensive spectroscopic analysis and computational calculations. All isolated compounds were tested for various bioactivities, including tyrosinase inhibitory ac-tivity. The results showed that neuropyrones A-C displayed potent inhibitory effects on tyrosinase with IC50 values of 0.38 +/- 0.07, 0.49 +/- 0.06, and 0.12 +/- 0.01 mM, respectively, which were comparable to that of the positive control, kojic acid (IC50 = 0.14 +/- 0.021 mM). A molecular docking study revealed the interaction be-tween 3 and the His263, His85, Val283, Asn260, Phe264, and Val248 residues of tyrosinase.

关键词： Aster tataricus L f Asteraceae Neurospora dictyophora Sordariaceae Pyrone derivatives NeuropyronesA-E Anti-tyrosinase activities

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Screening of major hepatotoxic components of Tripterygium wilfordii based on hepatotoxic injury patterns

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BMC COMPLEMENTARY MEDICINE AND THERAPIES 2023年第1期23卷 9-9页

作者： Li, Meng Luo, Qiong Chen, Xi Qiu, furong Tao, Yanyan Sun, Xin Liu, Chenghai Shanghai Univ Tradit Chinese Med Shuguang Hosp Inst Liver Dis 528 Zhangheng RdPudong New Area Shanghai 201203 Peoples R China Shanghai Key Lab Tradit Chinese Clin Med Shanghai 201203 Peoples R China Shanghai Univ Tradit Chinese Med Shuguang Hosp Lab Clin Pharmacokinet Shanghai 201203 Peoples R China Minist Educ Key Lab Liver & Kidney Dis Shanghai 201203 Peoples R China Shanghai Innovat Ctr TCM Hlth Serv Shanghai 201203 Peoples R China

Background Tripterygium wilfordii Hook. f. (TwHf), a traditional Chinese medicine, is widely used in the treatment of rheumatoid arthritis. Due to multiorgan toxicity, particularly hepatotoxicity, the application of TwHf is restricted. To clarify the hepatotoxic substances, zebrafish, hepatocytes and macrophages were used for screening based on hepatotoxic injury patterns. This study provides a basis for further elucidation of the hepatotoxic mechanism of *** first, 12 compounds were selected according to the chemical categories of TwHf. The fluorescence area and fluorescence intensity of zebrafish livers were observed and calculated. The viability of two hepatocyte lines was detected by CCK8 assay. TNf-alpha and IL-1 beta mRNA expression in bone marrow-derived macrophages was used to evaluate macrophage activation, a factor of potential indirect hepatotoxicity. finally, the hepatotoxic characteristics of 4 representative components were verified in mice in *** Parthenolide, triptolide, triptonide, triptobenzene H, celastrol, demethylzeylasteral, wilforlide A, triptotriterpenic acid A and regelidine significantly reduced the fluorescence area and fluorescence intensity of zebrafish livers. The viability of L-02 or AML-12 cells was significantly inhibited by parthenolide, triptolide, triptonide, celastrol, demethylzeylasteral, and triptotriterpenic acid A. Parthenolide, triptolide, triptonide, celastrol, demethylzeylasteral and triptobenzene H significantly increased TNf-alpha and IL-1 beta mRNA levels in macrophages, while triptophenolide, hypodiolide and wilforine significantly reduced TNf-alpha and IL-1 beta mRNA levels. Triptotriterpenic acid A, celastrol and triptobenzene H at a dose of 10 mg/kg significantly increased the levels of mouse serum alanine aminotransferase and aspartate aminotransferase and aggravated liver *** Parthenolide, triptolide, triptonide, celastrol, demethylzeylasteral, triptotriterpenic acid A and tr

关键词： Tripterygium wilfordii hook f Hepatotoxicity Drug-induced liver injury Herbal component Macrophage

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#Ledatoo: The morality of Leda and the Swan in teaching stylistics

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LANGUAGE AND LITERATURE 2021年第2期30卷 127-146页

作者： Cook, Guy Kings Coll London Language Educ London England

The article discusses the morality of W. B. Yeats' sonnet Leda and the Swan in the context of a widening gap between the sexual mores of earlier times and our own, and whether the poem remains a suitable choice for the teaching of stylistics. I begin by examining stylistics treatments of the poem, and its political, social and artistic context, then move on to consider charges of misogyny against the poem for eroticising and failing to condemn the rape it depicts. To assess these charges I examine other literary uses of the Leda myth both before and after Yeats, including earlier poems which romanticise the rape, and later ones which vilify it. I also consider the implications of my discussion for the teaching of other canonical poems on similar themes. The last part of the paper discusses more generally the place of morality in literature and literature teaching, including stylistics: whether teachers and analysts should promote a moral world view and moral behaviour through their choice of texts and comments on them, or whether there are other valid criteria for selecting and describing a text such as Leda and the Swan. To elucidate current views, I draw parallels with the moral didacticism of the highly influential literary critic f. R. Leavis in the mid twentieth century, and ask whether aspects of his patrician view have undergone a surreptitious revival in some contemporary pedagogy and criticism at the beginning of the twenty first.

关键词： Stylistics feminist stylistics W B Yeats Leda and the Swan literature teaching misogyny in literature rape in literature f R Leavis morality in literature feminist literary theory

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In vitro effect of some commercial fungicides on mycelial growth of fusarium species causing maize ear rot disease in China

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ARCHIVES Of PHYTOPATHOLOGY AND PLANT PROTECTION 2021年第11-12期54卷 557-569页

作者： Gxasheka, Masibonge Wang, Jun Gunya, Busisiwe Mbanjwa, Vusi Tyasi, Thobela Louis Dlamini, Phesheya Gao, Jie Jilin Agr Univ Dept Plant Protect Lab Plant Pathol Changchun 130118 Jilin Peoples R China Univ Limpopo Dept Plant Prod Soil Sci & Agr Engn Sch Agr & Environm Sci Limpopo South Africa Univ Limpopo Dept Agr Econ & Anim Prod Sch Agr & Environm Sci Limpopo South Africa

fusarium ear rot is an important disease of maize and requires several fungicide treatments to achieve satisfactory control in China. The extensive use of common fungicides to control this disease has caused fungicides resistance of pathogens. In this study, we tested the effect of different commercial fungicides on mycelial growth of fusarium graminearum and fusarium oxysporum isolates collected from different fields in the Jilin Province of China in 2014. The effect of concentration on mycelial growth varied significantly (p < 0.05) between tested commercial fungicides. Our results showed that among the 10 tested commercial fungicides, prochloraz and polyoxin-D highly reduced the mycelial growth of fusarium graminearum by 3.4 cm and 4.1 cm, respectively as compared to other fungicides at a concentration of 0.1 mg/L. Moreover, a 0.1 mg/L concentration of polyoxin-D, tebuconazole, fosetyl-Al, fludioxonil, azoxystrobin, and carbendazim were also highly effective to decrease the mycelial growth of fusarium oxysporum with 3.1 cm, 3.1 cm, 3.4 cm, 3.8 cm, and 4.4 cm as compared to other fungicides at the same concentration. These results will provide useful information to select suitable fungicides for management and control of maize ear rot disease caused by fusarium graminearum and fusarium oxysporum and further increase our understanding of the effects of different fungicides concentrations on fusarium graminearum and fusarium oxysporum.

关键词： Maize f graminearum f oxysporum mycelial growth commercial fungicides

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杧果‘金煌’×‘热农1号’后代果实性状遗传分析

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园艺学报 2022年第2期49卷 416-426页

作者：武红霞李星许文天郑斌马小卫苏穆清梁清志姚全胜王松标中国热带农业科学院南亚热带作物研究所农业农村部热带果树生物学重点实验室海南省热带园艺采后处理与保鲜重点实验室广东湛江524091

以杧果‘金煌’×‘热农1号’的f1代54个单株为材料,对其果实性状进行观测,并对单果质量等9个数量性状进行了遗传分析,对30个数量性状和描述性状进行了Shannon-Weaver多样性和主成分分析。结果表明,9个数量性状(单果质量、果实纵径... 详细信息

以杧果‘金煌’×‘热农1号’的f1代54个单株为材料,对其果实性状进行观测,并对单果质量等9个数量性状进行了遗传分析,对30个数量性状和描述性状进行了Shannon-Weaver多样性和主成分分析。结果表明,9个数量性状(单果质量、果实纵径、横径、侧径、果形指数、可溶性固形物、可食率、果核长度和果核质量)在后代中的遗传符合正态或偏正态分布,变异系数在7.98%~41.73%之间,多样性指数在1.65~2.04之间,遗传传递力在84.74%~117.00%之间,果实大小等性状呈趋中变异趋势,可溶性固形物呈超亲遗传趋势。21个描述性状的多样性指数在0.16~1.48之间。主成分分析发现前10个主成分的累积贡献率为75.19%,并筛选出单果质量、抗性、果形指数、果皮光滑度、果肉纤维长度、果核表面特征、果实风味、可溶性固形物、胚类型和果肉颜色作为评价杂交后代果实的主要性状。基于观测数据建立了杧果杂交后代果实性状综合评价模型,并利用该方法结合田间观察和实际观测结果筛选出8个优异的单株。

关键词：杧果 f 代果实性状遗传倾向分离模式

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The Implications of Parent-Reported Emotional and Behavioral Problems on the Modified Checklist for Autism in Toddlers

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JOURNAL Of AUTISM AND DEVELOPMENTAL DISORDERS 2021年第3期51卷 884-891页

作者： Christopher, Kourtney Bishop, Somer Carpenter, Laura Arnstein Warren, Zachary Kanne, Stephen Univ Missouri Dept Hlth Psychol 205 Portland St Columbia MO 65203 USA Univ Missouri Thompson Ctr Autism & Neurodev Disorders 205 Portland St Columbia MO 65203 USA Univ Calif San Francisco Dept Psychiat San Francisco CA USA Med Univ South Carolina Dept Pediat Charleston SC 29425 USA Vanderbilt Univ Med Ctr Dept Pediat Vanderbilt Kennedy Ctr Nashville TN 37232 USA Univ Calif Los Angeles Los Angeles CA USA

Studies have shown that Autism Spectrum Disorder (ASD) screening and diagnostic instruments may be affected by the presence of emotional and behavior problems (EBPs). This study assessed the impact of EBPs on the Modified Checklist for Autism in Toddlers, Revised with follow-up (M-CHAT-R/f). Participants included 290 children, 18-48 months of age, referred for ASD-related concerns. Those diagnosed with ASD had significantly lower externalizing EBPs compared to those who were not diagnosed with ASD. More externalizing symptoms and younger age were significantly predictive of an M-CHAT-R/f final score. Sensitivity and specificity was impacted by the age of the child. These results suggest that combining measures that assess EBPs and autism core symptoms may improve accuracy in this referred population.

关键词： Autism ASD Screening measure M-CHAT-R f Emotional Behavioral Problems EBP CBCL Sensitivity Specificity

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William Beveridge's "mock trial of economists"

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REVIEW Of AUSTRIAN ECONOMICS 2021年第2期34卷 221-252页

作者： Levy, David M. Peart, Sandra J. George Mason Univ Ctr Study Publ Choice Fairfax VA 22030 USA Univ Richmond Jepson Sch Leadership Studies Richmond VA 23173 USA

The 1933 Mock Trial of Economists is occasionally noticed and then interpreted as a representation of popular discontent with the economists' "crime" of "conspiracy to spread mental fog." William Beveridge's papers in the London School of Economics archives contain the written record of the performed composition and an unperformed frame for the Trial. Both are reproduced below. The performance singles out J. M. Keynes for his changing points of view. The unperformed frame provides evidence of Beveridge's defense of diverse viewpoints in light of his worries about totalitarian repression. Long after he had left LSE, f. A. Hayek called attention to Beveridge's worries about the fate of multiple viewpoints under socialism.

关键词： Beveridge J M Keynes f A Hayek-Mock trial Brainwashing Experts

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Vampiric Love: Autoimmunization, Romanticism and Sacrifice in fW Murnau's Nosferatu

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CONTINUUM-JOURNAL Of MEDIA & CULTURAL STUDIES 2021年第2期35卷 191-204页

作者： Mules, Warwick Southern Cross Univ Sch Arts & Social Sci Film & Media Studies Lismore NSW Australia

This article proposes the concept of vampiric love as love of the dreaded thing. Through an analysis of f.W. Murnau's 1922 film Nosferatu, I show how vampiric love is love turned back on itself to threaten the communal bond with its own excess. Through an act of sacrifice, catastrophe is averted and the community saved in leaping from dread to love. Drawing on Derrida's idea of autoimmunization as well as Hagglund's idea of secular love, the article examines vampiric love as an autoimmunization of the biopolitical community - an attack upon itself - that exposes the communal organism to death and chance as salvation from dread. The autoimmune process is traced back to Romantic yearning for impossibly lost love and its flipside in Gothic dread in Polidori's 1819 short story The Vampyre , where the outlines of the autoimmune process can be clearly seen. Employing Kierkegaard's concept of dread, I undertake an analysis of the sacrificial logic at work in Nosferatu, where dread must be passed through in an awakening of the spirit to possibility;a process enfolded into the performativity of the film itself in an autoimmune attack on its own formal system.

关键词： Vampire romanticism autoimmunization love sacrifice dread jacques derrida martin hagglund soren kierkegaard f w murnau nosferatu

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HN Saponin f通过雄激素受体抑制雄激素依赖的前列腺癌细胞LNCaP增殖

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中南药学 2019年第10期17卷 1591-1595页

作者：史梦瑶 Nuttapong Wichai 王雪妮王彧刘二伟邵瑞 Charupan Phosat 于海洋苗琳天津中医药大学中医药研究院方剂学教育部重点实验室

目的研究HN Saponin f的类雄激素活性,探讨其对雄激素依赖性前列腺癌细胞LNCa P增殖的调控作用及作用机制。方法细胞免疫荧光法检测HN Saponin f对LNCa P细胞中本底水平和双氧睾酮DHT刺激时雄激素受体AR的细胞核转位的影响;MTT法检测HN ... 详细信息

目的研究HN Saponin f的类雄激素活性,探讨其对雄激素依赖性前列腺癌细胞LNCa P增殖的调控作用及作用机制。方法细胞免疫荧光法检测HN Saponin f对LNCa P细胞中本底水平和双氧睾酮DHT刺激时雄激素受体AR的细胞核转位的影响;MTT法检测HN Saponin f对本底水平和DHT诱导的LNCa P细胞增殖的影响;转染AR的特异si RNA进一步检测HN Saponin f调节LNCa P细胞增殖的机制。结果与DHT类似,HN Saponin f剂量依赖性地促进LNCa P细胞中AR从细胞质转位到细胞核;与DHT联用后,HN Saponin f还可抑制DHT诱导的AR核转位。DHT可以明显促进LNCa P细胞增殖,HN Saponin f可以剂量依赖性地抑制LNCa P细胞的增殖,且可以抑制DHT诱导的LNCa P细胞增殖。AR的特异si RNA抑制AR的表达后,LNCa P细胞本底和DHT诱导的增殖水平被明显抑制,但HN Saponin f失去了进一步抑制LNCa P细胞增殖的作用。结论 HN Saponin f通过AR拮抗雄激素活性,抑制雄激素依赖的前列腺癌细胞增殖,提示HN Saponin f可以作为潜在的AR拮抗剂,用于雄激素依赖性前列腺癌药物的开发。

关键词： HN Saponin f 雄激素受体雄激素依赖性前列腺癌中药续断细胞增殖

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