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Evaluation of efficacy of peri-operative administration of hydrocortisone and dexamethasone in prevention of post-operative complications in oral and maxillofacial surgeries

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Revista Española de Cirugía Oral y Maxilofacial 2018年第4期40卷 163-168页

作者： Supriya G. Bhandage Manjunath S. Kurki Garima Sachdeva Nishanth Shetty Mainak Kundu Achla Bharti Yadav Department of Oral and Maxillofacial Surgery Sri Hasanamba Dental College and Hospital Vidyanagar Hassan 573201 Karnataka India Department of Oral Surgery Sri Hasanamba Dental College and Hospital Vidyanagar Hassan 573201 Karnataka India Armed Forces Hospital Muscat Oman Department of Oral Pathology PGIDS Rohtak 124001 India

Objective To evaluate the role of intra-operative hydrocortisone and post-operative dexamethasone on reducing post-operative complications following major surgeries involving oral cavity as in oral and maxillofacial surgeries performed under general anesthesia. Methodology The post-surgical stress induces changes in metabolic and endocrinal pathways and also results in activation of inflammatory pathways. Post-operative administration of steroids helps in blocking all the stages of inflammatory process. This study was conducted on a group of 20 patients undergoing major surgical procedures. These patients were administered a combination of intra-operative hydrocortisone and post-operative dexamethasone therapy. Efficacy of these drugs in reducing post-operative complications was evaluated, using parameters like post-operative pain, number of analgesic injections, edema, sore throat, nausea and vomiting. Results A 70% mean reduction in pain was seen on 2nd post-operative day and a drastic 97% pain reduction was noted on 4th post-operative day. An overall 12 mm reduction in swelling was noted over the span of 4 days of hospital stay. Post-operative administration of dexamethasone helped in reduction of sore throat up to 95% on 2nd post-operative day. A remarkable finding noted was, that, none of the patients developed nausea and vomiting post-operatively. Conclusion Surgeries done in and around the oral cavity are mostly prone to contamination as presence of saliva, bacteria, contaminants from stomach flora through acid reflux and post-operative events like vomiting, pollute the surgical site. A single intra-operative dose of hydrocortisone followed by post-operative tapered administration of dexamethasone helps in combating almost all of the post-operative complications after major oral and maxillofacial surgical procedures and hence hastens healing of surgical site. Objetivo Evaluar el papel de la administración intraoperatoria de hidrocortisona, y postoperatoria

关键词： ASA american Society of Anesthesiologists Hr hour PO post-operative P pain S swelling ST sore throat DI number of diclofenac injections administered STDEV standard deviation f f-factor P value probability df degree of freedom mm millimeters mg milligrams Post-operative wound healing Steroids Dexamethasone Hydrocortisone Curación de la herida postoperatoria Esteroides Dexametasona Hidrocortisona

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基于Relieff-PCA和SVM的发动机故障诊断方法研究

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北京化工大学学报（自然科学版） 2018年第1期45卷 55-59页

作者：朱丽娜王学杰张进杰北京化工大学机电工程学院高端机械装备健康监控与自愈化北京市重点实验室北京100029 海军海南地区装备修理监修室海南三亚572021

针对柴油发动机机组振动信号非线性和非平稳性以及机组实际故障案例样本数据少的特点,提出了一种基于Relief f、主成分分析(PCA)以及支持向量机(SVM)的柴油发动机故障诊断方法。首先提取发动机冲击信号的特征参数,运用Relief f选择出其... 详细信息

针对柴油发动机机组振动信号非线性和非平稳性以及机组实际故障案例样本数据少的特点,提出了一种基于Relief f、主成分分析(PCA)以及支持向量机(SVM)的柴油发动机故障诊断方法。首先提取发动机冲击信号的特征参数,运用Relief f选择出其中的敏感特征以降低处理过程的计算难度;然后采用PCA进一步提取敏感特征,消除各特征之间的相关性,避免冗余;最后利用SVM实现机组的故障分类,诊断不同类型的故障。将本文方法应用于柴油机实际典型故障案例中,结果表明该方法能有效提取柴油机缸盖振动信号中的故障敏感特征,并实现多种典型故障的诊断。

关键词：柴油发动机故障诊断 Relief f 主成分分析(PCA) 支持向量机(SVM)

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Diagnosis and Treatment Options for Pulmonary Embolism (PE) in the Acute Care Setting

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World Journal of Cardiovascular Diseases 2018年第2期8卷 152-161页

作者： Simona Campa Raymund Gantioque California State University Los Angeles CA USA

Thromboembolic diseases continue to be one of the most prevalent medical problems today and can lead to life-threatening conditions, such as pulmonary embolism (PE). Currently, PE diagnosis and treatment are a challenge because of acute onset right ventricular strain with right-sided heart failure, sudden death, pulmonary infarction, and cardiogenic shock, which limit the time for therapeutic success.?The aim of this study was to evaluate our perception, knowledge, and concerns regarding PE, discuss the importance of promptly diagnosing PE to provide appropriate treatment options for this life-threatening condition, list the most common clinical manifestations present when PE is suspected, and review the clinical approach to patients with suspected PE in an inpatient setting.?In addition, this study reviews the risk stratification of patients with PE and treatment options beyond anticoagulation, compares new treatment options for patients presenting with acute symptomatic PE, and compares aspiration catheters (10 f Pronto .035” and 14 f XL extraction catheter (Vascular Solutions, Minneapolis, MN)) and ultrasound-assisted catheter-directed thrombolysis (USAT) versus systemic *** literature review was limited by the quality and number of studies available regarding new treatment options for patients presenting with acute symptomatic PE. Thus, more studies are needed to prove the validity of newer treatment options being trialed, such as aspiration catheters (10 f Pronto .035” and 14 f XL extraction catheter) and USAT, with the hope that further studies will guide patient management and increase our understanding of next generation aspiration catheters, which may provide novel insights on treating acute symptomatic PE.

关键词： Pulmonary Embolism (PE) Aspiration Catheters (The 10 f Pronto .035” and 14 f XL Extraction Catheter (Vascular Solutions Minneapolis MN)) The Ultrasound-Assisted Catheter-Directed Thrombolysis (USAT) Systemic Thrombolysis

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Corrigendum to “Partial cohomology of groups” [J. Algebra 427 (2015) 142–182]

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Journal of Algebra 2018年 506卷 592-596页

作者： Mikhailo Dokuchaev Mykola Khrypchenko Instituto de Matemática e Estatística Universidade de São Paulo Rua do Matão 1010 São Paulo SP CEP: 05508-090 Brazil Departamento de Matemática Universidade Federal de Santa Catarina Campus Reitor João David Ferreira Lima Florianópolis SC CEP: 88040-900 Brazil

We prove a corrected version of [1, Theorem 5.4] .

关键词： primary 20M18 secondary 20M15 Max-generated f -inverse monoid Minimum group congruence Exel's monoid Epimorphism

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In situ surface protection for enhancing stability and performance of conversion-type cathodes

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MRS ENERGY & SUSTAINABILITY 2017年第1期4卷 9页

作者： Wu, feixiang Borodin, Oleg Yushin, Gleb Georgia Inst Technol Sch Mat Sci & Engn Atlanta GA 30332 USA Army Res Lab Electrochem Branch Sensors & Electron Devices Directorate Adelphi MD 20783 USA

The use of in situ formed protective layer on conversion cathodes was introduced as a cheap and simple strategy to shield these materials from undesirable interactions with liquid electrolytes. Conversion-type cathodes have been viewed as promising candidates to replace Ni-and Co-based intercalation-type cathodes for next-generation lithium (Li) and Li-ion batteries with higher specific energy, lower cost, and potentially longer cycle life. Typically, in conversion reactions two or three Li ions may be stored per just one atom of chalcogen (e.g., S or Se) or transition metal (e.g., fe or Cu used in halides). Unfortunately, in conversion chemistries the active materials or intermediate charge/discharge products suffer from various unfavorable interactions and dissolution in organic electrolytes. In this mini-review article, we discuss the current interfacial challenges and focus on the protective layers in situ formed on the cathode surface to effectively shield conversion materials from undesirable interactions with liquid electrolytes. We further explore the mechanisms and current progress of forming such protective layers by using various salts, solvents, and additives together with the insight from molecular modeling. finally, we discuss future opportunities and perspectives of in situ surface protection.

关键词： Li S f coating energy storage

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Progress on research of tissue culture of Bletilla striata

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Chinese Herbal Medicines 2018年第1期10卷 23-26页

作者： Xue-Min Wei Yang Liu Xiao-Yue Wang Zi-Tong Gao Shu-Ming Yao Jian-Ping Han Institute of Medicinal Plant Development Chinese Academy of Medical Sciences & Peking Union Medical CollegeBeijing 100193China Qingdao Guofeng Pharmaceutical Co. Ltdqingdao 266071China

Rhizoma Bletillae is in high demand as a traditional Chinese medicine, and the natural resources have been severely damaged due to excessive exploitation. Because Bletilla striata seeds are small and have no endosperm, the seed germination rate is low in natural conditions. Traditional division propagation could not meet the demands of large-scale cultivation. Tissue culture can provide many seedlings in a short time and is more effective and convenient than other methods. Most studies on tissue culture of B. striata selected seeds as explants. This review summarized the processes of the aseptic seed germination pathway. It included such stages as seed germination, proliferation of clusters of buds, induction of root- ing and transplanting of seedlings. Influential factors as well as optimum combination and concentration of the plant growth regulators of each stage were also summarized. The further research on tissue culture of B. striata was also prospected.

关键词： Aseptic seed germination Bletilla striata （Thunb.） Reichb f research progress tissue culture

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Lignan derivatives from Selaginella tamariscina and their nitric oxide inhibitory effects in LPS-stimulated RAW 264.7 cells

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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2017年第3期27卷 524-529页

作者： Le Duc Dat Zhao, Bing Tian Nguyen Duc Hung Lee, Jeong Hyung Min, Byung Sun Woo, Mi Hee Catholic Univ Daegu Coll Pharm Gyongsan 38430 South Korea Kangwon Natl Univ Coll Nat Sci Kangwon 200701 South Korea Phutho Coll Pharm Viettri City 290000 Phutho Province Vietnam

The chemical characterization of Selaginella tamariscina leaves resulted in the isolation of five lignanoside derivatives (1-4 and 6) and one neolignan (5). These compounds include three new lignanosides, tamariscinosides D-f (1-3), and one liriodendrin (4) that were isolated for the first time from this plant, together with two known compounds, (2R,3S)-dihydro-2-(3,5-dimethoxy-4-hydroxypheny1)-7-methoxy-5-acetyl-benzofuran (5) and moellenoside B (6). The chemical structures of these isolated compounds were determined using 1D and 2D NMR, MS, and CD spectroscopic data, and the results were compared to data previously reported in the literatures. These compounds were also evaluated in terms of their inhibition of NO production in lipopolysaccharide (LPS)-stimulated activity in the macrophage cell line RAW 264.7. Among them, compounds 1, 2, 5, and 6 exhibited a significant inhibition with IC50 values ranging from 32.3 to 55.8 mu M. (C) 2016 Elsevier Ltd. All rights reserved.

关键词： Selaginella tamariscina Lignan Tamariscinosides D f NO production inhibition

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^(18)f-Naf PET/CT对前列腺癌骨转移的诊断价值

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实用临床医药杂志 2016年第5期20卷 82-84页

作者：郑文璐四川医科大学附属第一医院核医学科四川泸州646000

目的探讨18f-Na f PET/CT在前列腺癌骨转移中的诊断价值及影像学特征。方法回顾性分析42例经病理证实为前列腺癌的患者的临床资料,均行18f-Na f PET/CT骨显像。比较18f-Na f PET/CT、18f-Na f PET和单独CT诊断前列腺癌骨转移灶的灵敏性... 详细信息

目的探讨18f-Na f PET/CT在前列腺癌骨转移中的诊断价值及影像学特征。方法回顾性分析42例经病理证实为前列腺癌的患者的临床资料,均行18f-Na f PET/CT骨显像。比较18f-Na f PET/CT、18f-Na f PET和单独CT诊断前列腺癌骨转移灶的灵敏性、准确性。结果18f-Na f PET/CT、18f-Na f PET、单独CT诊断前列腺癌骨转移瘤的灵敏度分别为100%、94.4%、77.8%,准确性分别为95.2%、87.0%、71.4%。18f-Na f PET/CT骨显像的准确性显著高于18f-Na f PET和单独CT(P<0.05)。结论18f-Na f PET/CT对前列腺癌骨转移诊断的灵敏度、特异性、准确性较高。

关键词：前列腺癌骨转移 18f-Na f PET/CT

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白细胞介素-33在过敏性哮喘小鼠体内的变化及作用

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中国寄生虫学与寄生虫病杂志 2018年第2期36卷 124-128,134页

作者：柴强宋红玉李朝品皖南医学院医学寄生虫学教研室芜湖241002

目的探讨白细胞介素-33(IL-33)在粉尘螨1类变应原(Der f 1)诱导的过敏性哮喘小鼠中的变化及作用。方法将40只雌性BALB/c小鼠用随机数字表法分为哮喘组、免疫治疗组、抑制剂组和阴性对照组(PBS组),每组10只。哮喘组、免疫治疗组和抑制剂... 详细信息

目的探讨白细胞介素-33(IL-33)在粉尘螨1类变应原(Der f 1)诱导的过敏性哮喘小鼠中的变化及作用。方法将40只雌性BALB/c小鼠用随机数字表法分为哮喘组、免疫治疗组、抑制剂组和阴性对照组(PBS组),每组10只。哮喘组、免疫治疗组和抑制剂组分别在第0、7和14天腹腔注射100μl粉尘螨变应原提取液(含100μg/ml Der f 1),抑制剂组小鼠同时注射抑制剂(可溶性ST2 100μl,用于抑制IL-33),PBS组注射等量PBS。第21天起,各组小鼠雾化吸入粉尘螨变应原提取液(0.5μg/ml),30 min/次,1次/d,连续7 d。免疫治疗组小鼠第25天起于雾化前0.5 h,分别用200μl的Der f 1蛋白溶液(100μg/ml)腹腔注射进行免疫治疗,PBS组用PBS代替粉尘螨变应原。第27天雾化吸入后24 h处死小鼠,收集小鼠支气管肺泡灌洗液(BALf)和眼球血,并对BALf中嗜酸粒细胞进行计数,制作肺组织病理切片。ELISA法检测BALf中IL-5、IL-13和γ干扰素(IfN-γ)的含量及血清中特异性Ig E和Ig G2a水平。结果除PBS组小鼠外,其他组小鼠自第21天开始出现不同程度的哮喘症状。自第25天开始,免疫治疗组小鼠的哮喘症状开始缓解。哮喘组和PBS组小鼠BALf中嗜酸粒细胞总数分别为(4.41±0.36)×10~5/ml和(0.37±0.08)×10~5/ml,两组差异有统计学意义(t=24.50,P<0.01);免疫治疗组和抑制剂组小鼠的嗜酸粒细胞总数分别为(1.43±0.14)×10~5/ml和(2.73±0.33)×10~5/ml,均明显低于哮喘组(f=129.72,P<0.01)。ELISA检测结果显示,哮喘组、免疫治疗组、抑制剂组和PBS组BALf中IfN-γ的水平分别为(83.06±11.38)、(277.97±22.46)、(175.13±13.41)和(224.77±19.97)pg/ml,免疫治疗组和抑制剂组均明显高于哮喘组(t=17.31,t=11.71,P<0.01)。哮喘组、免疫治疗组、抑制剂组和PBS组小鼠BALf中IL-5水平分别为(208.64±11.55)、(106.87±11.39)、(140.71±14.58)和(90.15±9.49)pg/ml,哮喘组的水平明显高于其他各组(f=97.19,P<0.01)。哮喘组和免疫治疗组BALf中IL-13水平分别为(308.37±13.67)pg/ml和(175.66±11.79)pg/ml,两者差异有统计学意义(P<0.01);抑制剂组小鼠的为(221.12±21.08)pg/ml,明显低于哮喘组(t=16.44,P<0.01);PBS组为(97.57±18.38)pg/ml。免疫治疗组与哮喘组相比,小鼠肺部炎性症状均减轻,几乎无炎症细胞。抑制剂组小鼠的支气管周围也有嗜酸粒细胞增多症、上皮细胞脱落和支气管上皮细胞肥大,但较哮喘组要减轻许多。血清Ig E抗体水平的检测结果显示,哮喘组、免疫治疗组、抑制剂组和PBS组分别为(31.97±3.48)、(12.86±2.22)、(18.43±2.30)和(9.68±1.27)IU/ml,免疫治疗组和抑制剂组均低于哮喘组(t=-7.77,P<0.01)。Ig G2a抗体水平的变化和Ig E相反,哮喘组、免疫治疗组和PBS组分别为(26.94±2.96)、(35.06±2.57)和(10.31±1.48)μg/ml,免疫治疗组高于哮喘组(t=6.55,P<0.01)。结论 ELISA检测结果表明IL-33/ST2信号通路在小鼠过敏性哮喘中发挥着重要的作用。

关键词：粉尘螨 Der f 1蛋白过敏性哮喘白细胞介素-33

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Procoagulant extracellular vesicles in amniotic fluid

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TRANSLATIONAL RESEARCH 2017年 184卷 12-20页

作者： Hell, Lena Wisgrill, Lukas Ay, Cihan Spitiler, Andreas Schwameis, Michael Jilma, Bernd Pabinger, Ingrid Altevogt, Peter Thaler, Johannes Med Univ Vienna Dept Med 1 Clin Div Haematol & Haemostaseol Waehringer Guertel 18-20 A-1090 Vienna Austria Med Univ Vienna Dept Paediat & Adolescent Med Clin Div Neonatol Paediat Intens Care & Neuropaed Vienna Austria Med Univ Vienna Dept Surg Vienna Austria Med Univ Vienna Dept Clin Pharmacol Vienna Austria German Canc Res Ctr Tumor Immunol Programme Heidelberg Germany

Embolization of amniotic fluid (Af) into the blood circulation leads to disseminated intravascular coagulation (DIC). Procoagulant phosphatidylserine (PS)- and tissue factor (Tf)-exposing extracellular vesicles (EVs) might play an important role in Af embolism-induced DIC. It was the aim of the present study to perform analyses of the procoagulant properties of Af with a panel of functional coagulation assays and flow cytometry. We applied a prothrombinase assay (that quantifies PS exposure on EVs), an EV-associated Tf activity assay, a fibrin generation assay, a thrombin generation assay, a whole blood clotting model, and flow cytometry in Af and control plasma. We found that PS exposure on EVs was 21-fold increased in Af compared with plasma. Also, EV-associated Tf activity was highly increased in Af compared with plasma. Af-derived EVs activated the blood coagulation cascade via PS and Tf in the fibrin and thrombin generation assays. In a whole blood clotting model, Af-derived EVs significantly shortened the clotting time from 734 139 seconds in the presence to 232 139 seconds in the absence of an anti-If antibody. The contact activation pathway via factor XII (fXII) was not affected. Applying flow cytometry, a sub population of PS+ and Tf+ EVs was identified in Af but not in control plasma. In conclusion, we investigated the effect of Af on blood coagulation and found that PS+ and Tf+ EVs determine their procoagulant potential. Taken together, our data further delineate the pathomechanisms underlying Af-induced coagulopathy.

关键词： Af amniotic fluid EVs extracellular vesicles DIC disseminated intravascular coagulation f factor NPP normal pooled plasma PS phosphatidylserine Tf tissue factor

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