Lung cancer commonly metastasizes to ipsilateral and contralateral lungs, to mediastinal lymph nodes, to skeletal level, to brain, and to adrenal gland. It is indeed very rare to find skeletal metastases at the extrem...
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Lung cancer commonly metastasizes to ipsilateral and contralateral lungs, to mediastinal lymph nodes, to skeletal level, to brain, and to adrenal gland. It is indeed very rare to find skeletal metastases at the extremities, especially at the onset of the disease. We share the case of a 53-year-old man with dyspnea and pain at the level of the first finger of the left hand under antibiotic treatment for suspected osteomyelitis.
The study includes the determination of the general background PCDD/f and dl-PCB levels in environmental (ambient air and soil) and food (meat, milk, egg, leafy vegetable, root vegetable and fruit samples) samples col...
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The study includes the determination of the general background PCDD/f and dl-PCB levels in environmental (ambient air and soil) and food (meat, milk, egg, leafy vegetable, root vegetable and fruit samples) samples collected in four sampling sites in the vicinity of IZAYDAS WIP and its possible health risks. The local and meteorological conditions (prevailing wind direction, season, raining, and soil structure) were taken into account in the selection of sampling sites. The concentrations of PCDD/f and dl-PCB in ambient air ranged from 0.00841 to 0.05881 pg I-TEQ/m(3). These results are quite low and it showed that there is no significant PCDD/f pollution in the vicinity of the plant. The results of PCDD/f and dl-PCB in eight soil samples (four in the range of 0-1.2 km, four in the range of 1.2-5 km) taken from the vicinity of IZAYDAS varied between 0.12681 and 0.4353 pg TEQ/g. The levels of PCDD/f and dl-PCBs measured in food samples were found to be significantly lower than both the limit values given by the Turkish food Codex and the levels measured in the previous studies (between 2008 and 2009). In the health risk assessment, carcinogenic risk was calculated for PCDD/f and dl-PCBs made according to the exposure scenarios established for the study. The total intake values for the sum of PCDD/f and dl-PCB were found between 0.08 and 0.37 pg TEQ/*** for adults. These values are well below the limit value, which is considered as 2 pg WHO-TEQ/kg body ***. In this context, it was concluded that carcinogenic risk due to PCDD/f and dl-PCB intake is significantly low in the vicinity of the plant.
Adrenal cortical carcinoma (ACC) is a rare aggressive endocrine tumor with poor prognosis. About 60% of ACC are functional tumors. Bilateral ACC is extremely rare, roughly 2%—10% of cases. Diagnosis and staging of AC...
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Adrenal cortical carcinoma (ACC) is a rare aggressive endocrine tumor with poor prognosis. About 60% of ACC are functional tumors. Bilateral ACC is extremely rare, roughly 2%—10% of cases. Diagnosis and staging of ACC by imaging modalities are crucial for preoperative planning and prognostication. Detection of hyperfunctional bilateral adrenocortical carcinoma by 18f-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (
Andrographis paniculata (Burm.f.) Nees is an essential traditional herbal medicine with various bioactivities in Asian countries. The quality of herbal medicines directly affects its clinical efficacy, so a comprehens...
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Andrographis paniculata (Burm.f.) Nees is an essential traditional herbal medicine with various bioactivities in Asian countries. The quality of herbal medicines directly affects its clinical efficacy, so a comprehensive strategy, including color assay, chemical profiles, quantitative analysis, and anti-inflammatory activity assay, is constructed to evaluate the quality of A. paniculata in this paper. Here, 16 batches of commercial A. paniculata were collected, and there were noticeable differences in appearance, chemical compounds, and bioactivity among batches. Principal component analysis (PCA) indicated the color and diterpenoid lactones could be used to classify A. paniculat. And then, correlation analysis found the batches with greener color have higher contents of diterpenoid lactones and more efficient anti-inflammatory activity. Based on the results above, the partial least squares (PLS) regression models were finally established to predict the contents of diterpenoid lactones using the color assay data. All diterpenoid lactones models showed good performance, especially neoandrographolide. Notably, PLS regression models were first used for the nondestructive quantitative analysis of A. paniculata. This comprehensive quality evaluation strategy can theoretically elucidate the relationship between good appearance, high contents of diterpenoid lactones, and superior bioactivity of A. paniculata, which is meaningful for its quality control and evaluation. It also laid a theoretical basis for appearance and bioactivity evaluations of high-quality traditional herbal medicine. (c) 2021 Elsevier B.V. All rights reserved.
Granulocyte colony-stimulating factor (G-CSf) can be produced by tumor cells and is known to promote tumor growth, thereby potentially accelerating disease progression. Squamous cell carcinoma (SCC) at maxillary sinus...
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Granulocyte colony-stimulating factor (G-CSf) can be produced by tumor cells and is known to promote tumor growth, thereby potentially accelerating disease progression. Squamous cell carcinoma (SCC) at maxillary sinus is aggressive growth with poor prognosis. Maxillary sinus carcinomas are rare and can be clinically silent in the early stages or manifest with the same signs and symptoms of more common illnesses, leading to their delayed diagnosis of disease. Hypermetabolic uptake of
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