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JBf Chairman Hiromasa Yonekura in China

Voice of friendship 2013年第1期 8-8页

作者： Wang Zheng

On November 23,2012,Tang Jiaxuan,President of the China-Japan friendship Association(CJfA), and Li Xiaolin,CPAffC President,met with Hiromasa Yonekura,Chairman of the Japan Business federation(JBf), and his party,and attended the signing ceremony of the Agreement on friendly Exchanges between CJfA and JBf. Tang spoke highly of the great ef-

关键词： Chairman welcome exchanges contributions friends f

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Bulky P-stereogenic ligands. A success story in asymmetric catalysis

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COORDINATION CHEMISTRY REVIEWS 2023年第1期489卷

作者： Rojo, Pep Riera, Antoni Verdaguer, Xavier Inst Res Biomed IRB Barcelona Barcelona Inst Sci & Technol BIST Baldiri Reixac 10 Barcelona 08028 Spain Univ Barcelona Dept Quim Inorgan & Organ Seccio Organ Fac Quim Marti i Franques 1 Barcelona 08028 Spain

Since the development of BisP* ligand by Imamoto, P-stereogenic phosphines bearing a bulky tert-butyl group and a smaller alkyl group have demonstrated extraordinary proficiency in a wide range of asymmetric processes. Over time, this class of ligands has brought about the introduction of more rigid backbones, the three-hindered quadrant concept, and the substitution of the tert-butyl group by adamantyl. The tert-butyl methyl fragment has also been introduced in phosphino-oxazoline-type ligands, and chemists in the industrial sector have also contributed to the evolution of this class of ligands by reporting the first successful P-ster-eogenic Buchwald-type monophosphines for asymmetric coupling reactions. The present review covers the synthesis and applications of bulky P-stereogenic phosphines that have been developed since the advent of BisP* in the late 1990s, with a special emphasis on ligands that have been successfully applied in asymmetric catalysis.

关键词： Ac acetyl ACN acetonitrile Ad adamantyl Alk alkyl Ar aryl Bn benzyl Boc tert -butoxycarbonyl BOM benzyloxymethyl BQ 1,4-benzoquinone Bpin pinacolborane, 4,4,5,5-tetramethyl-1,3,2-dioxaborolanyl Bz benzoyl Cbz benzyloxycarbonyl Cod cyclooctadiene CPME cyclopentyl methyl ether Cy cyclohexyl Cyp cyclopentyl DABCO 1,4-diazabicyclo[2.2.2]octane DAST diethylaminosulfur trifluoride Dba E,E -dibenzylidene acetone DBTA dibenzoyl tartaric acid DBU 1,8-diazabicyclo[5.4.0]undec-7-ene DCE 1,2-dichloroethane DCM dichloromethane DfT density-functional theory DME dimethoxyethane DMf N,N -dimethylformamide Dppp 1,3-bis(diphenylphosphino)propane HMPA hexamethylphosphoramide iAm isoamyl, 3-methylbutyl iBu isobutyl iPr isopropyl LDA lithium diisopropylamide Ms mesyl, methanesulfonyl Mes mesityl, 2,4,6-trimethylphenyl NaBAr f sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate Naph naphthyl n -Bu n -butyl n -Hex n -hexyl NMM N -methylmorpholine o -An ortho -anisyl, 2-methoxyphenyl Piv pivaloyl, trimethylacetyl PMP para -methoxyphenyl Py pyridine s -Bu sec -butyl SIP secondary iminophosphorane SPO secondary phosphine oxide SPB secondary phosphine borane TBAf tetrabutylammonium fluoride TBME tert -butyl methyl ether t -Bu tert -butyl Tf triflate trifluoromethanesulfonate TfA trifluoroacetic acid THf tetrahydrofurane THQs tetrahydroquinolines TMEDA N,N,N′,N′ -tetramethylethylenediamine TMS trimethylsilyl TPB tertiary phosphine borane TPO tertiary phosphine oxide Tripp 2,4,6-triisopropylphenyl Ts tosyl, p -toluenesulfonyl

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Long-term outcomes for pain relief from intraorbital frontal nerve resection in idiopathic versus postherpetic trigeminal neuralgia

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Advances in Oral and Maxillofacial Surgery 2022年 7卷 100308-100308页

作者： Laura Haas Susan Tucker Lahey Hospital and Medical Center USA Tufts University School of Medicine Boston USA

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PAGANI ZONDAf

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汽车杂志 2006年第3期 228-228页

1、在2005上海车展上展出了一部“Koeningsegg CDCR跑车”，请问能否揭开它内饰的抻秘面纱．看看它的内部都有些什么装备，再给点它的详细数据就再好不过了！2、在75届日内瓦车展上，一部PaganZonda f（帕格尼·宗塔f）让我神魂颠... 详细信息

1、在2005上海车展上展出了一部“Koeningsegg CDCR跑车”，请问能否揭开它内饰的抻秘面纱．看看它的内部都有些什么装备，再给点它的详细数据就再好不过了！ 2、在75届日内瓦车展上，一部PaganZonda f（帕格尼·宗塔f）让我神魂颠倒，据说它超越了它的“兄长”Zonda C12，请奉上几张Zonda f的内部、外部靓照吧!最好有它的详细参数。

关键词： Koeningsegg CDCR跑车 PaganZonda f 帕格尼·宗塔f 跑车

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Data on ADME parameters of bisphenol A and its metabolites for use in physiologically based pharmacokinetic modelling

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DATA IN BRIEf 2023年 48卷 109101页

作者： Wisniowska, Barbara Linke, Susanne Polak, Sebastian Bielecka, Zofia Luch, Andreas Pirow, Ralph Jagiellonian Univ Fac Pharm Med Coll Med 9 St PL-30688 Krakow Poland German Fed Inst Risk Assessment BfR Dept Chem & Prod Safety Max Dohrn Str 8-10 D-10589 Berlin Germany Free Univ Berlin Inst Pharm Dept Biol Chem Pharm Berlin Germany Certara UK Ltd Simcyp Div Level 2 Acero1 Concourse Way Sheffield S1 2BJ England

Abbreviations: ADAM, advanced dissolution, absorption and metabolism;ADME, absorption, distribution, metabolism, excretion;AUC, area under the concentration-time curve;B/P ratio, blood-to-plasma concentration ratio;BPA, bisphenol A;BPAG, glucuronidated BPA;BPAS, sulfated BPA;BW, body weight;CES, carboxylesterase;Cmax, maximum concentra-tion in plasma;CLint, in vitro intrinsic clearance;CLiv , total intravenous clearance;CLperm, permeability clearance;CLrenal, renal clearance;CLint,bile, in vitro intrinsic biliary clearance;CLuint,G, net intrinsic metabolic clearance in the gut based on unbound BPA concentration;CL int,gutlumen, gut lumen intrinsic clearance;EHR, enterohepatic recirculation;fa, fraction absorbed;fugut, fraction of BPA unbound in the enterocyte;fuinc, fraction unbound in in vitro incubation;fumic, frac-tion unbound in microsomal incubation;fup, fraction unbound in plasma;fg, fraction of BPA escaping gut metabolism;HBD, number of hydrogen bond donors;HPGL, hepatocytes per gram of liver;IV, intravenous;IVIVE, in vitro to in vivo extrapolation;ka, absorption rate constant;Ka, acid dissociation constant;Km, Michaelis-Menten constant;Kp, tissue -to-plasma partition coefficient;MechPeff, mechanistic permeability;MPPGL, microsomal protein per gram of liver;MW, molecular weight;Qgut, hybrid parameter of blood flow and compound permeability through enterocytes;QSAR, quanti-tative structure-activity relationship;P , octanol:water partition coefficient;Papp, apparent permeability;Peff,man, effective intestinal permeability in human;PBPK, physiologically based pharmacokinetics;PSA, polar surface area;RAf, relative activity factor;rhUGT, recombinant human UGT;SULT, sulfotransferase;UGT, UDP-glucuronosyltransferase;Vmax, maxi-mum velocity;Vss, volume of distribution at steady-state.

关键词： BPA Bisphenol A PBPK ADME Modelling Oral route ADAM advanced dissolution, absorption and metabolism ADME absorption, distribution, metabolism, excretion AUC area under the concentration-time curve B/P ratio blood-to-plasma concentration ratio BPA bisphenol A BPAG glucuronidated BPA BPAS sulfated BPA BW body weight CES carboxylesterase C max maximum concentration in plasma CL int in vitro intrinsic clearance CL iv total intravenous clearance CL perm permeability clearance CL renal renal clearance CL int,bile in vitro intrinsic biliary clearance CLu int,G net intrinsic metabolic clearance in the gut based on unbound BPA concentration CL int,gutlumen gut lumen intrinsic clearance EHR enterohepatic recirculation f a fraction absorbed fu gut fraction of BPA unbound in the enterocyte fu inc fraction unbound in in vitro incubation fu mic fraction unbound in microsomal incubation fu p fraction unbound in plasma f g fraction of BPA escaping gut metabolism HBD number of hydrogen bond donors HPGL hepatocytes per gram of liver IV intravenous IVIVE in vitro to in vivo extrapolation k a absorption rate constant K a acid dissociation constant K m Michaelis-Menten constant K p tissue-to-plasma partition coefficient MechPeff mechanistic permeability MPPGL microsomal protein per gram of liver MW molecular weight Q gut hybrid parameter of blood flow and compound permeability through enterocytes QSAR quantitative structure-activity relationship P octanol:water partition coefficient P app apparent permeability P eff,man effective intestinal permeability in human PBPK physiologically based pharmacokinetics PSA polar surface area RAf relative activity factor rhUGT recombinant human UGT SULT sulfotransferase UGT UDP-glucuronosyltransferase V max maximum velocity V ss volume of distribution at steady-state

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Cautyʼs space enhanced

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Topology and its Applications 2012年第1期159卷 28-33页

作者： Tadeusz Dobrowolski Nigel J. Kalton Department of Mathematics Pittsburg State University Pittsburg KS 66762 USA Faculty of Mathematics and Natural Sciences College of Sciences Cardinal Stefan Wyszyński University Wóycickiego 1/3 01-938 Warszawa Poland

The title refers to Cautyʼs example (Cauty, 1994 [3] ) of a metric vector space which is not an absolute retract. It is shown that Cautyʼs space can be refined to the effect that the completion of the refined space ca... 详细信息

关键词： 46A16 46A13 46T20 54C55 54C65 55M15 57N17 f -space Polar Cauty space Absolute retract Klee-admissible

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黑格尔

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丛书名：世界思想家译丛

2002年

作者： (美) 艾莉森·利·布朗

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A validation study of a multiplex INDEL assay for forensic use in four Chinese populations

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forensic Science International: Genetics 2014年 9卷 e22-e25页

作者： Yi-Liang Wei Cui-Jiao Qin Hui Dong Jing Jia Cai-Xia Li Key Laboratory of Forensic Genetics Institute of Forensic Science Ministry of Public Security Beijing 100038 PR China Key Laboratory of Medical Epigenetics Tianjin Research Center of Basic Medical Sciences Tianjin 300070 PR China Department of Forensic Science Chinese People's Public Security University Beijing 100038 PR China Department of Forensic Science Southern Medical University Guangzhou 510515 PR China Faculty of Basic Medical Sciences Chongqing Medical University Chongqing 400016 PR China

Insertion/deletion (INDELs) marker sets can serve as a useful supplementary tool for human identification. A commercial kit, the Qiagen DIPplex ® Investigator kit, multiplexes 30 biallelic autosomal INDELs and Amelogenin for forensic use. We performed a validation study based on the DIPplex ® kit in four Chinese populations: Han, Tibetan, Uyghur, and Kazakh. There were no significant departures from Hardy–Weinberg equilibrium or significant linkage disequilibrium (pair-wised r 2 < 0.2) between the 30 INDELs. The random match probabilities were in the range of 3.84 × 10 −11 to 1.20 × 10 −12 , and the power of exclusion was >0.99. The multiplex PCR was optimized for a 5-μL volume, full profiles were obtained with 0.062 ng/μL of template DNA, and excellent performance was obtained with degraded casework samples. This study demonstrates that the multiplex INDEL assay can be used as a supplementary method for degraded DNA detection in the studied Chinese populations.

关键词： INDEL Individual identification Population genetics Heterozygosity f st

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Total Synthesis and Structure-Activity Studies of Geodiamolide H

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Synfacts 2021年第9期17卷 1054-1054页

作者： Dirk Trauner Bruno Matos Paz

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Expansion potential of novel skin grafts simulants with I-shaped auxetic incisions

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Biomedical Engineering Advances 2023年 5卷

作者： Vivek Gupta Arnab Chanda Centre for Biomedical Engineering Indian Institute of Technology (IIT) Delhi India Department of Biomedical Engineering All India Institute of Medical Sciences (AIIMS) Delhi India

Skin grafts play an important role in treatment of severe burn injuries. Split-thickness skin grafting is one of the most common grafting technique, in which, parallel incision patterns are projected onto a small portion of excised skin for generating expansions and covering a larger burn site. However, to date, expansions reported through experiments on such grafts, have been much lower than claimed, which inhibits their application in severe burn injury mitigation. In this work, novel skin graft simulants were developed to study the expansion potential of skin grafts with I-shaped auxetic incision patterns. A range of I-shape dimensional parameters were tested, and the effective Poisson's effect, meshing ratios, and generated stresses, biaxial deformation and stress were estimated across all skin graft simulants, with strain loadings up to 200%. High spacing between I-shaped unit cells, was found to generate high negative Poisson's ratio and meshing ratio (MR). With high spacing, lowest stresses were generated for the maximum edge lengths of the I-shape. Maximum negative Poisson's ratio of -1.12 and meshing ratio of 3.84 were produced by the skin graft simulants, indicating expansions much higher than traditional skin grafts. Such results have not been realized with skin grafts to date, which would be indispensable for further research into skin graft expansions and treatment of severe burn injuries.

关键词： Burns Skin graft Expansion Meshing ratio Auxetics A Cross-section Area f force kPa kilopascal L Length mm millimeter MR Meshing Ratio NPR Negative Poisson's Ratio PLA Polylactic Acid STL Stereolithography STSG Split Thickness Skin Grafting UTS Ultimate Tensile Strength UTM Universal Testing Machine 3 D Three Dimensional σ stress ε strain

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