Purpose: To report the novel imaging findings in persistent placoid maculopathy (PPM) from the first case series of Asian subjects. Design: Retrospective observational case series. Subjects: Patients with PPM from 201...
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Purpose: To report the novel imaging findings in persistent placoid maculopathy (PPM) from the first case series of Asian subjects. Design: Retrospective observational case series. Subjects: Patients with PPM from 2013 to 2023. Methods: Medical records and multimodal images from each visit were analyzed. Main Outcome Measures: Imaging and follow-up findings. Results: Twenty-one eyes of 16 patients were included. Mean age was 61 (range, 48-84) years old. five patients showed bilateral involvement. Persistent placoid maculopathy lesions were unremarkable on color fundus photography, autofluorescence, and fluorescein angiography. Hypofluorescent spots with a lichen-like appearance presented in all phases of indocyanine green angiography, which were most prominent in the late phase and presented in a fused (71%) or clustered (29%) pattern. The hypofluorescence correlated with the lesions between the retinal pigment epithelium (RPE) and Bruch's membrane (BM) with moderate reflectivity on OCT, and the thickness ranged from slit-like to mound-like. The intensity of hypofluorescence sometimes varied in the same eye and correlated with the thickness of sub-RPE lesions on OCT. No abnormal blood flow signals were detected in either the sub-RPE space or choriocapillaris slab of OCT angiography across the PPM lesions. Peripapillary (5 eyes, 24%) and extra posterior pole (2 eyes, 10%) involvements were seen, the former sparing the b zones of optic discs. Ten eyes of 7 patients were followed up (median, 26 months;range, 2-121 months). During follow-up, the lichen-like lesions spread and migrated slowly without changing the plane patterns of the first visit and were limited to sub-RPE growth. The fused lichen-like pattern sprawled around the enlarged base. The clustered lichen-like pattern gradually loosened. Ten eyes (48%, 9 eyes in the fused pattern, 1 eye in the clustered pattern) had secondary choroidal neovascularization (CNV) at the first visit, with type I (6 eyes, 5 of whic
This study evaluated the effectiveness of the A.f. Genital System (Liofilchem(R), Italy) in detecting pathogens compared with multiplex real-time polymerase chain reaction (PCR) in men with acute urethritis. Men diagn...
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This study evaluated the effectiveness of the A.f. Genital System (Liofilchem(R), Italy) in detecting pathogens compared with multiplex real-time polymerase chain reaction (PCR) in men with acute urethritis. Men diagnosed as having acute urethritis between 1 April 2021 and 31 December 2021 were included. Urethral swab samples were obtained for A.f. Genital System and PCR testing in a randomly determined order. The efficacy of the A.f. Genital System was analysed by comparing the results of the two tests. The study included 83 patients (mean age 34.1 +/- 11.3 years). A urethritis pathogen was detected in 69 patients (83.1%) by PCR and only 15 patients (18.1%) with the A.f. Genital System. The sensitivity of the A.f. Genital System in detecting acute urethritis pathogens was 21.7% (95% confidence interval [CI]: 13.6-32.8), and the specificity was 100% (95% CI: 78.5-100). Its sensitivity was 20% (95% CI: 7.1-45.2) in the diagnosis of gonococcal urethritis and 19.1% (95% CI: 11.2-30.4) in the diagnosis of non-gonococcal urethritis. PCR detected two or more urethritis pathogens in 9 patients (13.0%), while no polymicrobial infection was detected with the A.f. Genital System. Based on the results of multiplex real-time PCR, the A.f. Genital System had very low sensitivity in the detection of pathogens in acute male urethritis. It should be kept in mind that using this test in patients with acute urethritis may result in a high missed diagnosis rate for urethritis pathogens.
Six undescribed abietane-type diterpenoids (tripterydinoids A-f) and five undescribed oleanane-type triterpenoids (tripterytrinoids A-E) were obtained and determined from the stem and branch of Tripterygium wilfordii ...
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Six undescribed abietane-type diterpenoids (tripterydinoids A-f) and five undescribed oleanane-type triterpenoids (tripterytrinoids A-E) were obtained and determined from the stem and branch of Tripterygium wilfordii Hook. f. (Celastraceae). Tripterydinoids A-C possessed the abietane-type diterpenoid skeleton with rare 8, 9epoxy ring. The structures of undescribed compounds were established by extensive spectroscopic studies [HRESIMS, 1D/2D-NMR and electronic circular dichroism (ECD) calculation]. The absolute configurations of tripterydinoids A, B, E and tripterytrinoid A were defined by X-ray crystallographic analyses. Bioactivity screening indicated that tripterydinoids A-C exhibited potent inhibitory effects against NO release in LPSactivated RAW 264.7 macrophages with IC50 values of 6.93, 4.46 and 2.98 mu M, respectively. Meanwhile, tripterydinoids A-D and tripterytrinoids B, C showed moderate and selective cytotoxicities against five human tumor cell lines (A375, Huh7, MCf-7, HCT-116 and NCI-H460).
Renal cell carcinomas (RCCs) commonly metastasize to the lungs and bones and rarely to the parathyroid, maxillary sinus, and adrenals. It is indeed very rare to have these all these metastases occurring simultaneously...
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Renal cell carcinomas (RCCs) commonly metastasize to the lungs and bones and rarely to the parathyroid, maxillary sinus, and adrenals. It is indeed very rare to have these all these metastases occurring simultaneously in an individual. We share a case of 67-year-old woman provisionally treated for parathyroid carcinoma but subsequently found to actually have metastatic RCC to the left maxillary sinus, parathyroid, lungs, and adrenals on
Purpose: There is a pressing need for safe venous thromboembolism (VTE) prophylaxis in orthopedic patients with the highest risks of both venous thrombosis and bleeding. Portable intermittent pneumatic compression dev...
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Purpose: There is a pressing need for safe venous thromboembolism (VTE) prophylaxis in orthopedic patients with the highest risks of both venous thrombosis and bleeding. Portable intermittent pneumatic compression device (IPCD) has proven to be effective and safe in patients with a high risk of venous thrombosis and low bleeding risk. Therefore, this study examined the effectiveness, safety, and wearing compliance of portable IPCD for postoperative VTE prophylaxis in patients with the highest risks of both venous thrombosis and bleeding. Methods: The cases consisted of 38 patients who had used a portable IPCD and had the highest risks of both venous thrombosis and bleeding. We examined the incidence of VTE to assess the effectiveness of the portable IPCD, the presence of hemorrhagic adverse events to assess safety, and the wearing rate to assess wearing compliance. Results: The incidences of asymptomatic and symptomatic deep vein thrombosis were 5.3% and 2.6%, respectively. The incidence of hemorrhagic adverse events was 21.1% in patients who received anticoagulants and wore an IPCD simultaneously and 0% in patients who wore an IPCD but did not receive anticoagulants. The wearing rate (i.e. >= 18 h/day) was 100%. Conclusion: Portable IPCD has the potential for safe VTE prophylaxis in patients at high risks for both venous thrombosis and bleeding. Therefore, we suggest that such patients use a portable IPCD for VTE prophylaxis.
We herein illustrate a case of benign tenosynovial giant cell tumor, which was incidentally detected as fDG-avid lesion on PET/CT in a patient with radioiodine refractory thyroid cancer, with predominantly non-iodine ...
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We herein illustrate a case of benign tenosynovial giant cell tumor, which was incidentally detected as fDG-avid lesion on PET/CT in a patient with radioiodine refractory thyroid cancer, with predominantly non-iodine concentrating disease. The lesion was followed up clinically and with local MRI annually for subsequent 3 years. The utility of hybrid PET-CT imaging, the non-iodine concentration of the tumor along with clinical knowledge, and findings on other imaging and pathological modalities in answering and diagnosing incidental benign musculoskeletal tumors in a patient with known thyroid malignancy are presented here.
Crown and root rot are among the most important wheat diseases caused by fusarium species. The aim of this study was the identification offusarium spp. isolates obtained from wheat with crown and root rot symptoms in...
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Crown and root rot are among the most important wheat diseases caused by fusarium species. The aim of this study was the identification offusarium spp. isolates obtained from wheat with crown and root rot symptoms in Yazd province of Iran, based on morphological and molecular characteristics. The ef1/ef2 and ITS4/ITS5 primers were used for molecular identification of the isolates. The results of morphological and molecular investigations revealed that among 40 isolates, 11 isolates were identified as f. equiseti, six isolates as f. pseudograminearum, five isolates as f. culmorum, five isolates as f. flocciferum, four isolates as f. acuminatum, four isolates as f. oxysporum, three isolates as f. solani and two isolates as f. proliferatum. Pathogenicity of the isolates was evaluated on wheat cultivar falat. Comparing pathogenicity of different fusarium spp. isolates on wheat seedlings revealed that the highest level of disease index was observed for f. pseudograminearum, f. culmorum, f. flocciferum and f. solani and the lowest disease severity was observed for f. equiseti. This is the first report on the identification offusarium spp., causing wheat crown and root rot in Yazd province of Iran, and on pathogenicity off. flocciferum on wheat.
Biotechnological strategies are needed to produce larger quantities of biomass and phytochemicals. In this study, callus cultures offagonia indicawere elicited with different concentrations of chemically and biologica...
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Biotechnological strategies are needed to produce larger quantities of biomass and phytochemicals. In this study, callus cultures offagonia indicawere elicited with different concentrations of chemically and biologically synthesized silver nanoparticles (chem- and bioAgNPs) to compare their effects on biomass, total phenolic content (TPC), total flavonoid content (TfC) and antioxidant activity of the extracts from callus. The results revealed that bioAgNPs being more biocompatible produced the highest biomass initially on day 10 (fW = 4.2152 +/- 0.13 g;DW = 0.18527 +/- 0.01 g) and day 20 (fW = 7.6558 +/- 0.10 g;DW = 0.3489 +/- 0.01 g) when supplemented in media as 62.5 mu g/mL and 250 mu g/mL, respectively. Initially, the highest TPC (319.32 +/- 8.28 mu g GAE/g of DW) was recorded on day 20 in chemAgNPs (31.25 mu g/mL) induced callus as compared to TPC = 302.85 +/- 3.002 mu g GAE/g of DW in bioAgNPs-induced callus. Compared to the highest values of TfC (108.15 +/- 2.10 mu g QE/g of DW) produced in 15.6 mu g/mL chemAgNPs-induced callus on day 20, TfC produced in bioAgNPs (62.5 mu g/mL) was 168.61 +/- 3.17 mu g GAE/g of DW on day 10. Similarly, chemAgNPs-induced callus (62.5 mu g/mL) showed the highest free radical scavenging activity (fRSA) i.e. 87.18% on day 20 while bioAgNPs (125 mu g/mL) showed 81.69% fRSA on day 20 compared to highest among control callus (63.98% on day 40). The highest total antioxidant capacity of chemAgNPs-(125 mu g/mL) induced callus was 330.42 +/- 13.65 mu g AAE/g of DW on day 20 compared to bioAgNPs-(62.5 mu g/mL) induced callus (312.96 +/- 1.73 mu g AAE/g of DW) on day 10. Conclusively, bioAgNPs are potent elicitors of callus cultures off. indica.
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