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Electrospinning technology controls spread of COVID-19

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MRS BULLETIN 2021年第8期46卷 670-670页

作者： Mendez-Roman, J. Arnaldo San Juan Puerto Rico

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Turning a Silk Purse into a Sow's Ear: A Speculative Note on Humay and Humayun in Philadelphia

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JOURNAL Of THE ROYAL ASIATIC SOCIETY 2022年第4期32卷 971-981页

作者： Simpson, Marianna Shreve Univ Penn Schoenberg Inst Manuscript Studies Philadelphia PA 19104 USA

The Rare Books department at the free Library of Philadelphia owns a deluxe manuscript of Sa'di's Kulliyat, originally produced in mid-sixteenth century Shiraz and substantially modified in more modern times. Among the alterations was the insertion of a copy of the famous Timurid painting "Humay and Humayun in a garden", belonging to the Musee des Arts Decoratifs, Paris. The Philadelphia version of the Paris painting was likely based on either a published reproduction or a photograph taken of the original composition when it was on view at the ground-breaking 1910 exhibition "Meisterwerke muhammedanischer Kunst" in Munich. That photographic reproductions could result in pictorial replicas reveals once again the market forces behind the great interest in, demand for, and production of classical Persian painting during the early twentieth century.

关键词： Kulliyat of Sa'di Khwaju Kirmani Humay and Humayun f R Martin free Library of Philadelphia

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A good balance between strength and ductility in Mg?Zn?Mn-Gd alloy

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INTERMETALLICS 2021年 132卷

作者： Zhao, Yang Zhang, Dingfei Xu, Junyao Zhong, Shiyu Jiang, Bin Pan, fusheng Chongqing Univ Coll Mat Sci & Engn Chongqing 400045 Peoples R China Chongqing Univ Natl Engn Res Ctr Magnesium Alloys Chongqing 400044 Peoples R China Chongqing Acad Sci & Technol Chongqing 401123 Peoples R China

Microstructure evolution, dynamic recrystallization (DRX) behavior and mechanical properties of Mg?6Zn?1MnxGd alloys (x = 0, 0.2, 1.0 and 3.0 wt%) were investigated. The results showed that the phase components of ascast Mg?6Zn?1Mn alloy were comprised of Mg7Zn3, ?-Mn and ?-Mg, while Mg3Zn6Gd (I phase) and Mg3Zn3Gd2 (W phase) were detected with the addition of Gd. Gd addition led to finer recrystallized grains, and it retarded DRX process due to the obstruction of nano-scale particles to grain boundaries. All as-extruded alloys exhibited typical basal texture, but Gd addition resulted in a low pole density of basal texture. Mg?6Zn?1Mn-3.0Gd alloy (ZMG613) exhibited a good balance between the strength and ductility with an ultimate tensile strength (UTS) of 354 MPa, yield strength (YS) of 306 MPa and elongation (EL) of 15.7%. fine grain strengthening, second phase strengthening and dislocation strengthening were mostly contributed to the achievement of high strength. And the excellent ductility was mainly ascribed to the finer grains, weak basal texture, nano-scale I phase and nonbasal slip activation.

关键词： A Mg?Zn?Mn-Gd alloys B Alloy design C Dynamic recrystallization D Microstructure E Mechanical properties f Orientation imaging microscopy

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In-vitro Renal Artery Stenting Using a Steerable Guide Wire Navigated by a Mobile Electromagnetic field

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Journal of Vascular Surgery Cases, Innovations and Techniques 2025年

作者： Christian Zielasek Jonas Lussi Silvia Viviani Vladimir Makaloski Daosos Kotelis Silvan Jungi Department of Vascular Surgery Inselspital Bern University Hospital University of Bern Bern Switzerland ETH Zurich Multi-Scale Robotics Lab Zurich Switzerland

Objective Endovascular procedures require precise guide wire control which often requires auxiliary devices. Therefore, catheterization can be time and resource intensive. A novel technology involves using a mobile external electromagnetic field to manipulate guide wires remotely, eliminating the need for additional devices. Design This experimental study evaluates the feasibility of this technology in a representative 3-D model mimicking the human vasculature, comparing it to conventional means. Methods We assessed the efficacy of a magnetically steerable guide wire (MGW) versus a conventional guide wire (CGW) in catheterizing the renal artery in a 3D silicone model of the abdominal aorta. Results A total of 20 procedures were performed, with 10 utilizing a MGW for renal artery catheterization and 10 using a CGW. Technical success was 100% for all procedures. Median procedure time was significantly shorter for MGW than for CGW (105 s vs. 181 s, p < 0.001). We observed a trend towards lower median fluoroscopic time (65 s vs 101 s, p = 0.06) and lower median fluoroscopic dose (6.84 mGycm2 vs. 10.98 mGycm2, p = 0.063) for MGW compared with CGW. Conclusion Precise control of a steerable guide wire using a mobile external electromagnetic field is technically feasible in a three-dimensional (3D) silicone-model of the human aorta. It facilitates in-vitro renal artery catheterization and stenting and reduces both procedure and fluoroscopy time. This novel technology could further improve numerous endovascular procedures.

关键词： Aortic Surgery Endovascular Surgery Magnetic Steering Basic Surgical Research Endovascular Therapy Renal Artery Stenting Aortic Aneurysm Radiation Protection 3D three-dimensional A Ampere CGW conventional guide wire eMNS electromagnetic navigation system ETH Eidgenössische Technische Hochschule (Swiss federal Institute of Technology) EUR Euro EVAR endovascular aortic repair f french Gy Gray MGW magnetically steerable guide wire mm millimetre NdfeB Neodymium-Iron-Boron s second USD United States Dollar

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The wage structure and gap between public and private sectors: an empirical study in urban China

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ECONOMIC RESEARCH-EKONOMSKA ISTRAZIVANJA 2022年第2期36卷 Article: 2106276页

作者： Li, Mingming Zhang, fumei Cent European Univ Dept Econ & Business Vienna Austria Corvinus Univ Budapest Doctoral Sch Int Relat & Polit Sci Budapest Hungary

The idea that the wage gap (W.G.) between the public sector (P.U.S.) and private sectors (P.R.S.) has widened is a point of contention among scholars, but to date, there has been no systematic discussion of changes in the W.G. and their causes in China. This article combines data from China's Urban Household Survey (U.H.S.) for 2004, 2008 and 2013 to examine changes in between-sector W.G.s and identify the causal factors by wage decomposition methods. Using ordinary least squares and a Heckman sample selection model, this study finds that public-sector workers consistently earn more than private-sector workers and that the W.G. is expanding, especially in upstream industries where state-owned enterprises (S.O.E.s) have monopoly status. In addition, the Oaxaca-Blinder (O.B.) decomposition method is adopted to reveal that the characteristic effect is the main cause of the W.G. further, the regression and decomposition of the recentered influence function show that the effect of characteristics and coefficient effects differ across wage quantiles. This article indicates that the intersectoral W.G. in China is widening mainly as a result of differences in labour endowments and provides evidence to support government decision-making.

关键词： wage structure wage gap (W G ) sector inequality Oaxaca-Blinder (O B ) decomposition recentred influence function (R I f ) decomposition

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Towards real-time process monitoring and control of physical properties of tablets using terahertz spectroscopy

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Chemical Engineering Science 2025年 316卷

作者： Moritz Anuschek Anders Nielsen Thomas Kvistgaard Vilhelmsen J. Axel Zeitler Jukka Rantanen Department of Pharmacy University of Copenhagen Copenhagen Denmark Novo Nordisk A/S CMC Oral Product Development Måløv Denmark Novo Nordisk A/S CMC Analysis and Characterisation Måløv Denmark Department of Chemical Engineering and Biotechnology University of Cambridge Cambridge UK

The modernisation of pharmaceutical manufacturing requires the implementation of process analysers for real-time assessment of both the process and product quality, as part of a process analytical technology (PAT) strategy. To meet the high standards for data integrity, it is essential that process analysers are integrated with a suitable sampling interface and workflow to ensure a reproducible sample presentation and robust data processing strategy. Terahertz time-domain spectroscopy (THz-TDS) with a reflection setup has recently been introduced as a potential process analyser for a fast assessment of tablet thickness, porosity, and mass, simultaneously. This study explores the potential of automated THz-TDS measurements, including the testing of a novel sampling interface prototype coupled with an algorithm for data treatment to select and group tablet measurements from background noise. Sampling interface and algorithm reliably presented, identified, and subsequently analysed THz-TDS signals of tablets. Comparable model errors were observed between the in-line interface and non-automated off-line manual measurements, with root mean square errors (RMSEs) of ≤ 0.012 mm, ≤ 1.23 %, ≤ 1.3 mg for tablet thickness, porosity, and mass, respectively. Additionally, the potential for off-line calibration, ongoing model maintenance of the analytical procedure, and integration within a PAT framework for monitoring and controlling tablet compression are discussed. The proposed automated tablet sampling strategy for in-line THz-TDS measurements proved to be feasible, enabling measurement speeds exceeding one tablet per second. While this strategy is specifically aimed at monitoring tablet compression, the developed algorithm is considered applicable in a broader range of automated THz-TDS measurement strategies.

关键词： A fS Reflected amplitude of the sample frontside A R Reflected amplitude of the reference mirror ALCOA Attributable, legible, contemporaneous, original, accurate API Active pharmaceutical ingredient c 1 ,c 2 , c 3 fitting parameters D Diameter d M Mahalanobis distance E max Strength of the signal maximum E min Strength of the signal minimum f nominal Nominal porosity fDA U.S. food and Drug Administration H Thickness HDf5 file Hierarchically data format version 5 file ICH International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use m Mass MCC Microcrystalline cellulose MCf Maximum compression force NIR Near infrared PAT Process analytical technology PC Principle component analysis PCA Principal components analysis R 2 Coefficient of determination RMSE Root mean squared error RTRT Real-time release testing t BS Time delay of the backside reflection t max Time of the signal maximum t min Time of the signal minimum THz-TDS Terahertz time-domain spectroscopy Φ chute Phase of the chute reflection Φ fS Phase of the frontside reflection ρ pyc Pycnometric density Terahertz time-domain spectroscopy Tablet compression Process analysis PAT Process analytical interface Tableting THz-TDS Real-time release QbD

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Being and holding responsible: Reconciling the disputants through a meaning-based Strawsonian account

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PHILOSOPHICAL STUDIES 2022年第6期179卷 1893-1913页

作者： De Mesel, Benjamin Katholieke Univ Leuven Inst Philosophy Res Polit Philosophy & Eth Leuven RIPPLE Leuven Belgium

A fundamental question in responsibility theory concerns the relation between being responsible and our practices of holding responsible. 'Strawsonians' often claim that being responsible is somehow a function of our practices of holding responsible, while others think that holding responsible depends on being responsible, and still others think of being and holding responsible as interdependent. Based on a Wittgensteinian reading of Strawson, I develop an account of the relation between being and holding responsible which respects major concerns of all parties in this debate. I characterize the way in which being responsible depends on holding responsible as genealogical, and the way in which holding responsible depends on being responsible as justificatory. I show how my account cuts across received ways of carving up the debate, and how it allows for all the kinds of fallibility about moral responsibility that are worth wanting.

关键词： Moral responsibility Being and holding responsible P f Strawson Genealogy Justification Meaning Wittgenstein Response-dependence

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Limited ventilatory reserve during exercise in HfpEf: Impact of lung size and adiposity

CHEST Pulmonary

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CHEST Pulmonary 2025年

作者： Gizem Cifci Daniel J. Brown Barry A. Borlaug Joshua R. Smith Department of Cardiovascular Medicine Mayo Clinic Rochester MN

Background Heart failure patients with preserved ejection fraction (HfpEf) exhibit a tachypneic breathing strategy during exercise. Patients with HfpEf have pulmonary system alterations that may contribute to the breathing strategy in HfpEf. Research Question Do patients with HfpEf have limited ventilatory reserve compared to controls during exercise? further, does greater upper body adiposity contribute to the lower ventilatory reserves in HfpEf? Study Design and Methods HfpEf patients (n=16; age: 70±8 yrs) and controls (n=19; age: 69±8 yrs) performed incremental cycling to volitional exhaustion. Trunk percent fat was quantified with dual-energy x-ray absorptiometry. Inspiratory capacity, inspiratory and expiratory reserve volumes, and ventilatory variables were compared between groups at rest and during exercise at 40 W and peak oxygen uptake ( V ˙ O 2 peak). Results HfpEf patients had lower total lung capacity (HfpEf: 5.4±1.1 vs. CTL: 6.4±1.2L), fVC (HfpEf: 3.1±0.7 vs. CTL: 3.8±0.6L), and fEV 1 than controls (all, p<0.04). During exercise at 40 W, HfpEf patients had higher breathing frequency as well as smaller inspiratory reserve volume (HfpEf: 1.2±0.4 vs. CTL: 1.5±0.3L) and expiratory reserve volume (HfpEf: 0.9±0.4 vs. CTL: 1.1±0.5L) than controls (both, p<0.05). At V ˙ O 2 peak, inspiratory and expiratory reserve volumes were not different between groups (both, p>0.21), but HfpEf patients had lower end inspiratory lung volume (p=0.02). HfpEf patients had higher trunk percent fat than controls (HfpEf: 49±7 vs. control: 40±8%) (p<0.01). Percent trunk fat was related to fVC (percent predicted) (r= -0.57) and tidal volume to fVC ratio during exercise at 40 W (r=0.53) for HfpEf patients (both, p<0.04), but not controls (both, p>0.72). Interpretation These findings demonstrate that patients with HfpEf have limited ventilatory reserve during exercise, in part due to their smaller lung capacity. further, our findings suggest that the greater distribution of upper body

关键词： operating lung volumes ventilatory limitation respiratory mechanics f B breathing frequency EELV end expiratory lung volume EILV end inspiratory lung volume fEV 1 forced expiratory volume in 1 second fVC forced vital capacity HfpEf heart failure with preserved ejection fraction IC inspiratory capacity TLC total lung capacity CO 2 carbon dioxide production O 2 peak peak oxygen uptake E minute ventilation V T tidal volume

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Phytochemical screening, antioxidant, and antimicrobial analysis of Portulaca oleracea seeds with in-silico molecular docking insights

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Journal of Genetic Engineering and Biotechnology 2025年第3期23卷

作者： Khursheed Ahmad Sheikh Reyaz Hassan Mir Mohammad Ovais Dar Adil farooq Wali Insha Qadir Sheeba Nazir Mohammed Iqbal Zargar Sirajunisa Talath Sathvik B. Sridhar Javedh Shareef Mubashir Hussain Masoodi Pharmaceutical Chemistry Division Department of Pharmaceutical Sciences School of Applied Sciences and Technology University of Kashmir Hazratbal Srinagar 190006 Kashmir India Pharmaceutical Chemistry School of Pharmaceutical Education and Research (SPER) Jamia Hamdard Hamdard Nagar New Delhi India Department of Pharmaceutical Chemistry M. M. College of Pharmacy Maharishi Markandeshwar (Deemed to be University) Mullana Ambala Haryana 133207 India Department of Pharmaceutical Chemistry RAK College of Pharmacy RAK Medical and Health Science University Ras Al Khaimah United Arab Emirates Pharmaceutical Biotechnology Division Department of Pharmaceutical Sciences School of Applied Sciences and Technology University of Kashmir Srinagar 190006 India Department of Clinical Pharmacy & Pharmacology RAK College of Pharmacy RAK Medical & Health Sciences University Ras Al Khaimah United Arab Emirates

Background Portulaca oleracea (PO), an annual succulent herb with global distribution, has been used medicinally since ancient times, earning the title “global panacea.” Aim This study aimed to perform phytochemical screening, antioxidant and antimicrobial analysis of PO seeds, including GCMS analysis of methanolic extract and molecular docking for antimicrobial mechanisms. Materials and Methods PO seeds underwent phytochemical screening and methanolic extract analysis via DPPH, NO radical scavenging, and reducing power assays. Antimicrobial activity was tested against bacteria and fungi, with GCMS identifying compounds. Molecular docking was conducted via Autodock vina, against targets beta-tubulin (5fNV) and ABC transporter (6J9W). Results Methanolic extract showed strong antioxidant activity (IC 50 : 125.2 µg/ml for DPPH, 402.89 µg/ml for NO) and concentration-dependent reducing power. It was highly effective against Saccharomyces cerevisiae and Hypochrea viridescens . GCMS identified colchicine, n-decanoic acid, and triepoxydecane, with colchicine showing high binding affinity to protein targets. Conclusion The methanolic extract’s potent antioxidant and antimicrobial effects, supported by colchicine’s binding affinity, validate PO’s medicinal potential, suggesting further therapeutic exploration.

关键词： GCMS Gas Chromatography-Mass Spectrometry DPPH 2,2-diphenyl-1-picrylhydrazy NO Nitric oxide RSA Radical Scavenging Activity TPC Total Phenolic Content TfC Total flavonoid Content GAE Gallic Acid Equivalent QE Quercetin Equivalent TLC Thin Layer Chromatography WHO World Health Organisation USA United States of America J&K Jammu and Kashmir GAA Glacial Acetic Acid KOH Potassium hydroxide NaOH Sodium hydroxide IP Indian Pharmacopoiea ADMET Absorption, Distribution, Metabolism, Excretion and Toxicity R f Retention factor µM Micro molar UV Ultra Violet λ max Wavelength of maximum absorbance CfU Colony forming Unit IMTECH Institute of Microbial Technology MTCC Microbial Type Culture Collection MHA Muller Hinton Agar PDA Potato Dextrose Agar NIST National Institute of Standards and Technology eV Electron Volt DMSO Dimethyl Sulphoxide rRNA Ribosomal Ribonucleic Acid tRNA Transfer Ribonucleic Acid MIC Minimum Inhibitory Concentration MBC Minimum Bactericidal Concentration Portulaca oleracea Purslane Natural compounds Antioxidant Antibacterial Antifungal antimicrobial Drug discovery DPPH Total phenolic content Total flavonoid content

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Rattling effect mechanism on the temperature stability of low-sintered Ca 1– x (Li 1/2 Eu 1/2 ) x WO 4 microwave dielectric ceramics for dielectric resonant antenna applications

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Journal of Materiomics 2025年

作者： Qingfeng Li Jie Li Ying Tang Huaicheng Xiang Di Zhou Kaixin Song Liang fang Guangxi Universities Key Laboratory of Non-ferrous Metal Oxide Electronic Functional Materials and Devices College of Materials Science and Engineering Guilin University of Technology Guilin 541004 China Key Laboratory of Multifunctional Materials and Structures Ministry of Education School of Electronic Science and Engineering Xi’an Jiaotong University Xi’an 710049 China College of Electronic Information Hangzhou Dianzi University Hangzhou 310018 China

The low dielectric constant ( ε r < 15) is the key to improving the signal transmission speed of microwave communication devices. However, the resonant frequency temperature coefficient ( τ f ) of most low- ε r microwave dielectric ceramics is usually negative. Aiming to modify the large negative τ f of scheelite CaWO 4 and explore the underlying mechanism between the structure and microwave dielectric properties, a series of Ca 1– x (Li 1/2 Eu 1/2 ) x WO 4 ( x = 0.1−1.0) (CLEWO x ) ceramics were prepared at low sintering temperatures (750−875 °C). The ε r increased from 10.46 to 18.55, and the Q × f decreased from 39,032 GHz to 7425 GHz, mainly due to the enhanced rattling effect of Li + . The τ f rapidly increased from negative (–19.91×10 −6 °C −1 ) to abnormally positive (+162.15×10 −6 °C −1 ), influenced by the reduced temperature coefficient of ion polarizability ( τ αm ) caused by the rattling Li + cation. The CLEWO 0.15 sample has good comprehensive performance ( ε r = 12.28, Q×f = 28,027 GHz, and τ f = –0.5×10 −6 °C −1 ) and compatibility with the Ag electrode, showing the potential of LTCC applications. Additionally, a dielectric resonator antenna based on CLEWO 0.15 ceramic was designed with a bandwidth of 254 MHz at 4.504−4.758 GHz and a gain of 4.87 dBi at 4.62 GHz, indicating that CLEWO 0.15 may be a potential candidate for dielectric resonator antennas.

关键词： Scheelite structure Microwave dielectric properties Rattling effect Abnormal positive τ f LTCC Dielectric resonator antenna

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