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分子植物育种 2024年

作者：韩伊曼王勤才梁程徐浩扬刘丹胡运高向珣朝西南科技大学植物分子遗传育种实验室西南科技大学水稻研究所

偏分离作为进化的重要动力影响水稻的遗传改良。本研究针对CG189R高产、综合农艺性状优但品质差的特性，将其作为母本，以优质品种‘越光’（Koshihikari）作父本构建的f2群体为材料。通过分析双亲和f2群体中SSR标记和淀粉合成相关基因... 详细信息

偏分离作为进化的重要动力影响水稻的遗传改良。本研究针对CG189R高产、综合农艺性状优但品质差的特性，将其作为母本，以优质品种‘越光’（Koshihikari）作父本构建的f2群体为材料。通过分析双亲和f2群体中SSR标记和淀粉合成相关基因标记的多态性和农艺性状，进一步解析f2群体223个单株的遗传偏分离及其对9个农艺性状的影响。结果显示16对在双亲间存在多态性的SSR标记，在f2群体中只有RM252出现分离，其余的12对标记与CG189R基因型相同，3对标记与‘越光’基因型相同。25对淀粉合成相关基因标记在双亲间存在多态性，在其f2群体中均出现偏分离，其中20对标记在该群体中未发生等位基因分离，不存在杂合带型，分离的5个PUL标记结果也远偏离理论值。所有分子标记检测结果均偏离了孟德尔遗传定律，存在对母本CG189R的遗传偏好性。f2群体9个农艺性状均偏离正态分布，一次枝梗数和结实率偏向父本‘越光’，其余性状偏向母本CG189R，千粒重和每穗实粒数偏离正态分布程度最高。农艺性状与SSR标记和淀粉合成相关基因标记的偏向性一致。从该f2偏分离群体筛选出综合农艺性状好、产量高的5个优异单株，其单株有效穗数与每穗粒数呈显著正相关，打破了二者之间的不利连锁关系，产生了优良变异，该群体可作为构建重组自交系的遗传群体或育种选择群体，以提高后代目标单株的选择效率。

关键词：水稻(Oryza sativa L.) f 群体偏分离淀粉合成相关基因标记农艺性状

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Iridoid derivatives from Vitex rotundifolia L. f. with their anti-inflammatory activity

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PHYTOCHEMISTRY 2023年第1期210卷 113649页

作者： Le, Duc Dat Han, Sanghee Yu, Jayeon Ahn, Jeongjun Kim, Chang-Kwon Lee, Mina Sunchon Natl Univ Coll Pharm 255 Jungangno Sunchon 57922 Jeonnam South Korea Sunchon Natl Univ Res Inst Life & Pharmaceut Sci 255 Jungangno Sunchon 57922 Jeonnam South Korea

Three undescribed iridoid glucosides and nine known compounds were isolated from Vitex rotundifolia L. f. Their structural elucidation was performed based on their spectroscopic data or acid hydrolysis followed by HPLC analysis and comparison of their NMR data with those reported in the literature. These iridoids were then evaluated for inflammatory effects through inhibition on NO production level in LPS-stimulated RAW264.7 cells. The active compounds, rotundifoliin C, isonishindacin A, agnuside, and eurostoside, were further investigated for their anti-inflammatory mechanisms of action on expression levels of iNOS and COX-2 proteins. In addition, V. rotundifolia fractions also significantly inhibited LPS-induced IL-8 production, with IC50 values ranging from 9.81 to 54.31 mu g/mL. Rotundifoliin A, agnuside, VR-I (10-O-vanilloyl aucubin), and eurostoside showed inhibition rates of 55.5%, 94.6%, 55.6%, and 81.9% on IL-8 production at concentrations of 100 mu M, respectively, compared to those of control without sample addition. The therapeutic properties of the plant might give rise to develop the functional products to treat inflammatory diseases.

关键词： Vitex rotundifolia L f Verbenaceae Iridoids Rotundifoliin a Rotundifoliin B Rotundifoliin C NO production IL-8 production iNOS COX-2

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绿色合成Li3Na3Ga2f12:Cr3+氟化物宽带近红外荧光材料

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激光与光电子学进展 2023年

作者：禹湘安喜梅谭巧玲刘红嘉李振彰张绍安李杨广州医科大学生物医学工程学院宁波大学信息科学与工程学院光+X交叉科学与技术研究院

近红外光源对生物组织具有穿透力强、无损检测、信噪比高等特点，广泛应用于成分检测、安防监控、生物医学、国防军工等领域。但是目前缺乏高效率、便携化的近红外光源，这成为了限制智能检测技术发展的关键。与传统的近红外光源相比，... 详细信息

近红外光源对生物组织具有穿透力强、无损检测、信噪比高等特点，广泛应用于成分检测、安防监控、生物医学、国防军工等领域。但是目前缺乏高效率、便携化的近红外光源，这成为了限制智能检测技术发展的关键。与传统的近红外光源相比，荧光粉转换的近红外LED光源（NIR pc-LED）具有便携、高效的特点。本研究采用工艺简单、绿色环保的水热法合成了Li3Na3Ga2f12:Cr3+近红外宽带荧光粉，并通过控制保温温度、保温时间等参数，确定了荧光材料的最佳合成方案，研究了氟化物颗粒尺寸、形貌演化以及Cr3+掺杂浓度对Li3Na3Ga2f12:Cr3+发光性能的影响。本Li3Na3Ga2f12:Cr3+材料能够实现630-980 nm范围宽带发射，半峰宽（fWHM）为110 nm，峰值为766 nm，其内量子效率高达74%。结合商用蓝光LED，成功封装了近红外宽带LED光源，其在50 mA驱动电流下的近红外光输出功率是10.32 mW，光电转换效率达到5.1%。最后通过鸡胸肉下的静脉NIR成像以及夜视成像演示，验证了其作为NIR宽带LED光源在医疗、军事以及食品检测等成像领域中的应用可行性。

关键词：绿色合成宽带近红外发光 Li Na Ga f :Cr LED器件

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fritillaria karakocanensis (Liliaceae), a new species of the f. crassifolia group from Anatolia (Turkey)

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NORDIC JOURNAL Of BOTANY 2023年第8期2023卷 e03903-e03903页

作者： Sonay, Veysel Teksen, Mehtap Balos, Hasan YildirimMehmet Maruf Akan, Hasan Harran Univ Fac Arts & Sci Dept Biol Haliliye Sanliurfa Turkiye Aksaray Univ Fac Sci & Literature Dept Biol Aksaray Turkiye Ege Univ Fac Sci Dept Biol Bornova Izmir Turkiye

fritillaria karakocanensis (Liliaceae) is described as a new species from Turkey. It is morphologically similar to f. michailovskyi, f. reuteri and f. rhodocanakis, but differs from f. michailovskyi mainly by its longer stem, canaliculate and narrower leaves, papillose style, and the caducous tepals, from f. reuteri by its many bulblets, canaliculate leaves, longer lower leaves, fewer flowers, and longer tepals, and from f. rhodocanakis by its longer and narrower lower leaves, longer tepals, nectaries and style, and the obovoid capsule. A detailed taxonomic description, diagnostic characters, original photographs, geographical distribution, habitat and ecology, conservation assessment, and taxonomic comments regarding the new species are given.

关键词： Elazig fritillaria michailovskyi f reuteri rhodocanakis Turkey

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Terpenoids from the roots of Chloranthus henryi Hemsl. var. hupehensis (Pamp.) K. f. Wu and their chemotaxonomic significance

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BIOCHEMICAL SYSTEMATICS AND ECOLOGY 2023年 106卷

作者： Liu, Shuai Zhang, Zi-Mo Yang, Hui Zou, Yun-He Wang, Ning Zhuang, Peng-Yu Wang, Xiao-Xia Liu, Hang North China Univ Sci & Technol Sch Pharm Tangshan 063210 Hebei Peoples R China Nanjing Univ Affiliated Drum Tower Hosp Dept Pharm Med Sch Nanjing 210008 Jiangsu Peoples R China Nanjing Med Ctr Clin Pharm Nanjing 210008 Jiangsu Peoples R China

Phytochemical research on the roots of Chloranthus henryi Hemsl. var. hupehensis (Pamp.) K. f. Wu afforded twenty-three terpenoids, including twenty-two sesquiterpenoids (1-22) and one diterpenoid (23). Their structures were identified by extensive spectroscopic analysis and comparison with literature data. Among them, six sesquiterpenoids (2, 3, 13-16) were first obtained from the family Chloranthaceae, two sesquiterpenoids (4 and 5) were first reported from the genus Chloranthus, and all the twenty-three terpenoids were isolated for the first time from the investigated plant. Moreover, the chemotaxonomic significance of constituents was also discussed.

关键词： Chloranthus henryi Hemsl var hupehensis (Pamp ) K f Wu Sesquiterpenoids Chemotaxonomy

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Vitex rotundifolia L. f. and Vitex trifolia L.: A review on their traditional medicine, phytochemistry, pharmacology

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JOURNAL Of ETHNOPHARMACOLOGY 2023年第1期308卷 116273页

作者： Yan, Chun-Xiao Wei, Ya-Wen Li, Hui Xu, Kuo Zhai, Run-Xiang Meng, De-Chuan fu, Xian-Jun Ren, Xia Shandong Univ Tradit Chinese Med Marine Tradit Chinese Med Res Ctr Jinan 250355 Peoples R China Shandong Univ Tradit Chinese Med Qingdao Acad Tradit Chinese Med Qingdao 266114 Peoples R China Qingdao Key Technol Innovat Ctr Marine Tradit Chin Qingdao 266114 Peoples R China Shandong Univ Tradit Chinese Med Qingdao Acad Tradit Chinese Med Marine Tradit Chinese Med Res Ctr 4566 HeDong Rd Qingdao 266114 Peoples R China

Ethnopharmacological relevance: Vitex rotundifolia L. f. and Vitex trifolia L. belong to the genus Vitex, and Vitex rotundifolia L. f. evolved from Vitex trifolia L. Both are essential ethnic medicinal plants with a long history, commonly used to treat headaches, fever, diarrhea, hair loss, wound recovery, and other diseases. Aim of the review: The research status of Vitex trifolia L. and its relative species Vitex rotundifolia L. f. were reviewed from the aspects of traditional medicinal use, phytochemistry, and pharmacological activities, to provide a reference for the further development and utilization of Vitex rotundifolia L. f. and Vitex trifolia L. Materials and methods: In this paper, a comprehensive search of published literature was conducted through various books and online databases to obtain relevant information on Vitex rotundifolia L. f. and Vitex trifolia L. The search terms "(Vitex rotundifolia) OR (Vitex trifolia) OR (fructus viticis)" were entered in PubMed, Web of Science, China national knowledge infrastructure (CNKI), Wanfang Data, Baidu Scholar, respectively. In addition to setting the year threshold of "2018-2022" on Baidu Scholar, other databases searched all fields and found 889, 283, 1263, 1023, and 147 articles, respectively. Among them, review, repetition, overlapping data, and other reasons were excluded, and finally, a total of 164 articles were included in the review study. Results: A total of 369 compounds have been identified, including 159 terpenoids, 51 flavonoids, 83 phenyl-propanoids, and 76 other compounds. Pharmacological studies have shown that Vitex rotundifolia L. f. and Vitex trifolia L. have a variety of pharmacological activities, such as anti-tumor, analgesic, antipyretic, anti-inflammatory, antioxidant, antibacterial, and estrogen-like activity. Modern clinical use for treating cold head-aches, diarrhea dysentery, irregular menstruation, and other diseases. Conclusions: As traditional medicinal plants, Vitex rotundifol

关键词： Vitex rotundifolia L f Vitex trifolia L Traditional medicinal Phytochemistry Pharmacological activity

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UPLC-Q-TOf-MS/MS-based urine metabolomics studies on the toxicity and detoxication of Tripterygium wilfordii Hook. f. after roasting

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JOURNAL Of PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 2023年 234卷 115573页

作者： Chen, Shu Liu, Li Jiang, Hong-Xia Sun, Qun Zhang, Liang Liu, Jian-Qun Liu, Li-fang Jiangxi Univ Chinese Med Key Lab Modern Preparat TCM Minist Educ 1688 Meiling Rd Nanchang 330004 Jiangxi Peoples R China China Pharmaceut Univ Sch Tradit Chinese Pharm Dept Chinese Med Anal State Key Lab Nat Med 24 Tongjia Lane Nanjing Peoples R China

Tripterygium wilfordii (TW), a well-known traditional Chinese medicine, was widely used in the treatment of autoimmune disorders and inflammatory diseases. However, the clinical use of TW was limited by severe tox-icities, such as hepatotoxicity and nephrotoxicity. Our previous studies indicated that roasting was an effective approach for reducing TW-induced toxicity. After roasting, celastrol was completely decomposed, partially converted into 1-hydroxy-2,5,8-trimethyl-9-fluorenone and the total alkaloids content were significantly reduced. However, the detoxication mechanisms of roasting on TW were poorly unknown. This study aimed to explore the toxicity and detoxification mechanisms of TW after roasting based on urine metabolomics. Promising biomarkers were evaluated by multiple comparison analyses. Sixteen toxicity biomarkers were identified be-tween control group and total extract group. Twelve toxicity biomarkers were identified between control group and total alkaloids group. Eight toxicity biomarkers were identified between control group and celastrol group. These metabolites were mainly involved in seven metabolic pathways, summarized as pentose and glucuronate interconversions, lipid metabolism (sphingolipid metabolism, glycerophospholipid metabolisms, fatty acid biosynthesis and steroid hormone biosynthesis) and amino acid metabolism (taurine and hypotaurine meta-bolism, tryptophan metabolism). After roasting, the toxicities of total extract, total alkaloids and celastrol were relieved by ameliorative serum parameters and pathological changes in hepatic and renal tissues which revealed that the reduction of celastrol and total alkaloids played important roles in the detoxification of roasting on TW. furthermore, roasting regulated the levels of fourteen potential biomarkers in the total extract group, ten po-tential biomarkers in the total alkaloids group and seven candidate biomarkers in the celastrol group to normal levels. Biological pathway analysis r

关键词： Tripterygium wilfordii Hook f Roasting Mechanism Toxicity Detoxication Metabolomics

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Voltage-gated sodium channels, potential targets of Tripterygium wilfordii Hook. f. to exert activity and produce toxicity

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JOURNAL Of ETHNOPHARMACOLOGY 2023年第1期311卷 116448页

作者： Xu, Yijia Li, Wenwen Wen, Ruojin Sun, Jianfang Liu, Xin Zhao, Shangfeng Zhang, Jinghai Liu, Yanfeng Zhao, Mingyi Shenyang Pharmaceut Univ Sch Life Sci & Biopharmaceut Sci Shenyang 110016 Liaoning Peoples R China

Ethnopharmacology relevance: Tripterygium wilfordii Hook. f. has been widely used in clinical practice due to its good anti-inflammatory and analgesic activities. However, its application is limited by potential toxicity and side effects. Aim of the study: The study aimed to identify the mechanisms responsible for the pharmacological activity and cardiotoxicity of the main monomers of Tripterygium wilfordii. Materials and methods: Database analysis predicted that ion channels may be potential targets of Tripterygium wilfordii. The regulatory effects of monomers (triptolide, celastrol, demethylzeylasteral, and wilforgine) on protein Nav1.5 and Nav1.7 were predicted and detected by Autodock and patch clamping. Then, we used the formalin-induced pain model and evaluated heart rate and myocardial zymograms to investigate the analgesic activity and cardiotoxicity of each monomer in vivo. Results: All four monomers were able to bind to Nav1.7 and Nav1.5 with different binding energies and subse-quently inhibited the peak currents of both Nav1.7 and Nav1.5. The monomers all exhibited analgesic effects on formalin-induced pain;therefore, we hypothesized that Nav1.7 is one of the key analgesic targets. Deme-thylzeylasteral reduced heart rate and increased the level of creatine kinase-MB, thus suggesting a potential cardiac risk;data suggested that the inhibitory effect on Nav1.5 might be an important factor underlying its cardiotoxicity. Conclusion: Our findings provide an important theoretical basis for the further screening of active monomers with higher levels of activity and lower levels of toxicity.

关键词： Tripterygium wilfordii Hook f VGSCs Analgesic activity and cardiac toxicity

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Tripterygium wilfordii Hook.f. ameliorates paraquat-induced lung injury by reducing oxidative stress and ferroptosis via Nrf2/HO-1 pathway

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ECOTOXICOLOGY AND ENVIRONMENTAL SAfETY 2023年 252卷 114575页

作者： Song, Cong-Ying feng, Meng-Xiao Li, Li Wang, Ping Lu, Xuan Lu, Yuan-Qiang Zhejiang Univ Affiliated Hosp 1 Sch Med Dept Emergency Med 79 Qingchun Rd Hangzhou 310003 Zhejiang Peoples R China Key Lab Diag & Treatment Aging & Phys Chem Injury Hangzhou 310003 Zhejiang Peoples R China

Paraquat (PQ) poisoning can induce acute lung injury and fibrosis and has an extremely high mortality rate. However, no effective treatments for PQ poisoning have been established. In this study, the potential efficacy of Tripterygium wilfordii Hook.f. (TwHf) in alleviating PQ-induced lung injury and fibrosis was investigated in a mouse model. Mice were randomly assigned to the control, PQ, PQ + TwHf1 (pretreatment before inducing poisoning), and PQ + TwHf2 (treatment after poisoning) groups. The mice in the PQ + TwHf1 group were pretreated with TwHf for 5 days before receiving one dose of PQ (120 mg/kg) and then received a daily oral gavage of the indicated dosages of TwHf until sacrifice. The mice in the PQ + TwHf2 group were treated with TwHf 2 h after PQ exposure until sacrifice. The pathological analysis and fapi PET/CT showed that treatment with TwHf attenuated lung injury. And TwHf reduced pulmonary oxidative stress, as indicated by the reduction in, malondialdehyde (MDA), glutathione (GSH), and reactive oxygen species (ROS) levels, as well as by the increase in superoxide dismutase (SOD) levels. Accordingly, the Perls DAB staining showed increased iron concentrations and western blotting revealed a decreased GPX4 expression after PQ exposure, as well as the mitigation of the overexpression of Nrf2 and HO-1 induced by PQ. In conclusion, our study demonstrated the potential of TwHf as a treatment for PQ-induced lung injury and fibrosis. The protective mechanism of this medicinal herb may involve the regulation of ferroptosis.

关键词： Paraquat Lung injury Tripterygium wilfordii Hook f ferroptosis Oxidative stress

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Is Indian sedition law colonial? J. f. Stephen and the jurisprudence on free speech

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INDIAN ECONOMIC AND SOCIAL HISTORY REVIEW 2021年第4期58卷 477-504页

作者： Kumar, Sunny Univ Delhi Dept Hist Miranda House Delhi India

This article critically evaluates the characterisation of sedition law as colonial by analysing the arguments made by J. f. Stephen in opposing such a claim. While Stephen obfuscated the close links between the sedition law and the requirements of colonial governance, he made a persuasive case for how the sedition law was completely consistent with British ideas of liberty, utility, and the rule of law. Stephen's arguments about legitimate limits to political liberties, particularly his critique of J. S. Mill in this regard, offer us an opportunity to question the presumed antithesis between colonial and metropolitan jurisprudence and trace their shared origins in British political thought. To that end, with Stephen as an interlocutor, this article critically analyses themes such as the defence of empire, colonialism, and the idea of improvement within a wider set of writings by British political philosophers, to arrive at an alternative understanding of British political liberalism. My article concludes that rather than 'colonial difference', the constitutive relation between sedition law and liberal jurisprudence better explains the prevalence of similar authoritarian laws within democratic regimes across the globe.

关键词： Sedition J f Stephen colonial law freedom of speech rule of law

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