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fluid-structure interaction simulations of patient-specific aortic dissection

BIOMECHANICS AND MODELING IN MECHANOBIOLOGY 2020年第5期19卷 1607-1628页

作者： Baeumler, Kathrin Vedula, Vijay Sailer, Anna M. Seo, Jongmin Chiu, Peter Mistelbauer, Gabriel Chan, Frandics P. Fischbein, Michael P. Marsden, Alison L. Fleischmann, Dominik Stanford Univ Dept Radiol 3D & Quantitat Imaging Lab Stanford CA 94305 USA Stanford Univ Dept Pediat Cardiol Stanford CA 94305 USA Stanford Univ Dept Cardiothorac Surg Stanford CA 94305 USA Univ Magdeburg Dept Simulat & Graph Magdeburg Germany Stanford Univ Dept Bioengn Stanford CA 94305 USA

Credible computational fluid dynamic (CFD) simulations of aortic dissection are challenging, because the defining parallel flow channels-the true and the false lumen-are separated from each other by a more or less mobile dissection membrane, which is made up of a delaminated portion of the elastic aortic wall. We present a comprehensive numerical framework for CFD simulations of aortic dissection, which captures the complex interplay between physiologic deformation, flow, pressures, and time-averaged wall shear stress (TAWSS) in a patient-specific model. Our numerical model includes (1) two-way fluid-structure interaction (FSI) to describe the dynamic deformation of the vessel wall and dissection flap;(2) prestress and (3) external tissue support of the structural domain to avoid unphysiologic dilation of the aortic wall and stretching of the dissection flap;(4) tethering of the aorta by intercostal and lumbar arteries to restrict translatory motion of the aorta;and a (5) independently defined elastic modulus for the dissection flap and the outer vessel wall to account for their different material properties. The patient-specific aortic geometry is derived from computed tomography angiography (CTA). Three-dimensional phase contrast magnetic resonance imaging (4D flow MRI) and the patient's blood pressure are used to inform physiologically realistic, patient-specific boundary conditions. Our simulations closely capture the cyclical deformation of the dissection membrane, with flow simulations in good agreement with 4D flow MRI. We demonstrate that decreasing flap stiffness from Eflap=800 kPa (a) increases the displacement of the dissection flap from 1.4 to 13.4 mm, (b) decreases the surface area of TAWSS by a factor of 2.3, (c) decreases the mean pressure difference between true lumen and false lumen by a factor of 0.63, and (d) decreases the true lumen flow rate by up to 20% in the abdominal aorta. We conclude that the mobility of the dissection flap substantially i

关键词： Aortic dissection Computational hemodynamics fluid-structure interaction Prestress Tissue support 4D flow MRI

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fluid-structure interaction Model of a Percutaneous Aortic Valve: Comparison with an In Vitro Test and Feasibility Study in a Patient-Specific Case

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ANNALS OF BIOMEDICAL ENGINEERING 2016年第2期44卷 590-603页

作者： Wu, Wei Pott, Desiree Mazza, Beniamino Sironi, Tommaso Dordoni, Elena Chiastra, Claudio Petrini, Lorenza Pennati, Giancarlo Dubini, Gabriele Steinseifer, Ulrich Sonntag, Simon Kuetting, Maximilian Migliavacca, Francesco Politecn Milan Lab Biol Struct Mech Dept Chem Mat & Chem Engn Giulio Natta Piazza Leonardo Vinci 32 I-20133 Milan Italy Rhein Westfal TH Aachen Dept Cardiovasc Engn Inst Appl Med Engn Helmholtz Inst Aachen Germany Erasmus Univ Med Ctr Dept Biomed Engn Thoraxctr Rotterdam Netherlands Politecn Milan Dept Civil & Environm Engn I-20133 Milan Italy

Transcatheter aortic valve replacement (TAVR) represents an established recent technology in a high risk patient base. To better understand TAVR performance, a fluid-structure interaction (FSI) model of a self-expandable transcatheter aortic valve was proposed. After an in vitro durability experiment was done to test the valve, the FSI model was built to reproduce the experimental test. Lastly, the FSI model was used to simulate the virtual implant and performance in a patient-specific case. Results showed that the leaflet opening area during the cycle was similar to that of the in vitro test and the difference of the maximum leaflet opening between the two methodologies was of 0.42%. Furthermore, the FSI simulation quantified the pressure and velocity fields. The computed strain amplitudes in the stent frame showed that this distribution in the patient-specific case is highly affected by the aortic root anatomy, suggesting that the in vitro tests that follow standards might not be representative of the real behavior of the percutaneous valve. The patient-specific case also compared in vivo literature data on fast opening and closing characteristics of the aortic valve during systolic ejection. FSI simulations represent useful tools in determining design errors or optimization potentials before the fabrication of aortic valve prototypes and the performance of tests.

关键词： fluid-structure interaction Valve mechanics Mathematical models Stent Transcatheter aortic valve

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fluid-structure interaction BASED ON HPC MULTICODE COUPLING

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SIAM JOURNAL ON SCIENTIFIC COMPUTING 2018年第6期40卷 C677-C703页

作者： Cajas, J. C. Houzeaux, G. Vazquez, M. Garcia, M. Casoni, E. Calmet, H. Artigues, A. Borrell, R. Lehmkuhl, O. Pastrana, D. Yanez, D. J. Pons, R. Martorell, J. Barcelona Supercomp Ctr Barcelona 08034 Spain CSIC IIIA Bellaterra 08193 Spain Vortex Bladeless Madrid 28232 Spain Univ Llull IQS Sch Engn Barcelona 08017 Spain

The fluid-structure interaction (FSI) problem has received great attention in the last few years, mainly because it is present in many physical systems, industrial applications, and almost every biological system. In the parallel computational field, outstanding advances have been achieved for the individual components of the problem, allowing, for instance, simulations around complex geometries at very high Reynolds numbers or simulations of the contraction of a beating heart. However, it is not an easy task to combine the advances of both fields, given that they have followed development paths in a rather independent way, and also because physical and numerical instabilities arise when dealing with two highly nonlinear partial differential equations. Nonetheless, in the last few years great advances in the coupled FSI field have been achieved, recognizing the most challenging problems to tackle and enabling a new generation of numerical simulations in aerodynamics, biological systems, and complex industrial devices. Keeping in mind that efficient parallel codes for the individual components already exist, this paper presents a framework to build a massively parallel FSI solver in a multicode coupling partitioned approach, with strong focus in the parallel implementation aspects and the parallel performance of the resulting application. The problem is casted in an algebraic form, and the main points of interest are the parallel environment needed to be able to transfer data among the codes, the location of the exchange surface, and the exchange of information among the parallel applications. The proposed framework has been implemented in the HPC multiphysics code Alya, and the multicode coupling is carried out running separated instances of this code. Two coupling algorithms with different acceleration schemes are revised, and three representative cases of different areas of interest showing the reach of the proposed framework are solved. Good agreement with litera

关键词： fluid-structure interaction HPC multicode coupling

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fluid-structure interaction Within Models of Patient-Specific Arteries: Computational Simulations and Experimental Validations

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IEEE REVIEWS IN BIOMEDICAL ENGINEERING 2024年 17卷 280-296页

作者： Schoenborn, Sabrina Pirola, Selene Woodruff, Maria A. Allenby, Mark C. Univ Queensland UQ Sch Chem Engn BioMimet Syst Engn BMSE Lab St Lucia Qld 4072 Australia Queensland Univ Technol QUT Fac Engn Ctr Biomed Technol Biofabricat & Tissue Morphol BTM Grp Kelvin Grove Qld 4059 Australia Imperial Coll London Inst Clin Sci Fac Med BHF Ctr Res Excellence South Kensington Campus London SW7 2AZ England Imperial Coll London Dept Chem Engn South Kensington Campus London SW7 2AZ England

Cardiovascular disease (CVD) is the leading cause of mortality worldwide and its incidence is rising due to an aging population. The development and progression of CVD is directly linked to adverse vascular hemodynamics and biomechanics, whose in-vivo measurement remains challenging but can be simulated numerically and experimentally. The ability to evaluate these parameters in patient-specific CVD cases is crucial to better predict future disease progression, risk of adverse events, and treatment efficacy. While significant progress has been made toward patient-specific hemodynamic simulations, blood vessels are often assumed to be rigid, which does not consider the compliant mechanical properties of vessels whose malfunction is implicated in disease. In an effort to simulate the biomechanics of flexible vessels, fluid-structure interaction (FSI) simulations have emerged as promising tools for the characterization of hemodynamics within patient-specific cardiovascular anatomies. Since FSI simulations combine the blood's fluid domain with the arterial structural domain, they pose novel challenges for their experimental validation. This paper reviews the scientific work related to FSI simulations for patient-specific arterial geometries and the current standard of FSI model validation including the use of compliant arterial phantoms, which offer novel potential for the experimental validation of FSI results.

关键词： Peripheral artery disease blood flow computational fluid dynamics fluid-structure interaction cardiovascular biomechanics

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fluid-structure interaction analysis of non-Darcian effects on natural convection in a porous enclosure

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INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER 2013年第1-2期58卷 382-394页

作者： Khanafer, KhaIil Univ Michigan Dept Biomed Engn Vasc Mech Lab Ann Arbor MI 48109 USA Univ Michigan Dept Surg Vasc Surg Sect Ann Arbor MI 48109 USA

Non-Darcian effects on natural convective flow and heat transfer in a square enclosure filled with a porous medium was analyzed numerically using fluid-structure interaction (FSI) model. The transport equations were solved for various pertinent parameters using a finite element formulation based on the Galerkin method of weighted residuals. Such parameters included Rayleigh number, porosity, elasticity of the flexible wall, and the effective thermal conductivity of the porous medium. Further, the fluid domain was described by an Arbitrary-Lagrangian-Eulerian (ALE) formulation that is fully coupled to the structure domain. Different flow models for porous media such as Darcy's law model and Darcy-Forchheimer model were considered in this investigation. Comparisons of isotherms, streamlines, and average Nusselt number are made between rigid and FSI models. The results of this investigation showed that Rayleigh number and the elasticity of the flexible wall had a profound effect on the shape of the flexible wall and consequently on the heat transfer enhancement within the enclosure. (C) 2012 Elsevier Ltd. All rights reserved.

关键词： Elasticity fluid-structure interaction Natural convection Non-Darcian effects

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fluid-structure interaction and multi-body contact: Application to aortic valves

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COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING 2009年第45-46期198卷 3603-3612页

作者： Astorino, Matteo Gerbeau, Jean-Frederic Pantz, Olivier Traore, Karim-Frederic INRIA Paris Rocquencourt F-78153 Le Chesnay France Ecole Polytech F-91128 Palaiseau France Univ Paris 06 Lab Jacques Louis Lions F-75252 Paris 05 France

In this article, we present a partitioned procedure for fluid-structure interaction problems in which contacts among different deformable bodies can occur. A typical situation is the movement of a thin valve (e.g. the aortic valve) immersed in an incompressible viscous fluid (e.g. the blood). In the proposed strategy the fluid and structure solvers are considered as independent "black-boxes" that exchange forces and displacements;the structure solvers are moreover not supposed to manage contact by themselves. The hypothesis of non-penetration among solid objects defines a non-convex optimization problem. To solve the latter, we use an internal approximation algorithm that is able to directly handle the cases of thin structures and self-contacts. A numerical simulation on an idealized aortic valve is finally realized with the aim of illustrating the proposed scheme. (C) 2008 Elsevier B.V. All rights reserved.

关键词： fluid-structure interaction Contact Cardiac valves

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fluid-structure interaction PROBLEMS IN BIO-fluid MECHANICS - A NUMERICAL STUDY OF THE MOTION OF AN ISOLATED PARTICLE FREELY SUSPENDED IN CHANNEL FLOW

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MEDICAL ENGINEERING & PHYSICS 1995年第8期17卷 609-617页

作者： DUBINI, G PIETRABISSA, R MONTEVECCHI, FM POLITECN MILAN DIPARTIMENTO BIOINGN I-20133 MILAN ITALY

In this paper a problem belonging to the moving boundary class is tackled with a 2-D application of computational fluid dynamics techniques. The motion of an isolated rigid particle freely suspended in an incompressible Newtonian fluid in a narrow channel is studied numerically at a low Reynolds number, yet different from zero. The actual problem consists of two coupled problems: the motion of the viscous fluid and that of the rigid particle suspended and convected with the fluid. The full Navier-Stokes equations (i.e. both transient and convective terms are included) are solved in the fluid domain by means of the finite element method while the motion of the particle is determined on the basis of a rigid act of motion. Results from simulations corresponding to differential initial positions of the particle are shown in this paper: they allow one to study the rotational motions of the particle as well as its displacements. The goal of the paper is to analyse the lateral displacement behaviour of the particle, already observed in experimental studies in microcirculation. In particular, lateral migrations are supposed to be due to inertial forces acting in the fluid around the moving particle combined with the proximity of the resting wall (wall effect). Preliminary results are in fairly good agreement with those available in the literature.

关键词： fluid-structure interaction COMPUTATIONAL fluid DYNAMICS PARTICLE SUSPENSIONS MICROCIRCULATION

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fluid-structure interaction within three-dimensional models of an idealized arterial wall

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INTERNATIONAL JOURNAL OF ENGINEERING SCIENCE 2014年第Nov.期84卷 113-126页

作者： El Baroudi, A. Razafimahery, F. Rakotomanana, L. Arts & Metiers ParisTech F-49035 Angers France Univ Rennes 1 IRMAR F-35042 Rennes France

The ascending branch of the aorta is one of the most stressed organ of the arterial system. We aim to design a biomechanical model for analysing the aorta dynamics under a shock. The model includes the aorta layers and the influence of the blood pressure. We undertake a three-dimensional modal analysis of the coupled aorta-blood system. We determine in the present work the coupled natural frequencies and the modes shapes of the system of the aorta and blood. Three models are presented in this study: three-layers model, two-layers model and one layer model. For the analytical solving a potential technique is used to obtain a general solution for an aorta domain. The finite element model is then validated by these original analytical solutions. The results from the proposed method are in good agreement with numerical solutions. (C) 2014 Elsevier Ltd. All rights reserved.

关键词： fluid-structure interaction Modal analysis Arterial wall Finite element method Multilayer

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fluid-structure interaction for a pressure driven flow

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MATHEMATICAL AND COMPUTER MODELLING 2008年第1-2期47卷 1-26页

作者： Pati, Arati Nanda Univ Houston Dept Math Houston TX 77204 USA

In this article we discuss the application of a Lagrange multiplier based fictitious domain method for the simulation of the motion of two rigid flaps in an unsteady flow generated by pressure gradients. The distributed Lagrange multiplier technique can be an important numerical tool to design a mechanical heart valve and investigate the flow around rigid flaps without assuming the motion of the flaps in advance. Here, we derive a mathematical formulation of a fluid-structure interaction model that includes the generalized Neumann boundary conditions on the upstream and downstream boundaries along with rigid flaps rotating around the fixed points. The solution method includes the finite element approximation for space and the Marchuk-Yanenko operator splitting scheme for time discretization. This study presents the numerical results obtained for flap motion for a simple sinusoidal wave. Furthermore, these simulations are extended to apply to a more complex biological system involving the systolic phase of the pulse pressure. (c) 2007 Elsevier Ltd. All rights reserved.

关键词： distributed Lagrange multiplier method Marchuk-Yanenko splitting scheme fluid-structure interaction pulse pressure

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fluid-structure interaction modeling of calcific aortic valve disease using patient-specific three-dimensional calcification scans

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MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING 2016年第11期54卷 1683-1694页

作者： Halevi, Rotem Hamdan, Ashraf Marom, Gil Lavon, Karin Ben-Zekry, Sagit Raanani, Ehud Bluestein, Danny Haj-Ali, Rami Tel Aviv Univ Sch Mech Engn Fleischman Fac Engn IL-69978 Ramat Aviv Israel Chaim Sheba Med Ctr Dept Cardiothorac Surg IL-52621 Tel Hashomer Israel Chaim Sheba Med Ctr Inst Heart Nucl Cardiol Unit IL-52621 Tel Hashomer Israel SUNY Stony Brook Dept Biomed Engn Stony Brook NY 11794 USA

Calcific aortic valve disease (CAVD) is characterized by calcification accumulation and thickening of the aortic valve cusps, leading to stenosis. The importance of fluid flow shear stress in the initiation and regulation of CAVD progression is well known and has been studied recently using fluid-structure interaction (FSI) models. While cusp calcifications are three-dimensional (3D) masses, previously published FSI models have represented them as either stiffened or thickened two-dimensional (2D) cusps. This study investigates the hemodynamic effect of these calcifications employing FSI models using 3D patient-specific calcification masses. A new reverse calcification technique (RCT) is used for modeling different stages of calcification growth based on the spatial distribution of calcification density. The RCT is applied to generate the 3D calcification deposits reconstructed from a patient-specific CT scans. Our results showed that consideration of 3D calcification deposits led to both higher fluid shear stresses and unique fluid shear stress distribution on the aortic side of the cusps that may have an impact on the calcification growth rate. However, the flow did not seem to affect the geometry of the calcification during the growth phase.

关键词： Aortic valve Calcification Stenosis fluid-structure interaction Flow Hemodynamics

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