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fluid structure interaction analysis for rupture risk assessment in patients with middle cerebral artery aneurysms

SCIENTIFIC REPORTS 2025年第1期15卷 1-14页

作者： Nagy, Jozsef Fenz, Wolfgang Thumfart, Stefan Maier, Julia Major, Zoltan Stefanits, Harald Gollwitzer, Maria Oberndorfer, Johannes Stroh, Nico Giretzlehner, Michael Sonnberger, Michael Gruber, Andreas Rauch, Philip-Rudolf Gmeiner, Matthias Eulerian Solut eU Leonfeldnerstr 245 Linz Austria RISC Software GmbH Unit Med Informat Softwarepk 32a Hagenberg Austria Johannes Kepler Univ Linz Inst Polymer Prod Engn Altenberger Str 69 Linz Austria Kepler Univ Hosp Dept Neurosurg Wagner Jauregg Weg 15 A-4020 Linz Austria Johannes Kepler Univ Linz Altenbergerstr 69 A-4040 Linz Austria Johannes Kepler Univ Linz Kepler Univ Hosp Inst Neuroradiol Linz Austria Johannes Kepler Univ Linz Clin Res Inst Neurosci Fac Med Wagner Jauregg Weg 15 A-4020 Linz Austria

Accurate rupture risk assessment is essential for optimizing treatment decisions in patients with cerebral aneurysms. While computational fluid dynamics (CFD) has provided critical insights into aneurysmal hemodynamics, most analyses focus on blood flow patterns, neglecting the biomechanical properties of the aneurysm wall. To address this limitation, we applied fluid-structure interaction (FSI) analysis, an integrative approach that simulates the dynamic interplay between hemodynamics and wall mechanics, offering a more comprehensive risk assessment. In this study, we used advanced FSI techniques to investigate the rupture risk of middle cerebral artery bifurcation (MCA) aneurysms, analyzing a cohort of 125 patients treated for a MCA aneurysm at Kepler University Hospital, Linz, Austria. Multivariate analysis identified two significant rupture predictors: High Equivalent Stress Area (HESA;p = 0.049), which quantifies stress distribution relative to the aneurysm surface, and Gaussian curvature (GLN;p = 0.031), which captures geometric complexity. We also introduce the HGD index, a novel composite metric combining HESA, GLN, and Maximum Wall Displacement, designed to enhance predictive accuracy. With a threshold of 0.075, the HGD index exhibited excellent diagnostic performance;in internal validation, 24 of 25 ruptured aneurysms surpassed this threshold, yielding a sensitivity of 0.96. In a 5-fold cross validation the reliability of results was confirmed. Our findings demonstrate that the HGD index provides superior rupture risk stratification compared to conventional single-parameter models, offering a more robust tool for the assessment of complex aneurysmal structures. Further multicenter studies are warranted to refine and validate the HGD index, advancing its potential for clinical application and improving patient outcomes.

关键词： Cerebral aneurysm Middle Cerebral Artery Rupture risk fluid-structure interaction

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fluid-structure interaction simulation for multi-body flexible morphing structures

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Chinese Journal of Aeronautics 2024年第2期37卷 137-147页

作者： Wenzhi GUO Yongtao SHUI Lu NIE Gang CHEN State Key Laboratory of Strength and Vibration for Mechanic Structures School of Aerospace EngineeringXi’an Jiaotong UniversityXi’an 710049China China Academy of Launch Vehicle Technology Beijing 100076China China Academy of Aerospace Science and Innovation Beijing 100086China Shannxi Key Laboratory of Service Environment and Control for Flight Vehicles Xi’an Jiaotong UniversityXi’an 710049China

The multi-body flexible morphing airfoil can improve the aerodynamic characteristics based on different flight missions *** researches have focused on the unsteady aerodynamic characteristics of flexible wings under passive ***,the unsteady aerodynamic characteristics with the fluid-structure interaction effects in the multi-body active actuation process of morphing airfoil deserve further *** this paper,a fluid-structure coupled simulation method for multi-body flexible morphing airfoil with active actuation subsystem was investigated,and the aerodynamic characteristics during deformation were compared with different skin flexibility,flow field environment,actuation mode and actuation *** numerical results show that for the steady aerodynamic,the skin flexibility can improve the stability *** the unsteady process,the change trend of the transient lift coefficient and pitching moment are consistent with those of the active drive characteristics,while the instantaneous lift-drag ratio coefficient is greatly affected by the driving mode and can be improved by increasing the driving duration.

关键词： fluid-structure interaction Multi-body dynamics modeling Flexible structures Aerodynamics Morphing wings

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fluid-structure interaction OF HYDRODYNAMIC DAMPER DURING THE RUSH INTO THE WATER CHANNEL

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Journal of Hydrodynamics 2008年第5期20卷 583-590页

作者： XU Qing-xin SHEN Rong-ying State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong University Shanghai 200240China

The hydrodynamic damper is a device to decrease the motion of armament carrier by use of the water resistance. When hydrodynamic damper rushes into the water channel with high velocity, it is a complicated flow phenomenon with fluid-structure interaction, free surface and moving interface. Numerical simulation using the Smoothed Particle Hydrodynamics （SPH） method coupled with the Finite Element （FE） method was successfully conducted to predict the dynamic characteristics of hydrodynamic damper. The water resistance, the pressure in the interface and the stress of structure were investigated, and the relationship among the peak of water resistance, initial velocity and actual draught was also discussed. The empirical formula was put forward to predict the water resistance. And it is found that the resistance coefficient is commonly in the range of 0.3 ≤ C ≤ 0.5, when the initial velocity is larger than 50 m/s. It can be seen that the SPH method coupled with the FE method has many obvious advantages over other numerical methods for this complicated flow problem with fluid-structure interaction.

关键词： hydrodynamic damper fluid-structure interaction Smoothed Particle Hydrodynamics (SPH) method Finite Element (FE) method

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fluid-structure interaction in Z-shaped pipe with different supports

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Acta Mechanica Sinica 2020年第2期36卷 513-523页

作者： Q.Guo J.X.Zhou X.L.Guan College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China Highway Science and Technology Research Institute Xinjiang Production and Construction Corpsürümqi 830002China

fluid-structure interaction(FSI)has a strong relation with layout of fluid delivery *** is liable to cause local ***,FSI analysis is necessary in many cases,especially for flexible pipe *** modeling consists of eight governing equations and then completely solved via the finite volume method(FVM).Friction,Poisson and joint couplings were discussed in detail to reveal the influence of a Z-shaped pipe with different supports and elbows on *** the feasibility of solving FSI by FVM was verified,the different effects of free,fixed and elastic supports on FSI in the commonly used and simplified Z-shaped pipe were further *** indicated that different support stiffness lead to various FSI *** coupling occurs at the elbow and less support is considered,then the pipe has a relatively large amplitude and complex pressure fluctuation.

关键词： fluid-structure interaction Finite volume method Z-shaped pipe Support stiffness

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fluid-structure interaction Analysis of Flexible Plate with Partitioned Coupling Method

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China Ocean Engineering 2019年第6期33卷 713-722页

作者： W.Z.,Lim R.Y.,Xiao Faculty of Computing Engineering and the Built EnvironmentBirmingham City UniversityBirminghamB47XGUnited Kingdom Department of Urban Engineering School of The Built Environment and ArchitectureLondon South Bank UniversityBorough RoadLondonSE10AAUnited Kingdom

The development and rapid usage of numerical codes for fluid-structure interaction(FSI) problems are of great relevance to researchers in many engineering fields such as civil engineering and ocean engineering. This multidisciplinary field known as FSI has been expanded to engineering fields such as offshore structures, tall slender structures and other flexible structures applications. The motivation of this paper is to investigate the numerical model of two-way coupling FSI partitioned flexible plate structure under fluid flow. The adopted partitioned method and approach utilized the advantage of the existing numerical algorithms in solving the two-way coupling fluid and structural interactions. The flexible plate was subjected to a fluid flow which causes large deformation on the fluid domain from the oscillation of the flexible plate. Both fluid and flexible plate are subjected to the interaction of load transfer within two physics by using the strong and weak coupling methods of MFS and Load Transfer Physics Environment, respectively. The oscillation and deformation results have been validated which demonstrate the reliability of both strong and weak method in resolving the two-way coupling problem in contribution of knowledge to the feasibility field study of ocean engineering and civil engineering.

关键词： fluid-structure interaction flexible plate structure two-way coupling partitioned method numerical simulation

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fluid-structure interaction analysis of mixed convection heat transfer in a lid-driven cavity with a flexible bottom wall

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INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER 2011年第17-18期54卷 3826-3836页

作者： Al-Amiri, Abdalla Khanafer, Khalil Univ Michigan Vasc Mech Lab Dept Biomed Engn Ann Arbor MI 48109 USA Univ Michigan Vasc Surg Sect Ann Arbor MI 48109 USA United Arab Emirates Univ Dept Mech Engn Al Ain U Arab Emirates

A numerical investigation of steady laminar mixed convection heat transfer in a lid driven cavity with a flexible bottom surface is analyzed. A stable thermal stratification configuration was considered by imposing a vertical temperature gradient while the vertical walls were considered to be insulated. In addition, the transport equations were solved using a finite element formulation based on the Galerkin method of weighted residuals. In essence, a fully coupled fluid-structure interaction (FSI) analysis was utilized in this investigation. Moreover, the fluid domain is described by an Arbitrary-Lagrangian-Eulerian (ALE) formulation that is fully coupled to the structure domain. Comparisons of streamlines, isotherms, bottom wall displacement and average Nusselt number were made between rigid and flexible bottom walls. The results of this investigation revealed that the elasticity of the bottom wall surface plays a significant role on the heat transfer enhancement. Furthermore, the contribution of the forced convection heat transfer to that offered by natural convection heat transfer has a profound effect on the behavior of the flexible wall as well as the momentum and energy transport processes within the cavity. This investigation paves the road for future research studies to consider flexible walls when augmentation of heat transfer is sought. (C) 2011 Elsevier Ltd. All rights reserved.

关键词： Elasticity fluid-structure interaction Lid-driven cavity Mixed convection

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fluid-structure interaction of a flapping flexible plate in quiescent fluid

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COMPUTERS & fluidS 2012年 57卷 124-137页

作者： Lee, JiSeok Shin, JaeHo Lee, SangHwan Hanyang Univ Dept Mech Engn Seoul 133791 South Korea

This paper presents the computational analysis of a fluid-structure interaction for a flapping flexible plate in quiescent fluid to investigate the effect of flexibility on the generation of propulsion that is critical for birds, insects, and micro-air vehicles with flapping wings. It is known that rotation of the flapping rigid plate or wing near the end of a translational stroke enhances propulsion. This study found that flexibility improves the efficiency of propulsion during the rotation process and creates an optimal point in the propulsion. The lattice Boltzmann method with an immersed boundary technique using a direct forcing scheme is used to simulate the fluid, while the finite element method with Euler beam elements is used to model structural deformation of the flexible plate. The direct forcing scheme of the lattice Boltzmann method was improved by introducing a participation ratio, which represents the ratio of fluid lattice points to effective interpolated points and modifies the force term for the zero-thickness plate. (C) 2011 Elsevier Ltd. All rights reserved.

关键词： fluid-structure interaction Flapping flexible plate Propulsion efficiency Lattice Boltzmann method Finite element method

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fluid-structure interaction simulations for a temperature-sensitive functionally graded hydrogel-based micro-channel

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JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND structureS 2021年第6期32卷 661-677页

作者： Ghasemkhani, Amir Mazaheri, Hashem Amiri, Arya Bu Ali Sina Univ Fac Engn Dept Mech Engn Hamadan *** Hamadan Iran Univ Tehran Coll Engn Sch Mech Engn Tehran Iran

The behavior of a temperature-sensitive micro-channel have been investigated in this study which mainly includes a functionally graded (FG) hydrogel as a sensor or an actuator. In order to achieve this goal, both fluid-structure interaction (FSI) and non-FSI simulations are conducted for hydrogel with homogeneous property distribution as well as FG hydrogels with different number of layers (2-16 layers). Moreover, this study investigates the FG hydrogel cross-linking density that obeys a general exponential form. In addition to all mentioned, the FG hydrogels are considered in both ascending and descending states with vertically and horizontally functionally graded property distributions (VFG and HFG hydrogels). Subsequently, the importance of the difference between the FG and homogenous hydrogels has been highlighted in the findings of the study. Besides, the FSI influence has a vital role in these structures especially once an FG material is utilized. According to the findings, the ascending and descending distributions of the hydrogel properties may significantly affect the micro-channel behavior, especially in horizontally graded type. This process can be done in a way that for descending distribution of HFG there exist no closing state for the micro-channel.

关键词： fluid-structure interaction numerical simulations functionally garaged hydrogel temperature-sensitive hydrogel

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fluid-structure interaction in blood flow capturing non-zero longitudinal structure displacement

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JOURNAL OF COMPUTATIONAL PHYSICS 2013年 235卷 515-541页

作者： Bukac, Martina Canic, Suncica Glowinski, Roland Tambaca, Josip Quaini, Annalisa Univ Houston Dept Math Houston TX 77204 USA Univ Paris 06 Lab Jacques Louis Lions F-75005 Paris France Univ Zagreb Dept Math Zagreb 10000 Croatia

We present a new model and a novel loosely coupled partitioned numerical scheme modeling fluid-structure interaction (FSI) in blood flow allowing non-zero longitudinal displacement. Arterial walls are modeled by a linearly viscoelastic, cylindrical Koiter shell model capturing both radial and longitudinal displacement. fluid flow is modeled by the Navier-Stokes equations for an incompressible, viscous fluid. The two are fully coupled via kinematic and dynamic coupling conditions. Our numerical scheme is based on a new modified Lie operator splitting that decouples the fluid and structure sub-problems in a way that leads to a loosely coupled scheme which is unconditionally stable. This was achieved by a clever use of the kinematic coupling condition at the fluid and structure sub-problems, leading to an implicit coupling between the fluid and structure velocities. The proposed scheme is a modification of the recently introduced "kinematically coupled scheme" for which the newly proposed modified Lie splitting significantly increases the accuracy. The performance and accuracy of the scheme were studied on a couple of instructive examples including a comparison with a monolithic scheme. It was shown that the accuracy of our scheme was comparable to that of the monolithic scheme, while our scheme retains all the main advantages of partitioned schemes, such as modularity, simple implementation, and low computational costs. (C) 2012 Elsevier Inc. All rights reserved.

关键词： fluid-structure interaction Loosely coupled scheme Blood flow

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fluid-structure interaction simulation of the brain-skull interface for acute subdural haematoma prediction

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BIOMECHANICS AND MODELING IN MECHANOBIOLOGY 2019年第1期18卷 155-173页

作者： Zhou, Zhou Li, Xiaogai Kleiven, Svein Royal Inst Technol KTH Neuron Engn Stockholm Sweden

Traumatic brain injury is a leading cause of disability and mortality. Finite element-based head models are promising tools for enhanced head injury prediction, mitigation and prevention. The reliability of such models depends heavily on adequate representation of the brain-skull interaction. Nevertheless, the brain-skull interface has been largely simplified in previous three-dimensional head models without accounting for the fluid behaviour of the cerebrospinal fluid (CSF) and its mechanical interaction with the brain and skull. In this study, the brain-skull interface in a previously developed head model is modified as a fluid-structure interaction (FSI) approach, in which the CSF is treated on a moving mesh using an arbitrary Lagrangian-Eulerian multi-material formulation and the brain on a deformable mesh using a Lagrangian formulation. The modified model is validated against brain-skull relative displacement and intracranial pressure responses and subsequently imposed to an experimentally determined loading known to cause acute subdural haematoma (ASDH). Compared to the original model, the modified model achieves an improved validation performance in terms of brain-skull relative motion and is able to predict the occurrence of ASDH more accurately, indicating the superiority of the FSI approach for brain-skull interface modelling. The introduction of the FSI approach to represent the fluid behaviour of the CSF and its interaction with the brain and skull is crucial for more accurate head injury predictions.

关键词： Traumatic brain injury Brain-skull interface fluid-structure interaction Arbitrary Lagrangian-Eulerian Finite element analysis

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