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IEEE International Ultrasonics Symposium (IEEE IUS)

作者： Manuel, Thomas J. Singh, Aparna Kusunose, Jiro Hawkes, Adrienne Rodriguez, William Dawant, Benoit M. Caskey, Charles F. Vanderbilt Univ Dept Biomed Engn Nashville TN 37235 USA Vanderbilt Univ Med Ctr Dept Radiol Nashville TN 37232 USA Vanderbilt Univ Inst Imaging Sci 221 Kirkland Hall Nashville TN 37235 USA Vanderbilt Inst Surg & Engn Nashville TN USA Vanderbilt Univ Dept Elect & Comp Engn 221 Kirkland Hall Nashville TN 37235 USA

ISBN: (纸本)9780738112091

Accurate targeting is paramount for transcranial ultrasound procedures. Here we describe a new method for targeting transcranial ultrasound dubbed acoustic signature which uses acoustic feedback from a target's unique reflection patterns to guide the transducer to a previously defined orientation. We characterize the uniqueness and convergence of acoustic signatures on a macaque head phantom. We demonstrate submillimeter targeting accuracy using acoustic signature feedback with two transcranial ultrasound mechanical systems. This method provides an accurate and repeatable method for therapeutic transducer array placement.

关键词： transcranial targeting guidance therapeutic ultrasound focused ultrasound

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Insights on identifying potential types of guidance for supporting student inquiry when using virtual and remote labs in science

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ETR&D-EDUCATIONAL TECHNOLOGY RESEARCH AND DEVELOPMENT 2021年第1期69卷 239-242页

作者： Gamor, Keysha I. KG2 Consulting 8300 Greensboro DrSTE L1-165 Mclean VA 22102 USA

This paper is in response to the literature review entitled "Identifying potential types of guidance for supporting student inquiry when using virtual and remote labs in science: a literature review" [Zacharia et al., Educational Technology Research and Development, 63, 257-302 (2015). ] and examines it from a value-add perspective. This literature review illuminates the benefits of leveraging the appropriate types of guidance during the relevant phases of inquiry, a much-needed type of guidance, as it aptly describes how and when to apply the types of guidance for optimal effect. In consideration of some of the weaknesses in the body of literature, as exposed via this literature review, revisiting automated guidance and leveraging any new technological affordances and awareness around adaptive feedback may provide additional insights into how more advanced technologies might contribute to enhanced guidance in computer supported inquiry learning environments.

关键词： guidance Computer supported learning Inquiry Process constraints Performance dashboard Prompts Heuristics Scaffolds Direct presentation of information Automated guidance Automated tutoring Adaptive feedback

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Wall-following searching or area coverage searching? Simulation study of the panic evacuation considering the guidance of a single rescuer

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PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS 2022年第0期603卷

作者： Wang, Guanning Chen, Tao Hu, Xiangmin Zheng, Huijie Jiang, Wenyu Tsinghua Univ Inst Publ Safety Res Dept Engn Phys Beijing 100084 Peoples R China Anhui Prov Key Lab Human Safety Hefei 230601 Anhui Peoples R China

The guidance strategy for a single rescuer plays a vital role in evacuation management which has yet to be thoroughly studied. Hence, one factor of panic evacuation involving the guidance of a single rescuer is investigated by an extended cellular automaton (CA) model in this paper. The effects of the global panic factor, the hazard position and the environmental familiarity on pedestrians' evacuation under different guidance strategies are discussed. The analysis of simulation results demonstrates that the panic makes a great impact on the pedestrians' evacuation process and their sensitivity to hazards increases consequently. When pedestrians' panic degree is relatively high, a wall-following searching (WFS) strategy should be adopted by a rescuer, otherwise an area coverage searching (ACS) strategy is a good choice. In addition, the position of the hazard hitting in the room significantly affects the pedestrians' panic evacuation process. When the hazard position is closer to the exit, the evacuation time lengthens without a rescuer present. Both ACS strategy and WFS strategy are helpful to increase the evacuation efficiency wherever the hazard is located, and WFS strategy works better. Furthermore, the pedestrians' environmental familiarity has a greater impact on their evacuation process. The better the environmental familiarity, the faster the pedestrian flow rate is. In the early stage of evacuation, the pedestrian flow rate is higher under the ACS strategy, while in the later period, the rate is higher under WFS strategy. For the entire stage of the evacuation, WFS strategy is always more useful than ACS strategy whether evacuees are familiar with the room or not. The study contributes to understanding the importance of the guidance strategy in pedestrians' evacuation and to developing an efficient evacuation strategy for evacuation management.(c) 2022 Published by Elsevier B.V.

关键词： Hazard Panic contagion guidance Cellular automaton Evacuation

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Systematic review and critical appraisal of guidance documents for extracorporeal membrane oxygenation

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BRITISH JOURNAL OF ANAESTHESIA 2023年第6期130卷 E466-E468页

作者： Liang, Hanwen Ye, Weiyan Xu, Yonghao Kong, Xuetao Liang, Zhenting Jiang, Mei Guangzhou Med Univ Guangzhou Inst Resp Hlth Natl Clin Res Ctr Resp Dis State Key Lab Resp DisAffiliated Hosp 1 Guangzhou Guangdong Peoples R China Guangzhou Blood Ctr Guangzhou Guangdong Peoples R China Guangzhou Med Univ Dept Intens Care Unit Affiliated Hosp 1 Guangzhou Guangdong Peoples R China

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Experimental study on evacuation behavior with guidance under high and low urgency conditions

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SAFETY SCIENCE 2022年第0期154卷

作者： Zhang, Ping Yang, Lizhong Lo, Siuming Wang, Dong Li, Maoyu Jiang, Jiajia Jiang, Nan Univ Sci & Technol China State Key Lab Fire Sci Hefei 230026 Peoples R China City Univ Hong Kong Dept Architecture & Civil Engn Hong Kong Peoples R China

In emergencies, guides play a significant role for evacuees who are unfamiliar with the environment. Proper guidance can improve evacuation efficiency, and the position of guidance is particularly important. However, most studies are focused on the simulation model to explore the optimal guidance position and the experiments are less conducted. In addition, the pedestrians' behaviors under emergency conditions are usually different from those in normal conditions. In this work, several controlled experiments were conducted to study the effect of guidance positions and stress levels on evacuation efficiency and pedestrians' behavior. The results show that the pedestrians have a better evacuation performance with guidance under high-stress conditions. Compared with the low-stress level, the pedestrians under the high-stress level evacuate faster and the flow is more continuous. The pedestrians under the high-stress level take longer to make decisions when the exit is unknown but show larger competitiveness when the goal is clear. Besides, guidance can improve evacuation efficiency due to providing exit information to pedestrians. It also reveals that guidance mainly influences the pedestrians who are located nearby and has the greatest effect on helping those far from the exit. These findings can provide empirical data about the effect of guidance on emergency evacuation and further the understanding of pedestrian behaviors in high-stress conditions, which are valuable for crowd management.

关键词： Pedestrian evacuation guidance Stress levels Controlled experiments

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Providing guidance in computer-supported inquiry environments: a research perspective

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ETR&D-EDUCATIONAL TECHNOLOGY RESEARCH AND DEVELOPMENT 2021年第1期69卷 243-247页

作者： Hoffman, Daniel L. Univ Hawaii Manoa Learning Design & Technol 1776 Univ Ave Honolulu HI 96822 USA

This paper is in response to the article entitled, "Identifying Potential Types of guidance for Supporting Student Inquiry When Using Virtual and Remote Labs in Science: A Literature Review" (Zacharia et al. in Educ Technol Res Dev 63(2):257-302, 2015). After a brief recap of the original study, this paper examines the impact of Zacharia et al.'s (2015) two-dimensional system for categorizing guidance tools in inquiry learning contexts. It suggests a number of ways researchers can apply the existing categorization system to advance the field's understanding of how to support student inquiry within digital environments. The paper addresses some limitations of the original study-such as the need to include learner perspectives when evaluating guidance tools-and ends with suggestions for future research on when and how to study guidance mechanisms in computer-supported environments.

关键词： guidance Computer supported learning Inquiry Scaffolds Science

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guidance Subsystem of the Solar Telescope with a Field of View Smaller than the Angular Size of the Solar Disk

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OPTOELECTRONICS INSTRUMENTATION AND DATA PROCESSING 2020年第3期56卷 288-296页

作者： Kotov, V. N. Lubkov, A. A. Popov, Yu A. Russian Acad Sci Inst Automat & Electrometry Siberian Branch Novosibirsk 630090 Russia

The article analyzes the method of pointing a high-spatial-resolution solar telescope with an angular field of view smaller than the angular size of the solar disk using an auxiliary guide telescope with the field of view covering the entire disk of the Sun and its surroundings. The requirements for the resolution of the telescope, pointing modes, and the structural diagram of the pointing are considered.

关键词： guidance solar telescope field of view target acquisition

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guidance from the Scientific and Standardization Committee for lupus anticoagulant/antiphospholipid antibodies of the International Society on Thrombosis and Haemostasis Update of the guidelines for lupus anticoagulant detection and interpretation

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JOURNAL OF THROMBOSIS AND HAEMOSTASIS 2020年第11期18卷 2828-2839页

作者： Devreese, Katrien M. J. de Groot, Philip G. de Laat, Bas Erkan, Doruk Favaloro, Emmanuel J. Mackie, Ian Martinuzzo, Marta Ortel, Thomas L. Pengo, Vittorio Rand, Jacob H. Tripodi, Armando Wahl, Denis Cohen, Hannah Ghent Univ Hosp Dept Lab Med Coagulat Lab Ghent Belgium Univ Ghent Dept Diagnost Sci Ghent Belgium Maastricht Univ Med Ctr Synapse Res Inst Maastricht Netherlands Weill Cornell Med Hosp Special Surg Barbara Volcker Ctr Women & Rheumat Dis New York NY USA Westmead Hosp NSW Hlth Pathol Inst Clin Pathol & Med Res ICPMR Dept HaematolSydney Ctr Thrombosis Westmead NSW Australia Westmead Hosp NSW Hlth Pathol Inst Clin Pathol & Med Res ICPMR Dept HaematolSydney Ctr Haemostasis Westmead NSW Australia UCL Dept Res Haematol Haemostasis Res Unit London England Inst Univ Hosp Italiano Dept Bioquim Aplicada Lab Cent Hosp Italiano Buenos Aires Buenos Aires DF Argentina Duke Univ Med Ctr Dept Med Div Hematol Durham NC 27710 USA Duke Univ Med Ctr Dept Pathol Durham NC 27710 USA Univ Padua Dept Cardiothorac Vasc Sci & Publ Hlth Padua Italy Cornell Univ Weill Cornell Med Coll Dept Pathol & Lab Med New York NY 10021 USA IRCCS Ca Granda Maggiore Policlin Hosp Fdn Angelo Bianchi Bonomi Hemophilia & Thrombosis Ctr Milan Italy Fdn Luigi Villa Milan Italy Nancy Univ Hosp Vasc Med Div Nancy France Nancy Univ Hosp Competence Ctr Rare Vasc & Syst Autoimmune Dis Nancy France Univ Lorraine UMRS 1116 INSERM Nancy France UCL Dept Haematol Haemostasis Res Unit London England Univ Coll London Hosp NHS Fdn Trust Dept Haematol London England

This guidance focuses on methodological aspects of lupus anticoagulant (LA) testing, as well as interpretation of results for clinicians. The main changes in how to test for LA compared with the International Society on Thrombosis and Haemostasis Scientific and Standardization Committee 2009 guidelines, in the preanalytical phase are more detailed recommendations on how to handle testing in anticoagulated patients, and the timing of testing. Also, routine coagulation tests are advised to obtain more information on the coagulation background of the patient, and when necessary, anti-Xa activity measurement for heparins or specific assays for direct oral anticoagulants should be performed. The three-step procedure with two test systems (diluted Russell's viper venom time and activated partial thromboplastin time [aPTT]) is essentially not changed. Silica remains the preferable activator in the aPTT assays, but ellagic acid is not excluded. We advise simultaneous performance of the mixing and confirmatory step, in each sample with a prolonged screening test. The confirmatory step can also be performed on a mixture of patient plasma and normal pooled plasma. Cutoff values should be established in-house on at least 120 normals, with transference of the manufacturer's cutoffs as an alternative. Reporting of results has not been changed, although more attention is focused on what clinicians should know. Patient selection for LA testing has been expanded.

关键词： antiphospholipid syndrome confirmatory testing cut‐ off values guidance laboratory diagnosis lupus anticoagulant pre‐ analytical

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Cooperative formation control of multiple aerial vehicles based on guidance route in a complex task environment

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Chinese Journal of Aeronautics 2020年第2期33卷 701-720页

作者： Guibin SUN Rui ZHOU Kun XU Zhi WENG Yuhang ZHANG Zhuoning DONG Yingxun WANG School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100083China State Key Laboratory of Software Development Environment Beihang UniversityBeijing 100083China College of Electronic Information Engineering Inner Mongolia UniversityHohhot 010021China

In recent years,formation control of multi-agent has been a significant research subject in the field of cooperative ***,previous works have mainly concentrated on formation control for simple point-mass model and linear *** contrast,this paper presents a novel cooperative algorithm for multiple air vehicles formation control,which aims to devise a control strategy based on guidance route to achieve precisely coordinated formation control for a group of fixed-wing aircraft in a complex task *** proposed method introduces the leader-follower structure for effective organization of the multi-agent ***,the Partial Integrated Formation and Control(PIFC)is adopted to design the control law for guidance-Route based Formation Control(GRFC).Additionally,the proposed approach designs two guidance-route generation strategies for two special situations to demonstrate the effectiveness of GRFC in complex task *** analysis reveals that the proposed control protocol for guidance command can ensure the overall stability and tracking accuracy of the *** simulations are performed to illustrate the theoretical results,and verify that the proposed approach can achieve coordinated formation control precisely in a complex task environment.

关键词： Complex task environments Cooperative formation control Fixed-wing aircraft guidance route Leader-follower structure Partial integrated formation and control

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Can we use existing guidance to support the development of robust real-world evidence for health technology assessment/payer decision-making?

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INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE 2022年第1期38卷 e79-e79页

作者： Capkun, Gorana Corry, Sorcha Dowling, Oonagh Kolaei, Fatemeh Asad Zadeh Vosta Takyar, Shweta Furtado, Claudia Jonsson, Pall Kleinermans, Diane Lambert, Laurie Schiel, Anja Facey, Karen Novartis Pharmaceut Basel Switzerland Novartis Oncol E Hanover NJ USA INFARMED HTA Div Lisbon Portugal Univ Nova Lisboa Natl Sch Publ Hlth Lisbon Portugal NICE Data & Real World Evidence London England INAMI Drugs Reimbursement Brussels Belgium CADTH Ottawa ON Canada NoMA Regulatory & Pharmacoecon Stat Oslo Norway FIPRA Brussels Belgium Univ Edinburgh Usher Inst Edinburgh Midlothian Scotland

Advances in the digitization of health systems and expedited regulatory approvals of innovative treatments have led to increased potential for the use of real-world data (RWD) to generate real-world evidence (RWE) to complement evidence from clinical trials. However, health technology assessment (HTA) bodies and payers have concerns about the ability to generate RWE of sufficient quality to be pivotal evidence of relative treatment effectiveness. Consequently, there is a growing need for HTA bodies and payers to develop guidance for the industry and other stakeholders about the use of RWD/RWE to support access, reimbursement, and pricing. We therefore sought to (i) understand barriers to the use of RWD/RWE by HTA bodies and payers;(ii) review potential solutions in the form of published guidance;and (iii) review findings with selected HTA/payer bodies. Four themes considered key to shaping the generation of robust RWE for HTA bodies and payers were identified as: (i) data (availability, governance, and quality);(ii) methodology (design and analytics);(iii) trust (transparency and reproducibility);and (iv) policy and partnerships. A range of guidance documents were found from trusted sources that could address these themes. These were discussed with HTA experts. This commentary summarizes the potential guidance solutions available to help resolve issues faced by HTA decision-makers in the adoption of RWD/RWE. It shows that there is alignment among stakeholders about the areas that need improvement in the development of RWE and that the key priority to move forward is better collaboration to make data usable for multiple purposes.

关键词： real-world data real-world evidence guidance health technology assessment payers

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